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Protein

Ras-like protein 2

Gene

RAS2

Organism
Mucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Activity regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi65 – 69GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein 2
Gene namesi
Name:RAS2
OrganismiMucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
Taxonomic identifieri29924 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMucoromycotaMucoromycotinaMucoromycetesMucoralesMucorineaeMucoraceaeMucor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826801 – 195Ras-like protein 2Add BLAST195
PropeptideiPRO_0000281323196 – 198Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei195Cysteine methyl esterBy similarity1
Lipidationi195S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Expressioni

Developmental stagei

No transcripts for RAS2 were detected in any developmental stage.

Structurei

3D structure databases

ProteinModelPortaliP22279
SMRiP22279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionCurated9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22279-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTKGAAFLK EYKIVMVGDG GVGKSAMTIQ FIQSTFVDEY DPTIEDSYRK
60 70 80 90 100
QCLIDSECAM LDILDTAGQE EYSAMRERFM RNGEGFVLIY SITSYHTFEQ
110 120 130 140 150
VQKLHEQIAR VKDLEHFPMV LVGNKCDLEQ DRQVPTSAGR DLAKQYNCQF
160 170 180 190
FEASAKQNVR IQDAFHGLVR EIRRSQQEKC KKQKQYDEKQ ASLCCIVM
Length:198
Mass (Da):22,782
Last modified:February 1, 1996 - v2
Checksum:i60BF7EDA4B679352
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55176 Genomic DNA Translation: AAA83994.1
PIRiB36365

Similar proteinsi

Entry informationi

Entry nameiRAS2_MUCCL
AccessioniPrimary (citable) accession number: P22279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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