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Entry version 155 (16 Oct 2019)
Sequence version 2 (01 Nov 1997)
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Protein

Killer toxin-resistance protein 5

Gene

KRE5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for (1->6)-beta-D-glucan synthesis and normal cell growth.

Miscellaneous

Present with 815 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33811-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT24 Glycosyltransferase Family 24

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Killer toxin-resistance protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRE5
Ordered Locus Names:YOR336W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YOR336W

Saccharomyces Genome Database

More...
SGDi
S000005863 KRE5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002156318 – 1365Killer toxin-resistance protein 5Add BLAST1348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi644N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi870N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1091N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1195N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P22023

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P22023

PRoteomics IDEntifications database

More...
PRIDEi
P22023

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22023

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34719, 249 interactors

Database of interacting proteins

More...
DIPi
DIP-5326N

Molecular INTeraction database

More...
MINTi
P22023

STRING: functional protein association networks

More...
STRINGi
4932.YOR336W

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1362 – 1365Prevents secretion from ER4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

To D.melanogaster UGGG.Curated

Keywords - Domaini

Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000000800

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P22023

KEGG Orthology (KO)

More...
KOi
K11718

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDLKYHI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040497 Glyco_transf_24
IPR009448 UDP-g_GGtrans
IPR040694 UGGT_TRXL_2
IPR040692 UGGT_TRXL_3

The PANTHER Classification System

More...
PANTHERi
PTHR11226 PTHR11226, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18404 Glyco_transf_24, 1 hit
PF18401 Thioredoxin_13, 1 hit
PF18402 Thioredoxin_14, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00014 ER_TARGET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P22023-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLALVLLL LCAPLRAWTY SLRYGIPESA QVWSILVHLL GDVDNQLLTN
60 70 80 90 100
LYPLVTGLDD EIDIQENLVA LTSNVLRERY DKEDVADLLE LYASLYPMGM
110 120 130 140 150
IQHDISSNAE QDDANSSYFV LNGNRYEKPD DVFYLKSKDL TIQQKVPDVD
160 170 180 190 200
VIQPYDVVIG TNSEAPILIL YGCPTVIDSD FEEFNRNLFM EAMNGEGKFR
210 220 230 240 250
FIWRSTCSLD GKSVEYPLTH PLEITLQNGS RMSSIPQLKK ILYTVPKEIL
260 270 280 290 300
VGADNDDQLH DLEPEELREL DLRVTSLISE FYQYKKDITA TLNFTKSIVN
310 320 330 340 350
NFPLISKQLI KVSSVNKDII TSNEELNSKG FDYNMLGLYI NGQNWKITSL
360 370 380 390 400
TPYNLLTALK TEYQSLLKIT NLLQELEPSK CILDSKFLLN KFSQFSLGKL
410 420 430 440 450
QNLQPIKMDL HTIPGFSESV IYFNDIESDP QYDELVNSVQ AFFDKSKFGE
460 470 480 490 500
LPEIKQNWSE IIFVIDFARL EDSEVKEALG GLVRAVNVVS QGYPQRVGLL
510 520 530 540 550
PFSSDSDKSV VNKIYELKNS TDNLTELKSF LETMLLADGL SANAKHSKHI
560 570 580 590 600
PVPDVFHLLD ELQIDETSII INGEIYPFRK NAWNYLIAKV IKKDTEFIRK
610 620 630 640 650
ELSNSSPKNK QISVRDLLHY KSANLRHNKY TPNYFADSVY SSVNNTALES
660 670 680 690 700
VCSERIGYYT KNEEYNLLHT ITLVDDFGSI HALKRLRNLL HTSFVGVRIR
710 720 730 740 750
IIHVGDISDI WYQLRGSLSQ KDPIGSINTF IDALKLKKVK SHTYKKSGLN
760 770 780 790 800
QLGLHKWLPD IPLFELQKGS FIALNGRFIH LDQNEVPETE HFEAIIKREA
810 820 830 840 850
LRTIDSVFAL DLLFPGFSQE IINPDLIEMI SSILTRLFYQ GTHIYNNGID
860 870 880 890 900
YTTESSLPRM DLSEFFRPNN LTMFEDGKSA SIDLLLILDP LEERTQMILS
910 920 930 940 950
LVEQFRPLKF VNIQVILMPT LELNIVPIRR IYVDDADIVK SITSEDSRSD
960 970 980 990 1000
PEVDIEMDVP NSFIVDNNYR IKKLLIELHS FSSKTVLSTG NIDGMGGVCL
1010 1020 1030 1040 1050
ALVDSAGNII DKTTTMKTFG YGQFHTDKFL KGCYIKSCDS RYTVQSFSTD
1060 1070 1080 1090 1100
GHPDFIPSDS LDILSYNPQK IAVKISEEPT HEEEYEEGRN NDTIINIFTI
1110 1120 1130 1140 1150
LESGPDEEER YMQMILSILS KCPETQKVNF FILDQPFISD TLRKSCEYIN
1160 1170 1180 1190 1200
SSDEMRGNVI FLNYEWPQWL RPQRFSSRRR DVSRFLFLDV LLPQNISKVL
1210 1220 1230 1240 1250
YMSPTEVPLD PFDIFQFQGL KRAPLGLFRM SGDGYWKEGY WEKMLRENNL
1260 1270 1280 1290 1300
EFYSTEPAFL VNLERFRELD AGDKYRIHYQ RISTDAMSLV NIGQDLVNNL
1310 1320 1330 1340 1350
QLEVPIRFLK GSYKKKLVIN DECVSEWKKK INKFASSPGD EDVPGESVSS
1360
KYQDSDNAAP LHDEL
Length:1,365
Mass (Da):156,477
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0F5851175CC0333
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti582Missing in AAA34725 (PubMed:2188106).Curated1
Sequence conflicti780 – 794HLDQN…EHFEA → ILIKMKCQKQNISKAK in AAA34725 (PubMed:2188106).CuratedAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M33556 Genomic DNA Translation: AAA34725.1
Z49821 Genomic DNA Translation: CAA89981.1
Z75244 Genomic DNA Translation: CAA99659.1
BK006948 Genomic DNA Translation: DAA11097.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S62066 BVBYK5

NCBI Reference Sequences

More...
RefSeqi
NP_014981.1, NM_001183756.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR336W_mRNA; YOR336W; YOR336W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854514

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR336W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33556 Genomic DNA Translation: AAA34725.1
Z49821 Genomic DNA Translation: CAA89981.1
Z75244 Genomic DNA Translation: CAA99659.1
BK006948 Genomic DNA Translation: DAA11097.1
PIRiS62066 BVBYK5
RefSeqiNP_014981.1, NM_001183756.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi34719, 249 interactors
DIPiDIP-5326N
MINTiP22023
STRINGi4932.YOR336W

Protein family/group databases

CAZyiGT24 Glycosyltransferase Family 24

PTM databases

iPTMnetiP22023

Proteomic databases

MaxQBiP22023
PaxDbiP22023
PRIDEiP22023

Genome annotation databases

EnsemblFungiiYOR336W_mRNA; YOR336W; YOR336W
GeneIDi854514
KEGGisce:YOR336W

Organism-specific databases

EuPathDBiFungiDB:YOR336W
SGDiS000005863 KRE5

Phylogenomic databases

HOGENOMiHOG000000800
InParanoidiP22023
KOiK11718
OMAiDDLKYHI

Enzyme and pathway databases

BioCyciYEAST:G3O-33811-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P22023

Family and domain databases

InterProiView protein in InterPro
IPR040497 Glyco_transf_24
IPR009448 UDP-g_GGtrans
IPR040694 UGGT_TRXL_2
IPR040692 UGGT_TRXL_3
PANTHERiPTHR11226 PTHR11226, 1 hit
PfamiView protein in Pfam
PF18404 Glyco_transf_24, 1 hit
PF18401 Thioredoxin_13, 1 hit
PF18402 Thioredoxin_14, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRE5_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22023
Secondary accession number(s): D6W331, Q12190
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: October 16, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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