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Entry version 188 (07 Apr 2021)
Sequence version 1 (01 Aug 1991)
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Protein

Clathrin heavy chain

Gene

CHC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. In yeast, it is involved in the retention of proteins in an intracellular membrane compartment, presumably the trans-Golgi.

1 Publication

Miscellaneous

Present with 28700 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • clathrin light chain binding Source: GO_Central
  • structural molecule activity Source: SGD

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-432720, Lysosome Vesicle Biogenesis
R-SCE-437239, Recycling pathway of L1
R-SCE-8856828, Clathrin-mediated endocytosis
R-SCE-8866427, VLDLR internalisation and degradation
R-SCE-8964038, LDL clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin heavy chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHC1
Ordered Locus Names:YGL206C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003174, CHC1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YGL206C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002057851 – 1653Clathrin heavy chainAdd BLAST1653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1107Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P22137

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P22137

PRoteomics IDEntifications database

More...
PRIDEi
P22137

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22137

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat.

Interacts with the auxilin-like clathrin uncoating factor SWA2.

Interacts with INP53.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33050, 126 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1616, Clathrin complex

Database of interacting proteins

More...
DIPi
DIP-2279N

Protein interaction database and analysis system

More...
IntActi
P22137, 104 interactors

Molecular INTeraction database

More...
MINTi
P22137

STRING: functional protein association networks

More...
STRINGi
4932.YGL206C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P22137, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P22137

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati543 – 689CHCR 1Add BLAST147
Repeati692 – 834CHCR 2Add BLAST143
Repeati839 – 978CHCR 3Add BLAST140
Repeati985 – 1130CHCR 4Add BLAST146
Repeati1134 – 1275CHCR 5Add BLAST142
Repeati1280 – 1426CHCR 6Add BLAST147
Repeati1429 – 1572CHCR 7Add BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni? – 1653Proximal segment
Regioni1 – 483Globular terminal domainAdd BLAST483
Regioni23 – 66WD40-like repeat 1Add BLAST44
Regioni67 – 107WD40-like repeat 2Add BLAST41
Regioni108 – 152WD40-like repeat 3Add BLAST45
Regioni153 – 198WD40-like repeat 4Add BLAST46
Regioni199 – 263WD40-like repeat 5Add BLAST65
Regioni264 – 307WD40-like repeat 6Add BLAST44
Regioni308 – 336WD40-like repeat 7Add BLAST29
Regioni453 – 469Binding site for the uncoating ATPase, involved in lattice disassemblySequence analysisAdd BLAST17
Regioni484 – 527Flexible linkerAdd BLAST44
Regioni528 – 1653Heavy chain armAdd BLAST1126
Regioni528 – ?Distal segment
Regioni1219 – 1528Involved in binding clathrin light chainBy similarityAdd BLAST310

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the clathrin heavy chain family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0985, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183166

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002136_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P22137

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQQCTAF

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 4 hits
2.130.10.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR000547, Clathrin_H-chain/VPS_repeat
IPR015348, Clathrin_H-chain_linker_core
IPR016025, Clathrin_H-chain_N
IPR022365, Clathrin_H-chain_propeller_rpt
IPR016341, Clathrin_heavy_chain
IPR011990, TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00637, Clathrin, 7 hits
PF09268, Clathrin-link, 1 hit
PF01394, Clathrin_propel, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002290, Clathrin_H_chain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00299, CLH, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 6 hits
SSF50989, SSF50989, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50236, CHCR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P22137-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDLPIEFTE LVDLMSLGIS PQFLDFRSTT FESDHFVTVR ETKDGTNSVA
60 70 80 90 100
IVDLAKGNEV TRKNMGGDSA IMHPSQMVIS VRANGTIVQI FNLETKSKLK
110 120 130 140 150
SFTLDEPVIF WRWLSETTLG FVTARSILTS NVFDGNVNAK PQLLTLRHAN
160 170 180 190 200
LNNTQIINFV ANKNLDWFAV VGILQENGRI AGRIQLFSKQ RNISQAIDGH
210 220 230 240 250
VAIFTNILLE GNGSTPVQVF VTGNRNATTG AGELRIIEID HDASLPSQYQ
260 270 280 290 300
KETTDIFFPP DATNDFPIAV QVSEKYGIIY LLTKYGFIHL YELETGTNLF
310 320 330 340 350
VNRITAESVF TAAPYNHENG IACINKKGQV LAVEISTSQI VPYILNKLSN
360 370 380 390 400
VALALIVATR GGLPGADDLF QKQFESLLLQ NDYQNAAKVA ASSTSLRNQN
410 420 430 440 450
TINRLKNIQA PPGAISPILL YFSTLLDKGK LNKEETIELA RPVLQQDRKQ
460 470 480 490 500
LFEKWLKEDK LECSEELGDI VKPFDTTLAL ACYLRAGAHA KVISCLAELQ
510 520 530 540 550
QFEKIIPYCQ KVGYQPNFLV LISSLIRSSP DRASEFAVSL LQNPETASQI
560 570 580 590 600
DIEKIADLFF SQNHIQQGTS LLLDALKGDT PDQGHLQTRV LEVNLLHAPQ
610 620 630 640 650
VADAILGNNI FSHYDKPTIA SLSEKAGLYQ RALENYTDIK DIKRCVVHTN
660 670 680 690 700
ALPIDWLVGY FGKLNVEQSL ACLKALMDNN IQANIQTVVQ VATKFSDLIG
710 720 730 740 750
PSTLIKLFED YNATEGLYYY LASLVNLTED KDVVYKYIEA AAKMKQYREI
760 770 780 790 800
ERIVKDNNVY DPERVKNFLK DANLEDQLPL VIVCDRFDFV HEMILYLYKS
810 820 830 840 850
QNLKFIETYV QQVNPSKTAQ VVGALLDMDC DEAFIQSLLQ SVLGQVPINE
860 870 880 890 900
LTTEVEKRNR LKILLPFLEQ SLSQGIQDQA VYNALAKIYI DSNNSPEKFL
910 920 930 940 950
KENDQYDTLD VGHYCEKRDP YLAYIAYEKG QNDDDLIRIT NENSMYKYQA
960 970 980 990 1000
RYLLERSDLD LWNKVLNQEN IHRRQLIDSV ISVGIPELTD PEPVSLTVQA
1010 1020 1030 1040 1050
FMTNGLKLEL IELLEKIILE PSPFNENVAL QGLLLLSAIK YEPTKVSSYI
1060 1070 1080 1090 1100
EKLDNYDADE IAPLCIEHDL KEEAFEIYDK HEMYGKALKV LIEDIMSLDR
1110 1120 1130 1140 1150
AASYADKINT PELWSQIGTA QLDGLRIPDA IESYIKAEDP SNYENVIDIA
1160 1170 1180 1190 1200
EQAGKYEELI PFLLMARKTL KEPKIDGALI LAYAELNKIH EIENLLAGSN
1210 1220 1230 1240 1250
VANLDHVGDK LFENKEYKAA RLCYSAVSNY SKLASTLVYL GDYQAAVDTA
1260 1270 1280 1290 1300
RKASNIKVWK LVNDACIEKK EFKLAQICGL NLIVHAEELD ELVERYESNG
1310 1320 1330 1340 1350
YFEELISLFE AGLGLERAHM GMFTELAILY SKYEPDKTFE HLKLFWSRIN
1360 1370 1380 1390 1400
IPKVIRAVEQ AHLWSELVFL YAHYDEWDNA ALTLIEKSTK DLDHAYFKEV
1410 1420 1430 1440 1450
VVKVSNLEIY YKAINFYVKF HPSLLVDLLT SLTPRLDIPR TVKIFSKSDN
1460 1470 1480 1490 1500
LPLIKPFLIN VLPKNNSVVN QAYHDLMIEE EDYKALQDAV DSYDKFDQLG
1510 1520 1530 1540 1550
LASRLESHKL IFFKKIGALL YRRNKKWAKS LSILKEEKLW KDAIETAAIS
1560 1570 1580 1590 1600
QDPKVVEALL TYFVETGNRE GFVALLYAAY NLVRIEFVLE ISWMNSLEDY
1610 1620 1630 1640 1650
IKPFEISIKK EQNDSIKKIT EELAKKSGSN EEHKDGQPLM LMNSAMNVQP

TGF
Length:1,653
Mass (Da):187,234
Last modified:August 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i622F3083DF2FE315
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X52900 Genomic DNA Translation: CAA37082.1
Z72728 Genomic DNA Translation: CAA96919.1
BK006941 Genomic DNA Translation: DAA07910.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A36349

NCBI Reference Sequences

More...
RefSeqi
NP_011309.1, NM_001181071.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL206C_mRNA; YGL206C; YGL206C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852666

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL206C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52900 Genomic DNA Translation: CAA37082.1
Z72728 Genomic DNA Translation: CAA96919.1
BK006941 Genomic DNA Translation: DAA07910.1
PIRiA36349
RefSeqiNP_011309.1, NM_001181071.1

3D structure databases

SMRiP22137
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi33050, 126 interactors
ComplexPortaliCPX-1616, Clathrin complex
DIPiDIP-2279N
IntActiP22137, 104 interactors
MINTiP22137
STRINGi4932.YGL206C

PTM databases

iPTMnetiP22137

Proteomic databases

MaxQBiP22137
PaxDbiP22137
PRIDEiP22137

Genome annotation databases

EnsemblFungiiYGL206C_mRNA; YGL206C; YGL206C
GeneIDi852666
KEGGisce:YGL206C

Organism-specific databases

SGDiS000003174, CHC1
VEuPathDBiFungiDB:YGL206C

Phylogenomic databases

eggNOGiKOG0985, Eukaryota
GeneTreeiENSGT00950000183166
HOGENOMiCLU_002136_0_0_1
InParanoidiP22137
OMAiVQQCTAF

Enzyme and pathway databases

ReactomeiR-SCE-432720, Lysosome Vesicle Biogenesis
R-SCE-437239, Recycling pathway of L1
R-SCE-8856828, Clathrin-mediated endocytosis
R-SCE-8866427, VLDLR internalisation and degradation
R-SCE-8964038, LDL clearance

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P22137
RNActiP22137, protein

Family and domain databases

Gene3Di1.25.40.10, 4 hits
2.130.10.110, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR000547, Clathrin_H-chain/VPS_repeat
IPR015348, Clathrin_H-chain_linker_core
IPR016025, Clathrin_H-chain_N
IPR022365, Clathrin_H-chain_propeller_rpt
IPR016341, Clathrin_heavy_chain
IPR011990, TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00637, Clathrin, 7 hits
PF09268, Clathrin-link, 1 hit
PF01394, Clathrin_propel, 1 hit
PIRSFiPIRSF002290, Clathrin_H_chain, 1 hit
SMARTiView protein in SMART
SM00299, CLH, 7 hits
SUPFAMiSSF48371, SSF48371, 6 hits
SSF50989, SSF50989, 1 hit
PROSITEiView protein in PROSITE
PS50236, CHCR, 7 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLH_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22137
Secondary accession number(s): D6VTU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: April 7, 2021
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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