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Protein

Tenascin-X

Gene

TNXB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.1 Publication

Caution

There are two genes for TN-X: TNXA and TNXB. TNXA can sometimes recombine with TNXB.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • cell adhesion Source: UniProtKB
  • collagen fibril organization Source: InterPro
  • collagen metabolic process Source: UniProtKB
  • elastic fiber assembly Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000178 ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tenascin-XCurated
Short name:
TN-X
Alternative name(s):
Hexabrachion-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNXBImported
Synonyms:HXBL, TNX, TNXB1, TNXB2, XB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168477.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11976 TNXB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600985 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22105

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ehlers-Danlos syndrome, classic-like (EDSCLL)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSCLL patients lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos syndrome. Delayed wound healing is only present in a subset of patients. EDSCLL inheritance is autosomal recessive.
See also OMIM:606408
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04649929R → W in EDSCLL. 1 Publication1
Natural variantiVAR_0465001108V → M in EDSCLL. 1 Publication1
Natural variantiVAR_0725824074R → C in EDSCLL. 1 Publication1
Vesicoureteral reflux 8 (VUR8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.
See also OMIM:615963
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0725801244T → R in VUR8. 1 Publication1
Natural variantiVAR_0725813212V → I in VUR8; shows significantly impaired migration in a wound-healing assay; associated with decreased expression of phosphorylated PTK2 protein. 1 Publication1

Keywords - Diseasei

Disease mutation, Ehlers-Danlos syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
7148

MalaCards human disease database

More...
MalaCardsi
TNXB
MIMi606408 phenotype
615963 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000168477

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
230839 Ehlers-Danlos syndrome due to tenascin-X deficiency
285 Ehlers-Danlos syndrome, hypermobility type
289365 Familial vesicoureteral reflux

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36662

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNXB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
290457668

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000775124 – 4244Tenascin-XAdd BLAST4221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi187 ↔ 197By similarity
Disulfide bondi191 ↔ 202By similarity
Disulfide bondi204 ↔ 213By similarity
Disulfide bondi218 ↔ 228By similarity
Disulfide bondi222 ↔ 233By similarity
Disulfide bondi235 ↔ 244By similarity
Disulfide bondi249 ↔ 259By similarity
Disulfide bondi253 ↔ 264By similarity
Disulfide bondi266 ↔ 275By similarity
Disulfide bondi280 ↔ 290By similarity
Disulfide bondi284 ↔ 295By similarity
Disulfide bondi297 ↔ 306By similarity
Disulfide bondi311 ↔ 321By similarity
Disulfide bondi315 ↔ 326By similarity
Disulfide bondi328 ↔ 337By similarity
Disulfide bondi342 ↔ 352By similarity
Disulfide bondi346 ↔ 357By similarity
Disulfide bondi359 ↔ 368By similarity
Disulfide bondi373 ↔ 383By similarity
Disulfide bondi377 ↔ 388By similarity
Disulfide bondi390 ↔ 399By similarity
Disulfide bondi404 ↔ 414By similarity
Disulfide bondi408 ↔ 419By similarity
Disulfide bondi421 ↔ 430By similarity
Disulfide bondi435 ↔ 445By similarity
Disulfide bondi439 ↔ 450By similarity
Disulfide bondi452 ↔ 461By similarity
Disulfide bondi466 ↔ 476By similarity
Disulfide bondi470 ↔ 481By similarity
Disulfide bondi483 ↔ 492By similarity
Disulfide bondi497 ↔ 507By similarity
Disulfide bondi501 ↔ 512By similarity
Disulfide bondi514 ↔ 523By similarity
Disulfide bondi528 ↔ 538By similarity
Disulfide bondi532 ↔ 543By similarity
Disulfide bondi545 ↔ 554By similarity
Disulfide bondi559 ↔ 569By similarity
Disulfide bondi563 ↔ 574By similarity
Disulfide bondi576 ↔ 585By similarity
Disulfide bondi590 ↔ 600By similarity
Disulfide bondi594 ↔ 605By similarity
Disulfide bondi607 ↔ 616By similarity
Disulfide bondi621 ↔ 631By similarity
Disulfide bondi625 ↔ 636By similarity
Disulfide bondi638 ↔ 647By similarity
Disulfide bondi652 ↔ 662By similarity
Disulfide bondi656 ↔ 667By similarity
Disulfide bondi669 ↔ 678By similarity
Disulfide bondi688 ↔ 698By similarity
Disulfide bondi692 ↔ 703By similarity
Disulfide bondi705 ↔ 714By similarity
Disulfide bondi719 ↔ 729By similarity
Disulfide bondi723 ↔ 734By similarity
Disulfide bondi736 ↔ 745By similarity
Glycosylationi3855N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3908N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3920N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4030 ↔ 4060By similarity
Glycosylationi4095N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4182 ↔ 4195By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P22105

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P22105

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P22105

PeptideAtlas

More...
PeptideAtlasi
P22105

PRoteomics IDEntifications database

More...
PRIDEi
P22105

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53963
53964 [P22105-2]
53965 [P22105-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1794

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22105

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P22105

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression levels are lower in adults than in children.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168477 Expressed in 112 organ(s), highest expression level in left adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P22105 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P22105 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer. Interacts with type I, III and V collagens and tropoelastin via its 29th fibronectin type-III domain.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N54EBI-2821024,EBI-744695

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113001, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1014 Tenascin-X complex

Protein interaction database and analysis system

More...
IntActi
P22105, 12 interactors

Molecular INTeraction database

More...
MINTi
P22105

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000407685

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P22105

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P22105

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P22105

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini156 – 168EGF-like 1; incompletePROSITE-ProRule annotationAdd BLAST13
Domaini183 – 213EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini214 – 244EGF-like 3PROSITE-ProRule annotationAdd BLAST31
Domaini245 – 275EGF-like 4PROSITE-ProRule annotationAdd BLAST31
Domaini276 – 306EGF-like 5PROSITE-ProRule annotationAdd BLAST31
Domaini307 – 337EGF-like 6PROSITE-ProRule annotationAdd BLAST31
Domaini338 – 368EGF-like 7PROSITE-ProRule annotationAdd BLAST31
Domaini369 – 399EGF-like 8PROSITE-ProRule annotationAdd BLAST31
Domaini400 – 430EGF-like 9PROSITE-ProRule annotationAdd BLAST31
Domaini431 – 461EGF-like 10PROSITE-ProRule annotationAdd BLAST31
Domaini462 – 492EGF-like 11PROSITE-ProRule annotationAdd BLAST31
Domaini493 – 523EGF-like 12PROSITE-ProRule annotationAdd BLAST31
Domaini524 – 554EGF-like 13PROSITE-ProRule annotationAdd BLAST31
Domaini555 – 585EGF-like 14PROSITE-ProRule annotationAdd BLAST31
Domaini586 – 616EGF-like 15PROSITE-ProRule annotationAdd BLAST31
Domaini617 – 647EGF-like 16PROSITE-ProRule annotationAdd BLAST31
Domaini648 – 679EGF-like 17PROSITE-ProRule annotationAdd BLAST32
Domaini684 – 714EGF-like 18PROSITE-ProRule annotationAdd BLAST31
Domaini715 – 746EGF-like 19PROSITE-ProRule annotationAdd BLAST32
Domaini959 – 1051Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini1064 – 1153Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST90
Domaini1161 – 1249Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST89
Domaini1263 – 1352Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST90
Domaini1374 – 1468Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST95
Domaini1476 – 1572Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST97
Domaini1574 – 1669Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini1674 – 1764Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST91
Domaini1778 – 1868Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST91
Domaini1883 – 1971Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST89
Domaini1989 – 2089Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST101
Domaini2097 – 2185Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST89
Domaini2196 – 2296Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST101
Domaini2305 – 2398Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST94
Domaini2408 – 2502Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST95
Domaini2519 – 2617Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST99
Domaini2625 – 2723Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST99
Domaini2733 – 2840Fibronectin type-III 18PROSITE-ProRule annotationAdd BLAST108
Domaini2841 – 2939Fibronectin type-III 19PROSITE-ProRule annotationAdd BLAST99
Domaini2949 – 3042Fibronectin type-III 20PROSITE-ProRule annotationAdd BLAST94
Domaini3062 – 3153Fibronectin type-III 21PROSITE-ProRule annotationAdd BLAST92
Domaini3168 – 3260Fibronectin type-III 22PROSITE-ProRule annotationAdd BLAST93
Domaini3264 – 3355Fibronectin type-III 23PROSITE-ProRule annotationAdd BLAST92
Domaini3357 – 3446Fibronectin type-III 24PROSITE-ProRule annotationAdd BLAST90
Domaini3451 – 3544Fibronectin type-III 25PROSITE-ProRule annotationAdd BLAST94
Domaini3553 – 3647Fibronectin type-III 26PROSITE-ProRule annotationAdd BLAST95
Domaini3657 – 3754Fibronectin type-III 27PROSITE-ProRule annotationAdd BLAST98
Domaini3758 – 3847Fibronectin type-III 28PROSITE-ProRule annotationAdd BLAST90
Domaini3848 – 3934Fibronectin type-III 29PROSITE-ProRule annotationAdd BLAST87
Domaini3935 – 4025Fibronectin type-III 30PROSITE-ProRule annotationAdd BLAST91
Domaini4021 – 4236Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST216

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1666 – 1668Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family.Curated

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2579 Eukaryota
ENOG410ZYS4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155565

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006855

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P22105

KEGG Orthology (KO)

More...
KOi
K06252

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEGHFDH

TreeFam database of animal gene trees

More...
TreeFami
TF329915

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 31 hits
cd00087 FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 31 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033081 TNX

The PANTHER Classification System

More...
PANTHERi
PTHR19143:SF244 PTHR19143:SF244, 21 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974 EGF_2, 2 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 31 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 18 hits
SM00186 FBG, 1 hit
SM00060 FN3, 32 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 29 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 18 hits
PS01186 EGF_2, 19 hits
PS50026 EGF_3, 8 hits
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 32 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: P22105-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMPAQYALTS SLVLLVLLST ARAGPFSSRS NVTLPAPRPP PQPGGHTVGA
60 70 80 90 100
GVGSPSSQLY EHTVEGGEKQ VVFTHRINLP PSTGCGCPPG TEPPVLASEV
110 120 130 140 150
QALRVRLEIL EELVKGLKEQ CTGGCCPASA QAGTGQTDVR TLCSLHGVFD
160 170 180 190 200
LSRCTCSCEP GWGGPTCSDP TDAEIPPSSP PSASGSCPDD CNDQGRCVRG
210 220 230 240 250
RCVCFPGYTG PSCGWPSCPG DCQGRGRCVQ GVCVCRAGFS GPDCSQRSCP
260 270 280 290 300
RGCSQRGRCE GGRCVCDPGY TGDDCGMRSC PRGCSQRGRC ENGRCVCNPG
310 320 330 340 350
YTGEDCGVRS CPRGCSQRGR CKDGRCVCDP GYTGEDCGTR SCPWDCGEGG
360 370 380 390 400
RCVDGRCVCW PGYTGEDCST RTCPRDCRGR GRCEDGECIC DTGYSGDDCG
410 420 430 440 450
VRSCPGDCNQ RGRCEDGRCV CWPGYTGTDC GSRACPRDCR GRGRCENGVC
460 470 480 490 500
VCNAGYSGED CGVRSCPGDC RGRGRCESGR CMCWPGYTGR DCGTRACPGD
510 520 530 540 550
CRGRGRCVDG RCVCNPGFTG EDCGSRRCPG DCRGHGLCED GVCVCDAGYS
560 570 580 590 600
GEDCSTRSCP GGCRGRGQCL DGRCVCEDGY SGEDCGVRQC PNDCSQHGVC
610 620 630 640 650
QDGVCICWEG YVSEDCSIRT CPSNCHGRGR CEEGRCLCDP GYTGPTCATR
660 670 680 690 700
MCPADCRGRG RCVQGVCLCH VGYGGEDCGQ EEPPASACPG GCGPRELCRA
710 720 730 740 750
GQCVCVEGFR GPDCAIQTCP GDCRGRGECH DGSCVCKDGY AGEDCGEEVP
760 770 780 790 800
TIEGMRMHLL EETTVRTEWT PAPGPVDAYE IQFIPTTEGA SPPFTARVPS
810 820 830 840 850
SASAYDQRGL APGQEYQVTV RALRGTSWGL PASKTITTMI DGPQDLRVVA
860 870 880 890 900
VTPTTLELGW LRPQAEVDRF VVSYVSAGNQ RVRLEVPPEA DGTLLTDLMP
910 920 930 940 950
GVEYVVTVTA ERGRAVSYPA SVRANTGSSP LGLLGTTDEP PPSGPSTTQG
960 970 980 990 1000
AQAPLLQQRP QELGELRVLG RDETGRLRVV WTAQPDTFAY FQLRMRVPEG
1010 1020 1030 1040 1050
PGAHEEVLPG DVRQALVPPP PPGTPYELSL HGVPPGGKPS DPIIYQGIMD
1060 1070 1080 1090 1100
KDEEKPGKSS GPPRLGELTV TDRTSDSLLL RWTVPEGEFD SFVIQYKDRD
1110 1120 1130 1140 1150
GQPQVVPVEG PQRSAVITSL DPGRKYKFVL YGFVGKKRHG PLVAEAKILP
1160 1170 1180 1190 1200
QSDPSPGTPP HLGNLWVTDP TPDSLHLSWT VPEGQFDTFM VQYRDRDGRP
1210 1220 1230 1240 1250
QVVPVEGPER SFVVSSLDPD HKYRFTLFGI ANKKRYGPLT ADGTTAPERK
1260 1270 1280 1290 1300
EEPPRPEFLE QPLLGELTVT GVTPDSLRLS WTVAQGPFDS FMVQYKDAQG
1310 1320 1330 1340 1350
QPQAVPVAGD ENEVTVPGLD PDRKYKMNLY GLRGRQRVGP ESVVAKTAPQ
1360 1370 1380 1390 1400
EDVDETPSPT ELGTEAPESP EEPLLGELTV TGSSPDSLSL FWTVPQGSFD
1410 1420 1430 1440 1450
SFTVQYKDRD GRPRAVRVGG KESEVTVGGL EPGHKYKMHL YGLHEGQRVG
1460 1470 1480 1490 1500
PVSAVGVTAP QQEETPPATE SPLEPRLGEL TVTDVTPNSV GLSWTVPEGQ
1510 1520 1530 1540 1550
FDSFIVQYKD KDGQPQVVPV AADQREVTVY NLEPERKYKM NMYGLHDGQR
1560 1570 1580 1590 1600
MGPLSVVIVT APLPPAPATE ASKPPLEPRL GELTVTDITP DSVGLSWTVP
1610 1620 1630 1640 1650
EGEFDSFVVQ YKDRDGQPQV VPVAADQREV TIPDLEPSRK YKFLLFGIQD
1660 1670 1680 1690 1700
GKRRSPVSVE AKTVARGDAS PGAPPRLGEL WVTDPTPDSL RLSWTVPEGQ
1710 1720 1730 1740 1750
FDSFVVQFKD KDGPQVVPVE GHERSVTVTP LDAGRKYRFL LYGLLGKKRH
1760 1770 1780 1790 1800
GPLTADGTTE ARSAMDDTGT KRPPKPRLGE ELQVTTVTQN SVGLSWTVPE
1810 1820 1830 1840 1850
GQFDSFVVQY KDRDGQPQVV PVEGSLREVS VPGLDPAHRY KLLLYGLHHG
1860 1870 1880 1890 1900
KRVGPISAVA ITAGREETET ETTAPTPPAP EPHLGELTVE EATSHTLHLS
1910 1920 1930 1940 1950
WMVTEGEFDS FEIQYTDRDG QLQMVRIGGD RNDITLSGLE SDHRYLVTLY
1960 1970 1980 1990 2000
GFSDGKHVGP VHVEALTVPE EEKPSEPPTA TPEPPIKPRL GELTVTDATP
2010 2020 2030 2040 2050
DSLSLSWTVP EGQFDHFLVQ YRNGDGQPKA VRVPGHEEGV TISGLEPDHK
2060 2070 2080 2090 2100
YKMNLYGFHG GQRMGPVSVV GVTAAEEETP SPTEPSMEAP EPAEEPLLGE
2110 2120 2130 2140 2150
LTVTGSSPDS LSLSWTVPQG RFDSFTVQYK DRDGRPQVVR VGGEESEVTV
2160 2170 2180 2190 2200
GGLEPGRKYK MHLYGLHEGR RVGPVSAVGV TAPEEESPDA PLAKLRLGQM
2210 2220 2230 2240 2250
TVRDITSDSL SLSWTVPEGQ FDHFLVQFKN GDGQPKAVRV PGHEDGVTIS
2260 2270 2280 2290 2300
GLEPDHKYKM NLYGFHGGQR VGPVSAVGLT APGKDEEMAP ASTEPPTPEP
2310 2320 2330 2340 2350
PIKPRLEELT VTDATPDSLS LSWTVPEGQF DHFLVQYKNG DGQPKATRVP
2360 2370 2380 2390 2400
GHEDRVTISG LEPDNKYKMN LYGFHGGQRV GPVSAIGVTA AEEETPSPTE
2410 2420 2430 2440 2450
PSMEAPEPPE EPLLGELTVT GSSPDSLSLS WTVPQGRFDS FTVQYKDRDG
2460 2470 2480 2490 2500
RPQVVRVGGE ESEVTVGGLE PGRKYKMHLY GLHEGRRVGP VSTVGVTAPQ
2510 2520 2530 2540 2550
EDVDETPSPT EPGTEAPGPP EEPLLGELTV TGSSPDSLSL SWTVPQGRFD
2560 2570 2580 2590 2600
SFTVQYKDRD GRPQAVRVGG QESKVTVRGL EPGRKYKMHL YGLHEGRRLG
2610 2620 2630 2640 2650
PVSAVGVTED EAETTQAVPT MTPEPPIKPR LGELTMTDAT PDSLSLSWTV
2660 2670 2680 2690 2700
PEGQFDHFLV QYRNGDGQPK AVRVPGHEDG VTISGLEPDH KYKMNLYGFH
2710 2720 2730 2740 2750
GGQRVGPISV IGVTAAEEET PSPTELSTEA PEPPEEPLLG ELTVTGSSPD
2760 2770 2780 2790 2800
SLSLSWTIPQ GHFDSFTVQY KDRDGRPQVM RVRGEESEVT VGGLEPGRKY
2810 2820 2830 2840 2850
KMHLYGLHEG RRVGPVSTVG VTAPEDEAET TQAVPTTTPE PPNKPRLGEL
2860 2870 2880 2890 2900
TVTDATPDSL SLSWMVPEGQ FDHFLVQYRN GDGQPKVVRV PGHEDGVTIS
2910 2920 2930 2940 2950
GLEPDHKYKM NLYGFHGGQR VGPISVIGVT AAEEETPAPT EPSTEAPEPP
2960 2970 2980 2990 3000
EEPLLGELTV TGSSPDSLSL SWTIPQGRFD SFTVQYKDRD GRPQVVRVRG
3010 3020 3030 3040 3050
EESEVTVGGL EPGCKYKMHL YGLHEGQRVG PVSAVGVTAP KDEAETTQAV
3060 3070 3080 3090 3100
PTMTPEPPIK PRLGELTVTD ATPDSLSLSW MVPEGQFDHF LVQYRNGDGQ
3110 3120 3130 3140 3150
PKAVRVPGHE DGVTISGLEP DHKYKMNLYG FHGGQRVGPV SAIGVTEEET
3160 3170 3180 3190 3200
PSPTEPSTEA PEAPEEPLLG ELTVTGSSPD SLSLSWTVPQ GRFDSFTVQY
3210 3220 3230 3240 3250
KDRDGQPQVV RVRGEESEVT VGGLEPGRKY KMHLYGLHEG QRVGPVSTVG
3260 3270 3280 3290 3300
ITAPLPTPLP VEPRLGELAV AAVTSDSVGL SWTVAQGPFD SFLVQYRDAQ
3310 3320 3330 3340 3350
GQPQAVPVSG DLRAVAVSGL DPARKYKFLL FGLQNGKRHG PVPVEARTAP
3360 3370 3380 3390 3400
DTKPSPRLGE LTVTDATPDS VGLSWTVPEG EFDSFVVQYK DKDGRLQVVP
3410 3420 3430 3440 3450
VAANQREVTV QGLEPSRKYR FLLYGLSGRK RLGPISADST TAPLEKELPP
3460 3470 3480 3490 3500
HLGELTVAEE TSSSLRLSWT VAQGPFDSFV VQYRDTDGQP RAVPVAADQR
3510 3520 3530 3540 3550
TVTVEDLEPG KKYKFLLYGL LGGKRLGPVS ALGMTAPEED TPAPELAPEA
3560 3570 3580 3590 3600
PEPPEEPRLG VLTVTDTTPD SMRLSWSVAQ GPFDSFVVQY EDTNGQPQAL
3610 3620 3630 3640 3650
LVDGDQSKIL ISGLEPSTPY RFLLYGLHEG KRLGPLSAEG TTGLAPAGQT
3660 3670 3680 3690 3700
SEESRPRLSQ LSVTDVTTSS LRLNWEAPPG AFDSFLLRFG VPSPSTLEPH
3710 3720 3730 3740 3750
PRPLLQRELM VPGTRHSAVL RDLRSGTLYS LTLYGLRGPH KADSIQGTAR
3760 3770 3780 3790 3800
TLSPVLESPR DLQFSEIRET SAKVNWMPPP SRADSFKVSY QLADGGEPQS
3810 3820 3830 3840 3850
VQVDGQARTQ KLQGLIPGAR YEVTVVSVRG FEESEPLTGF LTTVPDGPTQ
3860 3870 3880 3890 3900
LRALNLTEGF AVLHWKPPQN PVDTYDVQVT APGAPPLQAE TPGSAVDYPL
3910 3920 3930 3940 3950
HDLVLHTNYT ATVRGLRGPN LTSPASITFT TGLEAPRDLE AKEVTPRTAL
3960 3970 3980 3990 4000
LTWTEPPVRP AGYLLSFHTP GGQNQEILLP GGITSHQLLG LFPSTSYNAR
4010 4020 4030 4040 4050
LQAMWGQSLL PPVSTSFTTG GLRIPFPRDC GEEMQNGAGA SRTSTIFLNG
4060 4070 4080 4090 4100
NRERPLNVFC DMETDGGGWL VFQRRMDGQT DFWRDWEDYA HGFGNISGEF
4110 4120 4130 4140 4150
WLGNEALHSL TQAGDYSMRV DLRAGDEAVF AQYDSFHVDS AAEYYRLHLE
4160 4170 4180 4190 4200
GYHGTAGDSM SYHSGSVFSA RDRDPNSLLI SCAVSYRGAW WYRNCHYANL
4210 4220 4230 4240
NGLYGSTVDH QGVSWYHWKG FEFSVPFTEM KLRPRNFRSP AGGG
Note: No experimental confirmation available. May be due to competing acceptor splice site in exon 24.
Length:4,244
Mass (Da):458,388
Last modified:September 12, 2018 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45A3D29FDF133DBA
GO
Isoform 3 (identifier: P22105-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2823-2825: APE → E

Note: No experimental confirmation available.
Show »
Length:4,242
Mass (Da):458,220
Checksum:i7E07AC46BF6F2599
GO
Isoform XB-short (identifier: P22105-2) [UniParc]FASTAAdd to basket
Also known as: 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-3571: Missing.

Show »
Length:673
Mass (Da):74,030
Checksum:i2A14010E8A633FA1
GO
Isoform 5 (identifier: P22105-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: G → GEQG
     2823-2825: APE → E

Note: No experimental confirmation available. May be due to competing donor splice site in exon 1.
Show »
Length:4,245
Mass (Da):458,535
Checksum:iA004E187A210F3D8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWA5A0A087WWA5_HUMAN
Tenascin-X
TNXB
1,545Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8Y3A0A140T8Y3_HUMAN
Tenascin-X
TNXB
4,222Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9C0A0A140T9C0_HUMAN
Tenascin-X
TNXB
4,222Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T956A0A140T956_HUMAN
Tenascin-X
TNXB
2,280Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T902A0A140T902_HUMAN
Tenascin-X
TNXB
4,222Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA52A0A140TA52_HUMAN
Tenascin-X
TNXB
4,242Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA41A0A140TA41_HUMAN
Tenascin-X
TNXB
4,242Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA33A0A140TA33_HUMAN
Tenascin-X
TNXB
4,242Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7W4C9J7W4_HUMAN
Tenascin-X
TNXB
842Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0I0A0A087X0I0_HUMAN
Tenascin-X
TNXB
1,962Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB47488 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAB67981 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB89296 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3791Q → L in AAH33740 (PubMed:15489334).Curated1
Sequence conflicti3877V → I in AAI25115 (PubMed:15489334).Curated1
Sequence conflicti3877V → I in AAI25116 (PubMed:15489334).Curated1
Sequence conflicti3877V → I in BAD92249 (Ref. 10) Curated1
Sequence conflicti3974N → T in AAI25115 (PubMed:15489334).Curated1
Sequence conflicti3974N → T in AAI25116 (PubMed:15489334).Curated1
Sequence conflicti3974N → T in BAD92249 (Ref. 10) Curated1
Sequence conflicti3993P → G in AAB41287 (PubMed:8530023).Curated1
Sequence conflicti3993P → G in AAA35884 (PubMed:2475872).Curated1
Sequence conflicti4004M → T in AAI25116 (PubMed:15489334).Curated1
Sequence conflicti4004M → T in BAD92249 (Ref. 10) Curated1
Sequence conflicti4057N → I in AAI25115 (PubMed:15489334).Curated1
Sequence conflicti4118M → I in AAB41287 (PubMed:8530023).Curated1
Sequence conflicti4118M → I in AAA35884 (PubMed:2475872).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04649929R → W in EDSCLL. 1 Publication1
Natural variantiVAR_044347302T → A1 PublicationCorresponds to variant dbSNP:rs1150752EnsemblClinVar.1
Natural variantiVAR_021908511R → H. Corresponds to variant dbSNP:rs204896EnsemblClinVar.1
Natural variantiVAR_055781641G → C. Corresponds to variant dbSNP:rs17201609Ensembl.1
Natural variantiVAR_055782650R → H. Corresponds to variant dbSNP:rs17201602EnsemblClinVar.1
Natural variantiVAR_055783873S → A. Corresponds to variant dbSNP:rs204900Ensembl.1
Natural variantiVAR_0465001108V → M in EDSCLL. 1 Publication1
Natural variantiVAR_0242701161H → R. Corresponds to variant dbSNP:rs185819EnsemblClinVar.1
Natural variantiVAR_0725801244T → R in VUR8. 1 Publication1
Natural variantiVAR_0592761905E → K. Corresponds to variant dbSNP:rs17207923EnsemblClinVar.1
Natural variantiVAR_0201702301P → H. Corresponds to variant dbSNP:rs2269428Ensembl.1
Natural variantiVAR_0557842363P → H. Corresponds to variant dbSNP:rs2269428Ensembl.1
Natural variantiVAR_0592772412P → L. Corresponds to variant dbSNP:rs12524664EnsemblClinVar.1
Natural variantiVAR_0201712495G → S. Corresponds to variant dbSNP:rs2269429EnsemblClinVar.1
Natural variantiVAR_0201722518G → E2 PublicationsCorresponds to variant dbSNP:rs1009382EnsemblClinVar.1
Natural variantiVAR_0725813212V → I in VUR8; shows significantly impaired migration in a wound-healing assay; associated with decreased expression of phosphorylated PTK2 protein. 1 Publication1
Natural variantiVAR_0465013988L → I1 Publication1
Natural variantiVAR_0725824074R → C in EDSCLL. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0597921 – 3571Missing in isoform XB-short. Add BLAST3571
Alternative sequenceiVSP_059793135G → GEQG in isoform 5. 1
Alternative sequenceiVSP_0597942823 – 2825APE → E in isoform 3 and isoform 5. 3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U24488 mRNA Translation: AAB41287.1
AF019413 Genomic DNA Translation: AAB67981.1 Sequence problems.
U89337 Genomic DNA Translation: AAB47488.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89296.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89300.1
AL645922 Genomic DNA No translation available.
AL662828 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
AL772248 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03574.1
BC033740 mRNA Translation: AAH33740.1
BC125114 mRNA Translation: AAI25115.1
BC125115 mRNA Translation: AAI25116.1
BC130037 mRNA Translation: AAI30038.1
X71923 mRNA Translation: CAA50739.1
Y13782 mRNA Translation: CAA74109.1
Y13783 Genomic DNA Translation: CAA74110.1
U52696 mRNA Translation: AAC50889.1
AB209012 mRNA Translation: BAD92249.1
M25813 mRNA Translation: AAA35884.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4736.1 [P22105-2]

Protein sequence database of the Protein Information Resource

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PIRi
A40701
A42175
B42175
D42175

NCBI Reference Sequences

More...
RefSeqi
NP_061978.6, NM_019105.6 [P22105-1]
NP_115859.2, NM_032470.3 [P22105-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.485104

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000375244; ENSP00000364393; ENSG00000168477 [P22105-3]
ENST00000451343; ENSP00000407685; ENSG00000168477 [P22105-2]
ENST00000546684; ENSP00000447694; ENSG00000236236
ENST00000550539; ENSP00000448326; ENSG00000229353
ENST00000644971; ENSP00000496448; ENSG00000168477 [P22105-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7148

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7148

UCSC genome browser

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UCSCi
uc003nzg.1 human [P22105-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24488 mRNA Translation: AAB41287.1
AF019413 Genomic DNA Translation: AAB67981.1 Sequence problems.
U89337 Genomic DNA Translation: AAB47488.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89296.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89300.1
AL645922 Genomic DNA No translation available.
AL662828 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
AL772248 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03574.1
BC033740 mRNA Translation: AAH33740.1
BC125114 mRNA Translation: AAI25115.1
BC125115 mRNA Translation: AAI25116.1
BC130037 mRNA Translation: AAI30038.1
X71923 mRNA Translation: CAA50739.1
Y13782 mRNA Translation: CAA74109.1
Y13783 Genomic DNA Translation: CAA74110.1
U52696 mRNA Translation: AAC50889.1
AB209012 mRNA Translation: BAD92249.1
M25813 mRNA Translation: AAA35884.1
CCDSiCCDS4736.1 [P22105-2]
PIRiA40701
A42175
B42175
D42175
RefSeqiNP_061978.6, NM_019105.6 [P22105-1]
NP_115859.2, NM_032470.3 [P22105-2]
UniGeneiHs.485104

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CUHNMR-A3845-3946[»]
2CUINMR-A3654-3752[»]
2CUMNMR-A3933-4024[»]
ProteinModelPortaliP22105
SMRiP22105
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113001, 3 interactors
ComplexPortaliCPX-1014 Tenascin-X complex
IntActiP22105, 12 interactors
MINTiP22105
STRINGi9606.ENSP00000407685

PTM databases

GlyConnecti1794
iPTMnetiP22105
PhosphoSitePlusiP22105

Polymorphism and mutation databases

BioMutaiTNXB
DMDMi290457668

Proteomic databases

EPDiP22105
MaxQBiP22105
PaxDbiP22105
PeptideAtlasiP22105
PRIDEiP22105
ProteomicsDBi53963
53964 [P22105-2]
53965 [P22105-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7148
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375244; ENSP00000364393; ENSG00000168477 [P22105-3]
ENST00000451343; ENSP00000407685; ENSG00000168477 [P22105-2]
ENST00000546684; ENSP00000447694; ENSG00000236236
ENST00000550539; ENSP00000448326; ENSG00000229353
ENST00000644971; ENSP00000496448; ENSG00000168477 [P22105-3]
GeneIDi7148
KEGGihsa:7148
UCSCiuc003nzg.1 human [P22105-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7148
DisGeNETi7148
EuPathDBiHostDB:ENSG00000168477.17

GeneCards: human genes, protein and diseases

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GeneCardsi
TNXB

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0165968
HIX0207682
HGNCiHGNC:11976 TNXB
MalaCardsiTNXB
MIMi600985 gene
606408 phenotype
615963 phenotype
neXtProtiNX_P22105
OpenTargetsiENSG00000168477
Orphaneti230839 Ehlers-Danlos syndrome due to tenascin-X deficiency
285 Ehlers-Danlos syndrome, hypermobility type
289365 Familial vesicoureteral reflux
PharmGKBiPA36662

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00940000155565
HOVERGENiHBG006855
InParanoidiP22105
KOiK06252
OMAiPEGHFDH
TreeFamiTF329915

Enzyme and pathway databases

ReactomeiR-HSA-3000178 ECM proteoglycans

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TNXB human
EvolutionaryTraceiP22105

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Tenascin_X

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7148

Protein Ontology

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PROi
PR:P22105

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168477 Expressed in 112 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiP22105 baseline and differential
GenevisibleiP22105 HS

Family and domain databases

CDDicd00063 FN3, 31 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 31 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033081 TNX
PANTHERiPTHR19143:SF244 PTHR19143:SF244, 21 hits
PfamiView protein in Pfam
PF07974 EGF_2, 2 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 31 hits
SMARTiView protein in SMART
SM00181 EGF, 18 hits
SM00186 FBG, 1 hit
SM00060 FN3, 32 hits
SUPFAMiSSF49265 SSF49265, 29 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 18 hits
PS01186 EGF_2, 19 hits
PS50026 EGF_3, 8 hits
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 32 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENX_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22105
Secondary accession number(s): P78530
, P78531, Q08424, Q08AM0, Q08AM1, Q59GU7, Q5SQD3, Q5ST74, Q7L8Q4, Q8N4R1, Q9NPK9, Q9UC10, Q9UC11, Q9UC12, Q9UC13, Q9UMG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: September 12, 2018
Last modified: December 5, 2018
This is version 210 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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