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UniProtKB - P22001 (KCNA3_HUMAN)

Entry version 210 (25 May 2022)
Sequence version 3 (25 Nov 2008)
Previous versions | rss
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Protein

Potassium voltage-gated channel subfamily A member 3

Gene

KCNA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Caution

It is uncertain whether Met-1 or Met-53 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P22001

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296072, Voltage gated Potassium channels

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P22001

SIGNOR Signaling Network Open Resource

More...SIGNORi		P22001

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.1.2.4, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 3
Alternative name(s):
HGK5
HLK3
HPCN3
Voltage-gated K(+) channel HuKIII
Voltage-gated potassium channel subunit Kv1.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNA3
Synonyms:HGK5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6221, KCNA3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176263, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P22001

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000177272

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 234CytoplasmicSequence analysisAdd BLAST234
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei235 – 253Helical; Name=Segment S1Sequence analysisAdd BLAST19
Topological domaini254 – 294ExtracellularSequence analysisAdd BLAST41
Transmembranei295 – 316Helical; Name=Segment S2Sequence analysisAdd BLAST22
Topological domaini317 – 327CytoplasmicSequence analysisAdd BLAST11
Transmembranei328 – 348Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini349 – 362ExtracellularSequence analysisAdd BLAST14
Transmembranei363 – 381Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST19
Topological domaini382 – 397CytoplasmicSequence analysisAdd BLAST16
Transmembranei398 – 417Helical; Name=Segment S5Sequence analysisAdd BLAST20
Topological domaini418 – 458ExtracellularSequence analysisAdd BLAST41
Transmembranei459 – 481Helical; Name=Segment S6Sequence analysisAdd BLAST23
Topological domaini482 – 575CytoplasmicSequence analysisAdd BLAST94

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3738

Open Targets

More...OpenTargetsi		ENSG00000177272

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30021

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P22001, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4633

Drug and drug target database

More...DrugBanki		DB00845, Clofazimine
DB06637, Dalfampridine
DB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine

DrugCentral

More...DrugCentrali		P22001

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		540

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNA3

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274135

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539771 – 575Potassium voltage-gated channel subfamily A member 3Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi317S-palmitoyl cysteineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei520Phosphoserine; by PKASequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation promotes the cell surface expression.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P22001

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P22001

MaxQB - The MaxQuant DataBase

More...MaxQBi		P22001

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P22001

PeptideAtlas

More...PeptideAtlasi		P22001

PRoteomics IDEntifications database

More...PRIDEi		P22001

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53950

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P22001, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P22001

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P22001

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000177272, Expressed in leukocyte and 108 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P22001, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000177272, Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109941, 28 interactors

Database of interacting proteins

More...DIPi		DIP-44822N

Protein interaction database and analysis system

More...IntActi		P22001, 5 interactors

Molecular INTeraction database

More...MINTi		P22001

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358784

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P22001

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P22001, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P22001

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P22001

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52DisorderedSequence analysisAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi444 – 449Selectivity filterBy similarity6
Motifi573 – 575PDZ-bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1545, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011722_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P22001

Identification of Orthologs from Complete Genome Data

More...OMAi		GMNSAFK

Database of Orthologous Groups

More...OrthoDBi		695337at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P22001

TreeFam database of animal gene trees

More...TreeFami		TF313103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.350, 1 hit
3.30.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000210, BTB/POZ_dom
IPR005821, Ion_trans_dom
IPR003968, K_chnl_volt-dep_Kv
IPR003972, K_chnl_volt-dep_Kv1
IPR004050, K_chnl_volt-dep_Kv1.3
IPR011333, SKP1/BTB/POZ_sf
IPR003131, T1-type_BTB
IPR028325, VG_K_chnl
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11537, PTHR11537, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02214, BTB_2, 1 hit
PF00520, Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01510, KV13CHANNEL
PR01491, KVCHANNEL
PR01496, SHAKERCHANEL

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00225, BTB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54695, SSF54695, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P22001-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDERLSLLRS PPPPSARHRA HPPQRPASSG GAHTLVNHGY AEPAAGRELP 
        60         70         80         90        100
PDMTVVPGDH LLEPEVADGG GAPPQGGCGG GGCDRYEPLP PSLPAAGEQD 
       110        120        130        140        150
CCGERVVINI SGLRFETQLK TLCQFPETLL GDPKRRMRYF DPLRNEYFFD 
       160        170        180        190        200
RNRPSFDAIL YYYQSGGRIR RPVNVPIDIF SEEIRFYQLG EEAMEKFRED 
       210        220        230        240        250
EGFLREEERP LPRRDFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI 
       260        270        280        290        300
FCLETLPEFR DEKDYPASTS QDSFEAAGNS TSGSRAGASS FSDPFFVVET 
       310        320        330        340        350
LCIIWFSFEL LVRFFACPSK ATFSRNIMNL IDIVAIIPYF ITLGTELAER 
       360        370        380        390        400
QGNGQQAMSL AILRVIRLVR VFRIFKLSRH SKGLQILGQT LKASMRELGL 
       410        420        430        440        450
LIFFLFIGVI LFSSAVYFAE ADDPTSGFSS IPDAFWWAVV TMTTVGYGDM 
       460        470        480        490        500
HPVTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE TEGEEQSQYM 
       510        520        530        540        550
HVGSCQHLSS SAEELRKARS NSTLSKSEYM VIEEGGMNHS AFPQTPFKTG 
       560        570 
NSTATCTTNN NPNSCVNIKK IFTDV
Length:575
Mass (Da):63,842
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E98905187A85F48
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36425 differs from that shown. Reason: Frameshift.Curated
The sequence AAA36425 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA59457 differs from that shown. Reason: Frameshift.Curated
The sequence AAA59457 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAB88073 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC31761 differs from that shown. Reason: Frameshift.Curated
The sequence AAC31761 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72A → G in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti89L → V in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti113L → V in AAA59457 (PubMed:1373731).Curated1
Sequence conflicti143L → V in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti309E → K in AAC31761 (PubMed:7829094).Curated1
Sequence conflicti390T → S in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti471T → S in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti540S → T in AAA36425 (PubMed:1986382).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L23499 mRNA Translation: AAC31761.1 Sequence problems.
AL365361 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56457.1
BC035059 mRNA Translation: AAH35059.2
M55515 Genomic DNA Translation: AAA36425.1 Sequence problems.
M85217 mRNA Translation: AAA59457.1 Sequence problems.
M38217 Genomic DNA Translation: AAB88073.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS828.2

Protein sequence database of the Protein Information Resource

More...PIRi		A38101

NCBI Reference Sequences

More...RefSeqi		NP_002223.3, NM_002232.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369769.4; ENSP00000358784.2; ENSG00000177272.9

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3738

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3738

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000369769.4; ENSP00000358784.2; NM_002232.5; NP_002223.3

UCSC genome browser

More...UCSCi		uc001dzv.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23499 mRNA Translation: AAC31761.1 Sequence problems.
AL365361 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56457.1
BC035059 mRNA Translation: AAH35059.2
M55515 Genomic DNA Translation: AAA36425.1 Sequence problems.
M85217 mRNA Translation: AAA59457.1 Sequence problems.
M38217 Genomic DNA Translation: AAB88073.1 Different initiation.
CCDSiCCDS828.2
PIRiA38101
RefSeqiNP_002223.3, NM_002232.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGCX-ray1.20A104-204[»]
7EJ1electron microscopy3.20B/D/F/H1-575[»]
7EJ2electron microscopy3.30B/D/F/H1-575[»]
AlphaFoldDBiP22001
SMRiP22001
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109941, 28 interactors
DIPiDIP-44822N
IntActiP22001, 5 interactors
MINTiP22001
STRINGi9606.ENSP00000358784

Chemistry databases

BindingDBiP22001
ChEMBLiCHEMBL4633
DrugBankiDB00845, Clofazimine
DB06637, Dalfampridine
DB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine
DrugCentraliP22001
GuidetoPHARMACOLOGYi540

Protein family/group databases

TCDBi1.A.1.2.4, the voltage-gated ion channel (vic) superfamily

PTM databases

GlyGeniP22001, 1 site
iPTMnetiP22001
PhosphoSitePlusiP22001

Genetic variation databases

BioMutaiKCNA3
DMDMi215274135

Proteomic databases

jPOSTiP22001
MassIVEiP22001
MaxQBiP22001
PaxDbiP22001
PeptideAtlasiP22001
PRIDEiP22001
ProteomicsDBi53950

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P22001, 70 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33788, 377 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		3738

Genome annotation databases

EnsembliENST00000369769.4; ENSP00000358784.2; ENSG00000177272.9
GeneIDi3738
KEGGihsa:3738
MANE-SelectiENST00000369769.4; ENSP00000358784.2; NM_002232.5; NP_002223.3
UCSCiuc001dzv.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3738
DisGeNETi3738

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNA3
HGNCiHGNC:6221, KCNA3
HPAiENSG00000177272, Tissue enriched (lymphoid)
MIMi176263, gene
neXtProtiNX_P22001
OpenTargetsiENSG00000177272
PharmGKBiPA30021
VEuPathDBiHostDB:ENSG00000177272

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1545, Eukaryota
GeneTreeiENSGT00940000160210
HOGENOMiCLU_011722_4_0_1
InParanoidiP22001
OMAiGMNSAFK
OrthoDBi695337at2759
PhylomeDBiP22001
TreeFamiTF313103

Enzyme and pathway databases

PathwayCommonsiP22001
ReactomeiR-HSA-1296072, Voltage gated Potassium channels
SignaLinkiP22001
SIGNORiP22001

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3738, 13 hits in 1061 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNA3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3738
PharosiP22001, Tclin

Protein Ontology

More...PROi		PR:P22001
RNActiP22001, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000177272, Expressed in leukocyte and 108 other tissues
GenevisibleiP22001, HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
3.30.710.10, 1 hit
InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR005821, Ion_trans_dom
IPR003968, K_chnl_volt-dep_Kv
IPR003972, K_chnl_volt-dep_Kv1
IPR004050, K_chnl_volt-dep_Kv1.3
IPR011333, SKP1/BTB/POZ_sf
IPR003131, T1-type_BTB
IPR028325, VG_K_chnl
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR11537, PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214, BTB_2, 1 hit
PF00520, Ion_trans, 1 hit
PRINTSiPR01510, KV13CHANNEL
PR01491, KVCHANNEL
PR01496, SHAKERCHANEL
SMARTiView protein in SMART
SM00225, BTB, 1 hit
SUPFAMiSSF54695, SSF54695, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNA3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22001
Secondary accession number(s): Q5VWN2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 25, 2008
Last modified: May 25, 2022
This is version 210 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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