UniProtKB - P22004 (BMP6_HUMAN)
Protein
Bone morphogenetic protein 6
Gene
BMP6
Organism
Homo sapiens (Human)
Status
Functioni
Induces cartilage and bone formation.
GO - Molecular functioni
- BMP receptor binding Source: MGI
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- protein heterodimerization activity Source: MGI
GO - Biological processi
- BMP signaling pathway Source: BHF-UCL
- cartilage development Source: UniProtKB-KW
- cellular iron ion homeostasis Source: BHF-UCL
- cellular response to BMP stimulus Source: BHF-UCL
- cellular response to iron ion Source: BHF-UCL
- cellular response to mechanical stimulus Source: Ensembl
- endochondral ossification Source: Ensembl
- eye development Source: Ensembl
- immune response Source: BHF-UCL
- inflammatory response Source: Ensembl
- kidney development Source: Ensembl
- male genitalia development Source: Ensembl
- multicellular organismal iron ion homeostasis Source: BHF-UCL
- negative regulation of adherens junction organization Source: ARUK-UCL
- negative regulation of cell-cell adhesion mediated by cadherin Source: ARUK-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- osteoblast differentiation Source: Ensembl
- positive regulation of aldosterone biosynthetic process Source: UniProtKB
- positive regulation of aldosterone secretion Source: Ensembl
- positive regulation of bone mineralization Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of chondrocyte differentiation Source: Ensembl
- positive regulation of endothelial cell differentiation Source: Ensembl
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of epithelial cell proliferation Source: BHF-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of lipopolysaccharide-mediated signaling pathway Source: BHF-UCL
- positive regulation of neuron differentiation Source: Ensembl
- positive regulation of osteoblast differentiation Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
- positive regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCL
- positive regulation of protein secretion Source: BHF-UCL
- positive regulation of SMAD protein signal transduction Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of vascular permeability Source: ARUK-UCL
- response to activity Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to magnesium ion Source: Ensembl
- response to retinoic acid Source: Ensembl
- skeletal system development Source: ProtInc
- SMAD protein signal transduction Source: UniProtKB
- type B pancreatic cell development Source: BHF-UCL
Keywordsi
Molecular function | Cytokine, Developmental protein, Growth factor |
Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Enzyme and pathway databases
PathwayCommonsi | P22004 |
SignaLinki | P22004 |
Names & Taxonomyi
Protein namesi | Recommended name: Bone morphogenetic protein 6Short name: BMP-6 Alternative name(s): VG-1-related protein Short name: VG-1-R Short name: VGR-1 |
Gene namesi | Name:BMP6 Synonyms:VGR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000153162.8 |
HGNCi | HGNC:1073, BMP6 |
MIMi | 112266, gene |
neXtProti | NX_P22004 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 654 |
MalaCardsi | BMP6 |
OpenTargetsi | ENSG00000153162 |
Orphaneti | 447792, Hemochromatosis type 5 |
PharmGKBi | PA25383 |
Miscellaneous databases
Pharosi | P22004, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3286078 |
Polymorphism and mutation databases
BioMutai | BMP6 |
DMDMi | 115076 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000033870 | 21 – 374 | Sequence analysisAdd BLAST | 354 | |
ChainiPRO_0000033871 | 375 – 513 | Bone morphogenetic protein 6Add BLAST | 139 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 386 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 404 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 412 ↔ 478 | By similarity | ||
Disulfide bondi | 441 ↔ 510 | By similarity | ||
Disulfide bondi | 445 ↔ 512 | By similarity | ||
Glycosylationi | 454 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 477 | InterchainBy similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P22004 |
MaxQBi | P22004 |
PaxDbi | P22004 |
PeptideAtlasi | P22004 |
PRIDEi | P22004 |
ProteomicsDBi | 53952 |
PTM databases
GlyGeni | P22004, 5 sites |
iPTMneti | P22004 |
PhosphoSitePlusi | P22004 |
Expressioni
Gene expression databases
Bgeei | ENSG00000153162, Expressed in secondary oocyte and 162 other tissues |
Genevisiblei | P22004, HS |
Organism-specific databases
HPAi | ENSG00000153162, Tissue enhanced (placenta) |
Interactioni
Subunit structurei
Interacts with SOSTDC1.
By similarityGO - Molecular functioni
- BMP receptor binding Source: MGI
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- protein heterodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 107122, 8 interactors |
DIPi | DIP-5797N |
IntActi | P22004, 1 interactor |
STRINGi | 9606.ENSP00000283147 |
Chemistry databases
BindingDBi | P22004 |
Miscellaneous databases
RNActi | P22004, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P22004 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P22004 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000158768 |
HOGENOMi | CLU_020515_4_1_1 |
InParanoidi | P22004 |
OMAi | ERQQPWP |
OrthoDBi | 1063560at2759 |
PhylomeDBi | P22004 |
TreeFami | TF316134 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P22004-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP
60 70 80 90 100
GRTEQPPPSP QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ
110 120 130 140 150
QPQPPALRQQ EEQQQQQQLP RGEPPPGRLK SAPLFMLDLY NALSADNDED
160 170 180 190 200
GASEGERQQS WPHEAASSSQ RRQPPPGAAH PLNRKSLLAP GSGSGGASPL
210 220 230 240 250
TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF NLSQIPEGEV
260 270 280 290 300
VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA
310 320 330 340 350
SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD
360 370 380 390 400
GPYDKQPFMV AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA
410 420 430 440 450
SDYNSSELKT ACRKHELYVS FQDLGWQDWI IAPKGYAANY CDGECSFPLN
460 470 480 490 500
AHMNATNHAI VQTLVHLMNP EYVPKPCCAP TKLNAISVLY FDDNSNVILK
510
KYRNMVVRAC GCH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047055 | 257 | R → C. Corresponds to variant dbSNP:rs10458105Ensembl. | 1 | |
Natural variantiVAR_036200 | 343 | A → D in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_036201 | 476 | P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs909733732Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60315 mRNA Translation: AAA36737.1 AL135778 Genomic DNA No translation available. AL133541 Genomic DNA No translation available. |
CCDSi | CCDS4503.1 |
PIRi | B39263, BMHU6 |
RefSeqi | NP_001709.1, NM_001718.5 |
Genome annotation databases
Ensembli | ENST00000283147; ENSP00000283147; ENSG00000153162 |
GeneIDi | 654 |
KEGGi | hsa:654 |
UCSCi | uc003mxu.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Bone morphogenetic protein 6 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60315 mRNA Translation: AAA36737.1 AL135778 Genomic DNA No translation available. AL133541 Genomic DNA No translation available. |
CCDSi | CCDS4503.1 |
PIRi | B39263, BMHU6 |
RefSeqi | NP_001709.1, NM_001718.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2QCW | X-ray | 2.49 | A/B | 382-513 | [»] | |
2R52 | X-ray | 2.50 | A/B | 375-513 | [»] | |
2R53 | X-ray | 2.10 | A/B | 411-513 | [»] | |
6OMO | X-ray | 2.80 | I/J | 410-513 | [»] | |
SMRi | P22004 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107122, 8 interactors |
DIPi | DIP-5797N |
IntActi | P22004, 1 interactor |
STRINGi | 9606.ENSP00000283147 |
Chemistry databases
BindingDBi | P22004 |
ChEMBLi | CHEMBL3286078 |
PTM databases
GlyGeni | P22004, 5 sites |
iPTMneti | P22004 |
PhosphoSitePlusi | P22004 |
Polymorphism and mutation databases
BioMutai | BMP6 |
DMDMi | 115076 |
Proteomic databases
MassIVEi | P22004 |
MaxQBi | P22004 |
PaxDbi | P22004 |
PeptideAtlasi | P22004 |
PRIDEi | P22004 |
ProteomicsDBi | 53952 |
Protocols and materials databases
Antibodypediai | 3456, 442 antibodies |
DNASUi | 654 |
Genome annotation databases
Ensembli | ENST00000283147; ENSP00000283147; ENSG00000153162 |
GeneIDi | 654 |
KEGGi | hsa:654 |
UCSCi | uc003mxu.5, human |
Organism-specific databases
CTDi | 654 |
DisGeNETi | 654 |
EuPathDBi | HostDB:ENSG00000153162.8 |
GeneCardsi | BMP6 |
HGNCi | HGNC:1073, BMP6 |
HPAi | ENSG00000153162, Tissue enhanced (placenta) |
MalaCardsi | BMP6 |
MIMi | 112266, gene |
neXtProti | NX_P22004 |
OpenTargetsi | ENSG00000153162 |
Orphaneti | 447792, Hemochromatosis type 5 |
PharmGKBi | PA25383 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000158768 |
HOGENOMi | CLU_020515_4_1_1 |
InParanoidi | P22004 |
OMAi | ERQQPWP |
OrthoDBi | 1063560at2759 |
PhylomeDBi | P22004 |
TreeFami | TF316134 |
Enzyme and pathway databases
PathwayCommonsi | P22004 |
SignaLinki | P22004 |
Miscellaneous databases
BioGRID-ORCSi | 654, 0 hits in 842 CRISPR screens |
ChiTaRSi | BMP6, human |
EvolutionaryTracei | P22004 |
GeneWikii | Bone_morphogenetic_protein_6 |
GenomeRNAii | 654 |
Pharosi | P22004, Tbio |
PROi | PR:P22004 |
RNActi | P22004, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153162, Expressed in secondary oocyte and 162 other tissues |
Genevisiblei | P22004, HS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMP6_HUMAN | |
Accessioni | P22004Primary (citable) accession number: P22004 Secondary accession number(s): Q5TCP3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 192 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations