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Entry version 231 (29 Sep 2021)
Sequence version 2 (01 May 1992)
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Protein

Catechol O-methyltransferase

Gene

COMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcats are 6.8 min(-1), 3.4 min(-1), 3.3 min(-1) and 6.7 min(-1) with 2-hydroxy-17beta-estradiol, 4-hydroxy-17beta-estradiol, 2-hydroxyestrone and 4-hydroxyestrone as subrates, respectively.1 Publication
  1. KM=108 µM for 2-hydroxy-17beta-estradiol (at 37 degrees Celsius)1 Publication
  2. KM=24 µM for 4-hydroxy-17beta-estradiol (at 37 degrees Celsius)1 Publication
  3. KM=74 µM for 2-hydroxyestrone (at 37 degrees Celsius)1 Publication
  4. KM=53 µM for 4-hydroxyestrone (at 37 degrees Celsius)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei92S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1 Publication1
Binding sitei114S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei122S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei140S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei141S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei169S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi191Magnesium1 Publication1
Binding sitei191S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei194Substrate1
Metal bindingi219Magnesium1 Publication1
Metal bindingi220Magnesium1 Publication1
Binding sitei220Substrate1
Binding sitei249Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCatecholamine metabolism, Lipid metabolism, Neurotransmitter degradation
LigandMagnesium, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS01791-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.1.1.6, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P21964

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-156581, Methylation
R-HSA-379397, Enzymatic degradation of dopamine by COMT
R-HSA-379398, Enzymatic degradation of Dopamine by monoamine oxidase
R-HSA-9679191, Potential therapeutics for SARS

SIGNOR Signaling Network Open Resource

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SIGNORi
P21964

Chemistry databases

SwissLipids knowledge resource for lipid biology

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SwissLipidsi
SLP:000001714 [P21964-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Catechol O-methyltransferaseCurated (EC:2.1.1.63 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COMTImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:2228, COMT

Online Mendelian Inheritance in Man (OMIM)

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MIMi
116790, gene+phenotype

neXtProt; the human protein knowledge platform

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neXtProti
NX_P21964

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000093010

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini27 – 271ExtracellularSequence analysisAdd BLAST245

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Schizophrenia (SCZD)1 Publication
Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Related information in OMIM

Keywords - Diseasei

Schizophrenia

Organism-specific databases

DisGeNET

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DisGeNETi
1312

MalaCards human disease database

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MalaCardsi
COMT
MIMi103780, phenotype
116790, gene+phenotype
181500, phenotype

Open Targets

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OpenTargetsi
ENSG00000093010

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
567, 22q11.2 deletion syndrome
240863, Cisplatin toxicity
284121, Toxicity or absent response to clozapine

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA117

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P21964, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2023

Drug and drug target database

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DrugBanki
DB07462, (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE
DB02342, 2-Methoxyestradiol
DB02105, 3,5-Dinitrocatechol
DB08049, 7,8-dihydroxy-4-phenyl-2H-chromen-2-one
DB00118, Ademetionine
DB00714, Apomorphine
DB03336, BIA
DB00286, Conjugated estrogens
DB00255, Diethylstilbestrol
DB00841, Dobutamine
DB00988, Dopamine
DB15488, Echinacoside
DB00494, Entacapone
DB00668, Epinephrine
DB00783, Estradiol
DB00977, Ethinylestradiol
DB00968, Methyldopa
DB01141, Micafungin
DB03907, N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide
DB04820, Nialamide
DB06152, Nylidrin
DB11632, Opicapone
DB00252, Phenytoin
DB01420, Testosterone propionate
DB00323, Tolcapone

DrugCentral

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DrugCentrali
P21964

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2472

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
COMT

Domain mapping of disease mutations (DMDM)

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DMDMi
116907

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000209711 – 271Catechol O-methyltransferaseAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei267PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-482
CPTAC-483

Encyclopedia of Proteome Dynamics

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EPDi
P21964

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P21964

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P21964

MaxQB - The MaxQuant DataBase

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MaxQBi
P21964

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P21964

PeptideAtlas

More...
PeptideAtlasi
P21964

PRoteomics IDEntifications database

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PRIDEi
P21964

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
53945 [P21964-1]
53946 [P21964-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P21964-1 [P21964-1]
P21964-2 [P21964-2]

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00375513

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P21964, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P21964

MetOSite database of methionine sulfoxide sites

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MetOSitei
P21964

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P21964

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P21964

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, liver, placenta, lymphocytes and erythrocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000093010, Expressed in liver and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P21964, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P21964, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000093010, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P21964
With#Exp.IntAct
AQP7 [Q6P5T0]3EBI-372265,EBI-10489564
AVPR2 [P30518]3EBI-372265,EBI-11675746
BEST2 [Q8NFU1]3EBI-372265,EBI-19947314
CCL4L2 [Q8NHW4]3EBI-372265,EBI-10271156
CNR2 [P34972]3EBI-372265,EBI-2835940
CREB3L1 [Q96BA8]3EBI-372265,EBI-6942903
EMD [P50402]3EBI-372265,EBI-489887
FAM209A [Q5JX71]3EBI-372265,EBI-18304435
FFAR3 [O14843]3EBI-372265,EBI-17762181
GET1 [O00258]3EBI-372265,EBI-18908258
GJB1 [P08034]3EBI-372265,EBI-17565645
GJB3 [O75712]3EBI-372265,EBI-3908586
GJB4 [Q9NTQ9]3EBI-372265,EBI-12831526
GJB5 [O95377]3EBI-372265,EBI-3909454
GPR152 [Q8TDT2]3EBI-372265,EBI-13345167
GPR161 [Q8N6U8]3EBI-372265,EBI-6255622
GPR42 [O15529]3EBI-372265,EBI-18076404
HIBADH [P31937]3EBI-372265,EBI-11427100
HSD3B7 [Q9H2F3]3EBI-372265,EBI-3918847
KCNK5 [O95279]3EBI-372265,EBI-3934936
MFSD14B [Q5SR56]3EBI-372265,EBI-373355
MYADML2 [A6NDP7]3EBI-372265,EBI-17641390
NIPAL4 [Q0D2K0]3EBI-372265,EBI-9550165
OTOP3 [Q7RTS5]3EBI-372265,EBI-12853910
PGAP2 - isoform 5 [Q9UHJ9-5]3EBI-372265,EBI-12092917
PLPP6 [Q8IY26]3EBI-372265,EBI-11721828
REEP4 [Q9H6H4]3EBI-372265,EBI-7545592
RHBDD2 - isoform 3 [Q6NTF9-3]3EBI-372265,EBI-17589229
RHBDL1 [O75783]3EBI-372265,EBI-12104986
S1PR3 [Q99500]3EBI-372265,EBI-10634734
SELENOK [Q9Y6D0]3EBI-372265,EBI-9679163
SLC10A6 [Q3KNW5]3EBI-372265,EBI-18159983
SLC16A7 [O60669]3EBI-372265,EBI-3921243
SLC2A5 [P22732]3EBI-372265,EBI-2825135
SLC35A4 [Q96G79]3EBI-372265,EBI-12363689
SLC35F1 [Q5T1Q4]3EBI-372265,EBI-13365456
SLC39A1 [Q9NY26]3EBI-372265,EBI-726491
SLC39A2 [Q9NP94]3EBI-372265,EBI-12898013
SLC48A1 [Q6P1K1]3EBI-372265,EBI-1222191
SLC7A1 [P30825]3EBI-372265,EBI-4289564
SLC7A8 [Q9UHI5]3EBI-372265,EBI-13292283
SMIM1 [B2RUZ4]3EBI-372265,EBI-12188413
THSD7A [Q9UPZ6]3EBI-372265,EBI-310962
TLCD4 [Q96MV1]3EBI-372265,EBI-12947623
TMEM100 [Q9NV29]3EBI-372265,EBI-8644968
TMEM120B [A0PK00]3EBI-372265,EBI-10171534
TMEM14B [Q9NUH8]3EBI-372265,EBI-8638294
TMEM14C [Q9P0S9]3EBI-372265,EBI-2339195
TMEM187 [Q14656]3EBI-372265,EBI-13046724
TMEM205 [Q6UW68]3EBI-372265,EBI-6269551
TMEM222 [Q9H0R3]3EBI-372265,EBI-347385
TMEM50A [O95807]3EBI-372265,EBI-12903814
TRHR [P34981]3EBI-372265,EBI-18055230
TRIP13 [Q15645]3EBI-372265,EBI-358993
VAMP3 [Q15836]3EBI-372265,EBI-722343
VAMP5 [O95183]3EBI-372265,EBI-10191195
WFS1 [O76024]3EBI-372265,EBI-720609
Isoform Soluble [P21964-2]
With#Exp.IntAct
CDC27 [P30260]3EBI-10200977,EBI-994813
DCLRE1B [Q9H816]3EBI-10200977,EBI-3508943
DVL3 [Q92997]3EBI-10200977,EBI-739789
EPHB2 - isoform 3 [P29323-3]3EBI-10200977,EBI-25838727
FGFR3 [P22607]3EBI-10200977,EBI-348399
GSN [P06396]3EBI-10200977,EBI-351506
KRT31 [Q15323]3EBI-10200977,EBI-948001
KRT40 [Q6A162]3EBI-10200977,EBI-10171697
KRTAP5-9 [P26371]3EBI-10200977,EBI-3958099
LSM1 [O15116]3EBI-10200977,EBI-347619
M6PR [P20645]3EBI-10200977,EBI-2907262
PRMT5 [O14744]3EBI-10200977,EBI-351098
RARS2 [Q5T160]3EBI-10200977,EBI-1050546
RIMS3 [Q9UJD0]3EBI-10200977,EBI-3909436
RSPO1 [Q2MKA7]3EBI-10200977,EBI-10045219
RYBP [Q8N488]3EBI-10200977,EBI-752324
SCO1 [O75880]3EBI-10200977,EBI-6656171
SEPTIN6 [Q14141]3EBI-10200977,EBI-745901
STUB1 [Q9UNE7]3EBI-10200977,EBI-357085
TRIP13 [Q15645]3EBI-10200977,EBI-358993
UTP6 [Q9NYH9]3EBI-10200977,EBI-749211
WDR31 - isoform 2 [Q8NA23-2]3EBI-10200977,EBI-25835937

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107707, 143 interactors

Protein interaction database and analysis system

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IntActi
P21964, 114 interactors

Molecular INTeraction database

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MINTi
P21964

STRING: functional protein association networks

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STRINGi
9606.ENSP00000354511

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P21964

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P21964, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P21964

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P21964

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni167 – 170S-adenosyl-L-methionine binding4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1663, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155317

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_050461_5_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P21964

Identification of Orthologs from Complete Genome Data

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OMAi
YPSHLEY

Database of Orthologous Groups

More...
OrthoDBi
1274244at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21964

TreeFam database of animal gene trees

More...
TreeFami
TF329140

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017128, Catechol_O-MeTrfase_euk
IPR029063, SAM-dependent_MTases
IPR002935, SAM_O-MeTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01596, Methyltransf_3, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037177, Catechol_O-mtfrase_euk, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51682, SAM_OMT_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform Membrane-bound (identifier: P21964-1) [UniParc]FASTAAdd to basket
Also known as: MB-COMT

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL
60 70 80 90 100
MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV
110 120 130 140 150
DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ
160 170 180 190 200
RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD
210 220 230 240 250
TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY
260 270
REVVDGLEKA IYKGPGSEAG P
Length:271
Mass (Da):30,037
Last modified:May 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2547A1C399AC758
GO
Isoform Soluble (identifier: P21964-2) [UniParc]FASTAAdd to basket
Also known as: S-COMT

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:221
Mass (Da):24,449
Checksum:iF17399A01E493B63
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EMS6E7EMS6_HUMAN
Catechol O-methyltransferase
COMT
223Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUU8E7EUU8_HUMAN
Catechol O-methyltransferase
COMT
235Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V370A0A7I2V370_HUMAN
Catechol O-methyltransferase
COMT
302Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ45H7BZ45_HUMAN
Catechol O-methyltransferase
COMT
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V3G7A0A7I2V3G7_HUMAN
Catechol O-methyltransferase
COMT
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBW9F8WBW9_HUMAN
Catechol O-methyltransferase
COMT
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH00419 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence AAH05867 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence ACI46037 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti245Q → N AA sequence (PubMed:1993083).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Two alleles, COMT*1 or COMT*H with Val-158 and COMT*2 or COMT*L with Met-158 are responsible for a three to four-fold difference in enzymatic activity.4 Publications
Low enzyme activity alleles are associated with genetic susceptibility to alcoholism [MIMi:103780].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01392534C → S2 PublicationsCorresponds to variant dbSNP:rs6270Ensembl.1
Natural variantiVAR_01392672A → S Correlated with reduced enzyme activity; associated with increased risk for schizophrenia. 3 PublicationsCorresponds to variant dbSNP:rs6267EnsemblClinVar.1
Natural variantiVAR_020274102A → T. Corresponds to variant dbSNP:rs5031015EnsemblClinVar.1
Natural variantiVAR_020275146A → V. Corresponds to variant dbSNP:rs4986871Ensembl.1
Natural variantiVAR_005139158V → M in allele COMT*2; associated with low enzyme activity and thermolability; may increase the tendency to develop high blood pressure and abdominal obesity. 7 PublicationsCorresponds to variant dbSNP:rs4680EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0187781 – 50Missing in isoform Soluble. CuratedAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M65212 mRNA Translation: AAA68927.1
M65213 mRNA Translation: AAA68928.1
M58525 mRNA Translation: AAA68929.1
Z26491 Genomic DNA Translation: CAA81263.1
FJ224345 mRNA Translation: ACI46037.1 Different termination.
AK290440 mRNA Translation: BAF83129.1
CR456422 mRNA Translation: CAG30308.1
CR456997 mRNA Translation: CAG33278.1
AY341246 Genomic DNA Translation: AAP88929.1
AC000080 Genomic DNA No translation available.
AC000090 Genomic DNA No translation available.
AC005663 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03010.1
BC000419 mRNA Translation: AAH00419.2 Different termination.
BC005867 mRNA Translation: AAH05867.1 Different termination.
BC011935 mRNA Translation: AAH11935.1
BC100018 mRNA Translation: AAI00019.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13770.1 [P21964-1]
CCDS46663.1 [P21964-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I37256, A38459

NCBI Reference Sequences

More...
RefSeqi
NP_000745.1, NM_000754.3 [P21964-1]
NP_001128633.1, NM_001135161.1 [P21964-1]
NP_001128634.1, NM_001135162.1 [P21964-1]
NP_009294.1, NM_007310.2 [P21964-2]
XP_016884083.1, XM_017028594.1
XP_016884084.1, XM_017028595.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361682; ENSP00000354511; ENSG00000093010 [P21964-1]
ENST00000403710; ENSP00000385917; ENSG00000093010 [P21964-1]
ENST00000406520; ENSP00000385150; ENSG00000093010 [P21964-1]
ENST00000407537; ENSP00000384654; ENSG00000093010 [P21964-1]
ENST00000449653; ENSP00000416778; ENSG00000093010 [P21964-2]
ENST00000676678; ENSP00000503719; ENSG00000093010 [P21964-1]
ENST00000678255; ENSP00000504402; ENSG00000093010 [P21964-1]
ENST00000678868; ENSP00000503583; ENSG00000093010 [P21964-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1312

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1312

UCSC genome browser

More...
UCSCi
uc002zqu.4, human [P21964-1]

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Catechol-O-methyl transferase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65212 mRNA Translation: AAA68927.1
M65213 mRNA Translation: AAA68928.1
M58525 mRNA Translation: AAA68929.1
Z26491 Genomic DNA Translation: CAA81263.1
FJ224345 mRNA Translation: ACI46037.1 Different termination.
AK290440 mRNA Translation: BAF83129.1
CR456422 mRNA Translation: CAG30308.1
CR456997 mRNA Translation: CAG33278.1
AY341246 Genomic DNA Translation: AAP88929.1
AC000080 Genomic DNA No translation available.
AC000090 Genomic DNA No translation available.
AC005663 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03010.1
BC000419 mRNA Translation: AAH00419.2 Different termination.
BC005867 mRNA Translation: AAH05867.1 Different termination.
BC011935 mRNA Translation: AAH11935.1
BC100018 mRNA Translation: AAI00019.1
CCDSiCCDS13770.1 [P21964-1]
CCDS46663.1 [P21964-2]
PIRiI37256, A38459
RefSeqiNP_000745.1, NM_000754.3 [P21964-1]
NP_001128633.1, NM_001135161.1 [P21964-1]
NP_001128634.1, NM_001135162.1 [P21964-1]
NP_009294.1, NM_007310.2 [P21964-2]
XP_016884083.1, XM_017028594.1
XP_016884084.1, XM_017028595.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A7EX-ray2.80A51-264[»]
3BWMX-ray1.98A52-265[»]
3BWYX-ray1.30A52-265[»]
4PYIX-ray1.35A51-271[»]
4PYJX-ray1.90A51-271[»]
4PYKX-ray2.22A51-271[»]
4XUCX-ray1.80A48-265[»]
4XUDX-ray2.40A48-265[»]
4XUEX-ray2.30A/B52-265[»]
5LSAX-ray1.50A51-271[»]
6I3CX-ray1.34A52-271[»]
6I3DX-ray1.45A/B52-271[»]
SMRiP21964
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107707, 143 interactors
IntActiP21964, 114 interactors
MINTiP21964
STRINGi9606.ENSP00000354511

Chemistry databases

BindingDBiP21964
ChEMBLiCHEMBL2023
DrugBankiDB07462, (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE
DB02342, 2-Methoxyestradiol
DB02105, 3,5-Dinitrocatechol
DB08049, 7,8-dihydroxy-4-phenyl-2H-chromen-2-one
DB00118, Ademetionine
DB00714, Apomorphine
DB03336, BIA
DB00286, Conjugated estrogens
DB00255, Diethylstilbestrol
DB00841, Dobutamine
DB00988, Dopamine
DB15488, Echinacoside
DB00494, Entacapone
DB00668, Epinephrine
DB00783, Estradiol
DB00977, Ethinylestradiol
DB00968, Methyldopa
DB01141, Micafungin
DB03907, N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide
DB04820, Nialamide
DB06152, Nylidrin
DB11632, Opicapone
DB00252, Phenytoin
DB01420, Testosterone propionate
DB00323, Tolcapone
DrugCentraliP21964
GuidetoPHARMACOLOGYi2472
SwissLipidsiSLP:000001714 [P21964-2]

PTM databases

GlyGeniP21964, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP21964
MetOSiteiP21964
PhosphoSitePlusiP21964
SwissPalmiP21964

Genetic variation databases

BioMutaiCOMT
DMDMi116907

2D gel databases

REPRODUCTION-2DPAGEiIPI00375513

Proteomic databases

CPTACiCPTAC-482
CPTAC-483
EPDiP21964
jPOSTiP21964
MassIVEiP21964
MaxQBiP21964
PaxDbiP21964
PeptideAtlasiP21964
PRIDEiP21964
ProteomicsDBi53945 [P21964-1]
53946 [P21964-2]
TopDownProteomicsiP21964-1 [P21964-1]
P21964-2 [P21964-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
213, 638 antibodies

The DNASU plasmid repository

More...
DNASUi
1312

Genome annotation databases

EnsembliENST00000361682; ENSP00000354511; ENSG00000093010 [P21964-1]
ENST00000403710; ENSP00000385917; ENSG00000093010 [P21964-1]
ENST00000406520; ENSP00000385150; ENSG00000093010 [P21964-1]
ENST00000407537; ENSP00000384654; ENSG00000093010 [P21964-1]
ENST00000449653; ENSP00000416778; ENSG00000093010 [P21964-2]
ENST00000676678; ENSP00000503719; ENSG00000093010 [P21964-1]
ENST00000678255; ENSP00000504402; ENSG00000093010 [P21964-1]
ENST00000678868; ENSP00000503583; ENSG00000093010 [P21964-1]
GeneIDi1312
KEGGihsa:1312
UCSCiuc002zqu.4, human [P21964-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1312
DisGeNETi1312

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COMT
HGNCiHGNC:2228, COMT
HPAiENSG00000093010, Tissue enhanced (liver)
MalaCardsiCOMT
MIMi103780, phenotype
116790, gene+phenotype
181500, phenotype
neXtProtiNX_P21964
OpenTargetsiENSG00000093010
Orphaneti567, 22q11.2 deletion syndrome
240863, Cisplatin toxicity
284121, Toxicity or absent response to clozapine
PharmGKBiPA117
VEuPathDBiHostDB:ENSG00000093010

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1663, Eukaryota
GeneTreeiENSGT00940000155317
HOGENOMiCLU_050461_5_0_1
InParanoidiP21964
OMAiYPSHLEY
OrthoDBi1274244at2759
PhylomeDBiP21964
TreeFamiTF329140

Enzyme and pathway databases

BioCyciMetaCyc:HS01791-MONOMER
BRENDAi2.1.1.6, 2681
PathwayCommonsiP21964
ReactomeiR-HSA-156581, Methylation
R-HSA-379397, Enzymatic degradation of dopamine by COMT
R-HSA-379398, Enzymatic degradation of Dopamine by monoamine oxidase
R-HSA-9679191, Potential therapeutics for SARS
SIGNORiP21964

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1312, 20 hits in 1024 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COMT, human
EvolutionaryTraceiP21964

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Catechol-O-methyl_transferase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1312
PharosiP21964, Tclin

Protein Ontology

More...
PROi
PR:P21964
RNActiP21964, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000093010, Expressed in liver and 246 other tissues
ExpressionAtlasiP21964, baseline and differential
GenevisibleiP21964, HS

Family and domain databases

InterProiView protein in InterPro
IPR017128, Catechol_O-MeTrfase_euk
IPR029063, SAM-dependent_MTases
IPR002935, SAM_O-MeTrfase
PfamiView protein in Pfam
PF01596, Methyltransf_3, 1 hit
PIRSFiPIRSF037177, Catechol_O-mtfrase_euk, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51682, SAM_OMT_I, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOMT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21964
Secondary accession number(s): A8MPV9
, Q6IB07, Q6ICE6, Q9BWC7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 1, 1992
Last modified: September 29, 2021
This is version 231 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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