UniProtKB - P22180 (PMA1_SOLLC)
Protein
Plasma membrane ATPase 1
Gene
LHA1
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Functioni
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Miscellaneous
As many as 6 to 8 closely related genes may encode other isoforms of plasma membrane ATPase in tomato, like the LHA2 gene product which is 96% identical to the LHA1 gene product.
Catalytic activityi
- EC:7.1.2.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 333 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 592 | MagnesiumBy similarity | 1 | |
Metal bindingi | 596 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- proton-exporting ATPase activity, phosphorylative mechanism Source: GO_Central
GO - Biological processi
- proton export across plasma membrane Source: InterPro
- proton transmembrane transport Source: GO_Central
- regulation of intracellular pH Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Hydrogen ion transport, Ion transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.3.6, 3101 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:LHA1 |
Organismi | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) |
Taxonomic identifieri | 4081 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum › Solanum subgen. Lycopersicon |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 65 | CytoplasmicSequence analysisAdd BLAST | 65 | |
Transmembranei | 66 – 85 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 86 – 97 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 247 | CytoplasmicSequence analysisAdd BLAST | 129 | |
Transmembranei | 248 – 268 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 269 – 277 | ExtracellularSequence analysis | 9 | |
Transmembranei | 278 – 295 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 296 – 646 | CytoplasmicSequence analysisAdd BLAST | 351 | |
Transmembranei | 647 – 666 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 667 – 674 | ExtracellularSequence analysis | 8 | |
Transmembranei | 675 – 697 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 698 – 713 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 714 – 734 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 735 – 759 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 760 – 780 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 781 – 792 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 793 – 813 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 814 – 821 | ExtracellularSequence analysis | 8 | |
Transmembranei | 822 – 842 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 843 – 956 | CytoplasmicSequence analysisAdd BLAST | 114 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046289 | 1 – 956 | Plasma membrane ATPase 1Add BLAST | 956 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P22180 |
PRIDEi | P22180 |
PTM databases
iPTMneti | P22180 |
Interactioni
Subunit structurei
Possibly exists as a homodimer or a homotrimer.
Protein-protein interaction databases
STRINGi | 4081.Solyc03g113400.2.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0205, Eukaryota |
HOGENOMi | CLU_002360_6_4_1 |
InParanoidi | P22180 |
OMAi | FVGWYQE |
OrthoDBi | 188115at2759 |
Family and domain databases
CDDi | cd02076, P-type_ATPase_H, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit |
InterProi | View protein in InterPro IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR006534, P-type_ATPase_IIIA IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01647, ATPase-IIIA_H, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
P22180-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEKPEVLDA VLKETVDLEN IPIEEVFENL RCTREGLTAT AAQERLSIFG
60 70 80 90 100
YNKLEEKKES KFLKFLGFMW NPLSWVMEAA AIMAIALANG GGKPPDWQDF
110 120 130 140 150
VGIITLLIIN STISFIEENN AGNAAAALMA RLAPKAKVLR DGKWDEEDAS
160 170 180 190 200
VLVPGDIISI KLGDIIPADA RLLEGDPLKI DQSALTGESL PVTKGPGDGV
210 220 230 240 250
YSGSTCKQGE IEAVVIATGV HTFFGKAAHL VDSTNQVGHF QKVLTAIGNF
260 270 280 290 300
CICSIAVGMI IEIIVMYPIQ HRKYRPGIDN LLVLLIGGIP IAMPTVLSVT
310 320 330 340 350
MAIGSHRLAQ QGAITKRMTA IEEMAGMDVL CSDKTGTLTL NKLTVDKALI
360 370 380 390 400
EVFAKGIDAD TVVLMAARAS RIENQDAIDT AIVGMLADPK EARAGIREIH
410 420 430 440 450
FLPFNPTDKR TALTYLDGEG KMHRVSKGAP EQILNLAHNK SDIERRVHTV
460 470 480 490 500
IDKFAERGLR SLGVAYQEVP EGRKESAGGP WQFIALLPLF DPPRHDSAET
510 520 530 540 550
IRRALNLGVN VKMITGDQLA IGKETGRRLG MGTNMYPSSA LLGQTKDESI
560 570 580 590 600
AALPIDELIE KADGFAGVFP EHKYEIVKRL QARKHICGMT GDGVNDAPAL
610 620 630 640 650
KKADIGIAVD DATDAARSAS DIVLTEPGLS VIISAVLTSR AIFQRMKNYT
660 670 680 690 700
IYAVSITIRI VLGFMLLALI WKFDFPPFMV LIIAILNDGT IMTISKDRVK
710 720 730 740 750
PSPLPDSWKL AEIFTTGVVL GGYLAMMTVI FFWAAYKTNF FPRIFGVSTL
760 770 780 790 800
EKTATDDFRK LASAIYLQVS TISQALIFVT RSRSWSFVER PGLLLVFAFF
810 820 830 840 850
VAQLVATLIA VYANWSFAAI EGIGWGWAGV IWLYNIVTYI PLDLIKFLIR
860 870 880 890 900
YALSGKAWDL VLEQRIAFTR KKDFGKELRE LQWAHAQRTL HGLQVPDPKI
910 920 930 940 950
FSETTNFNEL NQLAEEAKRR AEIARLRELH TLKGHVESVV KLKGLDIETI
QQSYTV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60166 mRNA Translation: AAA34173.1 |
PIRi | A45506 |
RefSeqi | NP_001234775.1, NM_001247846.1 |
Genome annotation databases
GeneIDi | 543982 |
KEGGi | sly:543982 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60166 mRNA Translation: AAA34173.1 |
PIRi | A45506 |
RefSeqi | NP_001234775.1, NM_001247846.1 |
3D structure databases
SMRi | P22180 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4081.Solyc03g113400.2.1 |
PTM databases
iPTMneti | P22180 |
Proteomic databases
PaxDbi | P22180 |
PRIDEi | P22180 |
Genome annotation databases
GeneIDi | 543982 |
KEGGi | sly:543982 |
Phylogenomic databases
eggNOGi | KOG0205, Eukaryota |
HOGENOMi | CLU_002360_6_4_1 |
InParanoidi | P22180 |
OMAi | FVGWYQE |
OrthoDBi | 188115at2759 |
Enzyme and pathway databases
BRENDAi | 3.6.3.6, 3101 |
Gene expression databases
ExpressionAtlasi | P22180, baseline and differential |
Family and domain databases
CDDi | cd02076, P-type_ATPase_H, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit |
InterProi | View protein in InterPro IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR006534, P-type_ATPase_IIIA IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01647, ATPase-IIIA_H, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PMA1_SOLLC | |
Accessioni | P22180Primary (citable) accession number: P22180 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families