Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 166 (31 Jul 2019)
Sequence version 3 (14 Apr 2009)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Alpha-(1,3)-fucosyltransferase 4

Gene

FUT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Caution

It is uncertain whether Met-1 or Met-126 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS07593-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.152 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9037629 Lewis blood group biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT10 Glycosyltransferase Family 10

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
ELAM-1 ligand fucosyltransferase
Fucosyltransferase 4
Fucosyltransferase IV
Short name:
Fuc-TIV
Short name:
FucT-IV
Galactoside 3-L-fucosyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FUT4
Synonyms:ELFT, FCT3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4015 FUT4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
104230 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22083

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 147CytoplasmicSequence analysisAdd BLAST147
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei148 – 172Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST25
Topological domaini173 – 530LumenalSequence analysisAdd BLAST358

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2526

Open Targets

More...
OpenTargetsi
ENSG00000196371

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28431

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4996

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FUT4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226694189

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002211001 – 530Alpha-(1,3)-fucosyltransferase 4Add BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P22083

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P22083

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P22083

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P22083

PeptideAtlas

More...
PeptideAtlasi
P22083

PRoteomics IDEntifications database

More...
PRIDEi
P22083

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53958

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P22083

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22083

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P22083

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196371 Expressed in 165 organ(s), highest expression level in bone marrow

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P22083 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000014
CAB016129

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108802, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351602

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2619 Eukaryota
ENOG410ZIMX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162506

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000045583

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P22083

KEGG Orthology (KO)

More...
KOi
K07632

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANYERFM

Database of Orthologous Groups

More...
OrthoDBi
551308at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P22083

TreeFam database of animal gene trees

More...
TreeFami
TF316348

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11660, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11929 PTHR11929, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P22083-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRLWGAARK PSGAGWEKEW AEAPQEAPGA WSGRLGPGRS GRKGRAVPGW
60 70 80 90 100
ASWPAHLALA ARPARHLGGA GQGPRPLHSG TAPFHSRASG ERQRRLEPQL
110 120 130 140 150
QHESRCRSST PADAWRAEAA LPVRAMGAPW GSPTAAAGGR RGWRRGRGLP
160 170 180 190 200
WTVCVLAAAG LTCTALITYA CWGQLPPLPW ASPTPSRPVG VLLWWEPFGG
210 220 230 240 250
RDSAPRPPPD CRLRFNISGC RLLTDRASYG EAQAVLFHHR DLVKGPPDWP
260 270 280 290 300
PPWGIQAHTA EEVDLRVLDY EEAAAAAEAL ATSSPRPPGQ RWVWMNFESP
310 320 330 340 350
SHSPGLRSLA SNLFNWTLSY RADSDVFVPY GYLYPRSHPG DPPSGLAPPL
360 370 380 390 400
SRKQGLVAWV VSHWDERQAR VRYYHQLSQH VTVDVFGRGG PGQPVPEIGL
410 420 430 440 450
LHTVARYKFY LAFENSQHLD YITEKLWRNA LLAGAVPVVL GPDRANYERF
460 470 480 490 500
VPRGAFIHVD DFPSASSLAS YLLFLDRNPA VYRRYFHWRR SYAVHITSFW
510 520 530
DEPWCRVCQA VQRAGDRPKS IRNLASWFER
Length:530
Mass (Da):59,084
Last modified:April 14, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB10C1C3C67BE1562
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB20349 differs from that shown. Reason: Frameshift at position 114.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti212R → P in AAA92977 (PubMed:1716630).Curated1
Sequence conflicti366E → D in AAB20349 (PubMed:1718983).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055844255I → V. Corresponds to variant dbSNP:rs2230273Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M58596 mRNA Translation: AAA63172.1
M58597 mRNA Translation: AAA63173.1
AP000943 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66938.1
BC136373 mRNA Translation: AAI36374.1
BC136374 mRNA Translation: AAI36375.1
S65161 Genomic DNA Translation: AAB20349.1 Sequence problems.
M65030 Genomic DNA Translation: AAA92977.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8301.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B36340

NCBI Reference Sequences

More...
RefSeqi
NP_002024.1, NM_002033.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358752; ENSP00000351602; ENSG00000196371

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2526

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2526

UCSC genome browser

More...
UCSCi
uc001pez.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58596 mRNA Translation: AAA63172.1
M58597 mRNA Translation: AAA63173.1
AP000943 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66938.1
BC136373 mRNA Translation: AAI36374.1
BC136374 mRNA Translation: AAI36375.1
S65161 Genomic DNA Translation: AAB20349.1 Sequence problems.
M65030 Genomic DNA Translation: AAA92977.1
CCDSiCCDS8301.1
PIRiB36340
RefSeqiNP_002024.1, NM_002033.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi108802, 5 interactors
STRINGi9606.ENSP00000351602

Chemistry databases

ChEMBLiCHEMBL4996

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

PTM databases

iPTMnetiP22083
PhosphoSitePlusiP22083

Polymorphism and mutation databases

BioMutaiFUT4
DMDMi226694189

Proteomic databases

EPDiP22083
jPOSTiP22083
MaxQBiP22083
PaxDbiP22083
PeptideAtlasiP22083
PRIDEiP22083
ProteomicsDBi53958
TopDownProteomicsiP22083

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2526
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358752; ENSP00000351602; ENSG00000196371
GeneIDi2526
KEGGihsa:2526
UCSCiuc001pez.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2526
DisGeNETi2526

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FUT4
HGNCiHGNC:4015 FUT4
HPAiCAB000014
CAB016129
MIMi104230 gene
neXtProtiNX_P22083
OpenTargetsiENSG00000196371
PharmGKBiPA28431

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
GeneTreeiENSGT00940000162506
HOGENOMiHOG000045583
InParanoidiP22083
KOiK07632
OMAiANYERFM
OrthoDBi551308at2759
PhylomeDBiP22083
TreeFamiTF316348

Enzyme and pathway databases

UniPathwayiUPA00378
BioCyciMetaCyc:HS07593-MONOMER
BRENDAi2.4.1.152 2681
ReactomeiR-HSA-9037629 Lewis blood group biosynthesis

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2526

Protein Ontology

More...
PROi
PR:P22083

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196371 Expressed in 165 organ(s), highest expression level in bone marrow
GenevisibleiP22083 HS

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUT4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22083
Secondary accession number(s): B2RMS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 14, 2009
Last modified: July 31, 2019
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again