UniProtKB - P22091 (TAL1_MOUSE)
T-cell acute lymphocytic leukemia protein 1 homolog
Tal1
Functioni
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
1 PublicationGO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- E-box binding Source: MGI
- enzyme binding Source: MGI
- histone deacetylase binding Source: MGI
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
- transcription cis-regulatory region binding Source: BHF-UCL
- transmembrane receptor protein tyrosine kinase activator activity Source: MGI
GO - Biological processi
- angiogenesis Source: MGI
- astrocyte fate commitment Source: MGI
- basophil differentiation Source: Ensembl
- cell fate commitment Source: MGI
- definitive hemopoiesis Source: MGI
- embryonic hemopoiesis Source: UniProtKB
- erythrocyte differentiation Source: MGI
- erythrocyte maturation Source: MGI
- generation of neurons Source: MGI
- hemangioblast cell differentiation Source: MGI
- hematopoietic stem cell differentiation Source: MGI
- hemopoiesis Source: MGI
- locomotory behavior Source: MGI
- megakaryocyte development Source: MGI
- megakaryocyte differentiation Source: MGI
- myeloid cell differentiation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- neuron differentiation Source: MGI
- platelet formation Source: MGI
- positive regulation of cell division Source: MGI
- positive regulation of chromatin assembly or disassembly Source: MGI
- positive regulation of erythrocyte differentiation Source: BHF-UCL
- positive regulation of mitotic cell cycle Source: MGI
- positive regulation of protein-containing complex assembly Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of cell population proliferation Source: MGI
- regulation of mast cell differentiation Source: MGI
- regulation of myeloid cell differentiation Source: MGI
- regulation of stem cell population maintenance Source: MGI
- regulation of transcription by RNA polymerase II Source: BHF-UCL
- spinal cord association neuron differentiation Source: MGI
- transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell acute lymphocytic leukemia protein 1 homologShort name: TAL-1 Alternative name(s): Stem cell protein |
Gene namesi | Name:Tal1 Synonyms:Scl, Tal-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98480, Tal1 |
VEuPathDBi | HostDB:ENSMUSG00000028717 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- chromatin Source: MGI
- protein-containing complex Source: UniProtKB
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 122 | S → A: Remains stable, even in the face of severe hypoxia. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogenePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127455 | 1 – 329 | T-cell acute lymphocytic leukemia protein 1 homologAdd BLAST | 329 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | PhosphoserineBy similarity | 1 | |
Modified residuei | 122 | Phosphoserine; by MAPK1 Publication | 1 | |
Modified residuei | 172 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | P22091 |
PRIDEi | P22091 |
ProteomicsDBi | 263000 |
PTM databases
iPTMneti | P22091 |
PhosphoSitePlusi | P22091 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000028717, Expressed in blood and 192 other tissues |
ExpressionAtlasi | P22091, baseline and differential |
Genevisiblei | P22091, MM |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2.
Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (PubMed:9391090).
Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF (PubMed:23980096).
2 PublicationsBinary interactionsi
P22091
GO - Molecular functioni
- enzyme binding Source: MGI
- histone deacetylase binding Source: MGI
- protein dimerization activity Source: InterPro
- RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203962, 11 interactors |
CORUMi | P22091 |
DIPi | DIP-42839N |
IntActi | P22091, 22 interactors |
MINTi | P22091 |
STRINGi | 10090.ENSMUSP00000125202 |
Miscellaneous databases
RNActi | P22091, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 187 – 239 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 40 – 78 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 91 – 125 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 247 – 329 | DisorderedSequence analysisAdd BLAST | 83 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 94 – 108 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 281 – 298 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000159889 |
HOGENOMi | CLU_059203_0_0_1 |
InParanoidi | P22091 |
OMAi | EMPVIEL |
PhylomeDBi | P22091 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MTERPPSEAA RSDPQLEGQD AAEARMAPPH LVLLNGVAKE TSRAAPAEPP
60 70 80 90 100
VIELGARSGA GGGPASGGGA ARDLKGRDAV AAEARLRVPT TELCRPPGPA
110 120 130 140 150
PAPAPASAPA ELPGDGRMVQ LSPPALAAPA GPGRALLYSL SQPLASLGSG
160 170 180 190 200
FFGEPDAFPM FTNNNRVKRR PSPYEMEISD GPHTKVVRRI FTNSRERWRQ
210 220 230 240 250
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG
260 270 280 290 300
TQRAKPGKDP VVGAGGGGAG GGIPPEDLLQ DVLSPNSSCG SSLDGAASPD
310 320
SYTEEPTPKH TSRSLHPALL PAADGAGPR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2AD40 | A2AD40_MOUSE | T-cell acute lymphocytic leukemia p... | Tal1 | 146 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59764 mRNA Translation: AAA40097.1 U01530 Genomic DNA Translation: AAA86937.1 BC063060 mRNA Translation: AAH63060.1 |
CCDSi | CCDS18486.1 |
PIRi | A37864 |
RefSeqi | NP_001274317.1, NM_001287388.1 NP_035657.1, NM_011527.3 XP_006502973.1, XM_006502910.3 XP_006502975.1, XM_006502912.3 XP_006502976.1, XM_006502913.3 XP_006502977.1, XM_006502914.3 XP_006502978.1, XM_006502915.3 XP_006502979.1, XM_006502916.2 |
Genome annotation databases
Ensembli | ENSMUST00000030489; ENSMUSP00000030489; ENSMUSG00000028717 ENSMUST00000161601; ENSMUSP00000125202; ENSMUSG00000028717 ENSMUST00000162489; ENSMUSP00000124983; ENSMUSG00000028717 |
GeneIDi | 21349 |
KEGGi | mmu:21349 |
UCSCi | uc008uek.1, mouse |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59764 mRNA Translation: AAA40097.1 U01530 Genomic DNA Translation: AAA86937.1 BC063060 mRNA Translation: AAH63060.1 |
CCDSi | CCDS18486.1 |
PIRi | A37864 |
RefSeqi | NP_001274317.1, NM_001287388.1 NP_035657.1, NM_011527.3 XP_006502973.1, XM_006502910.3 XP_006502975.1, XM_006502912.3 XP_006502976.1, XM_006502913.3 XP_006502977.1, XM_006502914.3 XP_006502978.1, XM_006502915.3 XP_006502979.1, XM_006502916.2 |
3D structure databases
SMRi | P22091 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203962, 11 interactors |
CORUMi | P22091 |
DIPi | DIP-42839N |
IntActi | P22091, 22 interactors |
MINTi | P22091 |
STRINGi | 10090.ENSMUSP00000125202 |
PTM databases
iPTMneti | P22091 |
PhosphoSitePlusi | P22091 |
Proteomic databases
PaxDbi | P22091 |
PRIDEi | P22091 |
ProteomicsDBi | 263000 |
Protocols and materials databases
Antibodypediai | 4499, 759 antibodies from 39 providers |
DNASUi | 21349 |
Genome annotation databases
Ensembli | ENSMUST00000030489; ENSMUSP00000030489; ENSMUSG00000028717 ENSMUST00000161601; ENSMUSP00000125202; ENSMUSG00000028717 ENSMUST00000162489; ENSMUSP00000124983; ENSMUSG00000028717 |
GeneIDi | 21349 |
KEGGi | mmu:21349 |
UCSCi | uc008uek.1, mouse |
Organism-specific databases
CTDi | 6886 |
MGIi | MGI:98480, Tal1 |
VEuPathDBi | HostDB:ENSMUSG00000028717 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000159889 |
HOGENOMi | CLU_059203_0_0_1 |
InParanoidi | P22091 |
OMAi | EMPVIEL |
PhylomeDBi | P22091 |
TreeFami | TF315153 |
Enzyme and pathway databases
Reactomei | R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
Miscellaneous databases
BioGRID-ORCSi | 21349, 5 hits in 64 CRISPR screens |
PROi | PR:P22091 |
RNActi | P22091, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028717, Expressed in blood and 192 other tissues |
ExpressionAtlasi | P22091, baseline and differential |
Genevisiblei | P22091, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TAL1_MOUSE | |
Accessioni | P22091Primary (citable) accession number: P22091 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot