UniProtKB - P22224 (SEC15_YEAST)
Protein
Exocyst complex component SEC15
Gene
SEC15
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.1 Publication
Miscellaneous
Present with 4280 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- small GTPase binding Source: SGD
GO - Biological processi
- exocytosis Source: SGD
- Golgi to plasma membrane transport Source: SGD
- protein transport Source: UniProtKB-KW
- vesicle docking involved in exocytosis Source: InterPro
- vesicle tethering involved in exocytosis Source: SGD
Keywordsi
Biological process | Exocytosis, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-264876, Insulin processing |
Protein family/group databases
TCDBi | 1.F.2.1.1, the octameric exocyst (exocyst) family |
Names & Taxonomyi
Protein namesi | Recommended name: Exocyst complex component SEC15 |
Gene namesi | Name:SEC15 Ordered Locus Names:YGL233W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003202, SEC15 |
VEuPathDBi | FungiDB:YGL233W |
Subcellular locationi
Cytoplasm and Cytosol
Plasma membrane
Note: 25% cytoplasmic. 75% is associated with the cell membrane.
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cellular bud neck Source: SGD
- cellular bud tip Source: SGD
- exocyst Source: SGD
- incipient cellular bud site Source: SGD
- mating projection tip Source: SGD
- membrane Source: GO_Central
- prospore membrane Source: SGD
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118959 | 1 – 910 | Exocyst complex component SEC15Add BLAST | 910 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 286 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P22224 |
PaxDbi | P22224 |
PRIDEi | P22224 |
PTM databases
iPTMneti | P22224 |
Interactioni
Subunit structurei
The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.
Interacts with SEC4.
Binary interactionsi
Hide detailsGO - Molecular functioni
- small GTPase binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 33006, 256 interactors |
ComplexPortali | CPX-1890, Exocyst |
DIPi | DIP-2681N |
IntActi | P22224, 24 interactors |
MINTi | P22224 |
STRINGi | 4932.YGL233W |
Miscellaneous databases
RNActi | P22224, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 88 – 116 | Sequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the SEC15 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2176, Eukaryota |
GeneTreei | ENSGT00390000005739 |
HOGENOMi | CLU_009437_1_0_1 |
InParanoidi | P22224 |
OMAi | RDHYNEV |
Family and domain databases
Gene3Di | 1.10.357.30, 1 hit 1.20.58.670, 1 hit |
InterProi | View protein in InterPro IPR007225, EXOC6/Sec15 IPR042045, EXOC6/Sec15_C_dom1 IPR042044, EXOC6/Sec15_C_dom2 |
PANTHERi | PTHR12702, PTHR12702, 1 hit |
Pfami | View protein in Pfam PF04091, Sec15, 1 hit |
PIRSFi | PIRSF025007, Sec15, 1 hit |
i Sequence
Sequence statusi: Complete.
P22224-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDQEGQPLLS KDFQQVLLAT ASGNNSSWTE RAVLNNESTD AVKHEPALGQ
60 70 80 90 100
NDVFDLDPLS FDKWVPFLRR ALDKNQLDPV IDELENSIED NFQGLELQLL
110 120 130 140 150
QDSQMNDKLE TSIDEIANIQ GMVQDTLSSE ISKFQIRLSE SANELIVKKQ
160 170 180 190 200
MYVNNKKISL KISEATILIT KVVRILELSS KCQELITERK FFKVLQNLDS
210 220 230 240 250
LEKLYLQEFK NYNFQFLIEI YNSIPFLQKV TKDECINLIR NSLNLNLGKN
260 270 280 290 300
LIKVGQEFVA IYENELLPQW LETRSKMKLT NFKFNSPIEI SMRDESFLAK
310 320 330 340 350
LNLGEFFQLD DFHDSIMIFQ NLNELSVLSG EFNKEYELRK TKLMYPLIWK
360 370 380 390 400
KNKTAAYQMD SLLRGTGTTP GSTAHDVSTD DPFTQSLSLH FLQDYFLKIL
410 420 430 440 450
GFLLYDINLN KATEFILVDN NYNSTNEFWD GLMDRLSPYL SYFIDEKLKT
460 470 480 490 500
EEDMIKLKDF LCIYVAILEN FKLNIEPLYK ILVSIFEKFC SVSLRAFDDE
510 520 530 540 550
FQILLNDDDF MPLSINDKTL YEKVLKICWM KEGEHLSLPD PTNGEPFAVT
560 570 580 590 600
LPFSPLYPMT CTLAKKTYSK ITAFLSIFYR HELHTLNNIL VKTMDDIFND
610 620 630 640 650
IVNKKIRSKL ESTSREEIAQ ILVNLDYFII AAKEFSNFMT RENILQNPDM
660 670 680 690 700
EIRLSSIKYL AESRKLAETK LIELIDSKIS DILETIEIDW QITEVRQDPD
710 720 730 740 750
ISIIDLAQFL EMMFASTLQN LPYSVQTLLI FREFDSLTRQ FMGLLLHDTP
760 770 780 790 800
STITHESIMN FEVDVNYLES IIPRIFPSTP GTIDSNGYQS PMTPSTPTFP
810 820 830 840 850
NANGVDAPTL FENNIKSLEA TFMELKQCIE LLKTQGKDYN EPEIRLRKYS
860 870 880 890 900
RIRQEDAALL LSKIQHFVSS VEGANGDDTS VMDSSSIFNS ESASVIDSNT
910
SRIAKFFNRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72755 Genomic DNA Translation: CAA96951.1 BK006941 Genomic DNA Translation: DAA07885.1 |
PIRi | S07838 |
RefSeqi | NP_011281.1, NM_001181099.1 |
Genome annotation databases
EnsemblFungii | YGL233W_mRNA; YGL233W; YGL233W |
GeneIDi | 852618 |
KEGGi | sce:YGL233W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72755 Genomic DNA Translation: CAA96951.1 BK006941 Genomic DNA Translation: DAA07885.1 |
PIRi | S07838 |
RefSeqi | NP_011281.1, NM_001181099.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5YFP | electron microscopy | 4.40 | F | 1-910 | [»] | |
6VKL | electron microscopy | 4.40 | F | 1-910 | [»] | |
SMRi | P22224 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33006, 256 interactors |
ComplexPortali | CPX-1890, Exocyst |
DIPi | DIP-2681N |
IntActi | P22224, 24 interactors |
MINTi | P22224 |
STRINGi | 4932.YGL233W |
Protein family/group databases
TCDBi | 1.F.2.1.1, the octameric exocyst (exocyst) family |
PTM databases
iPTMneti | P22224 |
Proteomic databases
MaxQBi | P22224 |
PaxDbi | P22224 |
PRIDEi | P22224 |
Genome annotation databases
EnsemblFungii | YGL233W_mRNA; YGL233W; YGL233W |
GeneIDi | 852618 |
KEGGi | sce:YGL233W |
Organism-specific databases
SGDi | S000003202, SEC15 |
VEuPathDBi | FungiDB:YGL233W |
Phylogenomic databases
eggNOGi | KOG2176, Eukaryota |
GeneTreei | ENSGT00390000005739 |
HOGENOMi | CLU_009437_1_0_1 |
InParanoidi | P22224 |
OMAi | RDHYNEV |
Enzyme and pathway databases
Reactomei | R-SCE-264876, Insulin processing |
Miscellaneous databases
PROi | PR:P22224 |
RNActi | P22224, protein |
Family and domain databases
Gene3Di | 1.10.357.30, 1 hit 1.20.58.670, 1 hit |
InterProi | View protein in InterPro IPR007225, EXOC6/Sec15 IPR042045, EXOC6/Sec15_C_dom1 IPR042044, EXOC6/Sec15_C_dom2 |
PANTHERi | PTHR12702, PTHR12702, 1 hit |
Pfami | View protein in Pfam PF04091, Sec15, 1 hit |
PIRSFi | PIRSF025007, Sec15, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SEC15_YEAST | |
Accessioni | P22224Primary (citable) accession number: P22224 Secondary accession number(s): D6VVA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families