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Protein

Zinc finger protein 42

Gene

Zfp42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri258 – 281C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 42
Short name:
Zfp-42
Alternative name(s):
Reduced expression protein 1
Short name:
REX-1
Short name:
mREX-1
Gene namesi
Name:Zfp42
Synonyms:Rex-1, Rex1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99187 Zfp42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473001 – 288Zinc finger protein 42Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki213Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Polyubiquitinated by RNF12, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP22227
PaxDbiP22227
PeptideAtlasiP22227
PRIDEiP22227

PTM databases

iPTMnetiP22227
PhosphoSitePlusiP22227

Expressioni

Tissue specificityi

Restricted to testis, to germ cells in the early stages of spermatogenesis. Not expressed in spermatids, nor spermatozoa. Expressed in embryonic stem (ES) cells.4 Publications

Developmental stagei

Expressed in the inner cell mass of 4.5 dpc blastocysts, as well as in the polar trophoblast. At 6 dpc, abundant in the extraembryonic ectoderm and the ectoplacental cone. At this stage, not detected in the embryonic ectoderm. At 7 dpc, restricted to the extraembryonic ectoderm and the ectoplacental cone. Also expressed in the placenta. Expressed in male germ cells undergoing meiosis.1 Publication

Inductioni

Up-regulated by NANOG, up-regulation which is increased by SOX2 and POU5F1. Up-regulated by nicotine; up-regulation which is prevented with tubocurarine, a nicotinic acetylcholine receptor antagonist. Down-regulated by sodium vanadate and retinoic acid (RA). In ES cells, down-regulation correlates with differentiation.5 Publications

Gene expression databases

CleanExiMM_ZFP42

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RlimQ9WTV78EBI-2313372,EBI-15657872

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204664, 16 interactors
DIPiDIP-54911N
IntActiP22227, 3 interactors
MINTiP22227
STRINGi10090.ENSMUSP00000080765

Structurei

3D structure databases

ProteinModelPortaliP22227
SMRiP22227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 103Asp/Glu-rich (acidic)Add BLAST48

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri258 – 281C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000008232
HOVERGENiHBG006823
InParanoidiP22227
KOiK11516
PhylomeDBiP22227

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P22227-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEQKMNEQM KKTAKTSGQK GPGGRALDRL TLKQDEARPV QNTRVEAPRV
60 70 80 90 100
TYTIRDESEI SPETEEDGFP DGYLECIIRG EFSEPILEED FLFKSFESLE
110 120 130 140 150
EVEQNLSRQV LEASSLLESS LEYMTKGTKQ EKTEVTQETP PLRVGASSLL
160 170 180 190 200
AGGPAEKPEG GVYCGVLSML ECPQAGCKKK LRGKTALRKH MLVHGPRRHV
210 220 230 240 250
CAECGKAFTE SSKLKRHFLV HTGEKPYQCT FEGCGKRFSL DFNLRTHIRI
260 270 280
HTGERRFVCP FDGCEKSFIQ SNNQKIHILT HAKAGKKC
Length:288
Mass (Da):32,398
Last modified:August 1, 1991 - v1
Checksum:i4B1ABFDF372A7D7B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QK22E9QK22_MOUSE
Zinc finger protein 42
Zfp42
288Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13T → A in AAH53399 (PubMed:15489334).Curated1
Sequence conflicti133T → R in AAH53399 (PubMed:15489334).Curated1
Sequence conflicti155A → T in AAH53399 (PubMed:15489334).Curated1
Sequence conflicti183G → D in AAH53399 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28382 mRNA Translation: AAA40053.1
M97812 Genomic DNA Translation: AAA19700.1
BC053399 mRNA Translation: AAH53399.1
BC098467 mRNA Translation: AAH98467.1
CCDSiCCDS22267.1
PIRiA33828
RefSeqiNP_033582.2, NM_009556.3
UniGeneiMm.285848

Genome annotation databases

GeneIDi22702
KEGGimmu:22702

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28382 mRNA Translation: AAA40053.1
M97812 Genomic DNA Translation: AAA19700.1
BC053399 mRNA Translation: AAH53399.1
BC098467 mRNA Translation: AAH98467.1
CCDSiCCDS22267.1
PIRiA33828
RefSeqiNP_033582.2, NM_009556.3
UniGeneiMm.285848

3D structure databases

ProteinModelPortaliP22227
SMRiP22227
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204664, 16 interactors
DIPiDIP-54911N
IntActiP22227, 3 interactors
MINTiP22227
STRINGi10090.ENSMUSP00000080765

PTM databases

iPTMnetiP22227
PhosphoSitePlusiP22227

Proteomic databases

MaxQBiP22227
PaxDbiP22227
PeptideAtlasiP22227
PRIDEiP22227

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22702
KEGGimmu:22702

Organism-specific databases

CTDi132625
MGIiMGI:99187 Zfp42

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000008232
HOVERGENiHBG006823
InParanoidiP22227
KOiK11516
PhylomeDBiP22227

Miscellaneous databases

PROiPR:P22227
SOURCEiSearch...

Gene expression databases

CleanExiMM_ZFP42

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP42_MOUSE
AccessioniPrimary (citable) accession number: P22227
Secondary accession number(s): Q4KMN3, Q7TPU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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