Bone morphogenetic protein 6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• BMP receptor binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4."
    Yamaji N., Celeste A.J., Thies R.S., Song J.J., Bernier S.M., Goltzman D., Lyons K.M., Nove J., Rosen V., Wozney J.M.
    Biochem Biophys Res Commun 205:1944-1951(1994) [PubMed] [Europe PMC] [Abstract]
• cytokine activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• growth factor activity Source: UniProtKB-KW
• protein heterodimerization activity Source: MGIInferred from direct assayⁱ
  • "A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4."
    Yamaji N., Celeste A.J., Thies R.S., Song J.J., Bernier S.M., Goltzman D., Lyons K.M., Nove J., Rosen V., Wozney J.M.
    Biochem Biophys Res Commun 205:1944-1951(1994) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• BMP signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells."
    Lavery K., Swain P., Falb D., Alaoui-Ismaili M.H.
    J. Biol. Chem. 283:20948-20958(2008) [PubMed] [Europe PMC] [Abstract]
• cartilage development Source: UniProtKB-KW
• cellular iron ion homeostasis Source: BHF-UCL
• cellular response to BMP stimulus Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin."
    Xia Y., Babitt J.L., Sidis Y., Chung R.T., Lin H.Y.
    Blood 111:5195-5204(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to iron ion Source: BHF-UCL
• cellular response to mechanical stimulus Source: Ensembl
• endochondral ossification Source: Ensembl
• eye development Source: Ensembl
• immune response Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia."
    Adewoye A.H., Nolan V.G., Ma Q., Baldwin C., Wyszynski D.F., Farrell J.J., Farrer L.A., Steinberg M.H.
    Clin Infect Dis 43:593-598(2006) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: Ensembl
• kidney development Source: Ensembl
• male genitalia development Source: Ensembl
• multicellular organismal iron ion homeostasis Source: BHF-UCL
• negative regulation of adherens junction organization Source: ARUK-UCLInferred from direct assayⁱ
  • "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling."
    Benn A., Bredow C., Casanova I., Vukicevic S., Knaus P.
    J Cell Sci 129:206-218(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell-cell adhesion mediated by cadherin Source: ARUK-UCLInferred from direct assayⁱ
  • "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling."
    Benn A., Bredow C., Casanova I., Vukicevic S., Knaus P.
    J Cell Sci 129:206-218(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: BHF-UCL
• osteoblast differentiation Source: Ensembl
• positive regulation of aldosterone biosynthetic process Source: UniProtKBInferred from direct assayⁱ
  • "Involvement of bone morphogenetic protein-6 in differential regulation of aldosterone production by angiotensin II and potassium in human adrenocortical cells."
    Inagaki K., Otsuka F., Suzuki J., Kano Y., Takeda M., Miyoshi T., Otani H., Mimura Y., Ogura T., Makino H.
    Endocrinology 147:2681-2689(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of aldosterone secretion Source: Ensembl
• positive regulation of bone mineralization Source: BHF-UCLInferred from direct assayⁱ
  • "BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells."
    Lavery K., Swain P., Falb D., Alaoui-Ismaili M.H.
    J. Biol. Chem. 283:20948-20958(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells."
    Xu W.P., Shiba H., Mizuno N., Uchida Y., Mouri Y., Kawaguchi H., Kurihara H.
    Cell Biol Int 28:675-682(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of chondrocyte differentiation Source: Ensembl
• positive regulation of endothelial cell differentiation Source: Ensembl
• positive regulation of endothelial cell proliferation Source: Ensembl
• positive regulation of epithelial cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells."
    Jiang F.X., Stanley E.G., Gonez L.J., Harrison L.C.
    J Cell Sci 115:753-760(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling."
    Benn A., Bredow C., Casanova I., Vukicevic S., Knaus P.
    J Cell Sci 129:206-218(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lipopolysaccharide-mediated signaling pathway Source: BHF-UCL
• positive regulation of neuron differentiation Source: Ensembl
• positive regulation of osteoblast differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells."
    Lavery K., Swain P., Falb D., Alaoui-Ismaili M.H.
    J. Biol. Chem. 283:20948-20958(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKBInferred from direct assayⁱ
  • "Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation."
    Otani H., Otsuka F., Inagaki K., Takeda M., Miyoshi T., Suzuki J., Mukai T., Ogura T., Makino H.
    Am J Physiol Renal Physiol 292:F1513-25(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCLInferred from direct assayⁱ
  • "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling."
    Benn A., Bredow C., Casanova I., Vukicevic S., Knaus P.
    J Cell Sci 129:206-218(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein secretion Source: BHF-UCLNon-traceable author statementⁱ
  • "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells."
    Xu W.P., Shiba H., Mizuno N., Uchida Y., Mouri Y., Kawaguchi H., Kurihara H.
    Cell Biol Int 28:675-682(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of SMAD protein signal transduction Source: BHF-UCL
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • "Involvement of bone morphogenetic protein-6 in differential regulation of aldosterone production by angiotensin II and potassium in human adrenocortical cells."
    Inagaki K., Otsuka F., Suzuki J., Kano Y., Takeda M., Miyoshi T., Otani H., Mimura Y., Ogura T., Makino H.
    Endocrinology 147:2681-2689(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular permeability Source: ARUK-UCLInferred from direct assayⁱ
  • "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling."
    Benn A., Bredow C., Casanova I., Vukicevic S., Knaus P.
    J Cell Sci 129:206-218(2016) [PubMed] [Europe PMC] [Abstract]
• response to activity Source: Ensembl
• response to glucocorticoid Source: Ensembl
• response to magnesium ion Source: Ensembl
• response to retinoic acid Source: Ensembl
• skeletal system development Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo."
    Gitelman S.E., Kobrin M.S., Ye J.Q., Lopez A.R., Lee A., Derynck R.
    J. Cell Biol. 126:1595-1609(1994) [PubMed] [Europe PMC] [Abstract]
• SMAD protein signal transduction Source: UniProtKBInferred from direct assayⁱ
  • "Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation."
    Otani H., Otsuka F., Inagaki K., Takeda M., Miyoshi T., Suzuki J., Mukai T., Ogura T., Makino H.
    Am J Physiol Renal Physiol 292:F1513-25(2007) [PubMed] [Europe PMC] [Abstract]
• type B pancreatic cell development Source: BHF-UCLInferred from direct assayⁱ
  • "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells."
    Jiang F.X., Stanley E.G., Gonez L.J., Harrison L.C.
    J Cell Sci 115:753-760(2002) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• BMP receptor binding Source: MGIInferred from direct assayⁱ
  • "A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4."
    Yamaji N., Celeste A.J., Thies R.S., Song J.J., Bernier S.M., Goltzman D., Lyons K.M., Nove J., Rosen V., Wozney J.M.
    Biochem Biophys Res Commun 205:1944-1951(1994) [PubMed] [Europe PMC] [Abstract]
• cytokine activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• growth factor activity Source: UniProtKB-KW
• protein heterodimerization activity Source: MGIInferred from direct assayⁱ
  • "A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4."
    Yamaji N., Celeste A.J., Thies R.S., Song J.J., Bernier S.M., Goltzman D., Lyons K.M., Nove J., Rosen V., Wozney J.M.
    Biochem Biophys Res Commun 205:1944-1951(1994) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP 
        60         70         80         90        100
GRTEQPPPSP QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ 
       110        120        130        140        150
QPQPPALRQQ EEQQQQQQLP RGEPPPGRLK SAPLFMLDLY NALSADNDED 
       160        170        180        190        200
GASEGERQQS WPHEAASSSQ RRQPPPGAAH PLNRKSLLAP GSGSGGASPL 
       210        220        230        240        250
TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF NLSQIPEGEV 
       260        270        280        290        300
VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA 
       310        320        330        340        350
SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD 
       360        370        380        390        400
GPYDKQPFMV AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA 
       410        420        430        440        450
SDYNSSELKT ACRKHELYVS FQDLGWQDWI IAPKGYAANY CDGECSFPLN 
       460        470        480        490        500
AHMNATNHAI VQTLVHLMNP EYVPKPCCAP TKLNAISVLY FDDNSNVILK 
       510 
KYRNMVVRAC GCH                                         

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 6
   Human chromosome 6: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
6. SIMILARITY comments
   Index of protein domains and families