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Protein

Beta-glucosidase A

Gene

bglA

Organism
Paenibacillus polymyxa (Bacillus polymyxa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

BglA is intracellular and cleaves cellobiose probably through inorganic phosphate mediated hydrolysis.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166Proton donorSequence analysis1
Active sitei352NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BRENDAi3.2.1.21 683

Protein family/group databases

CAZyiGH1 Glycoside Hydrolase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase A (EC:3.2.1.21)
Short name:
BGA
Alternative name(s):
Amygdalase
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene namesi
Name:bglA
OrganismiPaenibacillus polymyxa (Bacillus polymyxa)
Taxonomic identifieri1406 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus

Pathology & Biotechi

Chemistry databases

DrugBankiDB04282 2-deoxy-2-fluoro-Alpha-D-glucose
DB04304 Gluconic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000638711 – 448Beta-glucosidase AAdd BLAST448

Interactioni

Subunit structurei

Homooctamer.

Structurei

Secondary structure

1448
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22073
SMRiP22073
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22073

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Phylogenomic databases

eggNOGiENOG4105CS2 Bacteria
COG2723 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR001360 Glyco_hydro_1
IPR018120 Glyco_hydro_1_AS
IPR017736 Glyco_hydro_1_beta-glucosidase
IPR033132 Glyco_hydro_1_N_CS
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10353 PTHR10353, 1 hit
PfamiView protein in Pfam
PF00232 Glyco_hydro_1, 1 hit
PRINTSiPR00131 GLHYDRLASE1
SUPFAMiSSF51445 SSF51445, 1 hit
TIGRFAMsiTIGR03356 BGL, 1 hit
PROSITEiView protein in PROSITE
PS00572 GLYCOSYL_HYDROL_F1_1, 1 hit
PS00653 GLYCOSYL_HYDROL_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P22073-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIFQFPQDF MWGTATAAYQ IEGAYQEDGR GLSIWDTFAH TPGKVFNGDN
60 70 80 90 100
GNVACDSYHR YEEDIRLMKE LGIRTYRFSV SWPRIFPNGD GEVNQEGLDY
110 120 130 140 150
YHRVVDLLND NGIEPFCTLY HWDLPQALQD AGGWGNRRTI QAFVQFAETM
160 170 180 190 200
FREFHGKIQH WLTFNEPWCI AFLSNMLGVH APGLTNLQTA IDVGHHLLVA
210 220 230 240 250
HGLSVRRFRE LGTSGQIGIA PNVSWAVPYS TSEEDKAACA RTISLHSDWF
260 270 280 290 300
LQPIYQGSYP QFLVDWFAEQ GATVPIQDGD MDIIGEPIDM IGINYYSMSV
310 320 330 340 350
NRFNPEAGFL QSEEINMGLP VTDIGWPVES RGLYEVLHYL QKYGNIDIYI
360 370 380 390 400
TENGACINDE VVNGKVQDDR RISYMQQHLV QVHRTIHDGL HVKGYMAWSL
410 420 430 440
LDNFEWAEGY NMRFGMIHVD FRTQVRTPKE SYYWYRNVVS NNWLETRR
Length:448
Mass (Da):51,649
Last modified:August 1, 1991 - v1
Checksum:iD971D2E61B6627C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60210 Genomic DNA Translation: AAA22263.1
PIRiJW0037

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60210 Genomic DNA Translation: AAA22263.1
PIRiJW0037

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BGAX-ray2.40A/B/C/D2-448[»]
1BGGX-ray2.30A/B/C/D1-448[»]
1E4IX-ray2.00A2-448[»]
1TR1X-ray2.20A/B/C/D2-448[»]
1UYQX-ray2.20A2-448[»]
ProteinModelPortaliP22073
SMRiP22073
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB04282 2-deoxy-2-fluoro-Alpha-D-glucose
DB04304 Gluconic Acid

Protein family/group databases

CAZyiGH1 Glycoside Hydrolase Family 1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CS2 Bacteria
COG2723 LUCA

Enzyme and pathway databases

BRENDAi3.2.1.21 683

Miscellaneous databases

EvolutionaryTraceiP22073

Family and domain databases

InterProiView protein in InterPro
IPR001360 Glyco_hydro_1
IPR018120 Glyco_hydro_1_AS
IPR017736 Glyco_hydro_1_beta-glucosidase
IPR033132 Glyco_hydro_1_N_CS
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10353 PTHR10353, 1 hit
PfamiView protein in Pfam
PF00232 Glyco_hydro_1, 1 hit
PRINTSiPR00131 GLHYDRLASE1
SUPFAMiSSF51445 SSF51445, 1 hit
TIGRFAMsiTIGR03356 BGL, 1 hit
PROSITEiView protein in PROSITE
PS00572 GLYCOSYL_HYDROL_F1_1, 1 hit
PS00653 GLYCOSYL_HYDROL_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBGLA_PAEPO
AccessioniPrimary (citable) accession number: P22073
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 5, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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