UniProtKB - P22272 (IL6RA_MOUSE)
Interleukin-6 receptor subunit alpha
Il6ra
Functioni
Activity regulationi
GO - Molecular functioni
- ciliary neurotrophic factor binding Source: MGI
- ciliary neurotrophic factor receptor activity Source: Ensembl
- cytokine binding Source: GO_Central
- cytokine receptor activity Source: GO_Central
- enzyme binding Source: MGI
- interleukin-11 binding Source: GO_Central
- interleukin-11 receptor activity Source: GO_Central
- interleukin-6 binding Source: MGI
- interleukin-6 receptor activity Source: UniProtKB
- interleukin-6 receptor binding Source: Ensembl
- protein homodimerization activity Source: MGI
GO - Biological processi
- ciliary neurotrophic factor-mediated signaling pathway Source: MGI
- cytokine-mediated signaling pathway Source: MGI
- developmental growth Source: MGI
- endocrine pancreas development Source: MGI
- interleukin-6-mediated signaling pathway Source: UniProtKB
- negative regulation of collagen biosynthetic process Source: MGI
- positive regulation of activation of Janus kinase activity Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of chemokine production Source: MGI
- positive regulation of glomerular mesangial cell proliferation Source: MGI
- positive regulation of interleukin-6 production Source: MGI
- positive regulation of MAPK cascade Source: MGI
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of smooth muscle cell proliferation Source: MGI
- positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
- response to cytokine Source: MGI
- T-helper 17 cell lineage commitment Source: UniProtKB
- vascular endothelial growth factor production Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
Reactomei | R-MMU-1059683, Interleukin-6 signaling R-MMU-110056, MAPK3 (ERK1) activation R-MMU-112411, MAPK1 (ERK2) activation |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-6 receptor subunit alphaCuratedShort name: IL-6 receptor subunit alpha Short name: IL-6R subunit alpha Short name: IL-6R-alpha Short name: IL-6RA Alternative name(s): IL-6R 1 CD_antigen: CD126 Cleaved into the following chain: |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105304, Il6ra |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: MGI
Plasma Membrane
- apical plasma membrane Source: MGI
- ciliary neurotrophic factor receptor complex Source: MGI
- external side of plasma membrane Source: GO_Central
- interleukin-6 receptor complex Source: UniProtKB
- neuronal cell body membrane Source: MGI
Other locations
- cell surface Source: MGI
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 364 | ExtracellularSequence analysisAdd BLAST | 345 | |
Transmembranei | 365 – 385 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 386 – 460 | CytoplasmicSequence analysisAdd BLAST | 75 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Add BLAST | 19 | |
ChainiPRO_0000010896 | 20 – 460 | Interleukin-6 receptor subunit alphaAdd BLAST | 441 | |
ChainiPRO_0000450731 | 20 – 354 | Soluble interleukin-6 receptor subunit alphaBy similarityAdd BLAST | 335 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 ↔ 190 | PROSITE-ProRule annotation | ||
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 47 ↔ 92 | PROSITE-ProRule annotation | ||
Glycosylationi | 55 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Disulfide bondi | 117 ↔ 128 | PROSITE-ProRule annotation | ||
Glycosylationi | 150 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 162 ↔ 173 | PROSITE-ProRule annotation | ||
Glycosylationi | 218 | N-linked (GlcNAc...) asparagineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 354 – 355 | Cleavage; by ADAM10 and ADAM17By similarity | 2 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | P22272 |
PaxDbi | P22272 |
PRIDEi | P22272 |
PTM databases
GlyGeni | P22272, 3 sites |
PhosphoSitePlusi | P22272 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000027947, Expressed in islet of Langerhans and 170 other tissues |
Genevisiblei | P22272, MM |
Interactioni
Subunit structurei
Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6 to associate with the signaling subunit IL6ST (PubMed:28265003).
Interacts (via N-terminal ectodomain) with SORL1; this interaction may affect IL6-binding to IL6R, hence decrease IL6 'classic-signaling' (PubMed:28265003).
1 PublicationAlso interacts with SORL1; this interaction leads to soluble IL6R internalization. May form a trimeric complex with the soluble SORL1 ectodomain and circulating IL6 receptor; this interaction might stabilize circulating IL6, hence promote IL6 'trans-signaling'.
By similarityGO - Molecular functioni
- ciliary neurotrophic factor binding Source: MGI
- cytokine binding Source: GO_Central
- enzyme binding Source: MGI
- interleukin-11 binding Source: GO_Central
- interleukin-6 binding Source: MGI
- interleukin-6 receptor binding Source: Ensembl
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
IntActi | P22272, 1 interactor |
STRINGi | 10090.ENSMUSP00000029559 |
Miscellaneous databases
RNActi | P22272, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 116 | Ig-like C2-typeAdd BLAST | 97 | |
Domaini | 109 – 214 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 215 – 313 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 99 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 300 – 304 | WSXWS motif | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 404 – 408 | Poly-Pro | 5 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RY0M, Eukaryota |
GeneTreei | ENSGT00940000161919 |
HOGENOMi | CLU_051451_0_0_1 |
InParanoidi | P22272 |
OrthoDBi | 783799at2759 |
PhylomeDBi | P22272 |
TreeFami | TF331210 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003530, Hematopoietin_rcpt_L_F3_CS IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR015321, TypeI_recpt_CBD |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF09240, IL6Ra-bind, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01354, HEMATOPO_REC_L_F3, 1 hit PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK
60 70 80 90 100
EAAGNVTIHW VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG
110 120 130 140 150
TVPLLVDVPP EEPKLSCFRK NPLVNAICEW RPSSTPSPTT KAVLFAKKIN
160 170 180 190 200
TTNGKSDFQV PCQYSQQLKS FSCQVEILEG DKVYHIVSLC VANSVGSKSS
210 220 230 240 250
HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET WDPSYYLLQF
260 270 280 290 300
QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW
310 320 330 340 350
SEWSPEVTGT PWIAEPRTTP AGILWNPTQV SVEDSANHED QYESSTEATS
360 370 380 390 400
VLAPVQESSS MSLPTFLVAG GSLAFGLLLC VFIILRLKQK WKSEAEKESK
410 420 430 440 450
TTSPPPPPYS LGPLKPTFLL VPLLTPHSSG SDNTVNHSCL GVRDAQSPYD
460
NSNRDYLFPR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JGF1 | A0A0G2JGF1_MOUSE | Interleukin-6 receptor subunit alph... | Il6ra | 459 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 374 | A → R in CAA37810 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51975 mRNA Translation: CAA36237.1 X53802 mRNA Translation: CAA37810.1 |
CCDSi | CCDS38496.1 |
PIRi | JL0144 JL0145 |
RefSeqi | NP_034689.2, NM_010559.3 |
Genome annotation databases
Ensembli | ENSMUST00000029559; ENSMUSP00000029559; ENSMUSG00000027947 |
GeneIDi | 16194 |
KEGGi | mmu:16194 |
UCSCi | uc008qaf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51975 mRNA Translation: CAA36237.1 X53802 mRNA Translation: CAA37810.1 |
CCDSi | CCDS38496.1 |
PIRi | JL0144 JL0145 |
RefSeqi | NP_034689.2, NM_010559.3 |
3D structure databases
SMRi | P22272 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P22272, 1 interactor |
STRINGi | 10090.ENSMUSP00000029559 |
PTM databases
GlyGeni | P22272, 3 sites |
PhosphoSitePlusi | P22272 |
Proteomic databases
MaxQBi | P22272 |
PaxDbi | P22272 |
PRIDEi | P22272 |
Protocols and materials databases
ABCDi | P22272, 22 sequenced antibodies |
Antibodypediai | 20397, 969 antibodies |
DNASUi | 16194 |
Genome annotation databases
Ensembli | ENSMUST00000029559; ENSMUSP00000029559; ENSMUSG00000027947 |
GeneIDi | 16194 |
KEGGi | mmu:16194 |
UCSCi | uc008qaf.1, mouse |
Organism-specific databases
CTDi | 16194 |
MGIi | MGI:105304, Il6ra |
Phylogenomic databases
eggNOGi | ENOG502RY0M, Eukaryota |
GeneTreei | ENSGT00940000161919 |
HOGENOMi | CLU_051451_0_0_1 |
InParanoidi | P22272 |
OrthoDBi | 783799at2759 |
PhylomeDBi | P22272 |
TreeFami | TF331210 |
Enzyme and pathway databases
Reactomei | R-MMU-1059683, Interleukin-6 signaling R-MMU-110056, MAPK3 (ERK1) activation R-MMU-112411, MAPK1 (ERK2) activation |
Miscellaneous databases
BioGRID-ORCSi | 16194, 1 hit in 19 CRISPR screens |
PROi | PR:P22272 |
RNActi | P22272, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027947, Expressed in islet of Langerhans and 170 other tissues |
Genevisiblei | P22272, MM |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003530, Hematopoietin_rcpt_L_F3_CS IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR015321, TypeI_recpt_CBD |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF09240, IL6Ra-bind, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01354, HEMATOPO_REC_L_F3, 1 hit PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL6RA_MOUSE | |
Accessioni | P22272Primary (citable) accession number: P22272 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 193 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families