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UniProtKB - P22105 (TENX_HUMAN)

Entry version 216 (18 Sep 2019)
Sequence version 5 (12 Sep 2018)
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Protein

Tenascin-X

Gene

TNXB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.1 Publication

Caution

There are two genes for TN-X: TNXA and TNXB. TNXA can sometimes recombine with TNXB.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3000178 ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tenascin-XCurated
Short name:
TN-X
Alternative name(s):
Hexabrachion-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNXBImported
Synonyms:HXBL, TNX, TNXB1, TNXB2, XB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11976 TNXB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600985 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P22105

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ehlers-Danlos syndrome, classic-like (EDSCLL)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSCLL patients lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos syndrome. Delayed wound healing is only present in a subset of patients. EDSCLL inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04649929R → W in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs368512272Ensembl.1
Natural variantiVAR_0465001108V → M in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs121912575EnsemblClinVar.1
Natural variantiVAR_0725824074R → C in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs587777682EnsemblClinVar.1
Vesicoureteral reflux 8 (VUR8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0725801244T → R in VUR8. 1 Publication1
Natural variantiVAR_0725813212V → I in VUR8; shows significantly impaired migration in a wound-healing assay; associated with decreased expression of phosphorylated PTK2 protein. 1 PublicationCorresponds to variant dbSNP:rs1473257039Ensembl.1

Keywords - Diseasei

Disease mutation, Ehlers-Danlos syndrome

Organism-specific databases

DisGeNET

More...DisGeNETi		7148

MalaCards human disease database

More...MalaCardsi		TNXB
MIMi606408 phenotype
615963 phenotype

Open Targets

More...OpenTargetsi		ENSG00000168477

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		230839 Classical-like Ehlers-Danlos syndrome type 1
289365 Familial vesicoureteral reflux

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36662

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P22105

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TNXB

Domain mapping of disease mutations (DMDM)

More...DMDMi		290457668

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000775124 – 4244Tenascin-XAdd BLAST4221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi187 ↔ 197By similarity
Disulfide bondi191 ↔ 202By similarity
Disulfide bondi204 ↔ 213By similarity
Disulfide bondi218 ↔ 228By similarity
Disulfide bondi222 ↔ 233By similarity
Disulfide bondi235 ↔ 244By similarity
Disulfide bondi249 ↔ 259By similarity
Disulfide bondi253 ↔ 264By similarity
Disulfide bondi266 ↔ 275By similarity
Disulfide bondi280 ↔ 290By similarity
Disulfide bondi284 ↔ 295By similarity
Disulfide bondi297 ↔ 306By similarity
Disulfide bondi311 ↔ 321By similarity
Disulfide bondi315 ↔ 326By similarity
Disulfide bondi328 ↔ 337By similarity
Disulfide bondi342 ↔ 352By similarity
Disulfide bondi346 ↔ 357By similarity
Disulfide bondi359 ↔ 368By similarity
Disulfide bondi373 ↔ 383By similarity
Disulfide bondi377 ↔ 388By similarity
Disulfide bondi390 ↔ 399By similarity
Disulfide bondi404 ↔ 414By similarity
Disulfide bondi408 ↔ 419By similarity
Disulfide bondi421 ↔ 430By similarity
Disulfide bondi435 ↔ 445By similarity
Disulfide bondi439 ↔ 450By similarity
Disulfide bondi452 ↔ 461By similarity
Disulfide bondi466 ↔ 476By similarity
Disulfide bondi470 ↔ 481By similarity
Disulfide bondi483 ↔ 492By similarity
Disulfide bondi497 ↔ 507By similarity
Disulfide bondi501 ↔ 512By similarity
Disulfide bondi514 ↔ 523By similarity
Disulfide bondi528 ↔ 538By similarity
Disulfide bondi532 ↔ 543By similarity
Disulfide bondi545 ↔ 554By similarity
Disulfide bondi559 ↔ 569By similarity
Disulfide bondi563 ↔ 574By similarity
Disulfide bondi576 ↔ 585By similarity
Disulfide bondi590 ↔ 600By similarity
Disulfide bondi594 ↔ 605By similarity
Disulfide bondi607 ↔ 616By similarity
Disulfide bondi621 ↔ 631By similarity
Disulfide bondi625 ↔ 636By similarity
Disulfide bondi638 ↔ 647By similarity
Disulfide bondi652 ↔ 662By similarity
Disulfide bondi656 ↔ 667By similarity
Disulfide bondi669 ↔ 678By similarity
Disulfide bondi688 ↔ 698By similarity
Disulfide bondi692 ↔ 703By similarity
Disulfide bondi705 ↔ 714By similarity
Disulfide bondi719 ↔ 729By similarity
Disulfide bondi723 ↔ 734By similarity
Disulfide bondi736 ↔ 745By similarity
Glycosylationi3855N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3908N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3920N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4030 ↔ 4060By similarity
Glycosylationi4095N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4182 ↔ 4195By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-2701

Encyclopedia of Proteome Dynamics

More...EPDi		P22105

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P22105

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P22105

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P22105

PeptideAtlas

More...PeptideAtlasi		P22105

PRoteomics IDEntifications database

More...PRIDEi		P22105

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53963 [P22105-1]
53964 [P22105-2]
53965 [P22105-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1794

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P22105

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P22105

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression levels are lower in adults than in children.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168477 Expressed in 112 organ(s), highest expression level in left adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P22105 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P22105 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

Interacts with type I, III and V collagens and tropoelastin via its 29th fibronectin type-III domain.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q8N9N54EBI-2821024,EBI-744695

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113001, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1014 Tenascin-X complex

Protein interaction database and analysis system

More...IntActi		P22105, 14 interactors

Molecular INTeraction database

More...MINTi		P22105

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000407685

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P22105

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P22105

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini156 – 168EGF-like 1; incompletePROSITE-ProRule annotationAdd BLAST13
Domaini183 – 213EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini214 – 244EGF-like 3PROSITE-ProRule annotationAdd BLAST31
Domaini245 – 275EGF-like 4PROSITE-ProRule annotationAdd BLAST31
Domaini276 – 306EGF-like 5PROSITE-ProRule annotationAdd BLAST31
Domaini307 – 337EGF-like 6PROSITE-ProRule annotationAdd BLAST31
Domaini338 – 368EGF-like 7PROSITE-ProRule annotationAdd BLAST31
Domaini369 – 399EGF-like 8PROSITE-ProRule annotationAdd BLAST31
Domaini400 – 430EGF-like 9PROSITE-ProRule annotationAdd BLAST31
Domaini431 – 461EGF-like 10PROSITE-ProRule annotationAdd BLAST31
Domaini462 – 492EGF-like 11PROSITE-ProRule annotationAdd BLAST31
Domaini493 – 523EGF-like 12PROSITE-ProRule annotationAdd BLAST31
Domaini524 – 554EGF-like 13PROSITE-ProRule annotationAdd BLAST31
Domaini555 – 585EGF-like 14PROSITE-ProRule annotationAdd BLAST31
Domaini586 – 616EGF-like 15PROSITE-ProRule annotationAdd BLAST31
Domaini617 – 647EGF-like 16PROSITE-ProRule annotationAdd BLAST31
Domaini648 – 679EGF-like 17PROSITE-ProRule annotationAdd BLAST32
Domaini684 – 714EGF-like 18PROSITE-ProRule annotationAdd BLAST31
Domaini715 – 746EGF-like 19PROSITE-ProRule annotationAdd BLAST32
Domaini959 – 1051Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini1064 – 1153Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST90
Domaini1161 – 1249Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST89
Domaini1263 – 1352Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST90
Domaini1374 – 1468Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST95
Domaini1476 – 1572Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST97
Domaini1574 – 1669Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini1674 – 1764Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST91
Domaini1778 – 1868Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST91
Domaini1883 – 1971Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST89
Domaini1989 – 2089Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST101
Domaini2097 – 2185Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST89
Domaini2196 – 2296Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST101
Domaini2305 – 2398Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST94
Domaini2408 – 2502Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST95
Domaini2519 – 2617Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST99
Domaini2625 – 2723Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST99
Domaini2733 – 2840Fibronectin type-III 18PROSITE-ProRule annotationAdd BLAST108
Domaini2841 – 2939Fibronectin type-III 19PROSITE-ProRule annotationAdd BLAST99
Domaini2949 – 3042Fibronectin type-III 20PROSITE-ProRule annotationAdd BLAST94
Domaini3062 – 3153Fibronectin type-III 21PROSITE-ProRule annotationAdd BLAST92
Domaini3168 – 3260Fibronectin type-III 22PROSITE-ProRule annotationAdd BLAST93
Domaini3264 – 3355Fibronectin type-III 23PROSITE-ProRule annotationAdd BLAST92
Domaini3357 – 3446Fibronectin type-III 24PROSITE-ProRule annotationAdd BLAST90
Domaini3451 – 3544Fibronectin type-III 25PROSITE-ProRule annotationAdd BLAST94
Domaini3553 – 3647Fibronectin type-III 26PROSITE-ProRule annotationAdd BLAST95
Domaini3657 – 3754Fibronectin type-III 27PROSITE-ProRule annotationAdd BLAST98
Domaini3758 – 3847Fibronectin type-III 28PROSITE-ProRule annotationAdd BLAST90
Domaini3848 – 3934Fibronectin type-III 29PROSITE-ProRule annotationAdd BLAST87
Domaini3935 – 4025Fibronectin type-III 30PROSITE-ProRule annotationAdd BLAST91
Domaini4021 – 4236Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST216

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1666 – 1668Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family.Curated

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2579 Eukaryota
ENOG410ZYS4 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155565

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P22105

KEGG Orthology (KO)

More...KOi		K06252

Identification of Orthologs from Complete Genome Data

More...OMAi		FNLYGMW

Database of Orthologous Groups

More...OrthoDBi		357340at2759

TreeFam database of animal gene trees

More...TreeFami		TF329915

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 31 hits
cd00087 FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 31 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033081 TNX

The PANTHER Classification System

More...PANTHERi		PTHR46708:SF3 PTHR46708:SF3, 9 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07974 EGF_2, 2 hits
PF18720 EGF_Tenascin, 10 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 31 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181 EGF, 18 hits
SM00186 FBG, 1 hit
SM00060 FN3, 32 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265 SSF49265, 29 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022 EGF_1, 18 hits
PS01186 EGF_2, 19 hits
PS50026 EGF_3, 8 hits
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 32 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: P22105-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMPAQYALTS SLVLLVLLST ARAGPFSSRS NVTLPAPRPP PQPGGHTVGA 
        60         70         80         90        100
GVGSPSSQLY EHTVEGGEKQ VVFTHRINLP PSTGCGCPPG TEPPVLASEV 
       110        120        130        140        150
QALRVRLEIL EELVKGLKEQ CTGGCCPASA QAGTGQTDVR TLCSLHGVFD 
       160        170        180        190        200
LSRCTCSCEP GWGGPTCSDP TDAEIPPSSP PSASGSCPDD CNDQGRCVRG 
       210        220        230        240        250
RCVCFPGYTG PSCGWPSCPG DCQGRGRCVQ GVCVCRAGFS GPDCSQRSCP 
       260        270        280        290        300
RGCSQRGRCE GGRCVCDPGY TGDDCGMRSC PRGCSQRGRC ENGRCVCNPG 
       310        320        330        340        350
YTGEDCGVRS CPRGCSQRGR CKDGRCVCDP GYTGEDCGTR SCPWDCGEGG 
       360        370        380        390        400
RCVDGRCVCW PGYTGEDCST RTCPRDCRGR GRCEDGECIC DTGYSGDDCG 
       410        420        430        440        450
VRSCPGDCNQ RGRCEDGRCV CWPGYTGTDC GSRACPRDCR GRGRCENGVC 
       460        470        480        490        500
VCNAGYSGED CGVRSCPGDC RGRGRCESGR CMCWPGYTGR DCGTRACPGD 
       510        520        530        540        550
CRGRGRCVDG RCVCNPGFTG EDCGSRRCPG DCRGHGLCED GVCVCDAGYS 
       560        570        580        590        600
GEDCSTRSCP GGCRGRGQCL DGRCVCEDGY SGEDCGVRQC PNDCSQHGVC 
       610        620        630        640        650
QDGVCICWEG YVSEDCSIRT CPSNCHGRGR CEEGRCLCDP GYTGPTCATR 
       660        670        680        690        700
MCPADCRGRG RCVQGVCLCH VGYGGEDCGQ EEPPASACPG GCGPRELCRA 
       710        720        730        740        750
GQCVCVEGFR GPDCAIQTCP GDCRGRGECH DGSCVCKDGY AGEDCGEEVP 
       760        770        780        790        800
TIEGMRMHLL EETTVRTEWT PAPGPVDAYE IQFIPTTEGA SPPFTARVPS 
       810        820        830        840        850
SASAYDQRGL APGQEYQVTV RALRGTSWGL PASKTITTMI DGPQDLRVVA 
       860        870        880        890        900
VTPTTLELGW LRPQAEVDRF VVSYVSAGNQ RVRLEVPPEA DGTLLTDLMP 
       910        920        930        940        950
GVEYVVTVTA ERGRAVSYPA SVRANTGSSP LGLLGTTDEP PPSGPSTTQG 
       960        970        980        990       1000
AQAPLLQQRP QELGELRVLG RDETGRLRVV WTAQPDTFAY FQLRMRVPEG 
      1010       1020       1030       1040       1050
PGAHEEVLPG DVRQALVPPP PPGTPYELSL HGVPPGGKPS DPIIYQGIMD 
      1060       1070       1080       1090       1100
KDEEKPGKSS GPPRLGELTV TDRTSDSLLL RWTVPEGEFD SFVIQYKDRD 
      1110       1120       1130       1140       1150
GQPQVVPVEG PQRSAVITSL DPGRKYKFVL YGFVGKKRHG PLVAEAKILP 
      1160       1170       1180       1190       1200
QSDPSPGTPP HLGNLWVTDP TPDSLHLSWT VPEGQFDTFM VQYRDRDGRP 
      1210       1220       1230       1240       1250
QVVPVEGPER SFVVSSLDPD HKYRFTLFGI ANKKRYGPLT ADGTTAPERK 
      1260       1270       1280       1290       1300
EEPPRPEFLE QPLLGELTVT GVTPDSLRLS WTVAQGPFDS FMVQYKDAQG 
      1310       1320       1330       1340       1350
QPQAVPVAGD ENEVTVPGLD PDRKYKMNLY GLRGRQRVGP ESVVAKTAPQ 
      1360       1370       1380       1390       1400
EDVDETPSPT ELGTEAPESP EEPLLGELTV TGSSPDSLSL FWTVPQGSFD 
      1410       1420       1430       1440       1450
SFTVQYKDRD GRPRAVRVGG KESEVTVGGL EPGHKYKMHL YGLHEGQRVG 
      1460       1470       1480       1490       1500
PVSAVGVTAP QQEETPPATE SPLEPRLGEL TVTDVTPNSV GLSWTVPEGQ 
      1510       1520       1530       1540       1550
FDSFIVQYKD KDGQPQVVPV AADQREVTVY NLEPERKYKM NMYGLHDGQR 
      1560       1570       1580       1590       1600
MGPLSVVIVT APLPPAPATE ASKPPLEPRL GELTVTDITP DSVGLSWTVP 
      1610       1620       1630       1640       1650
EGEFDSFVVQ YKDRDGQPQV VPVAADQREV TIPDLEPSRK YKFLLFGIQD 
      1660       1670       1680       1690       1700
GKRRSPVSVE AKTVARGDAS PGAPPRLGEL WVTDPTPDSL RLSWTVPEGQ 
      1710       1720       1730       1740       1750
FDSFVVQFKD KDGPQVVPVE GHERSVTVTP LDAGRKYRFL LYGLLGKKRH 
      1760       1770       1780       1790       1800
GPLTADGTTE ARSAMDDTGT KRPPKPRLGE ELQVTTVTQN SVGLSWTVPE 
      1810       1820       1830       1840       1850
GQFDSFVVQY KDRDGQPQVV PVEGSLREVS VPGLDPAHRY KLLLYGLHHG 
      1860       1870       1880       1890       1900
KRVGPISAVA ITAGREETET ETTAPTPPAP EPHLGELTVE EATSHTLHLS 
      1910       1920       1930       1940       1950
WMVTEGEFDS FEIQYTDRDG QLQMVRIGGD RNDITLSGLE SDHRYLVTLY 
      1960       1970       1980       1990       2000
GFSDGKHVGP VHVEALTVPE EEKPSEPPTA TPEPPIKPRL GELTVTDATP 
      2010       2020       2030       2040       2050
DSLSLSWTVP EGQFDHFLVQ YRNGDGQPKA VRVPGHEEGV TISGLEPDHK 
      2060       2070       2080       2090       2100
YKMNLYGFHG GQRMGPVSVV GVTAAEEETP SPTEPSMEAP EPAEEPLLGE 
      2110       2120       2130       2140       2150
LTVTGSSPDS LSLSWTVPQG RFDSFTVQYK DRDGRPQVVR VGGEESEVTV 
      2160       2170       2180       2190       2200
GGLEPGRKYK MHLYGLHEGR RVGPVSAVGV TAPEEESPDA PLAKLRLGQM 
      2210       2220       2230       2240       2250
TVRDITSDSL SLSWTVPEGQ FDHFLVQFKN GDGQPKAVRV PGHEDGVTIS 
      2260       2270       2280       2290       2300
GLEPDHKYKM NLYGFHGGQR VGPVSAVGLT APGKDEEMAP ASTEPPTPEP 
      2310       2320       2330       2340       2350
PIKPRLEELT VTDATPDSLS LSWTVPEGQF DHFLVQYKNG DGQPKATRVP 
      2360       2370       2380       2390       2400
GHEDRVTISG LEPDNKYKMN LYGFHGGQRV GPVSAIGVTA AEEETPSPTE 
      2410       2420       2430       2440       2450
PSMEAPEPPE EPLLGELTVT GSSPDSLSLS WTVPQGRFDS FTVQYKDRDG 
      2460       2470       2480       2490       2500
RPQVVRVGGE ESEVTVGGLE PGRKYKMHLY GLHEGRRVGP VSTVGVTAPQ 
      2510       2520       2530       2540       2550
EDVDETPSPT EPGTEAPGPP EEPLLGELTV TGSSPDSLSL SWTVPQGRFD 
      2560       2570       2580       2590       2600
SFTVQYKDRD GRPQAVRVGG QESKVTVRGL EPGRKYKMHL YGLHEGRRLG 
      2610       2620       2630       2640       2650
PVSAVGVTED EAETTQAVPT MTPEPPIKPR LGELTMTDAT PDSLSLSWTV 
      2660       2670       2680       2690       2700
PEGQFDHFLV QYRNGDGQPK AVRVPGHEDG VTISGLEPDH KYKMNLYGFH 
      2710       2720       2730       2740       2750
GGQRVGPISV IGVTAAEEET PSPTELSTEA PEPPEEPLLG ELTVTGSSPD 
      2760       2770       2780       2790       2800
SLSLSWTIPQ GHFDSFTVQY KDRDGRPQVM RVRGEESEVT VGGLEPGRKY 
      2810       2820       2830       2840       2850
KMHLYGLHEG RRVGPVSTVG VTAPEDEAET TQAVPTTTPE PPNKPRLGEL 
      2860       2870       2880       2890       2900
TVTDATPDSL SLSWMVPEGQ FDHFLVQYRN GDGQPKVVRV PGHEDGVTIS 
      2910       2920       2930       2940       2950
GLEPDHKYKM NLYGFHGGQR VGPISVIGVT AAEEETPAPT EPSTEAPEPP 
      2960       2970       2980       2990       3000
EEPLLGELTV TGSSPDSLSL SWTIPQGRFD SFTVQYKDRD GRPQVVRVRG 
      3010       3020       3030       3040       3050
EESEVTVGGL EPGCKYKMHL YGLHEGQRVG PVSAVGVTAP KDEAETTQAV 
      3060       3070       3080       3090       3100
PTMTPEPPIK PRLGELTVTD ATPDSLSLSW MVPEGQFDHF LVQYRNGDGQ 
      3110       3120       3130       3140       3150
PKAVRVPGHE DGVTISGLEP DHKYKMNLYG FHGGQRVGPV SAIGVTEEET 
      3160       3170       3180       3190       3200
PSPTEPSTEA PEAPEEPLLG ELTVTGSSPD SLSLSWTVPQ GRFDSFTVQY 
      3210       3220       3230       3240       3250
KDRDGQPQVV RVRGEESEVT VGGLEPGRKY KMHLYGLHEG QRVGPVSTVG 
      3260       3270       3280       3290       3300
ITAPLPTPLP VEPRLGELAV AAVTSDSVGL SWTVAQGPFD SFLVQYRDAQ 
      3310       3320       3330       3340       3350
GQPQAVPVSG DLRAVAVSGL DPARKYKFLL FGLQNGKRHG PVPVEARTAP 
      3360       3370       3380       3390       3400
DTKPSPRLGE LTVTDATPDS VGLSWTVPEG EFDSFVVQYK DKDGRLQVVP 
      3410       3420       3430       3440       3450
VAANQREVTV QGLEPSRKYR FLLYGLSGRK RLGPISADST TAPLEKELPP 
      3460       3470       3480       3490       3500
HLGELTVAEE TSSSLRLSWT VAQGPFDSFV VQYRDTDGQP RAVPVAADQR 
      3510       3520       3530       3540       3550
TVTVEDLEPG KKYKFLLYGL LGGKRLGPVS ALGMTAPEED TPAPELAPEA 
      3560       3570       3580       3590       3600
PEPPEEPRLG VLTVTDTTPD SMRLSWSVAQ GPFDSFVVQY EDTNGQPQAL 
      3610       3620       3630       3640       3650
LVDGDQSKIL ISGLEPSTPY RFLLYGLHEG KRLGPLSAEG TTGLAPAGQT 
      3660       3670       3680       3690       3700
SEESRPRLSQ LSVTDVTTSS LRLNWEAPPG AFDSFLLRFG VPSPSTLEPH 
      3710       3720       3730       3740       3750
PRPLLQRELM VPGTRHSAVL RDLRSGTLYS LTLYGLRGPH KADSIQGTAR 
      3760       3770       3780       3790       3800
TLSPVLESPR DLQFSEIRET SAKVNWMPPP SRADSFKVSY QLADGGEPQS 
      3810       3820       3830       3840       3850
VQVDGQARTQ KLQGLIPGAR YEVTVVSVRG FEESEPLTGF LTTVPDGPTQ 
      3860       3870       3880       3890       3900
LRALNLTEGF AVLHWKPPQN PVDTYDVQVT APGAPPLQAE TPGSAVDYPL 
      3910       3920       3930       3940       3950
HDLVLHTNYT ATVRGLRGPN LTSPASITFT TGLEAPRDLE AKEVTPRTAL 
      3960       3970       3980       3990       4000
LTWTEPPVRP AGYLLSFHTP GGQNQEILLP GGITSHQLLG LFPSTSYNAR 
      4010       4020       4030       4040       4050
LQAMWGQSLL PPVSTSFTTG GLRIPFPRDC GEEMQNGAGA SRTSTIFLNG 
      4060       4070       4080       4090       4100
NRERPLNVFC DMETDGGGWL VFQRRMDGQT DFWRDWEDYA HGFGNISGEF 
      4110       4120       4130       4140       4150
WLGNEALHSL TQAGDYSMRV DLRAGDEAVF AQYDSFHVDS AAEYYRLHLE 
      4160       4170       4180       4190       4200
GYHGTAGDSM SYHSGSVFSA RDRDPNSLLI SCAVSYRGAW WYRNCHYANL 
      4210       4220       4230       4240 
NGLYGSTVDH QGVSWYHWKG FEFSVPFTEM KLRPRNFRSP AGGG
Note: No experimental confirmation available. May be due to competing acceptor splice site in exon 24.
Length:4,244
Mass (Da):458,388
Last modified:September 12, 2018 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45A3D29FDF133DBA
GO
Isoform 3 (identifier: P22105-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2823-2825: APE → E

Note: No experimental confirmation available.
Show »
Length:4,242
Mass (Da):458,220
Checksum:i7E07AC46BF6F2599
GO
Isoform XB-short (identifier: P22105-2) [UniParc]FASTAAdd to basket
Also known as: 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-3571: Missing.

Show »
Length:673
Mass (Da):74,030
Checksum:i2A14010E8A633FA1
GO
Isoform 5 (identifier: P22105-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: G → GEQG
     2823-2825: APE → E

Note: No experimental confirmation available. May be due to competing donor splice site in exon 1.
Show »
Length:4,245
Mass (Da):458,535
Checksum:iA004E187A210F3D8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ISX9A0A3B3ISX9_HUMAN
Tenascin-X
TNXB
4,491Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8Y3A0A140T8Y3_HUMAN
Tenascin-X
TNXB
4,222Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T902A0A140T902_HUMAN
Tenascin-X
TNXB
4,222Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T956A0A140T956_HUMAN
Tenascin-X
TNXB
2,280Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9C0A0A140T9C0_HUMAN
Tenascin-X
TNXB
4,222Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA33A0A140TA33_HUMAN
Tenascin-X
TNXB
4,242Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA41A0A140TA41_HUMAN
Tenascin-X
TNXB
4,242Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA52A0A140TA52_HUMAN
Tenascin-X
TNXB
4,242Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7W4C9J7W4_HUMAN
Tenascin-X
TNXB
842Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWA5A0A087WWA5_HUMAN
Tenascin-X
TNXB
1,545Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB47488 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAB67981 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB89296 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3791Q → L in AAH33740 (PubMed:15489334).Curated1
Sequence conflicti3877V → I in AAI25115 (PubMed:15489334).Curated1
Sequence conflicti3877V → I in AAI25116 (PubMed:15489334).Curated1
Sequence conflicti3877V → I in BAD92249 (Ref. 10) Curated1
Sequence conflicti3974N → T in AAI25115 (PubMed:15489334).Curated1
Sequence conflicti3974N → T in AAI25116 (PubMed:15489334).Curated1
Sequence conflicti3974N → T in BAD92249 (Ref. 10) Curated1
Sequence conflicti3993P → G in AAB41287 (PubMed:8530023).Curated1
Sequence conflicti3993P → G in AAA35884 (PubMed:2475872).Curated1
Sequence conflicti4004M → T in AAI25116 (PubMed:15489334).Curated1
Sequence conflicti4004M → T in BAD92249 (Ref. 10) Curated1
Sequence conflicti4057N → I in AAI25115 (PubMed:15489334).Curated1
Sequence conflicti4118M → I in AAB41287 (PubMed:8530023).Curated1
Sequence conflicti4118M → I in AAA35884 (PubMed:2475872).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04649929R → W in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs368512272Ensembl.1
Natural variantiVAR_044347302T → A1 PublicationCorresponds to variant dbSNP:rs1150752EnsemblClinVar.1
Natural variantiVAR_021908511R → H. Corresponds to variant dbSNP:rs204896EnsemblClinVar.1
Natural variantiVAR_055781641G → C. Corresponds to variant dbSNP:rs17201609Ensembl.1
Natural variantiVAR_055782650R → H. Corresponds to variant dbSNP:rs17201602EnsemblClinVar.1
Natural variantiVAR_055783873S → A. Corresponds to variant dbSNP:rs204900Ensembl.1
Natural variantiVAR_0465001108V → M in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs121912575EnsemblClinVar.1
Natural variantiVAR_0242701161H → R. Corresponds to variant dbSNP:rs185819EnsemblClinVar.1
Natural variantiVAR_0725801244T → R in VUR8. 1 Publication1
Natural variantiVAR_0592761905E → K. Corresponds to variant dbSNP:rs17207923EnsemblClinVar.1
Natural variantiVAR_0201702301P → H. Corresponds to variant dbSNP:rs2269428Ensembl.1
Natural variantiVAR_0557842363P → H. Corresponds to variant dbSNP:rs2269428Ensembl.1
Natural variantiVAR_0592772412P → L. Corresponds to variant dbSNP:rs12524664EnsemblClinVar.1
Natural variantiVAR_0201712495G → S. Corresponds to variant dbSNP:rs2269429EnsemblClinVar.1
Natural variantiVAR_0201722518G → E2 PublicationsCorresponds to variant dbSNP:rs1009382EnsemblClinVar.1
Natural variantiVAR_0725813212V → I in VUR8; shows significantly impaired migration in a wound-healing assay; associated with decreased expression of phosphorylated PTK2 protein. 1 PublicationCorresponds to variant dbSNP:rs1473257039Ensembl.1
Natural variantiVAR_0465013988L → I1 PublicationCorresponds to variant dbSNP:rs7742632Ensembl.1
Natural variantiVAR_0725824074R → C in EDSCLL. 1 PublicationCorresponds to variant dbSNP:rs587777682EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0597921 – 3571Missing in isoform XB-short. Add BLAST3571
Alternative sequenceiVSP_059793135G → GEQG in isoform 5. 1
Alternative sequenceiVSP_0597942823 – 2825APE → E in isoform 3 and isoform 5. 3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U24488 mRNA Translation: AAB41287.1
AF019413 Genomic DNA Translation: AAB67981.1 Sequence problems.
U89337 Genomic DNA Translation: AAB47488.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89296.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89300.1
AL645922 Genomic DNA No translation available.
AL662828 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
AL772248 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03574.1
BC033740 mRNA Translation: AAH33740.1
BC125114 mRNA Translation: AAI25115.1
BC125115 mRNA Translation: AAI25116.1
BC130037 mRNA Translation: AAI30038.1
X71923 mRNA Translation: CAA50739.1
Y13782 mRNA Translation: CAA74109.1
Y13783 Genomic DNA Translation: CAA74110.1
U52696 mRNA Translation: AAC50889.1
AB209012 mRNA Translation: BAD92249.1
M25813 mRNA Translation: AAA35884.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4736.1 [P22105-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A40701
A42175
B42175
D42175

NCBI Reference Sequences

More...RefSeqi		NP_061978.6, NM_019105.6 [P22105-1]
NP_115859.2, NM_032470.3 [P22105-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000375244; ENSP00000364393; ENSG00000168477 [P22105-3]
ENST00000451343; ENSP00000407685; ENSG00000168477 [P22105-2]
ENST00000546684; ENSP00000447694; ENSG00000236236
ENST00000550539; ENSP00000448326; ENSG00000229353
ENST00000644971; ENSP00000496448; ENSG00000168477 [P22105-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7148

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7148

UCSC genome browser

More...UCSCi		uc003nzg.1 human [P22105-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24488 mRNA Translation: AAB41287.1
AF019413 Genomic DNA Translation: AAB67981.1 Sequence problems.
U89337 Genomic DNA Translation: AAB47488.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89296.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89300.1
AL645922 Genomic DNA No translation available.
AL662828 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
AL772248 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03574.1
BC033740 mRNA Translation: AAH33740.1
BC125114 mRNA Translation: AAI25115.1
BC125115 mRNA Translation: AAI25116.1
BC130037 mRNA Translation: AAI30038.1
X71923 mRNA Translation: CAA50739.1
Y13782 mRNA Translation: CAA74109.1
Y13783 Genomic DNA Translation: CAA74110.1
U52696 mRNA Translation: AAC50889.1
AB209012 mRNA Translation: BAD92249.1
M25813 mRNA Translation: AAA35884.1
CCDSiCCDS4736.1 [P22105-2]
PIRiA40701
A42175
B42175
D42175
RefSeqiNP_061978.6, NM_019105.6 [P22105-1]
NP_115859.2, NM_032470.3 [P22105-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CUHNMR-A3845-3946[»]
2CUINMR-A3654-3752[»]
2CUMNMR-A3933-4024[»]
SMRiP22105
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi113001, 3 interactors
ComplexPortaliCPX-1014 Tenascin-X complex
IntActiP22105, 14 interactors
MINTiP22105
STRINGi9606.ENSP00000407685

PTM databases

GlyConnecti1794
iPTMnetiP22105
PhosphoSitePlusiP22105

Polymorphism and mutation databases

BioMutaiTNXB
DMDMi290457668

Proteomic databases

CPTACinon-CPTAC-2701
EPDiP22105
jPOSTiP22105
MassIVEiP22105
PaxDbiP22105
PeptideAtlasiP22105
PRIDEiP22105
ProteomicsDBi53963 [P22105-1]
53964 [P22105-2]
53965 [P22105-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		7148

Genome annotation databases

EnsembliENST00000375244; ENSP00000364393; ENSG00000168477 [P22105-3]
ENST00000451343; ENSP00000407685; ENSG00000168477 [P22105-2]
ENST00000546684; ENSP00000447694; ENSG00000236236
ENST00000550539; ENSP00000448326; ENSG00000229353
ENST00000644971; ENSP00000496448; ENSG00000168477 [P22105-3]
GeneIDi7148
KEGGihsa:7148
UCSCiuc003nzg.1 human [P22105-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7148
DisGeNETi7148

GeneCards: human genes, protein and diseases

More...GeneCardsi		TNXB
HGNCiHGNC:11976 TNXB
MalaCardsiTNXB
MIMi600985 gene
606408 phenotype
615963 phenotype
neXtProtiNX_P22105
OpenTargetsiENSG00000168477
Orphaneti230839 Classical-like Ehlers-Danlos syndrome type 1
289365 Familial vesicoureteral reflux
PharmGKBiPA36662

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00940000155565
InParanoidiP22105
KOiK06252
OMAiFNLYGMW
OrthoDBi357340at2759
TreeFamiTF329915

Enzyme and pathway databases

ReactomeiR-HSA-3000178 ECM proteoglycans

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TNXB human
EvolutionaryTraceiP22105

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Tenascin_X

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7148
PharosiP22105

Protein Ontology

More...PROi		PR:P22105

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168477 Expressed in 112 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiP22105 baseline and differential
GenevisibleiP22105 HS

Family and domain databases

CDDicd00063 FN3, 31 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 31 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033081 TNX
PANTHERiPTHR46708:SF3 PTHR46708:SF3, 9 hits
PfamiView protein in Pfam
PF07974 EGF_2, 2 hits
PF18720 EGF_Tenascin, 10 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 31 hits
SMARTiView protein in SMART
SM00181 EGF, 18 hits
SM00186 FBG, 1 hit
SM00060 FN3, 32 hits
SUPFAMiSSF49265 SSF49265, 29 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 18 hits
PS01186 EGF_2, 19 hits
PS50026 EGF_3, 8 hits
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 32 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENX_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22105
Secondary accession number(s): P78530
, P78531, Q08424, Q08AM0, Q08AM1, Q59GU7, Q5SQD3, Q5ST74, Q7L8Q4, Q8N4R1, Q9NPK9, Q9UC10, Q9UC11, Q9UC12, Q9UC13, Q9UMG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: September 12, 2018
Last modified: September 18, 2019
This is version 216 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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