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Protein

Pyruvate kinase, cytosolic isozyme

Gene
N/A
Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Pyruvate kinase (102579422), Pyruvate kinase (102604947), Pyruvate kinase (102604947), Pyruvate kinase, cytosolic isozyme, Pyruvate kinase (102604947), Pyruvate kinase (102597674), Pyruvate kinase (PKc), Pyruvate kinase, Pyruvate kinase (102582462), Pyruvate kinase (102596468), Pyruvate kinase, Pyruvate kinase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50SubstrateBy similarity1
Metal bindingi52PotassiumBy similarity1
Metal bindingi54PotassiumBy similarity1
Metal bindingi84PotassiumBy similarity1
Metal bindingi85Potassium; via carbonyl oxygenBy similarity1
Sitei240Transition state stabilizerBy similarity1
Metal bindingi242MagnesiumSequence analysis1
Binding sitei265Substrate; via amide nitrogenBy similarity1
Metal bindingi266MagnesiumBy similarity1
Binding sitei266Substrate; via amide nitrogenBy similarity1
Binding sitei298SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase, cytosolic isozyme (EC:2.7.1.40)
Short name:
PK
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001121241 – 510Pyruvate kinase, cytosolic isozymeAdd BLAST510

Proteomic databases

PRIDEiP22200

Expressioni

Gene expression databases

ExpressionAtlasiP22200 baseline

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi4113.PGSC0003DMT400065094

Structurei

3D structure databases

ProteinModelPortaliP22200
SMRiP22200
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

eggNOGiKOG2323 Eukaryota
COG0469 LUCA
KOiK00873

Family and domain databases

CDDicd00288 Pyruvate_Kinase, 1 hit
Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P22200-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANIDIAGIM KDLPNDGRIP KTKIVCTLGP SSRTVPMLEK LLRAGMNVAR
60 70 80 90 100
FNFSHGTHEY HQETLDNLKI AMQNTQILCA VMLDTKGPEI RTGFLTDGKP
110 120 130 140 150
IQLKEGQEIT VSTDYTIKGN EEMISMSYKK LVMDLKPGNT ILCADGTITL
160 170 180 190 200
TVLSCDPPSG TVRCRCENTA TLGERKNVNL PGVVVDLPTL TEKDKEDILE
210 220 230 240 250
WGVPNNIDMI ALSFVRKGSD LVNVRKVLGP HAKRIQLMSK VENQEGVINF
260 270 280 290 300
DEILRETDSF MVARGDLGME IPVEKIFLAQ KMMIYKCNLA GKAVVTATQM
310 320 330 340 350
LESMIKSPAP TRAEATDVAN AVLDGTDCVM LSGESAAGAY PELAVKIMSR
360 370 380 390 400
ICIEAESSLD NEAIFKEMIR CTPLPMSPLE SLASSAVRTA NKARAKLIVV
410 420 430 440 450
LTRGGSTAKL VAKYRPAVPI LSVVVPVLTT DSFDWSISDE TPARHSLVYR
460 470 480 490 500
GLIPLLGEGS AKATDSESTE VILEAALKSA VTRGLCKPGD AVVALHRIGS
510
ASVIKICVVK
Length:510
Mass (Da):55,170
Last modified:August 1, 1991 - v1
Checksum:i1752C9ED920F2854
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti133M → V. 1
Natural varianti169T → S. 1
Natural varianti227V → A. 1
Natural varianti309A → R. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53688 mRNA Translation: CAA37727.1
PIRiJC1481
RefSeqiNP_001275085.1, NM_001288156.1
UniGeneiStu.18197

Genome annotation databases

GeneIDi102601328
KEGGisot:102601328

Similar proteinsi

Entry informationi

Entry nameiKPYC_SOLTU
AccessioniPrimary (citable) accession number: P22200
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: February 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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