UniProtKB - P22105 (TENX_HUMAN)
Tenascin-X
TNXB
Functioni
Caution
GO - Molecular functioni
- collagen fibril binding Source: UniProtKB
- extracellular matrix structural constituent Source: BHF-UCL
- heparin binding Source: UniProtKB
- integrin binding Source: UniProtKB
GO - Biological processi
- actin cytoskeleton organization Source: UniProtKB
- cell adhesion Source: UniProtKB
- collagen fibril organization Source: InterPro
- collagen metabolic process Source: UniProtKB
- elastic fiber assembly Source: UniProtKB
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | P22105 |
Reactomei | R-HSA-3000178, ECM proteoglycans |
Names & Taxonomyi
Protein namesi | Recommended name: Tenascin-XCuratedShort name: TN-X Alternative name(s): Hexabrachion-like protein |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168477.17 |
HGNCi | HGNC:11976, TNXB |
MIMi | 600985, gene |
neXtProti | NX_P22105 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular matrix Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: BHF-UCL
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Ehlers-Danlos syndrome, classic-like (EDSCLL)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046499 | 29 | R → W in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs368512272Ensembl. | 1 | |
Natural variantiVAR_046500 | 1108 | V → M in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs121912575EnsemblClinVar. | 1 | |
Natural variantiVAR_072582 | 4074 | R → C in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs587777682EnsemblClinVar. | 1 |
Vesicoureteral reflux 8 (VUR8)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072580 | 1244 | T → R in VUR8. 1 Publication | 1 | |
Natural variantiVAR_072581 | 3212 | V → I in VUR8; shows significantly impaired migration in a wound-healing assay; associated with decreased expression of phosphorylated PTK2 protein. 1 PublicationCorresponds to variant dbSNP:rs1473257039Ensembl. | 1 |
Keywords - Diseasei
Disease mutation, Ehlers-Danlos syndromeOrganism-specific databases
DisGeNETi | 7148 |
MalaCardsi | TNXB |
MIMi | 606408, phenotype 615963, phenotype |
OpenTargetsi | ENSG00000168477 |
Orphaneti | 230839, Classical-like Ehlers-Danlos syndrome type 1 289365, Familial vesicoureteral reflux |
PharmGKBi | PA36662 |
Miscellaneous databases
Pharosi | P22105, Tbio |
Polymorphism and mutation databases
BioMutai | TNXB |
DMDMi | 290457668 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000007751 | 24 – 4244 | Tenascin-XAdd BLAST | 4221 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 187 ↔ 197 | By similarity | ||
Disulfide bondi | 191 ↔ 202 | By similarity | ||
Disulfide bondi | 204 ↔ 213 | By similarity | ||
Disulfide bondi | 218 ↔ 228 | By similarity | ||
Disulfide bondi | 222 ↔ 233 | By similarity | ||
Disulfide bondi | 235 ↔ 244 | By similarity | ||
Disulfide bondi | 249 ↔ 259 | By similarity | ||
Disulfide bondi | 253 ↔ 264 | By similarity | ||
Disulfide bondi | 266 ↔ 275 | By similarity | ||
Disulfide bondi | 280 ↔ 290 | By similarity | ||
Disulfide bondi | 284 ↔ 295 | By similarity | ||
Disulfide bondi | 297 ↔ 306 | By similarity | ||
Disulfide bondi | 311 ↔ 321 | By similarity | ||
Disulfide bondi | 315 ↔ 326 | By similarity | ||
Disulfide bondi | 328 ↔ 337 | By similarity | ||
Disulfide bondi | 342 ↔ 352 | By similarity | ||
Disulfide bondi | 346 ↔ 357 | By similarity | ||
Disulfide bondi | 359 ↔ 368 | By similarity | ||
Disulfide bondi | 373 ↔ 383 | By similarity | ||
Disulfide bondi | 377 ↔ 388 | By similarity | ||
Disulfide bondi | 390 ↔ 399 | By similarity | ||
Disulfide bondi | 404 ↔ 414 | By similarity | ||
Disulfide bondi | 408 ↔ 419 | By similarity | ||
Disulfide bondi | 421 ↔ 430 | By similarity | ||
Disulfide bondi | 435 ↔ 445 | By similarity | ||
Disulfide bondi | 439 ↔ 450 | By similarity | ||
Disulfide bondi | 452 ↔ 461 | By similarity | ||
Disulfide bondi | 466 ↔ 476 | By similarity | ||
Disulfide bondi | 470 ↔ 481 | By similarity | ||
Disulfide bondi | 483 ↔ 492 | By similarity | ||
Disulfide bondi | 497 ↔ 507 | By similarity | ||
Disulfide bondi | 501 ↔ 512 | By similarity | ||
Disulfide bondi | 514 ↔ 523 | By similarity | ||
Disulfide bondi | 528 ↔ 538 | By similarity | ||
Disulfide bondi | 532 ↔ 543 | By similarity | ||
Disulfide bondi | 545 ↔ 554 | By similarity | ||
Disulfide bondi | 559 ↔ 569 | By similarity | ||
Disulfide bondi | 563 ↔ 574 | By similarity | ||
Disulfide bondi | 576 ↔ 585 | By similarity | ||
Disulfide bondi | 590 ↔ 600 | By similarity | ||
Disulfide bondi | 594 ↔ 605 | By similarity | ||
Disulfide bondi | 607 ↔ 616 | By similarity | ||
Disulfide bondi | 621 ↔ 631 | By similarity | ||
Disulfide bondi | 625 ↔ 636 | By similarity | ||
Disulfide bondi | 638 ↔ 647 | By similarity | ||
Disulfide bondi | 652 ↔ 662 | By similarity | ||
Disulfide bondi | 656 ↔ 667 | By similarity | ||
Disulfide bondi | 669 ↔ 678 | By similarity | ||
Disulfide bondi | 688 ↔ 698 | By similarity | ||
Disulfide bondi | 692 ↔ 703 | By similarity | ||
Disulfide bondi | 705 ↔ 714 | By similarity | ||
Disulfide bondi | 719 ↔ 729 | By similarity | ||
Disulfide bondi | 723 ↔ 734 | By similarity | ||
Disulfide bondi | 736 ↔ 745 | By similarity | ||
Glycosylationi | 3855 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 3908 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 3920 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 4030 ↔ 4060 | By similarity | ||
Glycosylationi | 4095 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 4182 ↔ 4195 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-2701 |
EPDi | P22105 |
jPOSTi | P22105 |
MassIVEi | P22105 |
PaxDbi | P22105 |
PeptideAtlasi | P22105 |
PRIDEi | P22105 |
ProteomicsDBi | 53963 [P22105-1] 53964 [P22105-2] 53965 [P22105-3] |
PTM databases
GlyConnecti | 1794, 7 N-Linked glycans (3 sites) |
GlyGeni | P22105, 42 sites, 6 O-linked glycans (37 sites) |
iPTMneti | P22105 |
PhosphoSitePlusi | P22105 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000168477, Expressed in left adrenal gland and 131 other tissues |
ExpressionAtlasi | P22105, baseline and differential |
Genevisiblei | P22105, HS |
Organism-specific databases
HPAi | ENSG00000168477, Low tissue specificity |
Interactioni
Subunit structurei
Homotrimer.
Interacts with type I, III and V collagens and tropoelastin via its 29th fibronectin type-III domain.
2 PublicationsBinary interactionsi
Hide detailsP22105
With | #Exp. | IntAct |
---|---|---|
BANP [Q8N9N5] | 4 | EBI-2821024,EBI-744695 |
Isoform 3 [P22105-1]
With | #Exp. | IntAct |
---|---|---|
BANP - isoform 2 [Q8N9N5-2] | 3 | EBI-20753895,EBI-11524452 |
CEACAM6 [P40199] | 3 | EBI-20753895,EBI-4314501 |
POU6F2 [P78424] | 3 | EBI-20753895,EBI-12029004 |
TGM7 [Q96PF1] | 3 | EBI-20753895,EBI-12029034 |
GO - Molecular functioni
- integrin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113001, 6 interactors |
ComplexPortali | CPX-1014, Tenascin-X complex |
IntActi | P22105, 13 interactors |
MINTi | P22105 |
STRINGi | 9606.ENSP00000407685 |
Miscellaneous databases
RNActi | P22105, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P22105 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P22105 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 156 – 168 | EGF-like 1; incompletePROSITE-ProRule annotationAdd BLAST | 13 | |
Domaini | 183 – 213 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 214 – 244 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 245 – 275 | EGF-like 4PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 276 – 306 | EGF-like 5PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 307 – 337 | EGF-like 6PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 338 – 368 | EGF-like 7PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 369 – 399 | EGF-like 8PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 400 – 430 | EGF-like 9PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 431 – 461 | EGF-like 10PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 462 – 492 | EGF-like 11PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 493 – 523 | EGF-like 12PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 524 – 554 | EGF-like 13PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 555 – 585 | EGF-like 14PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 586 – 616 | EGF-like 15PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 617 – 647 | EGF-like 16PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 648 – 679 | EGF-like 17PROSITE-ProRule annotationAdd BLAST | 32 | |
Domaini | 684 – 714 | EGF-like 18PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 715 – 746 | EGF-like 19PROSITE-ProRule annotationAdd BLAST | 32 | |
Domaini | 959 – 1051 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 1064 – 1153 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 1161 – 1249 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 1263 – 1352 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 1374 – 1468 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 1476 – 1572 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 1574 – 1669 | Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 1674 – 1764 | Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 1778 – 1868 | Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 1883 – 1971 | Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 1989 – 2089 | Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 2097 – 2185 | Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 2196 – 2296 | Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 2305 – 2398 | Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 2408 – 2502 | Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 2519 – 2617 | Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 2625 – 2723 | Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 2733 – 2840 | Fibronectin type-III 18PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 2841 – 2939 | Fibronectin type-III 19PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 2949 – 3042 | Fibronectin type-III 20PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 3062 – 3153 | Fibronectin type-III 21PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 3168 – 3260 | Fibronectin type-III 22PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 3264 – 3355 | Fibronectin type-III 23PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 3357 – 3446 | Fibronectin type-III 24PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 3451 – 3544 | Fibronectin type-III 25PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 3553 – 3647 | Fibronectin type-III 26PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 3657 – 3754 | Fibronectin type-III 27PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 3758 – 3847 | Fibronectin type-III 28PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 3848 – 3934 | Fibronectin type-III 29PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 3935 – 4025 | Fibronectin type-III 30PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 4021 – 4236 | Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST | 216 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1666 – 1668 | Cell attachment siteSequence analysis | 3 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000155565 |
HOGENOMi | CLU_026380_0_0_1 |
InParanoidi | P22105 |
OMAi | FNLYGMW |
TreeFami | TF329915 |
Family and domain databases
CDDi | cd00063, FN3, 31 hits cd00087, FReD, 1 hit |
Gene3Di | 2.60.40.10, 31 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR013111, EGF_extracell IPR041161, EGF_Tenascin IPR036056, Fibrinogen-like_C IPR002181, Fibrinogen_a/b/g_C_dom IPR020837, Fibrinogen_CS IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR033081, TNX |
PANTHERi | PTHR46708:SF3, PTHR46708:SF3, 9 hits |
Pfami | View protein in Pfam PF07974, EGF_2, 2 hits PF18720, EGF_Tenascin, 10 hits PF00147, Fibrinogen_C, 1 hit PF00041, fn3, 31 hits |
SMARTi | View protein in SMART SM00181, EGF, 18 hits SM00186, FBG, 1 hit SM00060, FN3, 32 hits |
SUPFAMi | SSF49265, SSF49265, 29 hits SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 18 hits PS01186, EGF_2, 19 hits PS50026, EGF_3, 8 hits PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit PS50853, FN3, 32 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMPAQYALTS SLVLLVLLST ARAGPFSSRS NVTLPAPRPP PQPGGHTVGA
60 70 80 90 100
GVGSPSSQLY EHTVEGGEKQ VVFTHRINLP PSTGCGCPPG TEPPVLASEV
110 120 130 140 150
QALRVRLEIL EELVKGLKEQ CTGGCCPASA QAGTGQTDVR TLCSLHGVFD
160 170 180 190 200
LSRCTCSCEP GWGGPTCSDP TDAEIPPSSP PSASGSCPDD CNDQGRCVRG
210 220 230 240 250
RCVCFPGYTG PSCGWPSCPG DCQGRGRCVQ GVCVCRAGFS GPDCSQRSCP
260 270 280 290 300
RGCSQRGRCE GGRCVCDPGY TGDDCGMRSC PRGCSQRGRC ENGRCVCNPG
310 320 330 340 350
YTGEDCGVRS CPRGCSQRGR CKDGRCVCDP GYTGEDCGTR SCPWDCGEGG
360 370 380 390 400
RCVDGRCVCW PGYTGEDCST RTCPRDCRGR GRCEDGECIC DTGYSGDDCG
410 420 430 440 450
VRSCPGDCNQ RGRCEDGRCV CWPGYTGTDC GSRACPRDCR GRGRCENGVC
460 470 480 490 500
VCNAGYSGED CGVRSCPGDC RGRGRCESGR CMCWPGYTGR DCGTRACPGD
510 520 530 540 550
CRGRGRCVDG RCVCNPGFTG EDCGSRRCPG DCRGHGLCED GVCVCDAGYS
560 570 580 590 600
GEDCSTRSCP GGCRGRGQCL DGRCVCEDGY SGEDCGVRQC PNDCSQHGVC
610 620 630 640 650
QDGVCICWEG YVSEDCSIRT CPSNCHGRGR CEEGRCLCDP GYTGPTCATR
660 670 680 690 700
MCPADCRGRG RCVQGVCLCH VGYGGEDCGQ EEPPASACPG GCGPRELCRA
710 720 730 740 750
GQCVCVEGFR GPDCAIQTCP GDCRGRGECH DGSCVCKDGY AGEDCGEEVP
760 770 780 790 800
TIEGMRMHLL EETTVRTEWT PAPGPVDAYE IQFIPTTEGA SPPFTARVPS
810 820 830 840 850
SASAYDQRGL APGQEYQVTV RALRGTSWGL PASKTITTMI DGPQDLRVVA
860 870 880 890 900
VTPTTLELGW LRPQAEVDRF VVSYVSAGNQ RVRLEVPPEA DGTLLTDLMP
910 920 930 940 950
GVEYVVTVTA ERGRAVSYPA SVRANTGSSP LGLLGTTDEP PPSGPSTTQG
960 970 980 990 1000
AQAPLLQQRP QELGELRVLG RDETGRLRVV WTAQPDTFAY FQLRMRVPEG
1010 1020 1030 1040 1050
PGAHEEVLPG DVRQALVPPP PPGTPYELSL HGVPPGGKPS DPIIYQGIMD
1060 1070 1080 1090 1100
KDEEKPGKSS GPPRLGELTV TDRTSDSLLL RWTVPEGEFD SFVIQYKDRD
1110 1120 1130 1140 1150
GQPQVVPVEG PQRSAVITSL DPGRKYKFVL YGFVGKKRHG PLVAEAKILP
1160 1170 1180 1190 1200
QSDPSPGTPP HLGNLWVTDP TPDSLHLSWT VPEGQFDTFM VQYRDRDGRP
1210 1220 1230 1240 1250
QVVPVEGPER SFVVSSLDPD HKYRFTLFGI ANKKRYGPLT ADGTTAPERK
1260 1270 1280 1290 1300
EEPPRPEFLE QPLLGELTVT GVTPDSLRLS WTVAQGPFDS FMVQYKDAQG
1310 1320 1330 1340 1350
QPQAVPVAGD ENEVTVPGLD PDRKYKMNLY GLRGRQRVGP ESVVAKTAPQ
1360 1370 1380 1390 1400
EDVDETPSPT ELGTEAPESP EEPLLGELTV TGSSPDSLSL FWTVPQGSFD
1410 1420 1430 1440 1450
SFTVQYKDRD GRPRAVRVGG KESEVTVGGL EPGHKYKMHL YGLHEGQRVG
1460 1470 1480 1490 1500
PVSAVGVTAP QQEETPPATE SPLEPRLGEL TVTDVTPNSV GLSWTVPEGQ
1510 1520 1530 1540 1550
FDSFIVQYKD KDGQPQVVPV AADQREVTVY NLEPERKYKM NMYGLHDGQR
1560 1570 1580 1590 1600
MGPLSVVIVT APLPPAPATE ASKPPLEPRL GELTVTDITP DSVGLSWTVP
1610 1620 1630 1640 1650
EGEFDSFVVQ YKDRDGQPQV VPVAADQREV TIPDLEPSRK YKFLLFGIQD
1660 1670 1680 1690 1700
GKRRSPVSVE AKTVARGDAS PGAPPRLGEL WVTDPTPDSL RLSWTVPEGQ
1710 1720 1730 1740 1750
FDSFVVQFKD KDGPQVVPVE GHERSVTVTP LDAGRKYRFL LYGLLGKKRH
1760 1770 1780 1790 1800
GPLTADGTTE ARSAMDDTGT KRPPKPRLGE ELQVTTVTQN SVGLSWTVPE
1810 1820 1830 1840 1850
GQFDSFVVQY KDRDGQPQVV PVEGSLREVS VPGLDPAHRY KLLLYGLHHG
1860 1870 1880 1890 1900
KRVGPISAVA ITAGREETET ETTAPTPPAP EPHLGELTVE EATSHTLHLS
1910 1920 1930 1940 1950
WMVTEGEFDS FEIQYTDRDG QLQMVRIGGD RNDITLSGLE SDHRYLVTLY
1960 1970 1980 1990 2000
GFSDGKHVGP VHVEALTVPE EEKPSEPPTA TPEPPIKPRL GELTVTDATP
2010 2020 2030 2040 2050
DSLSLSWTVP EGQFDHFLVQ YRNGDGQPKA VRVPGHEEGV TISGLEPDHK
2060 2070 2080 2090 2100
YKMNLYGFHG GQRMGPVSVV GVTAAEEETP SPTEPSMEAP EPAEEPLLGE
2110 2120 2130 2140 2150
LTVTGSSPDS LSLSWTVPQG RFDSFTVQYK DRDGRPQVVR VGGEESEVTV
2160 2170 2180 2190 2200
GGLEPGRKYK MHLYGLHEGR RVGPVSAVGV TAPEEESPDA PLAKLRLGQM
2210 2220 2230 2240 2250
TVRDITSDSL SLSWTVPEGQ FDHFLVQFKN GDGQPKAVRV PGHEDGVTIS
2260 2270 2280 2290 2300
GLEPDHKYKM NLYGFHGGQR VGPVSAVGLT APGKDEEMAP ASTEPPTPEP
2310 2320 2330 2340 2350
PIKPRLEELT VTDATPDSLS LSWTVPEGQF DHFLVQYKNG DGQPKATRVP
2360 2370 2380 2390 2400
GHEDRVTISG LEPDNKYKMN LYGFHGGQRV GPVSAIGVTA AEEETPSPTE
2410 2420 2430 2440 2450
PSMEAPEPPE EPLLGELTVT GSSPDSLSLS WTVPQGRFDS FTVQYKDRDG
2460 2470 2480 2490 2500
RPQVVRVGGE ESEVTVGGLE PGRKYKMHLY GLHEGRRVGP VSTVGVTAPQ
2510 2520 2530 2540 2550
EDVDETPSPT EPGTEAPGPP EEPLLGELTV TGSSPDSLSL SWTVPQGRFD
2560 2570 2580 2590 2600
SFTVQYKDRD GRPQAVRVGG QESKVTVRGL EPGRKYKMHL YGLHEGRRLG
2610 2620 2630 2640 2650
PVSAVGVTED EAETTQAVPT MTPEPPIKPR LGELTMTDAT PDSLSLSWTV
2660 2670 2680 2690 2700
PEGQFDHFLV QYRNGDGQPK AVRVPGHEDG VTISGLEPDH KYKMNLYGFH
2710 2720 2730 2740 2750
GGQRVGPISV IGVTAAEEET PSPTELSTEA PEPPEEPLLG ELTVTGSSPD
2760 2770 2780 2790 2800
SLSLSWTIPQ GHFDSFTVQY KDRDGRPQVM RVRGEESEVT VGGLEPGRKY
2810 2820 2830 2840 2850
KMHLYGLHEG RRVGPVSTVG VTAPEDEAET TQAVPTTTPE PPNKPRLGEL
2860 2870 2880 2890 2900
TVTDATPDSL SLSWMVPEGQ FDHFLVQYRN GDGQPKVVRV PGHEDGVTIS
2910 2920 2930 2940 2950
GLEPDHKYKM NLYGFHGGQR VGPISVIGVT AAEEETPAPT EPSTEAPEPP
2960 2970 2980 2990 3000
EEPLLGELTV TGSSPDSLSL SWTIPQGRFD SFTVQYKDRD GRPQVVRVRG
3010 3020 3030 3040 3050
EESEVTVGGL EPGCKYKMHL YGLHEGQRVG PVSAVGVTAP KDEAETTQAV
3060 3070 3080 3090 3100
PTMTPEPPIK PRLGELTVTD ATPDSLSLSW MVPEGQFDHF LVQYRNGDGQ
3110 3120 3130 3140 3150
PKAVRVPGHE DGVTISGLEP DHKYKMNLYG FHGGQRVGPV SAIGVTEEET
3160 3170 3180 3190 3200
PSPTEPSTEA PEAPEEPLLG ELTVTGSSPD SLSLSWTVPQ GRFDSFTVQY
3210 3220 3230 3240 3250
KDRDGQPQVV RVRGEESEVT VGGLEPGRKY KMHLYGLHEG QRVGPVSTVG
3260 3270 3280 3290 3300
ITAPLPTPLP VEPRLGELAV AAVTSDSVGL SWTVAQGPFD SFLVQYRDAQ
3310 3320 3330 3340 3350
GQPQAVPVSG DLRAVAVSGL DPARKYKFLL FGLQNGKRHG PVPVEARTAP
3360 3370 3380 3390 3400
DTKPSPRLGE LTVTDATPDS VGLSWTVPEG EFDSFVVQYK DKDGRLQVVP
3410 3420 3430 3440 3450
VAANQREVTV QGLEPSRKYR FLLYGLSGRK RLGPISADST TAPLEKELPP
3460 3470 3480 3490 3500
HLGELTVAEE TSSSLRLSWT VAQGPFDSFV VQYRDTDGQP RAVPVAADQR
3510 3520 3530 3540 3550
TVTVEDLEPG KKYKFLLYGL LGGKRLGPVS ALGMTAPEED TPAPELAPEA
3560 3570 3580 3590 3600
PEPPEEPRLG VLTVTDTTPD SMRLSWSVAQ GPFDSFVVQY EDTNGQPQAL
3610 3620 3630 3640 3650
LVDGDQSKIL ISGLEPSTPY RFLLYGLHEG KRLGPLSAEG TTGLAPAGQT
3660 3670 3680 3690 3700
SEESRPRLSQ LSVTDVTTSS LRLNWEAPPG AFDSFLLRFG VPSPSTLEPH
3710 3720 3730 3740 3750
PRPLLQRELM VPGTRHSAVL RDLRSGTLYS LTLYGLRGPH KADSIQGTAR
3760 3770 3780 3790 3800
TLSPVLESPR DLQFSEIRET SAKVNWMPPP SRADSFKVSY QLADGGEPQS
3810 3820 3830 3840 3850
VQVDGQARTQ KLQGLIPGAR YEVTVVSVRG FEESEPLTGF LTTVPDGPTQ
3860 3870 3880 3890 3900
LRALNLTEGF AVLHWKPPQN PVDTYDVQVT APGAPPLQAE TPGSAVDYPL
3910 3920 3930 3940 3950
HDLVLHTNYT ATVRGLRGPN LTSPASITFT TGLEAPRDLE AKEVTPRTAL
3960 3970 3980 3990 4000
LTWTEPPVRP AGYLLSFHTP GGQNQEILLP GGITSHQLLG LFPSTSYNAR
4010 4020 4030 4040 4050
LQAMWGQSLL PPVSTSFTTG GLRIPFPRDC GEEMQNGAGA SRTSTIFLNG
4060 4070 4080 4090 4100
NRERPLNVFC DMETDGGGWL VFQRRMDGQT DFWRDWEDYA HGFGNISGEF
4110 4120 4130 4140 4150
WLGNEALHSL TQAGDYSMRV DLRAGDEAVF AQYDSFHVDS AAEYYRLHLE
4160 4170 4180 4190 4200
GYHGTAGDSM SYHSGSVFSA RDRDPNSLLI SCAVSYRGAW WYRNCHYANL
4210 4220 4230 4240
NGLYGSTVDH QGVSWYHWKG FEFSVPFTEM KLRPRNFRSP AGGG
The sequence of this isoform differs from the canonical sequence as follows:
1-3571: Missing.
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ISX9 | A0A3B3ISX9_HUMAN | Tenascin-X | TNXB | 4,491 | Annotation score: | ||
A0A140T8Y3 | A0A140T8Y3_HUMAN | Tenascin-X | TNXB | 4,222 | Annotation score: | ||
A0A140T902 | A0A140T902_HUMAN | Tenascin-X | TNXB | 4,222 | Annotation score: | ||
A0A140T9C0 | A0A140T9C0_HUMAN | Tenascin-X | TNXB | 4,222 | Annotation score: | ||
A0A140TA33 | A0A140TA33_HUMAN | Tenascin-X | TNXB | 4,242 | Annotation score: | ||
A0A140TA41 | A0A140TA41_HUMAN | Tenascin-X | TNXB | 4,242 | Annotation score: | ||
A0A140TA52 | A0A140TA52_HUMAN | Tenascin-X | TNXB | 4,242 | Annotation score: | ||
A0A140T956 | A0A140T956_HUMAN | Tenascin-X | TNXB | 2,280 | Annotation score: | ||
A0A087WWA5 | A0A087WWA5_HUMAN | Tenascin-X | TNXB | 1,545 | Annotation score: | ||
C9J7W4 | C9J7W4_HUMAN | Tenascin-X | TNXB | 842 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3791 | Q → L in AAH33740 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 3877 | V → I in AAI25115 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 3877 | V → I in AAI25116 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 3877 | V → I in BAD92249 (Ref. 10) Curated | 1 | |
Sequence conflicti | 3974 | N → T in AAI25115 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 3974 | N → T in AAI25116 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 3974 | N → T in BAD92249 (Ref. 10) Curated | 1 | |
Sequence conflicti | 3993 | P → G in AAB41287 (PubMed:8530023).Curated | 1 | |
Sequence conflicti | 3993 | P → G in AAA35884 (PubMed:2475872).Curated | 1 | |
Sequence conflicti | 4004 | M → T in AAI25116 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 4004 | M → T in BAD92249 (Ref. 10) Curated | 1 | |
Sequence conflicti | 4057 | N → I in AAI25115 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 4118 | M → I in AAB41287 (PubMed:8530023).Curated | 1 | |
Sequence conflicti | 4118 | M → I in AAA35884 (PubMed:2475872).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046499 | 29 | R → W in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs368512272Ensembl. | 1 | |
Natural variantiVAR_044347 | 302 | T → A1 PublicationCorresponds to variant dbSNP:rs1150752EnsemblClinVar. | 1 | |
Natural variantiVAR_021908 | 511 | R → H. Corresponds to variant dbSNP:rs204896EnsemblClinVar. | 1 | |
Natural variantiVAR_055781 | 641 | G → C. Corresponds to variant dbSNP:rs17201609Ensembl. | 1 | |
Natural variantiVAR_055782 | 650 | R → H. Corresponds to variant dbSNP:rs17201602EnsemblClinVar. | 1 | |
Natural variantiVAR_055783 | 873 | S → A. Corresponds to variant dbSNP:rs204900Ensembl. | 1 | |
Natural variantiVAR_046500 | 1108 | V → M in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs121912575EnsemblClinVar. | 1 | |
Natural variantiVAR_024270 | 1161 | H → R. Corresponds to variant dbSNP:rs185819EnsemblClinVar. | 1 | |
Natural variantiVAR_072580 | 1244 | T → R in VUR8. 1 Publication | 1 | |
Natural variantiVAR_059276 | 1905 | E → K. Corresponds to variant dbSNP:rs17207923EnsemblClinVar. | 1 | |
Natural variantiVAR_020170 | 2301 | P → H. Corresponds to variant dbSNP:rs2269428Ensembl. | 1 | |
Natural variantiVAR_055784 | 2363 | P → H. Corresponds to variant dbSNP:rs2269428Ensembl. | 1 | |
Natural variantiVAR_059277 | 2412 | P → L. Corresponds to variant dbSNP:rs12524664EnsemblClinVar. | 1 | |
Natural variantiVAR_020171 | 2495 | G → S. Corresponds to variant dbSNP:rs2269429EnsemblClinVar. | 1 | |
Natural variantiVAR_020172 | 2518 | G → E2 PublicationsCorresponds to variant dbSNP:rs1009382EnsemblClinVar. | 1 | |
Natural variantiVAR_072581 | 3212 | V → I in VUR8; shows significantly impaired migration in a wound-healing assay; associated with decreased expression of phosphorylated PTK2 protein. 1 PublicationCorresponds to variant dbSNP:rs1473257039Ensembl. | 1 | |
Natural variantiVAR_046501 | 3988 | L → I1 PublicationCorresponds to variant dbSNP:rs7742632Ensembl. | 1 | |
Natural variantiVAR_072582 | 4074 | R → C in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs587777682EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059792 | 1 – 3571 | Missing in isoform XB-short. Add BLAST | 3571 | |
Alternative sequenceiVSP_059793 | 135 | G → GEQG in isoform 5. | 1 | |
Alternative sequenceiVSP_059794 | 2823 – 2825 | APE → E in isoform 3 and isoform 5. | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24488 mRNA Translation: AAB41287.1 AF019413 Genomic DNA Translation: AAB67981.1 Sequence problems. U89337 Genomic DNA Translation: AAB47488.1 Sequence problems. AL049547 Genomic DNA Translation: CAB89296.1 Sequence problems. AL049547 Genomic DNA Translation: CAB89300.1 AL645922 Genomic DNA No translation available. AL662828 Genomic DNA No translation available. AL662849 Genomic DNA No translation available. AL662884 Genomic DNA No translation available. AL772248 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03574.1 BC033740 mRNA Translation: AAH33740.1 BC125114 mRNA Translation: AAI25115.1 BC125115 mRNA Translation: AAI25116.1 BC130037 mRNA Translation: AAI30038.1 X71923 mRNA Translation: CAA50739.1 Y13782 mRNA Translation: CAA74109.1 Y13783 Genomic DNA Translation: CAA74110.1 U52696 mRNA Translation: AAC50889.1 AB209012 mRNA Translation: BAD92249.1 M25813 mRNA Translation: AAA35884.1 |
CCDSi | CCDS4736.1 [P22105-2] |
PIRi | A40701 A42175 B42175 D42175 |
RefSeqi | NP_061978.6, NM_019105.6 [P22105-1] NP_115859.2, NM_032470.3 [P22105-2] |
Genome annotation databases
Ensembli | ENST00000375244; ENSP00000364393; ENSG00000168477 [P22105-3] ENST00000451343; ENSP00000407685; ENSG00000168477 [P22105-2] ENST00000546684; ENSP00000447694; ENSG00000236236 ENST00000550539; ENSP00000448326; ENSG00000229353 ENST00000644971; ENSP00000496448; ENSG00000168477 [P22105-3] |
GeneIDi | 7148 |
KEGGi | hsa:7148 |
UCSCi | uc003nzg.1, human [P22105-3] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24488 mRNA Translation: AAB41287.1 AF019413 Genomic DNA Translation: AAB67981.1 Sequence problems. U89337 Genomic DNA Translation: AAB47488.1 Sequence problems. AL049547 Genomic DNA Translation: CAB89296.1 Sequence problems. AL049547 Genomic DNA Translation: CAB89300.1 AL645922 Genomic DNA No translation available. AL662828 Genomic DNA No translation available. AL662849 Genomic DNA No translation available. AL662884 Genomic DNA No translation available. AL772248 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03574.1 BC033740 mRNA Translation: AAH33740.1 BC125114 mRNA Translation: AAI25115.1 BC125115 mRNA Translation: AAI25116.1 BC130037 mRNA Translation: AAI30038.1 X71923 mRNA Translation: CAA50739.1 Y13782 mRNA Translation: CAA74109.1 Y13783 Genomic DNA Translation: CAA74110.1 U52696 mRNA Translation: AAC50889.1 AB209012 mRNA Translation: BAD92249.1 M25813 mRNA Translation: AAA35884.1 |
CCDSi | CCDS4736.1 [P22105-2] |
PIRi | A40701 A42175 B42175 D42175 |
RefSeqi | NP_061978.6, NM_019105.6 [P22105-1] NP_115859.2, NM_032470.3 [P22105-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CUH | NMR | - | A | 3845-3946 | [»] | |
2CUI | NMR | - | A | 3654-3752 | [»] | |
2CUM | NMR | - | A | 3933-4024 | [»] | |
SMRi | P22105 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113001, 6 interactors |
ComplexPortali | CPX-1014, Tenascin-X complex |
IntActi | P22105, 13 interactors |
MINTi | P22105 |
STRINGi | 9606.ENSP00000407685 |
PTM databases
GlyConnecti | 1794, 7 N-Linked glycans (3 sites) |
GlyGeni | P22105, 42 sites, 6 O-linked glycans (37 sites) |
iPTMneti | P22105 |
PhosphoSitePlusi | P22105 |
Polymorphism and mutation databases
BioMutai | TNXB |
DMDMi | 290457668 |
Proteomic databases
CPTACi | non-CPTAC-2701 |
EPDi | P22105 |
jPOSTi | P22105 |
MassIVEi | P22105 |
PaxDbi | P22105 |
PeptideAtlasi | P22105 |
PRIDEi | P22105 |
ProteomicsDBi | 53963 [P22105-1] 53964 [P22105-2] 53965 [P22105-3] |
Protocols and materials databases
Antibodypediai | 3947, 214 antibodies |
DNASUi | 7148 |
Genome annotation databases
Ensembli | ENST00000375244; ENSP00000364393; ENSG00000168477 [P22105-3] ENST00000451343; ENSP00000407685; ENSG00000168477 [P22105-2] ENST00000546684; ENSP00000447694; ENSG00000236236 ENST00000550539; ENSP00000448326; ENSG00000229353 ENST00000644971; ENSP00000496448; ENSG00000168477 [P22105-3] |
GeneIDi | 7148 |
KEGGi | hsa:7148 |
UCSCi | uc003nzg.1, human [P22105-3] |
Organism-specific databases
CTDi | 7148 |
DisGeNETi | 7148 |
EuPathDBi | HostDB:ENSG00000168477.17 |
GeneCardsi | TNXB |
HGNCi | HGNC:11976, TNXB |
HPAi | ENSG00000168477, Low tissue specificity |
MalaCardsi | TNXB |
MIMi | 600985, gene 606408, phenotype 615963, phenotype |
neXtProti | NX_P22105 |
OpenTargetsi | ENSG00000168477 |
Orphaneti | 230839, Classical-like Ehlers-Danlos syndrome type 1 289365, Familial vesicoureteral reflux |
PharmGKBi | PA36662 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000155565 |
HOGENOMi | CLU_026380_0_0_1 |
InParanoidi | P22105 |
OMAi | FNLYGMW |
TreeFami | TF329915 |
Enzyme and pathway databases
PathwayCommonsi | P22105 |
Reactomei | R-HSA-3000178, ECM proteoglycans |
Miscellaneous databases
BioGRID-ORCSi | 7148, 8 hits in 840 CRISPR screens |
ChiTaRSi | TNXB, human |
EvolutionaryTracei | P22105 |
GeneWikii | Tenascin_X |
GenomeRNAii | 7148 |
Pharosi | P22105, Tbio |
PROi | PR:P22105 |
RNActi | P22105, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168477, Expressed in left adrenal gland and 131 other tissues |
ExpressionAtlasi | P22105, baseline and differential |
Genevisiblei | P22105, HS |
Family and domain databases
CDDi | cd00063, FN3, 31 hits cd00087, FReD, 1 hit |
Gene3Di | 2.60.40.10, 31 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR013111, EGF_extracell IPR041161, EGF_Tenascin IPR036056, Fibrinogen-like_C IPR002181, Fibrinogen_a/b/g_C_dom IPR020837, Fibrinogen_CS IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR033081, TNX |
PANTHERi | PTHR46708:SF3, PTHR46708:SF3, 9 hits |
Pfami | View protein in Pfam PF07974, EGF_2, 2 hits PF18720, EGF_Tenascin, 10 hits PF00147, Fibrinogen_C, 1 hit PF00041, fn3, 31 hits |
SMARTi | View protein in SMART SM00181, EGF, 18 hits SM00186, FBG, 1 hit SM00060, FN3, 32 hits |
SUPFAMi | SSF49265, SSF49265, 29 hits SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 18 hits PS01186, EGF_2, 19 hits PS50026, EGF_3, 8 hits PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit PS50853, FN3, 32 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TENX_HUMAN | |
Accessioni | P22105Primary (citable) accession number: P22105 Secondary accession number(s): P78530 Q9UMG7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | September 12, 2018 | |
Last modified: | December 2, 2020 | |
This is version 223 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations