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Protein

Serum amyloid A-2 protein

Gene

SAA2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Biological processi

Keywordsi

Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-2 protein
Gene namesi
Name:SAA2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000003159720 – 122Serum amyloid A-2 proteinAdd BLAST103

Proteomic databases

PRIDEiP22000

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Upon cytokine stimulation.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000015130

Structurei

3D structure databases

SMRiP22000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXU4 Eukaryota
ENOG410YSBK LUCA
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP22000
KOiK17310

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22000-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLSGLLLC SLVLGVSGQG WFSFIGEAVR GAGDMWRAYS DMREANYINA
60 70 80 90 100
DKYFHARGNY DAAQRGPGGV WAAKVISDVR EDLQRLMGHG AEDSMADQAA
110 120
NEWGRSGKDP NHFRPKGLPD KY
Length:122
Mass (Da):13,451
Last modified:August 1, 1991 - v1
Checksum:iC135BEE727C57C15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40S → T (PubMed:1712590).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti96A → D. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16428 mRNA Translation: CAA34451.1
X16427 mRNA Translation: CAA34450.1
S71725 mRNA Translation: AAB20617.1
PIRiI46982
RefSeqiNP_001075861.1, NM_001082392.1
UniGeneiOcu.2070
Ocu.6288

Genome annotation databases

GeneIDi100009259
KEGGiocu:100009259

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16428 mRNA Translation: CAA34451.1
X16427 mRNA Translation: CAA34450.1
S71725 mRNA Translation: AAB20617.1
PIRiI46982
RefSeqiNP_001075861.1, NM_001082392.1
UniGeneiOcu.2070
Ocu.6288

3D structure databases

SMRiP22000
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000015130

Proteomic databases

PRIDEiP22000

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009259
KEGGiocu:100009259

Phylogenomic databases

eggNOGiENOG410IXU4 Eukaryota
ENOG410YSBK LUCA
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP22000
KOiK17310

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAA2_RABIT
AccessioniPrimary (citable) accession number: P22000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: March 15, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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