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Protein

Protein P-30

Gene
N/A
Organism
Lithobates pipiens (Northern leopard frog) (Rana pipiens)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10Proton acceptor1
Active sitei97Proton donor1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BRENDAi3.1.27.5 5287

Names & Taxonomyi

Protein namesi
Recommended name:
Protein P-30 (EC:3.1.27.-)
Alternative name(s):
Onconase
OrganismiLithobates pipiens (Northern leopard frog) (Rana pipiens)
Taxonomic identifieri8404 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRana

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000571741 – 104Protein P-30Add BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi19 ↔ 68
Disulfide bondi30 ↔ 75
Disulfide bondi48 ↔ 90
Disulfide bondi87 ↔ 104

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP22069

Expressioni

Developmental stagei

Early embryos (up to four blastomere stage).

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 10Combined sources8
Beta strandi11 – 16Combined sources6
Helixi19 – 22Combined sources4
Beta strandi23 – 25Combined sources3
Turni26 – 30Combined sources5
Beta strandi32 – 39Combined sources8
Helixi41 – 45Combined sources5
Helixi46 – 48Combined sources3
Beta strandi55 – 58Combined sources4
Beta strandi63 – 70Combined sources8
Beta strandi77 – 84Combined sources8
Beta strandi86 – 91Combined sources6
Beta strandi94 – 102Combined sources9

3D structure databases

ProteinModelPortaliP22069
SMRiP22069
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22069

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 35Substrate binding5

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Phylogenomic databases

HOVERGENiHBG008396

Family and domain databases

Gene3Di3.10.130.10, 1 hit
InterProiView protein in InterPro
IPR001427 RNaseA
IPR036816 RNaseA-like_dom_sf
IPR023411 RNaseA_AS
IPR023412 RNaseA_domain
PANTHERiPTHR11437 PTHR11437, 1 hit
PfamiView protein in Pfam
PF00074 RnaseA, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000535 RNaseA, 1 hit
SMARTiView protein in SMART
SM00092 RNAse_Pc, 1 hit
SUPFAMiSSF54076 SSF54076, 1 hit
PROSITEiView protein in PROSITE
PS00127 RNASE_PANCREATIC, 1 hit

Sequencei

Sequence statusi: Complete.

P22069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QDWLTFQKKH ITNTRDVDCD NIMSTNLFHC KDKNTFIYSR PEPVKAICKG
60 70 80 90 100
IIASKNVLTT SEFYLSDCNV TSRPCKYKLK KSTNKFCVTC ENQAPVHFVG

VGSC
Length:104
Mass (Da):11,845
Last modified:February 1, 1994 - v2
Checksum:i22A753C2F9E566B4
GO

Similar proteinsi

Entry informationi

Entry nameiRNP30_LITPI
AccessioniPrimary (citable) accession number: P22069
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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