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Protein

RNA-directed RNA polymerase

Gene

VP1

Organism
Infectious pancreatic necrosis virus (strain Jasper) (IPNV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi248 – 255GTPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RDRP
Alternative name(s):
Protein VP1
Gene namesi
Name:VP1
OrganismiInfectious pancreatic necrosis virus (strain Jasper) (IPNV)
Taxonomic identifieri11003 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesBirnaviridaeAquabirnavirus
Virus hostiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) [TaxID: 8022]
Salmo [TaxID: 8028]
Proteomesi
  • UP000007248 Componenti: Genome

Subcellular locationi

  • Virion By similarity
  • Note: Minor amounts are incorporated in the virion.By similarity

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002219631 – 845RNA-directed RNA polymeraseAdd BLAST845

Post-translational modificationi

Exists in multiple phosphorylated forms.

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRIDEiP22173

Interactioni

Subunit structurei

Interacts with VP3 in the cytoplasm.By similarity

Structurei

Secondary structure

1845
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22173
SMRiP22173
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22173

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini384 – 588RdRp catalyticPROSITE-ProRule annotationAdd BLAST205

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi766 – 769Poly-Gln4

Phylogenomic databases

OrthoDBiVOG0900001R

Family and domain databases

InterProiView protein in InterPro
IPR007100 RNA-dir_pol_birnavirus
IPR007098 RNA-dir_pol_mononegavirus
PfamiView protein in Pfam
PF04197 Birna_RdRp, 1 hit
PROSITEiView protein in PROSITE
PS50524 RDRP_DSRNA_BIR, 1 hit

Sequencei

Sequence statusi: Complete.

P22173-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDIFNSPQN KASILTALMK STTGDVEDVL IPKRFRPAKD PLDSPQAAAQ
60 70 80 90 100
FLKDNKYRIL RPRAIPTMVE LETDAALPRL RQMVEDGKLK DTVSVPEGTT
110 120 130 140 150
AFYPKYYPFH KPDHDEVGTF GAPDITLLKQ LTFFLLENDF PTGPETLRQV
160 170 180 190 200
REAIATLQYG SGSYSGQLNR LLAMKGVATG RNPNKTPKTV GYTNEQLAKL
210 220 230 240 250
LEQTLPINTP KHEDPDLRWA PSWLINYTGD LSTDKSYLPH VTIKSSAGLP
260 270 280 290 300
YIGKTKGDTT AEALVLADSF IRDLGRAATS ADPEAGVKKT ITDFWYLSCG
310 320 330 340 350
LLFPKGERYT QVDWDKKTRN IWSAPYPTHL LLSMVSTPVM NESKLNITNT
360 370 380 390 400
QTPSLYGFSP FHGGMDRIMT IIRDSLDNDE DLVMIYADNI YILQDNTWYS
410 420 430 440 450
IDLEKGEANC TPQHMQAMMY YLLTRGWTNE DGSPRYNPTW ATFAMNVAPS
460 470 480 490 500
MVVDSSCLLM NLQLKTYGQG SGNAFTFLNN HLMSTIVVAE WVKAGKPNPM
510 520 530 540 550
TKEFMDLEEK TGINFKIERE LKNLRETIVE AVETAPQDGY LADGSDLPPI
560 570 580 590 600
RPGKAVELDL LGWSAIYSRQ MEMFVPVLEN ERLIASAAYP KGLENKALAR
610 620 630 640 650
KPGAEIAYQI VRYEAIRLVG GWNNPLLETA AKHMSLDKRK RLEVKGIDVT
660 670 680 690 700
GFLDDWNNMS EFGGDLEGIT LSEPLTNQTL VDINTPLDSF DPKARPQTPR
710 720 730 740 750
SPKKTLDEVT TAITSGTYKD PKSAVWRLLD QRTKLRVSTL RDQALALKPA
760 770 780 790 800
SSSVDNWAEA TEELAQQQQL LMKANNLLKS SLTETREALE TIQSDKIIAG
810 820 830 840
KSNPEKNPGT AANPVVGYGE FSEKIPLTPT QKKNAKRREK QRRNQ
Length:845
Mass (Da):94,467
Last modified:August 1, 1991 - v1
Checksum:i45C392DF3AAF767A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58756 Genomic RNA Translation: AAA46243.1
PIRiA37946 RRXSJA
RefSeqiNP_047197.1, NC_001916.1

Genome annotation databases

GeneIDi956514
KEGGivg:956514

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58756 Genomic RNA Translation: AAA46243.1
PIRiA37946 RRXSJA
RefSeqiNP_047197.1, NC_001916.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YI8X-ray2.30A/B/C/D/E1-790[»]
2YI9X-ray2.20A/B/C/D/E1-790[»]
2YIAX-ray3.02A/B/C/D/E/F/G/H1-790[»]
2YIBX-ray3.80A/B/C1-845[»]
D1-687[»]
3ZEDX-ray2.20A/B/C1-845[»]
ProteinModelPortaliP22173
SMRiP22173
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP22173

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi956514
KEGGivg:956514

Phylogenomic databases

OrthoDBiVOG0900001R

Miscellaneous databases

EvolutionaryTraceiP22173

Family and domain databases

InterProiView protein in InterPro
IPR007100 RNA-dir_pol_birnavirus
IPR007098 RNA-dir_pol_mononegavirus
PfamiView protein in Pfam
PF04197 Birna_RdRp, 1 hit
PROSITEiView protein in PROSITE
PS50524 RDRP_DSRNA_BIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRDRP_IPNVJ
AccessioniPrimary (citable) accession number: P22173
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: March 15, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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