UniProtKB - P22289 (QCR9_YEAST)
Cytochrome b-c1 complex subunit 9, mitochondrial
QCR9
Functioni
Miscellaneous
GO - Biological processi
- aerobic respiration Source: SGD
- mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
- mitochondrial respiratory chain complex III assembly Source: SGD
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-611105, Respiratory electron transport |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 9, mitochondrialAlternative name(s): Complex III subunit 9 Complex III subunit X Cytochrome c1 non-heme 7.3 kDa protein Ubiquinol-cytochrome c oxidoreductase subunit 9 Ubiquinol-cytochrome c reductase 7.3 kDa protein |
Gene namesi | Name:QCR9 Synonyms:UCR9 Ordered Locus Names:YGR183C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YGR183C |
SGDi | S000003415, QCR9 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 2 Publications; Single-pass membrane protein 2 Publications
Mitochondrion
- mitochondrial respiratory chain complex III Source: SGD
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 17 | Mitochondrial matrix2 PublicationsAdd BLAST | 16 | |
Transmembranei | 18 – 43 | Helical2 PublicationsAdd BLAST | 26 | |
Topological domaini | 44 – 66 | Mitochondrial intermembrane2 PublicationsAdd BLAST | 23 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000193558 | 2 – 66 | Cytochrome b-c1 complex subunit 9, mitochondrialAdd BLAST | 65 |
Proteomic databases
MaxQBi | P22289 |
PaxDbi | P22289 |
PRIDEi | P22289 |
TopDownProteomicsi | P22289 |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III2IV and III2IV2) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
Interacts with the transmembrane segment of RIP1 (PubMed:30598556).
7 PublicationsProtein-protein interaction databases
BioGRIDi | 33435, 317 interactors |
ComplexPortali | CPX-567, Mitochondrial electron transport complex III |
IntActi | P22289, 6 interactors |
MINTi | P22289 |
STRINGi | 4932.YGR183C |
Miscellaneous databases
RNActi | P22289, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P22289 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P22289 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3494, Eukaryota |
HOGENOMi | CLU_171977_1_0_1 |
InParanoidi | P22289 |
OMAi | ANAGMQW |
Family and domain databases
Gene3Di | 1.20.5.260, 1 hit |
InterProi | View protein in InterPro IPR008027, QCR9 IPR036656, QCR9_sf |
PANTHERi | PTHR12980, PTHR12980, 1 hit |
Pfami | View protein in Pfam PF05365, UCR_UQCRX_QCR9, 1 hit |
SUPFAMi | SSF81514, SSF81514, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSFSSLYKTF FKRNAVFVGT IFAGAFVFQT VFDTAITSWY ENHNKGKLWK
60
DVKARIAAGD GDDDDE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59797 Genomic DNA Translation: AAA63575.1 Z72968 Genomic DNA Translation: CAA97209.1 BK006941 Genomic DNA Translation: DAA08277.1 |
PIRi | A38325 |
RefSeqi | NP_011699.1, NM_001181312.1 |
Genome annotation databases
EnsemblFungii | YGR183C_mRNA; YGR183C; YGR183C |
GeneIDi | 853095 |
KEGGi | sce:YGR183C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59797 Genomic DNA Translation: AAA63575.1 Z72968 Genomic DNA Translation: CAA97209.1 BK006941 Genomic DNA Translation: DAA08277.1 |
PIRi | A38325 |
RefSeqi | NP_011699.1, NM_001181312.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EZV | X-ray | 2.30 | I | 4-58 | [»] | |
1KB9 | X-ray | 2.30 | I | 4-58 | [»] | |
1KYO | X-ray | 2.97 | I/T | 2-58 | [»] | |
1P84 | X-ray | 2.50 | I | 4-58 | [»] | |
2IBZ | X-ray | 2.30 | I | 1-66 | [»] | |
3CX5 | X-ray | 1.90 | I/T | 2-66 | [»] | |
3CXH | X-ray | 2.50 | I/T | 2-66 | [»] | |
4PD4 | X-ray | 3.04 | I | 2-58 | [»] | |
6GIQ | electron microscopy | 3.23 | I/T | 1-66 | [»] | |
6HU9 | electron microscopy | 3.35 | I/T | 1-66 | [»] | |
6T0B | electron microscopy | 2.80 | I/T | 1-66 | [»] | |
6T15 | electron microscopy | 3.29 | I/T | 1-66 | [»] | |
SMRi | P22289 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33435, 317 interactors |
ComplexPortali | CPX-567, Mitochondrial electron transport complex III |
IntActi | P22289, 6 interactors |
MINTi | P22289 |
STRINGi | 4932.YGR183C |
Proteomic databases
MaxQBi | P22289 |
PaxDbi | P22289 |
PRIDEi | P22289 |
TopDownProteomicsi | P22289 |
Genome annotation databases
EnsemblFungii | YGR183C_mRNA; YGR183C; YGR183C |
GeneIDi | 853095 |
KEGGi | sce:YGR183C |
Organism-specific databases
EuPathDBi | FungiDB:YGR183C |
SGDi | S000003415, QCR9 |
Phylogenomic databases
eggNOGi | KOG3494, Eukaryota |
HOGENOMi | CLU_171977_1_0_1 |
InParanoidi | P22289 |
OMAi | ANAGMQW |
Enzyme and pathway databases
Reactomei | R-SCE-611105, Respiratory electron transport |
Miscellaneous databases
EvolutionaryTracei | P22289 |
PROi | PR:P22289 |
RNActi | P22289, protein |
Family and domain databases
Gene3Di | 1.20.5.260, 1 hit |
InterProi | View protein in InterPro IPR008027, QCR9 IPR036656, QCR9_sf |
PANTHERi | PTHR12980, PTHR12980, 1 hit |
Pfami | View protein in Pfam PF05365, UCR_UQCRX_QCR9, 1 hit |
SUPFAMi | SSF81514, SSF81514, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR9_YEAST | |
Accessioni | P22289Primary (citable) accession number: P22289 Secondary accession number(s): D6VUW6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names