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Protein

Potassium voltage-gated channel subfamily A member 3

Gene

KCNA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Caution

It is uncertain whether Met-1 or Met-53 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: GO_Central
  • outward rectifier potassium channel activity Source: GO_Central
  • voltage-gated ion channel activity Source: ProtInc
  • voltage-gated potassium channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296072 Voltage gated Potassium channels

SIGNOR Signaling Network Open Resource

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SIGNORi
P22001

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.2.4 the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 3
Alternative name(s):
HGK5
HLK3
HPCN3
Voltage-gated K(+) channel HuKIII
Voltage-gated potassium channel subunit Kv1.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNA3
Synonyms:HGK5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000177272.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6221 KCNA3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176263 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22001

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 234CytoplasmicSequence analysisAdd BLAST234
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei235 – 253Helical; Name=Segment S1Sequence analysisAdd BLAST19
Topological domaini254 – 294ExtracellularSequence analysisAdd BLAST41
Transmembranei295 – 316Helical; Name=Segment S2Sequence analysisAdd BLAST22
Topological domaini317 – 327CytoplasmicSequence analysisAdd BLAST11
Transmembranei328 – 348Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini349 – 362ExtracellularSequence analysisAdd BLAST14
Transmembranei363 – 381Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST19
Topological domaini382 – 397CytoplasmicSequence analysisAdd BLAST16
Transmembranei398 – 417Helical; Name=Segment S5Sequence analysisAdd BLAST20
Topological domaini418 – 458ExtracellularSequence analysisAdd BLAST41
Transmembranei459 – 481Helical; Name=Segment S6Sequence analysisAdd BLAST23
Topological domaini482 – 575CytoplasmicSequence analysisAdd BLAST94

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3738

Open Targets

More...
OpenTargetsi
ENSG00000177272

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30021

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4633

Drug and drug target database

More...
DrugBanki
DB06637 Dalfampridine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
540

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274135

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539771 – 575Potassium voltage-gated channel subfamily A member 3Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi317S-palmitoyl cysteineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei520Phosphoserine; by PKASequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation promotes the cell surface expression.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P22001

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P22001

PeptideAtlas

More...
PeptideAtlasi
P22001

PRoteomics IDEntifications database

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PRIDEi
P22001

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53950

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22001

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P22001

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177272 Expressed in 82 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

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CleanExi
HS_KCNA3

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22001 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA016625

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109941, 16 interactors

Database of interacting proteins

More...
DIPi
DIP-44822N

Protein interaction database and analysis system

More...
IntActi
P22001, 3 interactors

Molecular INTeraction database

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MINTi
P22001

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358784

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P22001

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P22001

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22001

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi444 – 449Selectivity filterBy similarity6
Motifi573 – 575PDZ-bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1545 Eukaryota
COG1226 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231015

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052230

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P22001

KEGG Orthology (KO)

More...
KOi
K04876

Identification of Orthologs from Complete Genome Data

More...
OMAi
CQFPETL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G10NU

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P22001

TreeFam database of animal gene trees

More...
TreeFami
TF313103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR004050 K_chnl_volt-dep_Kv1.3
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11537 PTHR11537, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00169 KCHANNEL
PR01510 KV13CHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P22001-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDERLSLLRS PPPPSARHRA HPPQRPASSG GAHTLVNHGY AEPAAGRELP
60 70 80 90 100
PDMTVVPGDH LLEPEVADGG GAPPQGGCGG GGCDRYEPLP PSLPAAGEQD
110 120 130 140 150
CCGERVVINI SGLRFETQLK TLCQFPETLL GDPKRRMRYF DPLRNEYFFD
160 170 180 190 200
RNRPSFDAIL YYYQSGGRIR RPVNVPIDIF SEEIRFYQLG EEAMEKFRED
210 220 230 240 250
EGFLREEERP LPRRDFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI
260 270 280 290 300
FCLETLPEFR DEKDYPASTS QDSFEAAGNS TSGSRAGASS FSDPFFVVET
310 320 330 340 350
LCIIWFSFEL LVRFFACPSK ATFSRNIMNL IDIVAIIPYF ITLGTELAER
360 370 380 390 400
QGNGQQAMSL AILRVIRLVR VFRIFKLSRH SKGLQILGQT LKASMRELGL
410 420 430 440 450
LIFFLFIGVI LFSSAVYFAE ADDPTSGFSS IPDAFWWAVV TMTTVGYGDM
460 470 480 490 500
HPVTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE TEGEEQSQYM
510 520 530 540 550
HVGSCQHLSS SAEELRKARS NSTLSKSEYM VIEEGGMNHS AFPQTPFKTG
560 570
NSTATCTTNN NPNSCVNIKK IFTDV
Length:575
Mass (Da):63,842
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E98905187A85F48
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36425 differs from that shown. Reason: Frameshift at position 42.Curated
The sequence AAA36425 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA59457 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAA59457 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB88073 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC31761 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAC31761 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72A → G in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti89L → V in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti113L → V in AAA59457 (PubMed:1373731).Curated1
Sequence conflicti143L → V in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti309E → K in AAC31761 (PubMed:7829094).Curated1
Sequence conflicti390T → S in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti471T → S in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti540S → T in AAA36425 (PubMed:1986382).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L23499 mRNA Translation: AAC31761.1 Sequence problems.
AL365361 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56457.1
BC035059 mRNA Translation: AAH35059.2
M55515 Genomic DNA Translation: AAA36425.1 Sequence problems.
M85217 mRNA Translation: AAA59457.1 Sequence problems.
M38217 Genomic DNA Translation: AAB88073.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS828.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A38101

NCBI Reference Sequences

More...
RefSeqi
NP_002223.3, NM_002232.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.169948
Hs.619197
Hs.628223

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369769; ENSP00000358784; ENSG00000177272

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3738

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3738

UCSC genome browser

More...
UCSCi
uc001dzv.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23499 mRNA Translation: AAC31761.1 Sequence problems.
AL365361 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56457.1
BC035059 mRNA Translation: AAH35059.2
M55515 Genomic DNA Translation: AAA36425.1 Sequence problems.
M85217 mRNA Translation: AAA59457.1 Sequence problems.
M38217 Genomic DNA Translation: AAB88073.1 Different initiation.
CCDSiCCDS828.2
PIRiA38101
RefSeqiNP_002223.3, NM_002232.4
UniGeneiHs.169948
Hs.619197
Hs.628223

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGCX-ray1.20A104-204[»]
ProteinModelPortaliP22001
SMRiP22001
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109941, 16 interactors
DIPiDIP-44822N
IntActiP22001, 3 interactors
MINTiP22001
STRINGi9606.ENSP00000358784

Chemistry databases

BindingDBiP22001
ChEMBLiCHEMBL4633
DrugBankiDB06637 Dalfampridine
GuidetoPHARMACOLOGYi540

Protein family/group databases

TCDBi1.A.1.2.4 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiP22001
PhosphoSitePlusiP22001

Polymorphism and mutation databases

DMDMi215274135

Proteomic databases

MaxQBiP22001
PaxDbiP22001
PeptideAtlasiP22001
PRIDEiP22001
ProteomicsDBi53950

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3738
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369769; ENSP00000358784; ENSG00000177272
GeneIDi3738
KEGGihsa:3738
UCSCiuc001dzv.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3738
DisGeNETi3738
EuPathDBiHostDB:ENSG00000177272.8

GeneCards: human genes, protein and diseases

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GeneCardsi
KCNA3
HGNCiHGNC:6221 KCNA3
HPAiHPA016625
MIMi176263 gene
neXtProtiNX_P22001
OpenTargetsiENSG00000177272
PharmGKBiPA30021

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00940000160210
HOGENOMiHOG000231015
HOVERGENiHBG052230
InParanoidiP22001
KOiK04876
OMAiCQFPETL
OrthoDBiEOG091G10NU
PhylomeDBiP22001
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels
SIGNORiP22001

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KCNA3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KCNA3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3738

Protein Ontology

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PROi
PR:P22001

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000177272 Expressed in 82 organ(s), highest expression level in leukocyte
CleanExiHS_KCNA3
GenevisibleiP22001 HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR004050 K_chnl_volt-dep_Kv1.3
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01510 KV13CHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNA3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22001
Secondary accession number(s): Q5VWN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 25, 2008
Last modified: December 5, 2018
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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