T-cell acute lymphocytic leukemia protein 1 homolog

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver."
    Landry J.R., Kinston S., Knezevic K., de Bruijn M.F., Wilson N., Nottingham W.T., Peitz M., Edenhofer F., Pimanda J.E., Ottersbach K., Gottgens B.
    Blood 111:3005-3014(2008) [PubMed] [Europe PMC] [Abstract]
  • "Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis."
    Kassouf M.T., Chagraoui H., Vyas P., Porcher C.
    Blood 112:1056-1067(2008) [PubMed] [Europe PMC] [Abstract]
  • "SCL and associated proteins distinguish active from repressive GATA transcription factor complexes."
    Tripic T., Deng W., Cheng Y., Zhang Y., Vakoc C.R., Gregory G.D., Hardison R.C., Blobel G.A.
    Blood 113:2191-2201(2009) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: MGIInferred from direct assayⁱ
  • "Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq."
    Tallack M.R., Magor G.W., Dartigues B., Sun L., Huang S., Fittock J.M., Fry S.V., Glazov E.A., Bailey T.L., Perkins A.C.
    Genome Res. 22:2385-2398(2012) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGI
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis."
    Kassouf M.T., Chagraoui H., Vyas P., Porcher C.
    Blood 112:1056-1067(2008) [PubMed] [Europe PMC] [Abstract]
• E-box binding Source: MGIInferred from direct assayⁱ
  • "Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis."
    Kassouf M.T., Chagraoui H., Vyas P., Porcher C.
    Blood 112:1056-1067(2008) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: MGI
• histone deacetylase binding Source: MGI
• protein heterodimerization activity Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice."
    O'Neil J., Billa M., Oikemus S., Kelliher M.
    Oncogene 20:3897-3905(2001) [PubMed] [Europe PMC] [Abstract]
  • "Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1."
    Schlaeger T.M., Schuh A., Flitter S., Fisher A., Mikkola H., Orkin S.H., Vyas P., Porcher C.
    Mol. Cell. Biol. 24:7491-7502(2004) [PubMed] [Europe PMC] [Abstract]
  • "LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons."
    Joshi K., Lee S., Lee B., Lee J.W., Lee S.K.
    Neuron 61:839-851(2009) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • Ref.7

    "Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP."
    Maruyama K., Uematsu S., Kondo T., Takeuchi O., Martino M.M., Kawasaki T., Akira S.
    J. Exp. Med. 210:1947-1960(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH SBNO2.
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: MGI
• transcription regulatory region DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • "LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis."
    Hu X., Li X., Valverde K., Fu X., Noguchi C., Qiu Y., Huang S.
    Proc. Natl. Acad. Sci. U.S.A. 106:10141-10146(2009) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Target-dependent effect of phosphorylation on the DNA binding activity of the TAL1/SCL oncoprotein."
    Prasad K.S., Brandt S.J.
    J. Biol. Chem. 272:11457-11462(1997) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• angiogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development."
    Schlaeger T.M., Mikkola H.K., Gekas C., Helgadottir H.B., Orkin S.H.
    Blood 105:3871-3874(2005) [PubMed] [Europe PMC] [Abstract]
  • "Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development."
    Visvader J.E., Fujiwara Y., Orkin S.H.
    Genes Dev. 12:473-479(1998) [PubMed] [Europe PMC] [Abstract]
• astrocyte fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • "Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube."
    Muroyama Y., Fujiwara Y., Orkin S.H., Rowitch D.H.
    Nature 438:360-363(2005) [PubMed] [Europe PMC] [Abstract]
• basophil differentiation Source: Ensembl
• cell fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • "Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse."
    Ema M., Faloon P., Zhang W.J., Hirashima M., Reid T., Stanford W.L., Orkin S., Choi K., Rossant J.
    Genes Dev. 17:380-393(2003) [PubMed] [Europe PMC] [Abstract]
• definitive hemopoiesis Source: MGIInferred from mutant phenotypeⁱ
  • "Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis."
    Kassouf M.T., Chagraoui H., Vyas P., Porcher C.
    Blood 112:1056-1067(2008) [PubMed] [Europe PMC] [Abstract]
  • "The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse."
    Robb L., Elwood N.J., Elefanty A.G., Kontgen F., Li R., Barnett L.D., Begley C.G.
    EMBO J. 15:4123-4129(1996) [PubMed] [Europe PMC] [Abstract]
• embryonic hemopoiesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival."
    Souroullas G.P., Salmon J.M., Sablitzky F., Curtis D.J., Goodell M.A.
    Cell Stem Cell 4:180-186(2009) [PubMed] [Europe PMC] [Abstract]
• erythrocyte differentiation Source: MGIInferred from direct assayⁱ
  • "Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer."
    Sanchez M.J., Bockamp E.O., Miller J., Gambardella L., Green A.R.
    Development 128:4815-4827(2001) [PubMed] [Europe PMC] [Abstract]
  • "Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1."
    Schlaeger T.M., Schuh A., Flitter S., Fisher A., Mikkola H., Orkin S.H., Vyas P., Porcher C.
    Mol. Cell. Biol. 24:7491-7502(2004) [PubMed] [Europe PMC] [Abstract]
• erythrocyte maturation Source: MGIInferred from mutant phenotypeⁱ
  • "Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis."
    Kassouf M.T., Chagraoui H., Vyas P., Porcher C.
    Blood 112:1056-1067(2008) [PubMed] [Europe PMC] [Abstract]
• generation of neurons Source: MGIInferred from mutant phenotypeⁱ
  • "The essential haematopoietic transcription factor Scl is also critical for neuronal development."
    Bradley C.K., Takano E.A., Hall M.A., Gothert J.R., Harvey A.R., Begley C.G., van Eekelen J.A.
    Eur. J. Neurosci. 23:1677-1689(2006) [PubMed] [Europe PMC] [Abstract]
• hemangioblast cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development."
    D'Souza S.L., Elefanty A.G., Keller G.
    Blood 105:3862-3870(2005) [PubMed] [Europe PMC] [Abstract]
  • "Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis."
    Kassouf M.T., Chagraoui H., Vyas P., Porcher C.
    Blood 112:1056-1067(2008) [PubMed] [Europe PMC] [Abstract]
  • "The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage."
    Lancrin C., Sroczynska P., Stephenson C., Allen T., Kouskoff V., Lacaud G.
    Nature 457:892-895(2009) [PubMed] [Europe PMC] [Abstract]
• hematopoietic stem cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "SCL is required for normal function of short-term repopulating hematopoietic stem cells."
    Curtis D.J., Hall M.A., Van Stekelenburg L.J., Robb L., Jane S.M., Begley C.G.
    Blood 103:3342-3348(2004) [PubMed] [Europe PMC] [Abstract]
  • "Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development."
    Schlaeger T.M., Mikkola H.K., Gekas C., Helgadottir H.B., Orkin S.H.
    Blood 105:3871-3874(2005) [PubMed] [Europe PMC] [Abstract]
• hemopoiesis Source: MGIInferred from direct assayⁱ
  • "SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation."
    Endoh M., Ogawa M., Orkin S., Nishikawa S.
    EMBO J. 21:6700-6708(2002) [PubMed] [Europe PMC] [Abstract]
• locomotory behavior Source: MGIInferred from mutant phenotypeⁱ
  • "The essential haematopoietic transcription factor Scl is also critical for neuronal development."
    Bradley C.K., Takano E.A., Hall M.A., Gothert J.R., Harvey A.R., Begley C.G., van Eekelen J.A.
    Eur. J. Neurosci. 23:1677-1689(2006) [PubMed] [Europe PMC] [Abstract]
• megakaryocyte development Source: MGIInferred from mutant phenotypeⁱ
  • "A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis."
    McCormack M.P., Hall M.A., Schoenwaelder S.M., Zhao Q., Ellis S., Prentice J.A., Clarke A.J., Slater N.J., Salmon J.M., Jackson S.P., Jane S.M., Curtis D.J.
    Blood 108:2248-2256(2006) [PubMed] [Europe PMC] [Abstract]
• megakaryocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12."
    Hall M.A., Curtis D.J., Metcalf D., Elefanty A.G., Sourris K., Robb L., Gothert J.R., Jane S.M., Begley C.G.
    Proc. Natl. Acad. Sci. U.S.A. 100:992-997(2003) [PubMed] [Europe PMC] [Abstract]
• myeloid cell differentiation Source: MGIInferred from direct assayⁱ
  • "Stem cell leukemia protein directs hematopoietic stem cell fate."
    Kunisato A., Chiba S., Saito T., Kumano K., Nakagami-Yamaguchi E., Yamaguchi T., Hirai H.
    Blood 103:3336-3341(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of erythrocyte differentiation Source: MGIInferred from direct assayⁱ
  • "MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation."
    Xu Y., Leung C.G., Lee D.C., Kennedy B.K., Crispino J.D.
    Leukemia 20:1261-1269(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice."
    Chervinsky D.S., Zhao X.F., Lam D.H., Ellsworth M., Gross K.W., Aplan P.D.
    Mol. Cell. Biol. 19:5025-5035(1999) [PubMed] [Europe PMC] [Abstract]
  • "RFP represses transcriptional activation by bHLH transcription factors."
    Bloor A.J., Kotsopoulou E., Hayward P., Champion B.R., Green A.R.
    Oncogene 24:6729-6736(2005) [PubMed] [Europe PMC] [Abstract]
  • "The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation."
    Hofmann T.J., Cole M.D.
    Oncogene 13:617-624(1996) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube."
    Muroyama Y., Fujiwara Y., Orkin S.H., Rowitch D.H.
    Nature 438:360-363(2005) [PubMed] [Europe PMC] [Abstract]
• platelet formation Source: MGIInferred from mutant phenotypeⁱ
  • "A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis."
    McCormack M.P., Hall M.A., Schoenwaelder S.M., Zhao Q., Ellis S., Prentice J.A., Clarke A.J., Slater N.J., Salmon J.M., Jackson S.P., Jane S.M., Curtis D.J.
    Blood 108:2248-2256(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell division Source: MGI
• positive regulation of chromatin assembly or disassembly Source: MGI
• positive regulation of erythrocyte differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis."
    Hu X., Li X., Valverde K., Fu X., Noguchi C., Qiu Y., Huang S.
    Proc. Natl. Acad. Sci. U.S.A. 106:10141-10146(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mitotic cell cycle Source: MGI
• positive regulation of protein complex assembly Source: MGI
• positive regulation of protein tyrosine kinase activity Source: MGIInferred from direct assayⁱ
  • "MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation."
    Xu Y., Leung C.G., Lee D.C., Kennedy B.K., Crispino J.D.
    Leukemia 20:1261-1269(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of signaling receptor activity Source: MGIInferred from direct assayⁱ
  • "MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation."
    Xu Y., Leung C.G., Lee D.C., Kennedy B.K., Crispino J.D.
    Leukemia 20:1261-1269(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from genetic interactionⁱ
  • "Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1."
    Schlaeger T.M., Schuh A., Flitter S., Fisher A., Mikkola H., Orkin S.H., Vyas P., Porcher C.
    Mol. Cell. Biol. 24:7491-7502(2004) [PubMed] [Europe PMC] [Abstract]
  • "Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver."
    Landry J.R., Kinston S., Knezevic K., de Bruijn M.F., Wilson N., Nottingham W.T., Peitz M., Edenhofer F., Pimanda J.E., Ottersbach K., Gottgens B.
    Blood 111:3005-3014(2008) [PubMed] [Europe PMC] [Abstract]
  • "LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons."
    Joshi K., Lee S., Lee B., Lee J.W., Lee S.K.
    Neuron 61:839-851(2009) [PubMed] [Europe PMC] [Abstract]
  • "Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors."
    Cai Y., Xu Z., Xie J., Ham A.J., Koury M.J., Hiebert S.W., Brandt S.J.
    Biochem. Biophys. Res. Commun. 390:295-301(2009) [PubMed] [Europe PMC] [Abstract]
  • "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3."
    Ono Y., Fukuhara N., Yoshie O.
    Mol. Cell. Biol. 18:6939-6950(1998) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors."
    Dey S., Curtis D.J., Jane S.M., Brandt S.J.
    Mol. Cell. Biol. 30:2181-2192(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of mast cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene."
    Salmon J.M., Slater N.J., Hall M.A., McCormack M.P., Nutt S.L., Jane S.M., Curtis D.J.
    Blood 110:3573-3581(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of myeloid cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis."
    McCormack M.P., Hall M.A., Schoenwaelder S.M., Zhao Q., Ellis S., Prentice J.A., Clarke A.J., Slater N.J., Salmon J.M., Jackson S.P., Jane S.M., Curtis D.J.
    Blood 108:2248-2256(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of stem cell population maintenance Source: MGIInferred from mutant phenotypeⁱ
  • "Scl regulates the quiescence and the long-term competence of hematopoietic stem cells."
    Lacombe J., Herblot S., Rojas-Sutterlin S., Haman A., Barakat S., Iscove N.N., Sauvageau G., Hoang T.
    Blood 115:792-803(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis."
    Hu X., Li X., Valverde K., Fu X., Noguchi C., Qiu Y., Huang S.
    Proc. Natl. Acad. Sci. U.S.A. 106:10141-10146(2009) [PubMed] [Europe PMC] [Abstract]
• spinal cord association neuron differentiation Source: MGIInferred from genetic interactionⁱ
  • "LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons."
    Joshi K., Lee S., Lee B., Lee J.W., Lee S.K.
    Neuron 61:839-851(2009) [PubMed] [Europe PMC] [Abstract]
• transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation."
    Xu Y., Leung C.G., Lee D.C., Kennedy B.K., Crispino J.D.
    Leukemia 20:1261-1269(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• enzyme binding Source: MGI
• histone deacetylase binding Source: MGI
• protein heterodimerization activity Source: MGIInferred from physical interactionⁱ
  • "The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice."
    O'Neil J., Billa M., Oikemus S., Kelliher M.
    Oncogene 20:3897-3905(2001) [PubMed] [Europe PMC] [Abstract]
  • "Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1."
    Schlaeger T.M., Schuh A., Flitter S., Fisher A., Mikkola H., Orkin S.H., Vyas P., Porcher C.
    Mol. Cell. Biol. 24:7491-7502(2004) [PubMed] [Europe PMC] [Abstract]
  • "LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons."
    Joshi K., Lee S., Lee B., Lee J.W., Lee S.K.
    Neuron 61:839-851(2009) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MTERPPSEAA RSDPQLEGQD AAEARMAPPH LVLLNGVAKE TSRAAPAEPP 
        60         70         80         90        100
VIELGARSGA GGGPASGGGA ARDLKGRDAV AAEARLRVPT TELCRPPGPA 
       110        120        130        140        150
PAPAPASAPA ELPGDGRMVQ LSPPALAAPA GPGRALLYSL SQPLASLGSG 
       160        170        180        190        200
FFGEPDAFPM FTNNNRVKRR PSPYEMEISD GPHTKVVRRI FTNSRERWRQ 
       210        220        230        240        250
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG 
       260        270        280        290        300
TQRAKPGKDP VVGAGGGGAG GGIPPEDLLQ DVLSPNSSCG SSLDGAASPD 
       310        320 
SYTEEPTPKH TSRSLHPALL PAADGAGPR                        

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot