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Protein

Lactoperoxidase

Gene

LPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection.By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:
  • Ca2+PROSITE-ProRule annotationNote: Binds 1 Ca2+ ion per heterodimer.PROSITE-ProRule annotation
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei225Heme (covalent; via 2 links)By similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei226Proton acceptorPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi227CalciumPROSITE-ProRule annotation1
Metal bindingi301CalciumPROSITE-ProRule annotation1
Metal bindingi303Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi305CalciumPROSITE-ProRule annotation1
Metal bindingi307CalciumPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei372Transition state stabilizerPROSITE-ProRule annotation1
Binding sitei375Heme (covalent; via 2 links)By similarity1
Metal bindingi468Iron (heme axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • peroxidase activity Source: GO_Central
  • thiocyanate peroxidase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntimicrobial, Oxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
3316 HsLPO

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lactoperoxidase (EC:1.11.1.7)
Short name:
LPO
Alternative name(s):
Salivary peroxidase
Short name:
SPO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LPO
Synonyms:SAPX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167419.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6678 LPO

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
150205 gene
170990 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22079

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4025

Open Targets

More...
OpenTargetsi
ENSG00000167419

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30439

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5898

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LPO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643419

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002364927 – 801 PublicationAdd BLAST54
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002365081 – 712Lactoperoxidase1 PublicationAdd BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi132 ↔ 145PROSITE-ProRule annotation
Glycosylationi212N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi246 ↔ 256PROSITE-ProRule annotation
Disulfide bondi250 ↔ 274PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei315PhosphoserineBy similarity1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 365PROSITE-ProRule annotation
Glycosylationi358N-linked (GlcNAc...) asparagine2 Publications1
Modified residuei482Nitrated tyrosineBy similarity1
Disulfide bondi573 ↔ 630PROSITE-ProRule annotation
Disulfide bondi671 ↔ 696PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P22079

PeptideAtlas

More...
PeptideAtlasi
P22079

PRoteomics IDEntifications database

More...
PRIDEi
P22079

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53957

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22079

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P22079

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mammary gland; milk and salivary gland. Found in bronchial submucosal glands.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167419 Expressed in 67 organ(s), highest expression level in parotid gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_LPO

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P22079 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P22079 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028688

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110207, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262290

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P22079

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P22079

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P22079

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2408 Eukaryota
ENOG410XPZ3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160488

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016084

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000071

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P22079

KEGG Orthology (KO)

More...
KOi
K12550

Identification of Orthologs from Complete Genome Data

More...
OMAi
FTEKQRD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0236

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P22079

TreeFam database of animal gene trees

More...
TreeFami
TF314316

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.640.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR029587 LPO

The PANTHER Classification System

More...
PANTHERi
PTHR11475:SF67 PTHR11475:SF67, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03098 An_peroxidase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00457 ANPEROXIDASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48113 SSF48113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50292 PEROXIDASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P22079-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVLLHLPAL LASLILLQAA ASTTRAQTTR TSAISDTVSQ AKVQVNKAFL
60 70 80 90 100
DSRTRLKTAM SSETPTSRQL SEYLKHAKGR TRTAIRNGQV WEESLKRLRQ
110 120 130 140 150
KASLTNVTDP SLDLTSLSLE VGCGAPAPVV RCDPCSPYRT ITGDCNNRRK
160 170 180 190 200
PALGAANRAL ARWLPAEYED GLSLPFGWTP GKTRNGFPLP LAREVSNKIV
210 220 230 240 250
GYLNEEGVLD QNRSLLFMQW GQIVDHDLDF APDTELGSSE YSKAQCDEYC
260 270 280 290 300
IQGDNCFPIM FPPNDPKAGT QGKCMPFFRA GFVCPTPPYK SLAREQINAL
310 320 330 340 350
TSFLDASFVY SSEPSLASRL RNLSSPLGLM AVNQEVSDHG LPYLPYDSKK
360 370 380 390 400
PSPCEFINTT ARVPCFLAGD SRASEHILLA TSHTLFLREH NRLARELKRL
410 420 430 440 450
NPQWDGEKLY QEARKILGAF VQIITFRDYL PILLGDHMQK WIPPYQGYSE
460 470 480 490 500
SVDPRISNVF TFAFRFGHLE VPSSMFRLDE NYQPWGPEPE LPLHTLFFNT
510 520 530 540 550
WRMVKDGGID PLVRGLLAKK SKLMKQNKMM TGELRNKLFQ PTHRIHGFDL
560 570 580 590 600
AAINTQRCRD HGQPGYNSWR AFCDLSQPQT LEELNTVLKS KMLAKKLLGL
610 620 630 640 650
YGTPDNIDIW IGAIAEPLVE RGRVGPLLAC LLGKQFQQIR DGDRFWWENP
660 670 680 690 700
GVFTNEQKDS LQKMSFSRLV CDNTRITKVP RDPFWANSYP YDFVDCSAID
710
KLDLSPWASV KN
Length:712
Mass (Da):80,288
Last modified:January 24, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC7AA410997198C0
GO
Isoform 2 (identifier: P22079-2) [UniParc]FASTAAdd to basket
Also known as: V3

The sequence of this isoform differs from the canonical sequence as follows:
     26-108: Missing.

Show »
Length:629
Mass (Da):70,984
Checksum:i8A8BBBB5E48C8BBD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H386F5H386_HUMAN
Lactoperoxidase
LPO
653Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT11J3KT11_HUMAN
Lactoperoxidase
LPO
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3I2H0Y3I2_HUMAN
Lactoperoxidase
LPO
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSD8J3QSD8_HUMAN
Lactoperoxidase
LPO
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti255N → S in ABQ53140 (PubMed:19059195).Curated1
Sequence conflicti678K → M in ABQ53140 (PubMed:19059195).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018809105T → I1 PublicationCorresponds to variant dbSNP:rs8178318Ensembl.1
Natural variantiVAR_018810244A → T1 PublicationCorresponds to variant dbSNP:rs8178338Ensembl.1
Natural variantiVAR_018811414R → Q1 PublicationCorresponds to variant dbSNP:rs8178355Ensembl.1
Natural variantiVAR_018812421V → M3 PublicationsCorresponds to variant dbSNP:rs2301870Ensembl.1
Natural variantiVAR_018813514R → Q1 PublicationCorresponds to variant dbSNP:rs8178401Ensembl.1
Natural variantiVAR_018814614I → T1 PublicationCorresponds to variant dbSNP:rs8178408Ensembl.1
Natural variantiVAR_018815700D → N1 PublicationCorresponds to variant dbSNP:rs8178412Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04447326 – 108Missing in isoform 2. CuratedAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U39573 mRNA Translation: AAC50717.1
EF579964 mRNA Translation: ABQ53140.1
AY324876 Genomic DNA Translation: AAP72968.1
AC004687 Genomic DNA No translation available.
AC005962 Genomic DNA No translation available.
BC107166 mRNA Translation: AAI07167.1
BC107167 mRNA Translation: AAI07168.1
M58151 mRNA Translation: AAA63213.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32689.1 [P22079-1]
CCDS54149.1 [P22079-2]

Protein sequence database of the Protein Information Resource

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PIRi
JC4935

NCBI Reference Sequences

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RefSeqi
NP_001153574.1, NM_001160102.1 [P22079-2]
NP_006142.1, NM_006151.2 [P22079-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.234742

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262290; ENSP00000262290; ENSG00000167419 [P22079-1]
ENST00000421678; ENSP00000400245; ENSG00000167419 [P22079-2]
ENST00000582328; ENSP00000464636; ENSG00000167419 [P22079-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4025

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4025

UCSC genome browser

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UCSCi
uc002ivt.3 human [P22079-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39573 mRNA Translation: AAC50717.1
EF579964 mRNA Translation: ABQ53140.1
AY324876 Genomic DNA Translation: AAP72968.1
AC004687 Genomic DNA No translation available.
AC005962 Genomic DNA No translation available.
BC107166 mRNA Translation: AAI07167.1
BC107167 mRNA Translation: AAI07168.1
M58151 mRNA Translation: AAA63213.1
CCDSiCCDS32689.1 [P22079-1]
CCDS54149.1 [P22079-2]
PIRiJC4935
RefSeqiNP_001153574.1, NM_001160102.1 [P22079-2]
NP_006142.1, NM_006151.2 [P22079-1]
UniGeneiHs.234742

3D structure databases

ProteinModelPortaliP22079
SMRiP22079
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110207, 2 interactors
STRINGi9606.ENSP00000262290

Chemistry databases

BindingDBiP22079
ChEMBLiCHEMBL5898

Protein family/group databases

PeroxiBasei3316 HsLPO

PTM databases

iPTMnetiP22079
PhosphoSitePlusiP22079

Polymorphism and mutation databases

BioMutaiLPO
DMDMi12643419

Proteomic databases

PaxDbiP22079
PeptideAtlasiP22079
PRIDEiP22079
ProteomicsDBi53957

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262290; ENSP00000262290; ENSG00000167419 [P22079-1]
ENST00000421678; ENSP00000400245; ENSG00000167419 [P22079-2]
ENST00000582328; ENSP00000464636; ENSG00000167419 [P22079-2]
GeneIDi4025
KEGGihsa:4025
UCSCiuc002ivt.3 human [P22079-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4025
DisGeNETi4025
EuPathDBiHostDB:ENSG00000167419.10

GeneCards: human genes, protein and diseases

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GeneCardsi
LPO
HGNCiHGNC:6678 LPO
HPAiHPA028688
MIMi150205 gene
170990 gene
neXtProtiNX_P22079
OpenTargetsiENSG00000167419
PharmGKBiPA30439

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00940000160488
HOGENOMiHOG000016084
HOVERGENiHBG000071
InParanoidiP22079
KOiK12550
OMAiFTEKQRD
OrthoDBiEOG091G0236
PhylomeDBiP22079
TreeFamiTF314316

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LPO human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Lactoperoxidase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4025

Protein Ontology

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PROi
PR:P22079

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167419 Expressed in 67 organ(s), highest expression level in parotid gland
CleanExiHS_LPO
ExpressionAtlasiP22079 baseline and differential
GenevisibleiP22079 HS

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR029587 LPO
PANTHERiPTHR11475:SF67 PTHR11475:SF67, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50292 PEROXIDASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPERL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22079
Secondary accession number(s): A5JUY4
, E7EMJ3, Q13408, Q3KNQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 24, 2001
Last modified: December 5, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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