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Protein

T-cell acute lymphocytic leukemia protein 1 homolog

Gene

Tal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.1 Publication

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • E-box binding Source: MGI
  • enzyme binding Source: MGI
  • histone deacetylase binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: MGI
  • RNA polymerase II transcription factor binding Source: MGI
  • transcription regulatory region DNA binding Source: BHF-UCL
  • transcription regulatory region sequence-specific DNA binding Source: MGI

GO - Biological processi

  • angiogenesis Source: MGI
  • astrocyte fate commitment Source: MGI
  • basophil differentiation Source: Ensembl
  • cell fate commitment Source: MGI
  • definitive hemopoiesis Source: MGI
  • embryonic hemopoiesis Source: UniProtKB
  • erythrocyte differentiation Source: MGI
  • erythrocyte maturation Source: MGI
  • generation of neurons Source: MGI
  • hemangioblast cell differentiation Source: MGI
  • hematopoietic stem cell differentiation Source: MGI
  • hemopoiesis Source: MGI
  • locomotory behavior Source: MGI
  • megakaryocyte development Source: MGI
  • megakaryocyte differentiation Source: MGI
  • myeloid cell differentiation Source: MGI
  • negative regulation of erythrocyte differentiation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • neuron differentiation Source: MGI
  • platelet formation Source: MGI
  • positive regulation of cell division Source: MGI
  • positive regulation of chromatin assembly or disassembly Source: MGI
  • positive regulation of erythrocyte differentiation Source: BHF-UCL
  • positive regulation of mitotic cell cycle Source: MGI
  • positive regulation of protein complex assembly Source: MGI
  • positive regulation of protein tyrosine kinase activity Source: MGI
  • positive regulation of signaling receptor activity Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of cell proliferation Source: MGI
  • regulation of mast cell differentiation Source: MGI
  • regulation of myeloid cell differentiation Source: MGI
  • regulation of stem cell population maintenance Source: MGI
  • regulation of transcription by RNA polymerase II Source: BHF-UCL
  • spinal cord association neuron differentiation Source: MGI
  • transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 1 homolog
Short name:
TAL-1
Alternative name(s):
Stem cell protein
Gene namesi
Name:Tal1
Synonyms:Scl, Tal-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98480 Tal1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi122S → A: Remains stable, even in the face of severe hypoxia. 1 Publication1

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274551 – 329T-cell acute lymphocytic leukemia protein 1 homologAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei122Phosphoserine; by MAPK1 Publication1
Modified residuei172PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylation of Ser-122 by MAPK is strongly stimulated by hypoxia.1 Publication
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP22091
PRIDEiP22091

PTM databases

iPTMnetiP22091
PhosphoSitePlusiP22091

Expressioni

Tissue specificityi

Erythroid and myeloid cells.

Gene expression databases

BgeeiENSMUSG00000028717
CleanExiMM_TAL1
ExpressionAtlasiP22091 baseline and differential
GenevisibleiP22091 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (PubMed:9391090). Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF (PubMed:23980096).2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203962, 11 interactors
CORUMiP22091
DIPiDIP-42839N
IntActiP22091, 21 interactors
MINTiP22091
STRINGi10090.ENSMUSP00000030489

Structurei

3D structure databases

ProteinModelPortaliP22091
SMRiP22091
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 239bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi263 – 272Poly-Gly10

Domaini

The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000113414
HOVERGENiHBG005018
InParanoidiP22091
KOiK09068
OMAiQELCPGS
OrthoDBiEOG091G0ESI
PhylomeDBiP22091
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P22091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERPPSEAA RSDPQLEGQD AAEARMAPPH LVLLNGVAKE TSRAAPAEPP
60 70 80 90 100
VIELGARSGA GGGPASGGGA ARDLKGRDAV AAEARLRVPT TELCRPPGPA
110 120 130 140 150
PAPAPASAPA ELPGDGRMVQ LSPPALAAPA GPGRALLYSL SQPLASLGSG
160 170 180 190 200
FFGEPDAFPM FTNNNRVKRR PSPYEMEISD GPHTKVVRRI FTNSRERWRQ
210 220 230 240 250
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG
260 270 280 290 300
TQRAKPGKDP VVGAGGGGAG GGIPPEDLLQ DVLSPNSSCG SSLDGAASPD
310 320
SYTEEPTPKH TSRSLHPALL PAADGAGPR
Length:329
Mass (Da):34,279
Last modified:August 1, 1991 - v1
Checksum:i189480B6B93CB371
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59764 mRNA Translation: AAA40097.1
U01530 Genomic DNA Translation: AAA86937.1
BC063060 mRNA Translation: AAH63060.1
CCDSiCCDS18486.1
PIRiA37864
RefSeqiNP_001274317.1, NM_001287388.1
NP_035657.1, NM_011527.3
XP_006502973.1, XM_006502910.3
XP_006502975.1, XM_006502912.3
XP_006502976.1, XM_006502913.3
XP_006502977.1, XM_006502914.3
XP_006502978.1, XM_006502915.3
XP_006502979.1, XM_006502916.2
UniGeneiMm.239869
Mm.439685

Genome annotation databases

EnsembliENSMUST00000030489; ENSMUSP00000030489; ENSMUSG00000028717
ENSMUST00000161601; ENSMUSP00000125202; ENSMUSG00000028717
ENSMUST00000162489; ENSMUSP00000124983; ENSMUSG00000028717
GeneIDi21349
KEGGimmu:21349
UCSCiuc008uek.1 mouse

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiTAL1_MOUSE
AccessioniPrimary (citable) accession number: P22091
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 18, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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