UniProtKB - P22001 (KCNA3_HUMAN)

BLAST

>sp|P22001|KCNA3_HUMAN Potassium voltage-gated channel subfamily A member 3 OS=Homo sapiens OX=9606 GN=KCNA3 PE=1 SV=3
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDH
LLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLK
TLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIF
SEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVS
VLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVET
LCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSL
AILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE
ADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIV
SNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHS
AFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

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History
Entry version 190 (07 Nov 2018)
Sequence version 3 (25 Nov 2008)
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Protein

Potassium voltage-gated channel subfamily A member 3

Gene

KCNA3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Caution

It is uncertain whether Met-1 or Met-53 is the initiator.Curated

GO - Molecular functionⁱ

delayed rectifier potassium channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
outward rectifier potassium channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
voltage-gated ion channel activity
Source: ProtInc
Traceable author statementⁱ
- 1373731
voltage-gated potassium channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

potassium ion export
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
potassium ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
potassium ion transport
Source: ProtInc
Traceable author statementⁱ
- 1373731
protein homooligomerization Source: InterPro
regulation of ion transmembrane transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Potassium channel, Voltage-gated channel
Biological process	Ion transport, Potassium transport, Transport
Ligand	Potassium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1296072 Voltage gated Potassium channels
SIGNORⁱ	P22001

Protein family/group databases

TCDBⁱ	1.A.1.2.4 the voltage-gated ion channel (vic) superfamily

TCDBⁱ

1.A.1.2.4 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium voltage-gated channel subfamily A member 3 Alternative name(s): HGK5 HLK3 HPCN3 Voltage-gated K(+) channel HuKIII Voltage-gated potassium channel subunit Kv1.3
Gene namesⁱ	Name:KCNA3 Synonyms:HGK5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177272.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6221 KCNA3
MIMⁱ	176263 gene
neXtProtⁱ	NX_P22001

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 234	CytoplasmicSequence analysisAdd BLAST	234
Transmembraneⁱ	235 – 253	Helical; Name=Segment S1Sequence analysisAdd BLAST	19
Topological domainⁱ	254 – 294	ExtracellularSequence analysisAdd BLAST	41
Transmembraneⁱ	295 – 316	Helical; Name=Segment S2Sequence analysisAdd BLAST	22
Topological domainⁱ	317 – 327	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	328 – 348	Helical; Name=Segment S3Sequence analysisAdd BLAST	21
Topological domainⁱ	349 – 362	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	363 – 381	Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST	19
Topological domainⁱ	382 – 397	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	398 – 417	Helical; Name=Segment S5Sequence analysisAdd BLAST	20
Topological domainⁱ	418 – 458	ExtracellularSequence analysisAdd BLAST	41
Transmembraneⁱ	459 – 481	Helical; Name=Segment S6Sequence analysisAdd BLAST	23
Topological domainⁱ	482 – 575	CytoplasmicSequence analysisAdd BLAST	94

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3738
Open Targets More...OpenTargetsⁱ	ENSG00000177272
PharmGKBⁱ	PA30021

Chemistry databases

ChEMBLⁱ	CHEMBL4633
Drug and drug target database More...DrugBankⁱ	DB06637 Dalfampridine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	540

Polymorphism and mutation databases

DMDMⁱ	215274135

DMDMⁱ

215274135

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053977	1 – 575	Potassium voltage-gated channel subfamily A member 3Add BLAST		575

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	279	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	317	S-palmitoyl cysteineSequence analysis	1
Modified residueⁱ	520	Phosphoserine; by PKASequence analysis	1

Post-translational modificationⁱ

N-glycosylation promotes the cell surface expression.By similarity

Keywords - PTMⁱ

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P22001
PaxDbⁱ	P22001
PeptideAtlas More...PeptideAtlasⁱ	P22001
PRIDEⁱ	P22001
ProteomicsDBⁱ	53950

PTM databases

iPTMnetⁱ	P22001
PhosphoSitePlusⁱ	P22001

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177272 Expressed in 82 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_KCNA3
Genevisibleⁱ	P22001 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA016625

HPAⁱ

HPA016625

Interactionⁱ

Subunit structureⁱ

Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BAX	Q07812	2	EBI-8627664,EBI-516580
DOLK	Q9UPQ8	5	EBI-8627664,EBI-8645574

Protein-protein interaction databases

BioGridⁱ	109941, 16 interactors
Database of interacting proteins More...DIPⁱ	DIP-44822N
IntActⁱ	P22001, 3 interactors
Molecular INTeraction database More...MINTⁱ	P22001
STRINGⁱ	9606.ENSP00000358784

Chemistry databases

BindingDBⁱ

P22001

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	105 – 110	Combined sources	6
Beta strandⁱ	113 – 118	Combined sources	6
Helixⁱ	119 – 122	Combined sources	4
Turnⁱ	129 – 131	Combined sources	3
Helixⁱ	133 – 136	Combined sources	4
Helixⁱ	137 – 139	Combined sources	3
Turnⁱ	142 – 145	Combined sources	4
Beta strandⁱ	146 – 149	Combined sources	4
Helixⁱ	153 – 164	Combined sources	12
Helixⁱ	177 – 186	Combined sources	10
Helixⁱ	191 – 201	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P22001
SMRⁱ	P22001
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	444 – 449	Selectivity filterBy similarity		6
Motifⁱ	573 – 575	PDZ-bindingBy similarity		3

Domainⁱ

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesⁱ

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1545 Eukaryota COG1226 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118846
HOGENOMⁱ	HOG000231015
HOVERGENⁱ	HBG052230
InParanoidⁱ	P22001
KEGG Orthology (KO) More...KOⁱ	K04876
OMAⁱ	CQFPETL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10NU
PhylomeDBⁱ	P22001
TreeFamⁱ	TF313103

Family and domain databases

Gene3Dⁱ	1.20.120.350, 1 hit
InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR005821 Ion_trans_dom IPR003968 K_chnl_volt-dep_Kv IPR003972 K_chnl_volt-dep_Kv1 IPR004050 K_chnl_volt-dep_Kv1.3 IPR011333 SKP1/BTB/POZ_sf IPR003131 T1-type_BTB IPR028325 VG_K_chnl IPR027359 Volt_channel_dom_sf
PANTHERⁱ	PTHR11537 PTHR11537, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02214 BTB_2, 1 hit PF00520 Ion_trans, 1 hit
PRINTSⁱ	PR00169 KCHANNEL PR01510 KV13CHANNEL PR01491 KVCHANNEL PR01496 SHAKERCHANEL
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P22001-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDERLSLLRS PPPPSARHRA HPPQRPASSG GAHTLVNHGY AEPAAGRELP 
        60         70         80         90        100
PDMTVVPGDH LLEPEVADGG GAPPQGGCGG GGCDRYEPLP PSLPAAGEQD 
       110        120        130        140        150
CCGERVVINI SGLRFETQLK TLCQFPETLL GDPKRRMRYF DPLRNEYFFD 
       160        170        180        190        200
RNRPSFDAIL YYYQSGGRIR RPVNVPIDIF SEEIRFYQLG EEAMEKFRED 
       210        220        230        240        250
EGFLREEERP LPRRDFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI 
       260        270        280        290        300
FCLETLPEFR DEKDYPASTS QDSFEAAGNS TSGSRAGASS FSDPFFVVET 
       310        320        330        340        350
LCIIWFSFEL LVRFFACPSK ATFSRNIMNL IDIVAIIPYF ITLGTELAER 
       360        370        380        390        400
QGNGQQAMSL AILRVIRLVR VFRIFKLSRH SKGLQILGQT LKASMRELGL 
       410        420        430        440        450
LIFFLFIGVI LFSSAVYFAE ADDPTSGFSS IPDAFWWAVV TMTTVGYGDM 
       460        470        480        490        500
HPVTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE TEGEEQSQYM 
       510        520        530        540        550
HVGSCQHLSS SAEELRKARS NSTLSKSEYM VIEEGGMNHS AFPQTPFKTG 
       560        570 
NSTATCTTNN NPNSCVNIKK IFTDV

Length:575

Mass (Da):63,842

Last modified:November 25, 2008 - v3

Checksum:ⁱ0E98905187A85F48

Sequence cautionⁱ

The sequence AAA36425 differs from that shown. Reason: Frameshift at position 42.Curated

The sequence AAA36425 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAA59457 differs from that shown. Reason: Frameshift at several positions.Curated

The sequence AAA59457 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAB88073 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAC31761 differs from that shown. Reason: Frameshift at several positions.Curated

The sequence AAC31761 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	72	A → G in AAA36425 (PubMed:1986382).Curated	1
Sequence conflictⁱ	89	L → V in AAA36425 (PubMed:1986382).Curated	1
Sequence conflictⁱ	113	L → V in AAA59457 (PubMed:1373731).Curated	1
Sequence conflictⁱ	143	L → V in AAA36425 (PubMed:1986382).Curated	1
Sequence conflictⁱ	309	E → K in AAC31761 (PubMed:7829094).Curated	1
Sequence conflictⁱ	390	T → S in AAA36425 (PubMed:1986382).Curated	1
Sequence conflictⁱ	471	T → S in AAA36425 (PubMed:1986382).Curated	1
Sequence conflictⁱ	540	S → T in AAA36425 (PubMed:1986382).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L23499 mRNA Translation: AAC31761.1 Sequence problems. AL365361 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56457.1 BC035059 mRNA Translation: AAH35059.2 M55515 Genomic DNA Translation: AAA36425.1 Sequence problems. M85217 mRNA Translation: AAA59457.1 Sequence problems. M38217 Genomic DNA Translation: AAB88073.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS828.2
PIRⁱ	A38101
NCBI Reference Sequences More...RefSeqⁱ	NP_002223.3, NM_002232.4
UniGeneⁱ	Hs.169948 Hs.619197 Hs.628223

Genome annotation databases

Ensemblⁱ	ENST00000369769; ENSP00000358784; ENSG00000177272
GeneIDⁱ	3738
KEGGⁱ	hsa:3738
UCSC genome browser More...UCSCⁱ	uc001dzv.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22001	Uncharacterized protein (Fragment)		HUMAN		557	UniRef100_P22001
HCG1642166, isoform CRA_b		HUMAN		523

Protein	Similar proteins		Species	Score	Length	Source
P22001	Uncharacterized protein (Fragment)		HUMAN		557	UniRef90_P22001
Uncharacterized protein		MONDO		589
potassium voltage-gated channel subfamily A member 3		DELLE		580
Uncharacterized protein		FELCA		580
potassium voltage-gated channel subfamily A member 3		PHYCD		580
+67

Protein	Similar proteins		Species	Score	Length	Source
P22001	Potassium voltage-gated channel subfamily A member 10		HUMAN		511	UniRef50_P22001
Potassium voltage-gated channel subfamily A member 10		MOUSE		511
Uncharacterized protein		MONDO		589
potassium voltage-gated channel subfamily A member 3		DELLE		580
potassium voltage-gated channel subfamily A member 3		PHYCD		580
+271

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L23499 mRNA Translation: AAC31761.1 Sequence problems. AL365361 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56457.1 BC035059 mRNA Translation: AAH35059.2 M55515 Genomic DNA Translation: AAA36425.1 Sequence problems. M85217 mRNA Translation: AAA59457.1 Sequence problems. M38217 Genomic DNA Translation: AAB88073.1 Different initiation.
CCDSⁱ	CCDS828.2
PIRⁱ	A38101
RefSeqⁱ	NP_002223.3, NM_002232.4
UniGeneⁱ	Hs.169948 Hs.619197 Hs.628223

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4BGC	X-ray	1.20	A	104-204	[»]
ProteinModelPortalⁱ	P22001
SMRⁱ	P22001
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109941, 16 interactors
DIPⁱ	DIP-44822N
IntActⁱ	P22001, 3 interactors
MINTⁱ	P22001
STRINGⁱ	9606.ENSP00000358784

Chemistry databases

BindingDBⁱ	P22001
ChEMBLⁱ	CHEMBL4633
DrugBankⁱ	DB06637 Dalfampridine
GuidetoPHARMACOLOGYⁱ	540

Protein family/group databases

TCDBⁱ	1.A.1.2.4 the voltage-gated ion channel (vic) superfamily

TCDBⁱ

1.A.1.2.4 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetⁱ	P22001
PhosphoSitePlusⁱ	P22001

Polymorphism and mutation databases

DMDMⁱ	215274135

DMDMⁱ

215274135

Proteomic databases

MaxQBⁱ	P22001
PaxDbⁱ	P22001
PeptideAtlasⁱ	P22001
PRIDEⁱ	P22001
ProteomicsDBⁱ	53950

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3738
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369769; ENSP00000358784; ENSG00000177272
GeneIDⁱ	3738
KEGGⁱ	hsa:3738
UCSCⁱ	uc001dzv.3 human

Organism-specific databases

CTDⁱ	3738
DisGeNETⁱ	3738
EuPathDBⁱ	HostDB:ENSG00000177272.8
GeneCardsⁱ	KCNA3
HGNCⁱ	HGNC:6221 KCNA3
HPAⁱ	HPA016625
MIMⁱ	176263 gene
neXtProtⁱ	NX_P22001
OpenTargetsⁱ	ENSG00000177272
PharmGKBⁱ	PA30021
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1545 Eukaryota COG1226 LUCA
GeneTreeⁱ	ENSGT00760000118846
HOGENOMⁱ	HOG000231015
HOVERGENⁱ	HBG052230
InParanoidⁱ	P22001
KOⁱ	K04876
OMAⁱ	CQFPETL
OrthoDBⁱ	EOG091G10NU
PhylomeDBⁱ	P22001
TreeFamⁱ	TF313103

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1296072 Voltage gated Potassium channels
SIGNORⁱ	P22001

Miscellaneous databases

ChiTaRSⁱ	KCNA3 human
GeneWikiⁱ	KCNA3
GenomeRNAiⁱ	3738
Protein Ontology More...PROⁱ	PR:P22001
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177272 Expressed in 82 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_KCNA3
Genevisibleⁱ	P22001 HS

Family and domain databases

Gene3Dⁱ	1.20.120.350, 1 hit
InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR005821 Ion_trans_dom IPR003968 K_chnl_volt-dep_Kv IPR003972 K_chnl_volt-dep_Kv1 IPR004050 K_chnl_volt-dep_Kv1.3 IPR011333 SKP1/BTB/POZ_sf IPR003131 T1-type_BTB IPR028325 VG_K_chnl IPR027359 Volt_channel_dom_sf
PANTHERⁱ	PTHR11537 PTHR11537, 1 hit
Pfamⁱ	View protein in Pfam PF02214 BTB_2, 1 hit PF00520 Ion_trans, 1 hit
PRINTSⁱ	PR00169 KCHANNEL PR01510 KV13CHANNEL PR01491 KVCHANNEL PR01496 SHAKERCHANEL
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCNA3_HUMAN
Accessionⁱ	P22001Primary (citable) accession number: P22001 Secondary accession number(s): Q5VWN2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 190 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P22001 (KCNA3_HUMAN)

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Potassium voltage-gated channel subfamily A member 3

KCNA3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ