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UniProtKB - P22174 (RDRP_IPNVS)
Protein
RNA-directed RNA polymerase
Gene
VP1
Organism
Infectious pancreatic necrosis virus (strain Sp) (IPNV)
Status
Functioni
RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).
By similarityCatalytic activityi
- EC:2.7.7.48PROSITE-ProRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 248 – 255 | GTPSequence analysis | 8 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- RNA-protein covalent cross-linking Source: UniProtKB-KW
- viral genome replication Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase |
Biological process | Viral RNA replication |
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-directed RNA polymerase (EC:2.7.7.48)Short name: RDRP Alternative name(s): Protein VP1 |
Gene namesi | Name:VP1 |
Organismi | Infectious pancreatic necrosis virus (strain Sp) (IPNV) |
Taxonomic identifieri | 11005 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Birnaviridae › Aquabirnavirus › |
Virus hosti | Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) [TaxID: 8022] Salmo [TaxID: 8028] |
Proteomesi |
|
Subcellular locationi
- Virion By similarity Note: Minor amounts are incorporated in the virion.By similarity
Keywords - Cellular componenti
VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221964 | 1 – 844 | RNA-directed RNA polymeraseAdd BLAST | 844 |
Post-translational modificationi
Exists in multiple phosphorylated forms.
Keywords - PTMi
Covalent protein-RNA linkage, PhosphoproteinInteractioni
Subunit structurei
Interacts with VP3 in the cytoplasm.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 384 – 588 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 205 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 820 – 844 | DisorderedSequence analysisAdd BLAST | 25 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR007100, RNA-dir_pol_birnavirus IPR007098, RNA-dir_pol_mononegavirus |
Pfami | View protein in Pfam PF04197, Birna_RdRp, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50524, RDRP_DSRNA_BIR, 1 hit |
i Sequence
Sequence statusi: Complete.
P22174-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDIFNSPQN KASILNALMK STQGDVEDVL IPKRFRPAKD PLDSPQAAAA
60 70 80 90 100
FLKEHKYRIL RPRAIPTMVE IETDAALPRL AAMVDDGKLK EMVNVPEGTT
110 120 130 140 150
AFYPKYYPFH RPDHDDVGTF GAPDITLLKQ LTFFLLENDF PTGPETLRQV
160 170 180 190 200
REAIATLQYG SGSYSGQLNR LLAMKGVATG RNPNKTPLAV GYTNEQMARL
210 220 230 240 250
MEQTLPINPP KNEDPDLRWA PSWLIQYTGD ASTDKSYLPH VTAKSSAGLP
260 270 280 290 300
YIGKTKGDTT AEALVLADSF IRDLGKAATS ADPGAAAKKV LSDFWYLSCG
310 320 330 340 350
LLFPKGERYT QKDWDLKTRN IWSAPYPTHL LLSMVSSPVM DESKLNITNT
360 370 380 390 400
QTPSLYGFSP FHGGINRIMT IIREHLDQEQ DLVMIYADNI YILQDNTWYS
410 420 430 440 450
IDLEKGEANC TPQHMQAMMY YRLTREWTNE DGSPRYNPTW ATFAMYVGPS
460 470 480 490 500
MVVDSTCLLM NLQLKTTGQG SGNAFTFLNN HLMSTIVVAE WHKAGRPNPM
510 520 530 540 550
SKEFMDLEAK TGINFKIERE LKDLRSIIME AVDTAPLDGY LADGSDLPPR
560 570 580 590 600
VPGKAVELDL LGWSAVYSRQ LEMFVPVLEN ERLIASVAYP KGLENKSLAR
610 620 630 640 650
KPGAEIAYQI VRYEAIRLIG GWNNPLIETA AKHMSLDKRK RLEVKGIDVT
660 670 680 690 700
GFLDDWNTMS EFGGDLEGIS LTAPLTNQTL LDINTPETEF DVKDRPPTPR
710 720 730 740 750
SPGKTLAEVT AAITSGTYKD PKSAVWRLLD QRTKLRVSTL RDHAHALKPA
760 770 780 790 800
ASTSDFWGDA TEELAEQQQL LMKANNLLKS SLTEAREALE TVQSDKIISG
810 820 830 840
KTSPEKNPGT AANPVVAYGE FSEKIPLTPT QKKNAKRREK QRRN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58757 Genomic RNA Translation: AAA46244.1 |
PIRi | B37946, RRXSSP |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58757 Genomic RNA Translation: AAA46244.1 |
PIRi | B37946, RRXSSP |
3D structure databases
SMRi | P22174 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR007100, RNA-dir_pol_birnavirus IPR007098, RNA-dir_pol_mononegavirus |
Pfami | View protein in Pfam PF04197, Birna_RdRp, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50524, RDRP_DSRNA_BIR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDRP_IPNVS | |
Accessioni | P22174Primary (citable) accession number: P22174 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | September 29, 2021 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |