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Entry version 155 (08 May 2019)
Sequence version 2 (01 Oct 1996)
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Protein

Exocyst complex component SEC15

Gene

SEC15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.1 Publication

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-30707-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-264876 Insulin processing

Protein family/group databases

Transport Classification Database

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TCDBi
1.F.2.1.1 the octameric exocyst (exocyst) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component SEC15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC15
Ordered Locus Names:YGL233W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YGL233W

Saccharomyces Genome Database

More...
SGDi
S000003202 SEC15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189591 – 910Exocyst complex component SEC15Add BLAST910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei286PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P22224

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22224

PRoteomics IDEntifications database

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PRIDEi
P22224

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22224

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.

Interacts with SEC4.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33006, 256 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1890 Exocyst

Database of interacting proteins

More...
DIPi
DIP-2681N

Protein interaction database and analysis system

More...
IntActi
P22224, 24 interactors

Molecular INTeraction database

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MINTi
P22224

STRING: functional protein association networks

More...
STRINGi
4932.YGL233W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22224

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili88 – 116Sequence analysisAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC15 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005739

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065975

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22224

KEGG Orthology (KO)

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KOi
K19985

Identification of Orthologs from Complete Genome Data

More...
OMAi
RDHYNEV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.357.30, 1 hit
1.20.58.670, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007225 EXOC6/Sec15
IPR042045 EXOC6/Sec15_C_dom1
IPR042044 EXOC6/Sec15_C_dom2

The PANTHER Classification System

More...
PANTHERi
PTHR12702 PTHR12702, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04091 Sec15, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF025007 Sec15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P22224-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQEGQPLLS KDFQQVLLAT ASGNNSSWTE RAVLNNESTD AVKHEPALGQ
60 70 80 90 100
NDVFDLDPLS FDKWVPFLRR ALDKNQLDPV IDELENSIED NFQGLELQLL
110 120 130 140 150
QDSQMNDKLE TSIDEIANIQ GMVQDTLSSE ISKFQIRLSE SANELIVKKQ
160 170 180 190 200
MYVNNKKISL KISEATILIT KVVRILELSS KCQELITERK FFKVLQNLDS
210 220 230 240 250
LEKLYLQEFK NYNFQFLIEI YNSIPFLQKV TKDECINLIR NSLNLNLGKN
260 270 280 290 300
LIKVGQEFVA IYENELLPQW LETRSKMKLT NFKFNSPIEI SMRDESFLAK
310 320 330 340 350
LNLGEFFQLD DFHDSIMIFQ NLNELSVLSG EFNKEYELRK TKLMYPLIWK
360 370 380 390 400
KNKTAAYQMD SLLRGTGTTP GSTAHDVSTD DPFTQSLSLH FLQDYFLKIL
410 420 430 440 450
GFLLYDINLN KATEFILVDN NYNSTNEFWD GLMDRLSPYL SYFIDEKLKT
460 470 480 490 500
EEDMIKLKDF LCIYVAILEN FKLNIEPLYK ILVSIFEKFC SVSLRAFDDE
510 520 530 540 550
FQILLNDDDF MPLSINDKTL YEKVLKICWM KEGEHLSLPD PTNGEPFAVT
560 570 580 590 600
LPFSPLYPMT CTLAKKTYSK ITAFLSIFYR HELHTLNNIL VKTMDDIFND
610 620 630 640 650
IVNKKIRSKL ESTSREEIAQ ILVNLDYFII AAKEFSNFMT RENILQNPDM
660 670 680 690 700
EIRLSSIKYL AESRKLAETK LIELIDSKIS DILETIEIDW QITEVRQDPD
710 720 730 740 750
ISIIDLAQFL EMMFASTLQN LPYSVQTLLI FREFDSLTRQ FMGLLLHDTP
760 770 780 790 800
STITHESIMN FEVDVNYLES IIPRIFPSTP GTIDSNGYQS PMTPSTPTFP
810 820 830 840 850
NANGVDAPTL FENNIKSLEA TFMELKQCIE LLKTQGKDYN EPEIRLRKYS
860 870 880 890 900
RIRQEDAALL LSKIQHFVSS VEGANGDDTS VMDSSSIFNS ESASVIDSNT
910
SRIAKFFNRR
Length:910
Mass (Da):105,064
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i818A5D27A1691D17
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z72755 Genomic DNA Translation: CAA96951.1
BK006941 Genomic DNA Translation: DAA07885.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S07838

NCBI Reference Sequences

More...
RefSeqi
NP_011281.1, NM_001181099.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL233W_mRNA; YGL233W_mRNA; YGL233W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852618

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL233W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72755 Genomic DNA Translation: CAA96951.1
BK006941 Genomic DNA Translation: DAA07885.1
PIRiS07838
RefSeqiNP_011281.1, NM_001181099.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YFPelectron microscopy4.40F1-910[»]
SMRiP22224
ModBaseiSearch...

Protein-protein interaction databases

BioGridi33006, 256 interactors
ComplexPortaliCPX-1890 Exocyst
DIPiDIP-2681N
IntActiP22224, 24 interactors
MINTiP22224
STRINGi4932.YGL233W

Protein family/group databases

TCDBi1.F.2.1.1 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiP22224

Proteomic databases

MaxQBiP22224
PaxDbiP22224
PRIDEiP22224

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL233W_mRNA; YGL233W_mRNA; YGL233W
GeneIDi852618
KEGGisce:YGL233W

Organism-specific databases

EuPathDBiFungiDB:YGL233W
SGDiS000003202 SEC15

Phylogenomic databases

GeneTreeiENSGT00390000005739
HOGENOMiHOG000065975
InParanoidiP22224
KOiK19985
OMAiRDHYNEV

Enzyme and pathway databases

BioCyciYEAST:G3O-30707-MONOMER
ReactomeiR-SCE-264876 Insulin processing

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P22224

Family and domain databases

Gene3Di1.10.357.30, 1 hit
1.20.58.670, 1 hit
InterProiView protein in InterPro
IPR007225 EXOC6/Sec15
IPR042045 EXOC6/Sec15_C_dom1
IPR042044 EXOC6/Sec15_C_dom2
PANTHERiPTHR12702 PTHR12702, 1 hit
PfamiView protein in Pfam
PF04091 Sec15, 1 hit
PIRSFiPIRSF025007 Sec15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEC15_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22224
Secondary accession number(s): D6VVA1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1996
Last modified: May 8, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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