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Protein

Heat shock protein SSA4

Gene

SSA4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 17900 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • unfolded protein binding Source: SGD

GO - Biological processi

  • cellular response to heat Source: SGD
  • protein folding Source: SGD
  • SRP-dependent cotranslational protein targeting to membrane, translocation Source: SGD

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30268-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein SSA4
Gene namesi
Name:SSA4
Ordered Locus Names:YER103W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER103W
SGDiS000000905 SSA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783881 – 642Heat shock protein SSA4Add BLAST642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei552PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP22202
PaxDbiP22202
PRIDEiP22202

PTM databases

iPTMnetiP22202

Expressioni

Inductioni

HSP SSA4 expression is restricted to conditions of stress.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SSA2P105923EBI-8621,EBI-8603

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi36849, 74 interactors
DIPiDIP-3916N
IntActiP22202, 56 interactors
MINTiP22202
STRINGi4932.YER103W

Structurei

Secondary structure

1642
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi637 – 639Combined sources3

3D structure databases

ProteinModelPortaliP22202
SMRiP22202
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000144045
HOGENOMiHOG000228135
InParanoidiP22202
KOiK03283
OMAiEAYLGCK
OrthoDBiEOG092C1VPN

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

P22202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAVGIDLG TTYSCVAHFA NDRVEIIAND QGNRTTPSYV AFTDTERLIG
60 70 80 90 100
DAAKNQAAMN PHNTVFDAKR LIGRKFDDPE VTNDAKHYPF KVIDKGGKPV
110 120 130 140 150
VQVEYKGETK TFTPEEISSM ILTKMKETAE NFLGTEVKDA VVTVPAYFND
160 170 180 190 200
SQRQATKDAG TIAGLNVLRI INEPTAAAIA YGLDKKSQKE HNVLIFDLGG
210 220 230 240 250
GTFDVSLLSI DEGVFEVKAT AGDTHLGGED FDSRLVNFLA EEFKRKNKKD
260 270 280 290 300
LTTNQRSLRR LRTAAERAKR TLSSSAQTSI EIDSLFEGID FYTSITRARF
310 320 330 340 350
EELCADLFRS TLEPVEKVLA DSKLDKSQID EIVLVGGSTR IPKVQKLVSD
360 370 380 390 400
FFNGKEPNRS INPDEAVAYG AAVQAAILTG DQSSTTQDLL LLDVAPLSLG
410 420 430 440 450
IETAGGIMTK LIPRNSTIPT KKSEVFSTYA DNQPGVLIQV FEGERTRTKD
460 470 480 490 500
NNLLGKFELS GIPPAPRGVP QIEVTFDIDA NGILNVSAVE KGTGKSNKIT
510 520 530 540 550
ITNDKGRLSK EDIDKMVAEA EKFKAEDEQE AQRVQAKNQL ESYAFTLKNS
560 570 580 590 600
VSENNFKEKV GEEDARKLEA AAQDAINWLD ASQAASTEEY KERQKELEGV
610 620 630 640
ANPIMSKFYG AAGGAPGAGP VPGAGAGPTG APDNGPTVEE VD
Length:642
Mass (Da):69,651
Last modified:January 23, 2007 - v3
Checksum:i7A976357AC35C352
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05637 Genomic DNA Translation: AAA63574.1
U18839 Genomic DNA Translation: AAB64658.1
BK006939 Genomic DNA Translation: DAA07764.1
PIRiB36590
RefSeqiNP_011029.3, NM_001178994.3

Genome annotation databases

EnsemblFungiiYER103W; YER103W; YER103W
GeneIDi856840
KEGGisce:YER103W

Similar proteinsi

Entry informationi

Entry nameiHSP74_YEAST
AccessioniPrimary (citable) accession number: P22202
Secondary accession number(s): D3DM10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

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