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Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

Tgm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

A protein-L-glutamine + a protein-L-lysine = a protein with an N6-(gamma-glutamyl)-L-lysine cross-link + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei277PROSITE-ProRule annotation1
Active sitei335PROSITE-ProRule annotation1
Active sitei358PROSITE-ProRule annotation1
Metal bindingi398CalciumBy similarity1
Metal bindingi400CalciumBy similarity1
Metal bindingi447CalciumBy similarity1
Metal bindingi452CalciumBy similarity1

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • GTP binding Source: MGI
  • protein domain specific binding Source: MGI
  • protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB
  • transaminase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name:
TG(C)
Short name:
TGC
Short name:
TGase C
Transglutaminase-2
Short name:
TGase-2
Gene namesi
Name:Tgm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98731 Tgm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2079853

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002137082 – 686Protein-glutamine gamma-glutamyltransferase 2Add BLAST685

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei468N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP21981
MaxQBiP21981
PaxDbiP21981
PeptideAtlasiP21981
PRIDEiP21981

PTM databases

iPTMnetiP21981
PhosphoSitePlusiP21981
SwissPalmiP21981

Expressioni

Gene expression databases

BgeeiENSMUSG00000037820 Expressed in 304 organ(s), highest expression level in cornea
CleanExiMM_TGM2
ExpressionAtlasiP21981 baseline and differential
GenevisibleiP21981 MM

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204168, 2 interactors
IntActiP21981, 4 interactors
MINTiP21981
STRINGi10090.ENSMUSP00000099411

Chemistry databases

BindingDBiP21981

Structurei

3D structure databases

ProteinModelPortaliP21981
SMRiP21981
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
GeneTreeiENSGT00760000119108
HOGENOMiHOG000231695
HOVERGENiHBG004342
InParanoidiP21981
KOiK05625
OMAiAHITNNT
OrthoDBiEOG091G030K
PhylomeDBiP21981
TreeFamiTF324278

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR038765 Papain_like_cys_pep_sf
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF54001 SSF54001, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P21981-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEELLLERC DLEIQANGRD HHTADLCQEK LVLRRGQRFR LTLYFEGRGY
60 70 80 90 100
EASVDSLTFG AVTGPDPSEE AGTKARFSLS DNVEEGSWSA SVLDQQDNVL
110 120 130 140 150
SLQLCTPANA PIGLYRLSLE ASTGYQGSSF VLGHFILLYN AWCPADDVYL
160 170 180 190 200
DSEEERREYV LTQQGFIYQG SVKFIKSVPW NFGQFEDGIL DTCLMLLDMN
210 220 230 240 250
PKFLKNRSRD CSRRSSPIYV GRVVSAMVNC NDDQGVLLGR WDNNYGDGIS
260 270 280 290 300
PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN
310 320 330 340 350
YNSAHDQNSN LLIEYFRNEF GELESNKSEM IWNFHCWVES WMTRPDLQPG
360 370 380 390 400
YEGWQAIDPT PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA PFVFAEVNAD
410 420 430 440 450
VVDWIRQEDG SVLKSINRSL VVGQKISTKS VGRDDREDIT HTYKYPEGSP
460 470 480 490 500
EEREVFTKAN HLNKLAEKEE TGVAMRIRVG DSMSMGNDFD VFAHIGNDTS
510 520 530 540 550
ETRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS IPLRILYEKY
560 570 580 590 600
SGCLTESNLI KVRGLLIEPA ANSYLLAERD LYLENPEIKI RVLGEPKQNR
610 620 630 640 650
KLVAEVSLKN PLSDPLYDCI FTVEGAGLTK EQKSVEVSDP VPAGDLVKAR
660 670 680
VDLFPTDIGL HKLVVNFQCD KLKSVKGYRN VIIGPA
Length:686
Mass (Da):77,061
Last modified:March 18, 2008 - v4
Checksum:i9B64B074D3F837DE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UXE8G3UXE8_MOUSE
Protein-glutamine gamma-glutamyltra...
Tgm2
146Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32 – 33VL → LV in AAA40420 (PubMed:1670766).Curated2
Sequence conflicti51E → Q in AAA40420 (PubMed:1670766).Curated1
Sequence conflicti51E → Q in AAD37501 (PubMed:10334875).Curated1
Sequence conflicti186E → Q in AAA40420 (PubMed:1670766).Curated1
Sequence conflicti226A → D in AAA40420 (PubMed:1670766).Curated1
Sequence conflicti325S → T in AAA40420 (PubMed:1670766).Curated1
Sequence conflicti357I → L in AAA40420 (PubMed:1670766).Curated1
Sequence conflicti357I → L in AAD37501 (PubMed:10334875).Curated1
Sequence conflicti396E → K in BAC40899 (PubMed:16141072).Curated1
Sequence conflicti408 – 409ED → DE in AAA40420 (PubMed:1670766).Curated2
Sequence conflicti415 – 416SI → WM in AAA40420 (PubMed:1670766).Curated2
Sequence conflicti421V → I in AAA40420 (PubMed:1670766).Curated1
Sequence conflicti481 – 485DSMSM → QYEH in AAA40420 (PubMed:1670766).Curated5
Sequence conflicti539N → K in BAE38690 (PubMed:16141072).Curated1
Sequence conflicti552G → D in AAA40420 (PubMed:1670766).Curated1
Sequence conflicti583L → V in AAA40420 (PubMed:1670766).Curated1
Sequence conflicti583L → V in AAD37501 (PubMed:10334875).Curated1
Sequence conflicti654F → S in AAA40420 (PubMed:1670766).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55154 mRNA Translation: AAA40420.1
AF114266 mRNA Translation: AAD37501.1
AF076928 mRNA Translation: AAC62014.1
AK052912 mRNA Translation: BAC35200.1
AK080224 mRNA Translation: BAC37852.1
AK080593 mRNA Translation: BAC37952.1
AK089481 mRNA Translation: BAC40899.1
AK143712 mRNA Translation: BAE25511.1
AK151776 mRNA Translation: BAE30682.1
AK152152 mRNA Translation: BAE30987.1
AK152627 mRNA Translation: BAE31370.1
AK159255 mRNA Translation: BAE34936.1
AK166302 mRNA Translation: BAE38690.1
AK168990 mRNA Translation: BAE40790.1
AK169356 mRNA Translation: BAE41105.1
AL669824 Genomic DNA Translation: CAM23188.1
BC016492 mRNA Translation: AAH16492.1
U24148 Genomic DNA No translation available.
CCDSiCCDS16985.1
PIRiB39045
RefSeqiNP_033399.1, NM_009373.3
UniGeneiMm.330731

Genome annotation databases

EnsembliENSMUST00000103122; ENSMUSP00000099411; ENSMUSG00000037820
GeneIDi21817
KEGGimmu:21817
UCSCiuc008npr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55154 mRNA Translation: AAA40420.1
AF114266 mRNA Translation: AAD37501.1
AF076928 mRNA Translation: AAC62014.1
AK052912 mRNA Translation: BAC35200.1
AK080224 mRNA Translation: BAC37852.1
AK080593 mRNA Translation: BAC37952.1
AK089481 mRNA Translation: BAC40899.1
AK143712 mRNA Translation: BAE25511.1
AK151776 mRNA Translation: BAE30682.1
AK152152 mRNA Translation: BAE30987.1
AK152627 mRNA Translation: BAE31370.1
AK159255 mRNA Translation: BAE34936.1
AK166302 mRNA Translation: BAE38690.1
AK168990 mRNA Translation: BAE40790.1
AK169356 mRNA Translation: BAE41105.1
AL669824 Genomic DNA Translation: CAM23188.1
BC016492 mRNA Translation: AAH16492.1
U24148 Genomic DNA No translation available.
CCDSiCCDS16985.1
PIRiB39045
RefSeqiNP_033399.1, NM_009373.3
UniGeneiMm.330731

3D structure databases

ProteinModelPortaliP21981
SMRiP21981
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204168, 2 interactors
IntActiP21981, 4 interactors
MINTiP21981
STRINGi10090.ENSMUSP00000099411

Chemistry databases

BindingDBiP21981
ChEMBLiCHEMBL2079853

PTM databases

iPTMnetiP21981
PhosphoSitePlusiP21981
SwissPalmiP21981

Proteomic databases

EPDiP21981
MaxQBiP21981
PaxDbiP21981
PeptideAtlasiP21981
PRIDEiP21981

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103122; ENSMUSP00000099411; ENSMUSG00000037820
GeneIDi21817
KEGGimmu:21817
UCSCiuc008npr.1 mouse

Organism-specific databases

CTDi7052
MGIiMGI:98731 Tgm2

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
GeneTreeiENSGT00760000119108
HOGENOMiHOG000231695
HOVERGENiHBG004342
InParanoidiP21981
KOiK05625
OMAiAHITNNT
OrthoDBiEOG091G030K
PhylomeDBiP21981
TreeFamiTF324278

Miscellaneous databases

PROiPR:P21981
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037820 Expressed in 304 organ(s), highest expression level in cornea
CleanExiMM_TGM2
ExpressionAtlasiP21981 baseline and differential
GenevisibleiP21981 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR038765 Papain_like_cys_pep_sf
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF54001 SSF54001, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTGM2_MOUSE
AccessioniPrimary (citable) accession number: P21981
Secondary accession number(s): O88901
, Q3TLV2, Q8C217, Q91VG9, Q9R1F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 18, 2008
Last modified: September 12, 2018
This is version 168 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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