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Protein

Cadherin-3

Gene

CDH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Sensory transduction, Vision
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418990 Adherens junctions interactions

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P22223

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-3
Alternative name(s):
Placental cadherin
Short name:
P-cadherin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDH3
Synonyms:CDHP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000062038.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1762 CDH3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
114021 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22223

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini108 – 654ExtracellularSequence analysisAdd BLAST547
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei655 – 677HelicalSequence analysisAdd BLAST23
Topological domaini678 – 829CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypotrichosis congenital with juvenile macular dystrophy (HJMD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life.
See also OMIM:601553
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015422503R → H in HJMD. 1 PublicationCorresponds to variant dbSNP:rs121434542EnsemblClinVar.1
Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.
See also OMIM:225280
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033010322N → I in EEMS. 1 PublicationCorresponds to variant dbSNP:rs121434543EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Hypotrichosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
1001

MalaCards human disease database

More...
MalaCardsi
CDH3
MIMi225280 phenotype
601553 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000062038

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1897 EEM syndrome
1573 Hypotrichosis with juvenile macular degeneration

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26299

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3989384

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDH3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
146345382

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000374525 – 107Add BLAST83
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000003746108 – 829Cadherin-3Add BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P22223

MaxQB - The MaxQuant DataBase

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MaxQBi
P22223

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22223

PeptideAtlas

More...
PeptideAtlasi
P22223

PRoteomics IDEntifications database

More...
PRIDEi
P22223

ProteomicsDB human proteome resource

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ProteomicsDBi
53966
53967 [P22223-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22223

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P22223

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in some normal epithelial tissues and in some carcinoma cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000062038 Expressed in 145 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_CDH3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P22223 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22223 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB002487
HPA001767

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDCP1 and CTNNB1.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107436, 11 interactors

Protein interaction database and analysis system

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IntActi
P22223, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264012

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1829
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P22223

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22223

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 215Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini216 – 328Cadherin 2PROSITE-ProRule annotationAdd BLAST113
Domaini329 – 440Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini441 – 546Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini547 – 650Cadherin 5PROSITE-ProRule annotationAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi785 – 800Ser-richAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154848

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231254

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG106438

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22223

KEGG Orthology (KO)

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KOi
K06796

Identification of Orthologs from Complete Genome Data

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OMAi
PQKYEAR

Database of Orthologous Groups

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OrthoDBi
EOG091G05OA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P22223

TreeFam database of animal gene trees

More...
TreeFami
TF316817

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR24027 PTHR24027, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 4 hits
SM01055 Cadherin_pro, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49313 SSF49313, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P22223-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLPRGPLAS LLLLQVCWLQ CAASEPCRAV FREAEVTLEA GGAEQEPGQA
60 70 80 90 100
LGKVFMGCPG QEPALFSTDN DDFTVRNGET VQERRSLKER NPLKIFPSKR
110 120 130 140 150
ILRRHKRDWV VAPISVPENG KGPFPQRLNQ LKSNKDRDTK IFYSITGPGA
160 170 180 190 200
DSPPEGVFAV EKETGWLLLN KPLDREEIAK YELFGHAVSE NGASVEDPMN
210 220 230 240 250
ISIIVTDQND HKPKFTQDTF RGSVLEGVLP GTSVMQVTAT DEDDAIYTYN
260 270 280 290 300
GVVAYSIHSQ EPKDPHDLMF TIHRSTGTIS VISSGLDREK VPEYTLTIQA
310 320 330 340 350
TDMDGDGSTT TAVAVVEILD ANDNAPMFDP QKYEAHVPEN AVGHEVQRLT
360 370 380 390 400
VTDLDAPNSP AWRATYLIMG GDDGDHFTIT THPESNQGIL TTRKGLDFEA
410 420 430 440 450
KNQHTLYVEV TNEAPFVLKL PTSTATIVVH VEDVNEAPVF VPPSKVVEVQ
460 470 480 490 500
EGIPTGEPVC VYTAEDPDKE NQKISYRILR DPAGWLAMDP DSGQVTAVGT
510 520 530 540 550
LDREDEQFVR NNIYEVMVLA MDNGSPPTTG TGTLLLTLID VNDHGPVPEP
560 570 580 590 600
RQITICNQSP VRQVLNITDK DLSPHTSPFQ AQLTDDSDIY WTAEVNEEGD
610 620 630 640 650
TVVLSLKKFL KQDTYDVHLS LSDHGNKEQL TVIRATVCDC HGHVETCPGP
660 670 680 690 700
WKGGFILPVL GAVLALLFLL LVLLLLVRKK RKIKEPLLLP EDDTRDNVFY
710 720 730 740 750
YGEEGGGEED QDYDITQLHR GLEARPEVVL RNDVAPTIIP TPMYRPRPAN
760 770 780 790 800
PDEIGNFIIE NLKAANTDPT APPYDTLLVF DYEGSGSDAA SLSSLTSSAS
810 820
DQDQDYDYLN EWGSRFKKLA DMYGGGEDD
Length:829
Mass (Da):91,418
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C03C8536CD98C7B
GO
Isoform 2 (identifier: P22223-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     761-829: NLKAANTDPT...ADMYGGGEDD → GRGERGSQRGNGGLQLARGRTRRS

Note: No experimental confirmation available.
Show »
Length:784
Mass (Da):86,552
Checksum:i0BE52C6E9C281154
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QL41J3QL41_HUMAN
Cadherin-3
CDH3
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR60J3QR60_HUMAN
Cadherin-3
CDH3
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL75J3QL75_HUMAN
Cadherin-3
CDH3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKW6J3QKW6_HUMAN
Cadherin-3
CDH3
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRQ1J3KRQ1_HUMAN
Cadherin-3
CDH3
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR34J3QR34_HUMAN
Cadherin-3
CDH3
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031929237V → M1 PublicationCorresponds to variant dbSNP:rs17854171Ensembl.1
Natural variantiVAR_033010322N → I in EEMS. 1 PublicationCorresponds to variant dbSNP:rs121434543EnsemblClinVar.1
Natural variantiVAR_031930477R → H. Corresponds to variant dbSNP:rs34494880EnsemblClinVar.1
Natural variantiVAR_015422503R → H in HJMD. 1 PublicationCorresponds to variant dbSNP:rs121434542EnsemblClinVar.1
Natural variantiVAR_031931563Q → H4 PublicationsCorresponds to variant dbSNP:rs1126933EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024820761 – 829NLKAA…GGEDD → GRGERGSQRGNGGLQLARGR TRRS in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X63629 mRNA Translation: CAA45177.1
AK312554 mRNA Translation: BAG35451.1
CH471092 Genomic DNA Translation: EAW83238.1
BC014462 mRNA Translation: AAH14462.1
BC041846 mRNA Translation: AAH41846.1
X95824 Genomic DNA Translation: CAA65093.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10868.1 [P22223-1]
CCDS82004.1 [P22223-2]

Protein sequence database of the Protein Information Resource

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PIRi
A33659 IJHUCP

NCBI Reference Sequences

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RefSeqi
NP_001304124.1, NM_001317195.1 [P22223-2]
NP_001304125.1, NM_001317196.1
NP_001784.2, NM_001793.5 [P22223-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.191842

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264012; ENSP00000264012; ENSG00000062038 [P22223-1]
ENST00000429102; ENSP00000398485; ENSG00000062038 [P22223-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1001

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1001

UCSC genome browser

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UCSCi
uc002ewf.3 human [P22223-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mutations of the CDH3 gene

Retina International's Scientific Newsletter

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63629 mRNA Translation: CAA45177.1
AK312554 mRNA Translation: BAG35451.1
CH471092 Genomic DNA Translation: EAW83238.1
BC014462 mRNA Translation: AAH14462.1
BC041846 mRNA Translation: AAH41846.1
X95824 Genomic DNA Translation: CAA65093.1
CCDSiCCDS10868.1 [P22223-1]
CCDS82004.1 [P22223-2]
PIRiA33659 IJHUCP
RefSeqiNP_001304124.1, NM_001317195.1 [P22223-2]
NP_001304125.1, NM_001317196.1
NP_001784.2, NM_001793.5 [P22223-1]
UniGeneiHs.191842

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OY9X-ray1.62A108-320[»]
4ZMLX-ray1.85A108-320[»]
4ZMNX-ray2.60A108-338[»]
4ZMOX-ray2.48A108-320[»]
4ZMPX-ray2.15A108-320[»]
4ZMQX-ray2.20A/B108-320[»]
4ZMTX-ray2.70A/B/C/D/E/F108-338[»]
4ZMVX-ray2.40A/B108-320[»]
4ZMWX-ray2.30A/B108-320[»]
4ZMXX-ray3.10A/B108-320[»]
4ZMYX-ray1.50A108-320[»]
4ZMZX-ray2.05A107-320[»]
5JYLX-ray2.55A/C108-207[»]
5JYMX-ray2.45A/C108-320[»]
ProteinModelPortaliP22223
SMRiP22223
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107436, 11 interactors
IntActiP22223, 5 interactors
STRINGi9606.ENSP00000264012

Chemistry databases

ChEMBLiCHEMBL3989384

PTM databases

iPTMnetiP22223
PhosphoSitePlusiP22223

Polymorphism and mutation databases

BioMutaiCDH3
DMDMi146345382

Proteomic databases

EPDiP22223
MaxQBiP22223
PaxDbiP22223
PeptideAtlasiP22223
PRIDEiP22223
ProteomicsDBi53966
53967 [P22223-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1001
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264012; ENSP00000264012; ENSG00000062038 [P22223-1]
ENST00000429102; ENSP00000398485; ENSG00000062038 [P22223-2]
GeneIDi1001
KEGGihsa:1001
UCSCiuc002ewf.3 human [P22223-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1001
DisGeNETi1001
EuPathDBiHostDB:ENSG00000062038.13

GeneCards: human genes, protein and diseases

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GeneCardsi
CDH3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0026973
HGNCiHGNC:1762 CDH3
HPAiCAB002487
HPA001767
MalaCardsiCDH3
MIMi114021 gene
225280 phenotype
601553 phenotype
neXtProtiNX_P22223
OpenTargetsiENSG00000062038
Orphaneti1897 EEM syndrome
1573 Hypotrichosis with juvenile macular degeneration
PharmGKBiPA26299

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000154848
HOGENOMiHOG000231254
HOVERGENiHBG106438
InParanoidiP22223
KOiK06796
OMAiPQKYEAR
OrthoDBiEOG091G05OA
PhylomeDBiP22223
TreeFamiTF316817

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions
SIGNORiP22223

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CDH3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CDH3_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1001

Protein Ontology

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PROi
PR:P22223

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000062038 Expressed in 145 organ(s), highest expression level in secondary oocyte
CleanExiHS_CDH3
ExpressionAtlasiP22223 baseline and differential
GenevisibleiP22223 HS

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SM01055 Cadherin_pro, 1 hit
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCADH3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22223
Secondary accession number(s): B2R6F4, Q05DI6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 1, 2007
Last modified: December 5, 2018
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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