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Protein

Alpha-2C adrenergic receptor

Gene

Adra2c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei131Implicated in ligand bindingBy similarity1
Sitei214Implicated in catechol agonist binding and receptor activationBy similarity1
Sitei218Implicated in catechol agonist binding and receptor activationBy similarity1

GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • alpha-2A adrenergic receptor binding Source: Ensembl
  • alpha2-adrenergic receptor activity Source: RGD
  • epinephrine binding Source: Ensembl
  • protein heterodimerization activity Source: Ensembl
  • protein homodimerization activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390696 Adrenoceptors
R-RNO-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-RNO-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-RNO-418594 G alpha (i) signalling events
R-RNO-418597 G alpha (z) signalling events
R-RNO-5683826 Surfactant metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2 adrenergic receptor subtype C4
Alpha-2C adrenoreceptor
Short name:
Alpha-2C adrenoceptor
Short name:
Alpha-2CAR
Gene namesi
Name:Adra2c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2058 Adra2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51ExtracellularBy similarityAdd BLAST51
Transmembranei52 – 76Helical; Name=1By similarityAdd BLAST25
Topological domaini77 – 88CytoplasmicBy similarityAdd BLAST12
Transmembranei89 – 114Helical; Name=2By similarityAdd BLAST26
Topological domaini115 – 124ExtracellularBy similarity10
Transmembranei125 – 147Helical; Name=3By similarityAdd BLAST23
Topological domaini148 – 168CytoplasmicBy similarityAdd BLAST21
Transmembranei169 – 191Helical; Name=4By similarityAdd BLAST23
Topological domaini192 – 207ExtracellularBy similarityAdd BLAST16
Transmembranei208 – 231Helical; Name=5By similarityAdd BLAST24
Topological domaini232 – 379CytoplasmicBy similarityAdd BLAST148
Transmembranei380 – 403Helical; Name=6By similarityAdd BLAST24
Topological domaini404 – 416ExtracellularBy similarityAdd BLAST13
Transmembranei417 – 437Helical; Name=7By similarityAdd BLAST21
Topological domaini438 – 458CytoplasmicBy similarityAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL314

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691071 – 458Alpha-2C adrenergic receptorAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22086
PRIDEiP22086

PTM databases

PhosphoSitePlusiP22086

Expressioni

Gene expression databases

BgeeiENSRNOG00000009299 Expressed in 5 organ(s), highest expression level in brain
GenevisibleiP22086 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012322

Chemistry databases

BindingDBiP22086

Structurei

3D structure databases

ProteinModelPortaliP22086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi291 – 305Arg-rich (basic)Add BLAST15

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP22086
KOiK04140
OMAiELMNYWY
OrthoDBiEOG091G06VI
PhylomeDBiP22086
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000735 ADRA2C_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF25 PTHR24248:SF25, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00560 ADRENRGCA2CR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P22086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPALAAAL AAAAAEGPNG SDAGEWGSGG GANASGTDWG PPPGQYSAGA
60 70 80 90 100
VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV
110 120 130 140 150
ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY
160 170 180 190 200
WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSF YRRPDGAAYP
210 220 230 240 250
QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRGP
260 270 280 290 300
AGPDGASPTT ENGLGKAAGE NGHCAPPRTE VEPDESSAAE RRRRRGALRR
310 320 330 340 350
GGRRREGAEG DTGSADGPGP GLAAEQGART ASRSPGPGGR LSRASSRSVE
360 370 380 390 400
FFLSRRRRAR SSVCRRKVAQ AREKRFTFVL AVVMGVFVLC WFPFFFSYSL
410 420 430 440 450
YGICREACQL PEPLFKFFFW IGYCNSSLNP VIYTVFNQDF RRSFKHILFR

RRRRGFRQ
Length:458
Mass (Da):49,864
Last modified:April 1, 1993 - v2
Checksum:i6846C2AF963B33BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24G → R in BAA00700 (Ref. 4) Curated1
Sequence conflicti40G → A in AAA40634 (PubMed:1704126).Curated1
Sequence conflicti69N → T in AAA40634 (PubMed:1704126).Curated1
Sequence conflicti155Q → E in CAA40861 (PubMed:1704314).Curated1
Sequence conflicti245S → T in AAA40634 (PubMed:1704126).Curated1
Sequence conflicti252G → R in AAA42033 (PubMed:1645350).Curated1
Sequence conflicti275A → R in BAA00700 (Ref. 4) Curated1
Sequence conflicti298L → V in AAA42033 (PubMed:1645350).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58316 mRNA Translation: AAA40634.1
X57659 Genomic DNA Translation: CAA40861.1
M62371 Genomic DNA Translation: AAA42033.1
D00819 Genomic DNA Translation: BAA00700.1
PIRiA37869
A40392
RefSeqiNP_612515.1, NM_138506.1
UniGeneiRn.10297

Genome annotation databases

EnsembliENSRNOT00000012322; ENSRNOP00000012322; ENSRNOG00000009299
GeneIDi24175
KEGGirno:24175

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58316 mRNA Translation: AAA40634.1
X57659 Genomic DNA Translation: CAA40861.1
M62371 Genomic DNA Translation: AAA42033.1
D00819 Genomic DNA Translation: BAA00700.1
PIRiA37869
A40392
RefSeqiNP_612515.1, NM_138506.1
UniGeneiRn.10297

3D structure databases

ProteinModelPortaliP22086
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012322

Chemistry databases

BindingDBiP22086
ChEMBLiCHEMBL314

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP22086

Proteomic databases

PaxDbiP22086
PRIDEiP22086

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012322; ENSRNOP00000012322; ENSRNOG00000009299
GeneIDi24175
KEGGirno:24175

Organism-specific databases

CTDi152
RGDi2058 Adra2c

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP22086
KOiK04140
OMAiELMNYWY
OrthoDBiEOG091G06VI
PhylomeDBiP22086
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-RNO-390696 Adrenoceptors
R-RNO-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-RNO-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-RNO-418594 G alpha (i) signalling events
R-RNO-418597 G alpha (z) signalling events
R-RNO-5683826 Surfactant metabolism

Miscellaneous databases

PROiPR:P22086

Gene expression databases

BgeeiENSRNOG00000009299 Expressed in 5 organ(s), highest expression level in brain
GenevisibleiP22086 RN

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000735 ADRA2C_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF25 PTHR24248:SF25, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00560 ADRENRGCA2CR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA2C_RAT
AccessioniPrimary (citable) accession number: P22086
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 1, 1993
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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