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Zinc metalloproteinase-disintegrin-like botrocetin

Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Reviewed-Annotation score: -Experimental evidence at protein leveli


Metalloproteinase that binds to von Willebrand factor (VWF) and induces its interaction with GPIb (GP1BA), resulting in platelet aggregation.


There are two distinct forms of the vWF-dependent platelet coagglutinin. The dimeric form (snaclec) is 34-fold more active than the metalloprotease botrocetin in promoting vWF binding to platelets (PubMed:1993206).1 Publication


Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Calcium; via carbonyl oxygenBy similarity1
Metal bindingi9CalciumBy similarity1
Metal bindingi11Calcium; via carbonyl oxygenBy similarity1
Metal bindingi13CalciumBy similarity1
Metal bindingi16CalciumBy similarity1
Metal bindingi19CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of platelet aggregation in other organism Source: CACAO


Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Hydrolase, Platelet aggregation activating toxin, Toxin
LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase-disintegrin-like botrocetin (EC:3.4.24.-)
Alternative name(s):
Snake venom metalloproteinase
Short name:
von Willebrand factor-dependent platelet coagglutinin
Cleaved into the following chain:
OrganismiBothrops jararaca (Jararaca) (Bothrops jajaraca)
Taxonomic identifieri8724 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeBothrops

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti


PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000046696‹1 – ›25Zinc metalloproteinase-disintegrin-like botrocetinAdd BLAST›25
ChainiPRO_00004224241 – ›25Disintegrin-like botrocetinAdd BLAST›25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18 ↔ ?By similarity
Disulfide bondi20 ↔ ?By similarity

Keywords - PTMi

Disulfide bond


Tissue specificityi

Expressed by the venom gland.


Subunit structurei

Monomer. Botrocetin and vWF form a soluble complex.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – ›25DisintegrinPROSITE-ProRule annotationAdd BLAST›22


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi17 – 19D/ECD-tripeptide3

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR036436 Disintegrin_dom_sf


Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22028-1 [UniParc]FASTAAdd to basket

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        10         20 
Mass (Da):2,648
Last modified:May 29, 2013 - v2

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence uncertaintyi20Assigned by comparison with orthologs1
Non-terminal residuei251

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti2I → V. 1

Similar proteinsi

Entry informationi

Entry nameiVM3B_BOTJA
AccessioniPrimary (citable) accession number: P22028
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 29, 2013
Last modified: February 28, 2018
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program


Keywords - Technical termi

Direct protein sequencing


  1. SIMILARITY comments
    Index of protein domains and families

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