T-cell acute lymphocytic leukemia protein 1 homolog

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 18184866
  • 18550854
  • 19011221
• DNA-binding transcription factor activity Source: MGI
• E-box binding Source: MGIInferred from direct assayⁱ
  • 18550854
• enzyme binding Source: MGI
• histone deacetylase binding Source: MGI
• protein heterodimerization activity Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 11439353
  • 15314159
  • 19323994
• RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 17962413
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 23980096
• RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 18550854
• RNA polymerase II transcription factor binding Source: MGI
• transcription regulatory region DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • 19497860
• transcription regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 9111058

GO - Biological processⁱ

• angiogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 15677556
  • 9472016
• astrocyte fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • 16292311
• basophil differentiation Source: Ensembl
• cell fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • 12569129
• definitive hemopoiesis Source: MGIInferred from mutant phenotypeⁱ
  • 18550854
  • 8861941
• embryonic hemopoiesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19200805
• erythrocyte differentiation Source: MGIInferred from direct assayⁱ
  • 11731461
  • 15314159
• erythrocyte maturation Source: MGIInferred from mutant phenotypeⁱ
  • 18550854
• generation of neurons Source: MGIInferred from mutant phenotypeⁱ
  • 16623824
• hemangioblast cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 15677567
  • 18550854
  • 19182774
• hematopoietic stem cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 14726374
  • 15677556
• hemopoiesis Source: MGIInferred from direct assayⁱ
  • 12485991
• locomotory behavior Source: MGIInferred from mutant phenotypeⁱ
  • 16623824
• megakaryocyte development Source: MGIInferred from mutant phenotypeⁱ
  • 16763211
• megakaryocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 12552125
• myeloid cell differentiation Source: MGIInferred from direct assayⁱ
  • 14726394
• negative regulation of erythrocyte differentiation Source: MGIInferred from direct assayⁱ
  • 16673016
• negative regulation of transcription by RNA polymerase II Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 10373552
  • 16007160
  • 8760303
• neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 16292311
• platelet formation Source: MGIInferred from mutant phenotypeⁱ
  • 16763211
• positive regulation of cell division Source: MGI
• positive regulation of chromatin assembly or disassembly Source: MGI
• positive regulation of erythrocyte differentiation Source: BHF-UCLInferred from direct assayⁱ
  • 19497860
• positive regulation of mitotic cell cycle Source: MGI
• positive regulation of protein complex assembly Source: MGI
• positive regulation of protein tyrosine kinase activity Source: MGIInferred from direct assayⁱ
  • 16673016
• positive regulation of signaling receptor activity Source: MGIInferred from direct assayⁱ
  • 16673016
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from genetic interactionⁱ
  • 15314159
  • 18184866
  • 19323994
  • 19799863
  • 9819382
• regulation of cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • 20194619
• regulation of mast cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 17644741
• regulation of myeloid cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 16763211
• regulation of stem cell population maintenance Source: MGIInferred from mutant phenotypeⁱ
  • 19850742
• regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • 19497860
• spinal cord association neuron differentiation Source: MGIInferred from genetic interactionⁱ
  • 19323994
• transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 16673016

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• enzyme binding Source: MGI
• histone deacetylase binding Source: MGI
• protein heterodimerization activity Source: MGIInferred from physical interactionⁱ
  • 11439353
  • 15314159
  • 19323994
• RNA polymerase II transcription factor binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MTERPPSEAA RSDPQLEGQD AAEARMAPPH LVLLNGVAKE TSRAAPAEPP 
        60         70         80         90        100
VIELGARSGA GGGPASGGGA ARDLKGRDAV AAEARLRVPT TELCRPPGPA 
       110        120        130        140        150
PAPAPASAPA ELPGDGRMVQ LSPPALAAPA GPGRALLYSL SQPLASLGSG 
       160        170        180        190        200
FFGEPDAFPM FTNNNRVKRR PSPYEMEISD GPHTKVVRRI FTNSRERWRQ 
       210        220        230        240        250
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG 
       260        270        280        290        300
TQRAKPGKDP VVGAGGGGAG GGIPPEDLLQ DVLSPNSSCG SSLDGAASPD 
       310        320 
SYTEEPTPKH TSRSLHPALL PAADGAGPR                        

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot