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Protein

Lactoperoxidase

Gene

LPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection.By similarity1 Publication

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+PROSITE-ProRule annotationNote: Binds 1 Ca2+ ion per heterodimer.PROSITE-ProRule annotation
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei225Heme (covalent; via 2 links)By similarity1
Active sitei226Proton acceptorPROSITE-ProRule annotation1
Metal bindingi227CalciumPROSITE-ProRule annotation1
Metal bindingi301CalciumPROSITE-ProRule annotation1
Metal bindingi303Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi305CalciumPROSITE-ProRule annotation1
Metal bindingi307CalciumPROSITE-ProRule annotation1
Sitei372Transition state stabilizerPROSITE-ProRule annotation1
Binding sitei375Heme (covalent; via 2 links)By similarity1
Metal bindingi468Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • thiocyanate peroxidase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Oxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3316 HsLPO

Names & Taxonomyi

Protein namesi
Recommended name:
Lactoperoxidase (EC:1.11.1.7)
Short name:
LPO
Alternative name(s):
Salivary peroxidase
Short name:
SPO
Gene namesi
Name:LPO
Synonyms:SAPX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167419.10
HGNCiHGNC:6678 LPO
MIMi150205 gene
170990 gene
neXtProtiNX_P22079

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4025
OpenTargetsiENSG00000167419
PharmGKBiPA30439

Chemistry databases

ChEMBLiCHEMBL5898

Polymorphism and mutation databases

BioMutaiLPO
DMDMi12643419

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000002364927 – 801 PublicationAdd BLAST54
ChainiPRO_000002365081 – 712Lactoperoxidase1 PublicationAdd BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 145PROSITE-ProRule annotation
Glycosylationi212N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi246 ↔ 256PROSITE-ProRule annotation
Disulfide bondi250 ↔ 274PROSITE-ProRule annotation
Modified residuei315PhosphoserineBy similarity1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 365PROSITE-ProRule annotation
Glycosylationi358N-linked (GlcNAc...) asparagine2 Publications1
Modified residuei482Nitrated tyrosineBy similarity1
Disulfide bondi573 ↔ 630PROSITE-ProRule annotation
Disulfide bondi671 ↔ 696PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration, Phosphoprotein

Proteomic databases

PaxDbiP22079
PeptideAtlasiP22079
PRIDEiP22079
ProteomicsDBi53957

PTM databases

iPTMnetiP22079
PhosphoSitePlusiP22079

Expressioni

Tissue specificityi

Mammary gland; milk and salivary gland. Found in bronchial submucosal glands.1 Publication

Gene expression databases

BgeeiENSG00000167419 Expressed in 67 organ(s), highest expression level in parotid gland
CleanExiHS_LPO
ExpressionAtlasiP22079 baseline and differential
GenevisibleiP22079 HS

Organism-specific databases

HPAiHPA028688

Interactioni

Protein-protein interaction databases

BioGridi110207, 2 interactors
STRINGi9606.ENSP00000262290

Chemistry databases

BindingDBiP22079

Structurei

3D structure databases

ProteinModelPortaliP22079
SMRiP22079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00550000074325
HOGENOMiHOG000016084
HOVERGENiHBG000071
InParanoidiP22079
KOiK12550
OMAiVCDNTHI
OrthoDBiEOG091G0236
PhylomeDBiP22079
TreeFamiTF314316

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR029587 LPO
PANTHERiPTHR11475:SF67 PTHR11475:SF67, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50292 PEROXIDASE_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P22079-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVLLHLPAL LASLILLQAA ASTTRAQTTR TSAISDTVSQ AKVQVNKAFL
60 70 80 90 100
DSRTRLKTAM SSETPTSRQL SEYLKHAKGR TRTAIRNGQV WEESLKRLRQ
110 120 130 140 150
KASLTNVTDP SLDLTSLSLE VGCGAPAPVV RCDPCSPYRT ITGDCNNRRK
160 170 180 190 200
PALGAANRAL ARWLPAEYED GLSLPFGWTP GKTRNGFPLP LAREVSNKIV
210 220 230 240 250
GYLNEEGVLD QNRSLLFMQW GQIVDHDLDF APDTELGSSE YSKAQCDEYC
260 270 280 290 300
IQGDNCFPIM FPPNDPKAGT QGKCMPFFRA GFVCPTPPYK SLAREQINAL
310 320 330 340 350
TSFLDASFVY SSEPSLASRL RNLSSPLGLM AVNQEVSDHG LPYLPYDSKK
360 370 380 390 400
PSPCEFINTT ARVPCFLAGD SRASEHILLA TSHTLFLREH NRLARELKRL
410 420 430 440 450
NPQWDGEKLY QEARKILGAF VQIITFRDYL PILLGDHMQK WIPPYQGYSE
460 470 480 490 500
SVDPRISNVF TFAFRFGHLE VPSSMFRLDE NYQPWGPEPE LPLHTLFFNT
510 520 530 540 550
WRMVKDGGID PLVRGLLAKK SKLMKQNKMM TGELRNKLFQ PTHRIHGFDL
560 570 580 590 600
AAINTQRCRD HGQPGYNSWR AFCDLSQPQT LEELNTVLKS KMLAKKLLGL
610 620 630 640 650
YGTPDNIDIW IGAIAEPLVE RGRVGPLLAC LLGKQFQQIR DGDRFWWENP
660 670 680 690 700
GVFTNEQKDS LQKMSFSRLV CDNTRITKVP RDPFWANSYP YDFVDCSAID
710
KLDLSPWASV KN
Length:712
Mass (Da):80,288
Last modified:January 24, 2001 - v2
Checksum:iBC7AA410997198C0
GO
Isoform 2 (identifier: P22079-2) [UniParc]FASTAAdd to basket
Also known as: V3

The sequence of this isoform differs from the canonical sequence as follows:
     26-108: Missing.

Show »
Length:629
Mass (Da):70,984
Checksum:i8A8BBBB5E48C8BBD
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H386F5H386_HUMAN
Lactoperoxidase
LPO
653Annotation score:
J3KT11J3KT11_HUMAN
Lactoperoxidase
LPO
95Annotation score:
J3QSD8J3QSD8_HUMAN
Lactoperoxidase
LPO
123Annotation score:
H0Y3I2H0Y3I2_HUMAN
Lactoperoxidase
LPO
117Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255N → S in ABQ53140 (PubMed:19059195).Curated1
Sequence conflicti678K → M in ABQ53140 (PubMed:19059195).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018809105T → I1 PublicationCorresponds to variant dbSNP:rs8178318Ensembl.1
Natural variantiVAR_018810244A → T1 PublicationCorresponds to variant dbSNP:rs8178338Ensembl.1
Natural variantiVAR_018811414R → Q1 PublicationCorresponds to variant dbSNP:rs8178355Ensembl.1
Natural variantiVAR_018812421V → M3 PublicationsCorresponds to variant dbSNP:rs2301870Ensembl.1
Natural variantiVAR_018813514R → Q1 PublicationCorresponds to variant dbSNP:rs8178401Ensembl.1
Natural variantiVAR_018814614I → T1 PublicationCorresponds to variant dbSNP:rs8178408Ensembl.1
Natural variantiVAR_018815700D → N1 PublicationCorresponds to variant dbSNP:rs8178412Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04447326 – 108Missing in isoform 2. CuratedAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39573 mRNA Translation: AAC50717.1
EF579964 mRNA Translation: ABQ53140.1
AY324876 Genomic DNA Translation: AAP72968.1
AC004687 Genomic DNA No translation available.
AC005962 Genomic DNA No translation available.
BC107166 mRNA Translation: AAI07167.1
BC107167 mRNA Translation: AAI07168.1
M58151 mRNA Translation: AAA63213.1
CCDSiCCDS32689.1 [P22079-1]
CCDS54149.1 [P22079-2]
PIRiJC4935
RefSeqiNP_001153574.1, NM_001160102.1 [P22079-2]
NP_006142.1, NM_006151.2 [P22079-1]
UniGeneiHs.234742

Genome annotation databases

EnsembliENST00000262290; ENSP00000262290; ENSG00000167419 [P22079-1]
ENST00000421678; ENSP00000400245; ENSG00000167419 [P22079-2]
ENST00000582328; ENSP00000464636; ENSG00000167419 [P22079-2]
GeneIDi4025
KEGGihsa:4025
UCSCiuc002ivt.3 human [P22079-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39573 mRNA Translation: AAC50717.1
EF579964 mRNA Translation: ABQ53140.1
AY324876 Genomic DNA Translation: AAP72968.1
AC004687 Genomic DNA No translation available.
AC005962 Genomic DNA No translation available.
BC107166 mRNA Translation: AAI07167.1
BC107167 mRNA Translation: AAI07168.1
M58151 mRNA Translation: AAA63213.1
CCDSiCCDS32689.1 [P22079-1]
CCDS54149.1 [P22079-2]
PIRiJC4935
RefSeqiNP_001153574.1, NM_001160102.1 [P22079-2]
NP_006142.1, NM_006151.2 [P22079-1]
UniGeneiHs.234742

3D structure databases

ProteinModelPortaliP22079
SMRiP22079
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110207, 2 interactors
STRINGi9606.ENSP00000262290

Chemistry databases

BindingDBiP22079
ChEMBLiCHEMBL5898

Protein family/group databases

PeroxiBasei3316 HsLPO

PTM databases

iPTMnetiP22079
PhosphoSitePlusiP22079

Polymorphism and mutation databases

BioMutaiLPO
DMDMi12643419

Proteomic databases

PaxDbiP22079
PeptideAtlasiP22079
PRIDEiP22079
ProteomicsDBi53957

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262290; ENSP00000262290; ENSG00000167419 [P22079-1]
ENST00000421678; ENSP00000400245; ENSG00000167419 [P22079-2]
ENST00000582328; ENSP00000464636; ENSG00000167419 [P22079-2]
GeneIDi4025
KEGGihsa:4025
UCSCiuc002ivt.3 human [P22079-1]

Organism-specific databases

CTDi4025
DisGeNETi4025
EuPathDBiHostDB:ENSG00000167419.10
GeneCardsiLPO
HGNCiHGNC:6678 LPO
HPAiHPA028688
MIMi150205 gene
170990 gene
neXtProtiNX_P22079
OpenTargetsiENSG00000167419
PharmGKBiPA30439
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00550000074325
HOGENOMiHOG000016084
HOVERGENiHBG000071
InParanoidiP22079
KOiK12550
OMAiVCDNTHI
OrthoDBiEOG091G0236
PhylomeDBiP22079
TreeFamiTF314316

Miscellaneous databases

ChiTaRSiLPO human
GeneWikiiLactoperoxidase
GenomeRNAii4025
PROiPR:P22079
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167419 Expressed in 67 organ(s), highest expression level in parotid gland
CleanExiHS_LPO
ExpressionAtlasiP22079 baseline and differential
GenevisibleiP22079 HS

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR029587 LPO
PANTHERiPTHR11475:SF67 PTHR11475:SF67, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50292 PEROXIDASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPERL_HUMAN
AccessioniPrimary (citable) accession number: P22079
Secondary accession number(s): A5JUY4
, E7EMJ3, Q13408, Q3KNQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 24, 2001
Last modified: October 10, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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