Gap junction beta-2 protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium ion binding Source: UniProtKB
• gap junction channel activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6."
    Dash-Wagh S., Jacob S., Lindberg S., Fridberger A., Langel U., Ulfendahl M.
    Mol Ther Nucleic Acids 1:e61-e61(2012) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: Ensembl

GO - Biological processⁱ

• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Reduced expression of Connexin26 and its DNA promoter hypermethylation in the inner ear of mimetic aging rats induced by d-galactose."
    Wu X., Wang Y., Sun Y., Chen S., Zhang S., Shen L., Huang X., Lin X., Kong W.
    Biochem. Biophys. Res. Commun. 452:340-346(2014) [PubMed] [Europe PMC] [Abstract]
• cell-cell signaling Source: UniProtKB
• cellular response to dexamethasone stimulus Source: RGDInferred from expression patternⁱ
  • "Induction and regulation of connexin26 by glucagon in primary cultures of adult rat hepatocytes."
    Kojima T., Mitaka T., Shibata Y., Mochizuki Y.
    J. Cell. Sci. 108:2771-2780(1995) [PubMed] [Europe PMC] [Abstract]
• cellular response to glucagon stimulus Source: RGDInferred from expression patternⁱ
  • "Induction and regulation of connexin26 by glucagon in primary cultures of adult rat hepatocytes."
    Kojima T., Mitaka T., Shibata Y., Mochizuki Y.
    J. Cell. Sci. 108:2771-2780(1995) [PubMed] [Europe PMC] [Abstract]
• cellular response to oxidative stress Source: RGDInferred from expression patternⁱ
  • "Effects of oxygen radical scavengers on connexins 32 and 26 expression in primary cultures of adult rat hepatocytes."
    Kojima T., Mitaka T., Mizuguchi T., Mochizuki Y.
    Carcinogenesis 17:537-544(1996) [PubMed] [Europe PMC] [Abstract]
• decidualization Source: RGDInferred from expression patternⁱ
  • "Expression of different connexin genes in rat uterus during decidualization and at term."
    Winterhager E., Stutenkemper R., Traub O., Beyer E., Willecke K.
    Eur. J. Cell Biol. 55:133-142(1991) [PubMed] [Europe PMC] [Abstract]
  • "Rat endometrial stromal cells express the gap junction genes connexins 26 and 43 and form functional gap junctions during in vitro decidualization."
    Orlando-Mathur C.E., Bechberger J.F., Goldberg G.S., Naus C.C., Kidder G.M., Kennedy T.G.
    Biol. Reprod. 54:905-913(1996) [PubMed] [Europe PMC] [Abstract]
• epididymis development Source: RGDInferred from expression patternⁱ
  • "Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication."
    Dufresne J., Finnson K.W., Gregory M., Cyr D.G.
    Am. J. Physiol., Cell Physiol. 284:C33-43(2003) [PubMed] [Europe PMC] [Abstract]
• female pregnancy Source: RGDInferred from expression patternⁱ
  • "Connexin-26 and connexin-43 are differentially expressed and regulated in the rat myometrium throughout late pregnancy and with the onset of labor."
    Orsino A., Taylor C.V., Lye S.J.
    Endocrinology 137:1545-1553(1996) [PubMed] [Europe PMC] [Abstract]
  • "Expression of connexin-43 and connexin-26 in the rat myometrium during pregnancy and labor is differentially regulated by mechanical and hormonal signals."
    Ou C.W., Orsino A., Lye S.J.
    Endocrinology 138:5398-5407(1997) [PubMed] [Europe PMC] [Abstract]
• gap junction assembly Source: Ensembl
• gap junction-mediated intercellular transport Source: UniProtKB
• inner ear development Source: RGDInferred from expression patternⁱ
  • "Developmental expression patterns of connexin26 and -30 in the rat cochlea."
    Lautermann J., Frank H.G., Jahnke K., Traub O., Winterhager E.
    Dev. Genet. 25:306-311(1999) [PubMed] [Europe PMC] [Abstract]
• response to antibiotic Source: RGDInferred from expression patternⁱ
  • "Gentamicin affects connexin 26 expression in the cochlear lateral wall."
    Hu P., Lai R., Xie D.
    B-ENT 8:77-84(2012) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Gap junction connexin genes cx26 and cx43 are differentially regulated by ovarian steroid hormones in rat endometrium."
    Grummer R., Traub O., Winterhager E.
    Endocrinology 140:2509-2516(1999) [PubMed] [Europe PMC] [Abstract]
• response to human chorionic gonadotropin Source: RGDInferred from expression patternⁱ
  • "Direct modulation of tumor suppressor connexin 26 gene by human chorionic gonadotropin in rat mammary glands."
    You S., Tu Z.J., Kiang D.T.
    Cancer Res. 58:1498-1502(1998) [PubMed] [Europe PMC] [Abstract]
• response to ischemia Source: RGDInferred from expression patternⁱ
  • "Urinary bladder mucosal responses to ischemia."
    Sunagawa M., Wolf-Johnston A., Nomiya M., Sawada N., Andersson K.E., Hisamitsu T., Birder L.A.
    World J Urol 33:275-280(2015) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: RGDInferred from expression patternⁱ
  • "Interruption of hepatic gap junctional communication in the rat during inflammation induced by bacterial lipopolysaccharide."
    De Maio A., Gingalewski C., Theodorakis N.G., Clemens M.G.
    Shock 14:53-59(2000) [PubMed] [Europe PMC] [Abstract]
• response to progesterone Source: RGDInferred from expression patternⁱ
  • "Gap junction connexin genes cx26 and cx43 are differentially regulated by ovarian steroid hormones in rat endometrium."
    Grummer R., Traub O., Winterhager E.
    Endocrinology 140:2509-2516(1999) [PubMed] [Europe PMC] [Abstract]
  • "Connexin-26 and connexin-43 are differentially expressed and regulated in the rat myometrium throughout late pregnancy and with the onset of labor."
    Orsino A., Taylor C.V., Lye S.J.
    Endocrinology 137:1545-1553(1996) [PubMed] [Europe PMC] [Abstract]
• response to retinoic acid Source: RGDInferred from expression patternⁱ
  • "Modulation of gap junction expression during transient hyperplasia of rat epidermis."
    Risek B., Pozzi A., Gilula N.B.
    J. Cell. Sci. 111:1395-1404(1998) [PubMed] [Europe PMC] [Abstract]
• sensory perception of sound Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDWGTLQSIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD 
        60         70         80         90        100
FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIMVSTPALL VAMHVAYRRH 
       110        120        130        140        150
EKKRKFMKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTTSI FFRVIFEAVF 
       160        170        180        190        200
MYVFYIMYNG FFMQRLVKCN AWPCPNTVDC FISRPTEKTV FTVFMISVSG 
       210        220 
ICILLNITEL CYLFIRYCSG KSKRPV                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families