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Protein

Alpha-(1,3)-fucosyltransferase 4

Gene

FUT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Caution

It is uncertain whether Met-1 or Met-126 is the initiator.Curated

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
  • fucosyltransferase activity Source: ProtInc

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • L-fucose catabolic process Source: UniProtKB
  • protein glycosylation Source: UniProtKB

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS07593-MONOMER
BRENDAi2.4.1.152 2681
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
ELAM-1 ligand fucosyltransferase
Fucosyltransferase 4
Fucosyltransferase IV
Short name:
Fuc-TIV
Short name:
FucT-IV
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:FUT4
Synonyms:ELFT, FCT3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000196371.3
HGNCiHGNC:4015 FUT4
MIMi104230 gene
neXtProtiNX_P22083

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 147CytoplasmicSequence analysisAdd BLAST147
Transmembranei148 – 172Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST25
Topological domaini173 – 530LumenalSequence analysisAdd BLAST358

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2526
OpenTargetsiENSG00000196371
PharmGKBiPA28431

Chemistry databases

ChEMBLiCHEMBL4996

Polymorphism and mutation databases

BioMutaiFUT4
DMDMi226694189

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211001 – 530Alpha-(1,3)-fucosyltransferase 4Add BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP22083
MaxQBiP22083
PaxDbiP22083
PeptideAtlasiP22083
PRIDEiP22083
ProteomicsDBi53958
TopDownProteomicsiP22083

PTM databases

iPTMnetiP22083
PhosphoSitePlusiP22083

Expressioni

Gene expression databases

BgeeiENSG00000196371
CleanExiHS_FUT4
GenevisibleiP22083 HS

Organism-specific databases

HPAiCAB000014
CAB016129

Interactioni

Protein-protein interaction databases

BioGridi108802, 5 interactors
STRINGi9606.ENSP00000351602

Structurei

3D structure databases

ProteinModelPortaliP22083
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
GeneTreeiENSGT00680000099679
HOGENOMiHOG000045583
HOVERGENiHBG000274
InParanoidiP22083
KOiK07632
OMAiCRLRFNI
OrthoDBiEOG091G0846
PhylomeDBiP22083
TreeFamiTF316348

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

Sequencei

Sequence statusi: Complete.

P22083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLWGAARK PSGAGWEKEW AEAPQEAPGA WSGRLGPGRS GRKGRAVPGW
60 70 80 90 100
ASWPAHLALA ARPARHLGGA GQGPRPLHSG TAPFHSRASG ERQRRLEPQL
110 120 130 140 150
QHESRCRSST PADAWRAEAA LPVRAMGAPW GSPTAAAGGR RGWRRGRGLP
160 170 180 190 200
WTVCVLAAAG LTCTALITYA CWGQLPPLPW ASPTPSRPVG VLLWWEPFGG
210 220 230 240 250
RDSAPRPPPD CRLRFNISGC RLLTDRASYG EAQAVLFHHR DLVKGPPDWP
260 270 280 290 300
PPWGIQAHTA EEVDLRVLDY EEAAAAAEAL ATSSPRPPGQ RWVWMNFESP
310 320 330 340 350
SHSPGLRSLA SNLFNWTLSY RADSDVFVPY GYLYPRSHPG DPPSGLAPPL
360 370 380 390 400
SRKQGLVAWV VSHWDERQAR VRYYHQLSQH VTVDVFGRGG PGQPVPEIGL
410 420 430 440 450
LHTVARYKFY LAFENSQHLD YITEKLWRNA LLAGAVPVVL GPDRANYERF
460 470 480 490 500
VPRGAFIHVD DFPSASSLAS YLLFLDRNPA VYRRYFHWRR SYAVHITSFW
510 520 530
DEPWCRVCQA VQRAGDRPKS IRNLASWFER
Length:530
Mass (Da):59,084
Last modified:April 14, 2009 - v3
Checksum:iB10C1C3C67BE1562
GO

Sequence cautioni

The sequence AAB20349 differs from that shown. Reason: Frameshift at position 114.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212R → P in AAA92977 (PubMed:1716630).Curated1
Sequence conflicti366E → D in AAB20349 (PubMed:1718983).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055844255I → V. Corresponds to variant dbSNP:rs2230273Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58596 mRNA Translation: AAA63172.1
M58597 mRNA Translation: AAA63173.1
AP000943 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66938.1
BC136373 mRNA Translation: AAI36374.1
BC136374 mRNA Translation: AAI36375.1
S65161 Genomic DNA Translation: AAB20349.1 Sequence problems.
M65030 Genomic DNA Translation: AAA92977.1
CCDSiCCDS8301.1
PIRiB36340
RefSeqiNP_002024.1, NM_002033.3
UniGeneiHs.390420
Hs.572064
Hs.623098

Genome annotation databases

EnsembliENST00000358752; ENSP00000351602; ENSG00000196371
GeneIDi2526
KEGGihsa:2526
UCSCiuc001pez.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFUT4_HUMAN
AccessioniPrimary (citable) accession number: P22083
Secondary accession number(s): B2RMS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 14, 2009
Last modified: June 20, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

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