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Entry version 226 (07 Oct 2020)
Sequence version 2 (01 May 1992)
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Protein

Catechol O-methyltransferase

Gene

COMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcats are 6.8 min(-1), 3.4 min(-1), 3.3 min(-1) and 6.7 min(-1) with 2-hydroxy-17beta-estradiol, 4-hydroxy-17beta-estradiol, 2-hydroxyestrone and 4-hydroxyestrone as subrates, respectively.1 Publication
  1. KM=108 µM for 2-hydroxy-17beta-estradiol (at 37 degrees Celsius)1 Publication
  2. KM=24 µM for 4-hydroxy-17beta-estradiol (at 37 degrees Celsius)1 Publication
  3. KM=74 µM for 2-hydroxyestrone (at 37 degrees Celsius)1 Publication
  4. KM=53 µM for 4-hydroxyestrone (at 37 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei92S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1 Publication1
    Binding sitei114S-adenosyl-L-methioninePROSITE-ProRule annotation1
    Binding sitei122S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
    Binding sitei140S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
    Binding sitei141S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
    Binding sitei169S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi191Magnesium1 Publication1
    Binding sitei191S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
    Binding sitei194Substrate1
    Metal bindingi219Magnesium1 Publication1
    Metal bindingi220Magnesium1 Publication1
    Binding sitei220Substrate1
    Binding sitei249Substrate1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMethyltransferase, Transferase
    Biological processCatecholamine metabolism, Neurotransmitter degradation
    LigandMagnesium, Metal-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS01791-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.1.1.6, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    P21964

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-156581, Methylation
    R-HSA-379397, Enzymatic degradation of dopamine by COMT
    R-HSA-379398, Enzymatic degradation of Dopamine by monoamine oxidase
    R-HSA-9679191, Potential therapeutics for SARS

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    P21964

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001714 [P21964-2]

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Catechol O-methyltransferaseCurated (EC:2.1.1.63 Publications)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:COMTImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000093010.11

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:2228, COMT

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    116790, gene+phenotype

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P21964

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
    Topological domaini27 – 271ExtracellularSequence analysisAdd BLAST245

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Schizophrenia (SCZD)1 Publication
    Disease susceptibility may be associated with variations affecting the gene represented in this entry.
    Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
    Related information in OMIM

    Keywords - Diseasei

    Schizophrenia

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    1312

    MalaCards human disease database

    More...
    MalaCardsi
    COMT
    MIMi103780, phenotype
    116790, gene+phenotype
    181500, phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000093010

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    567, 22q11.2 deletion syndrome
    240863, Cisplatin toxicity
    284121, Toxicity or absent response to clozapine

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA117

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P21964, Tclin

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2023

    Drug and drug target database

    More...
    DrugBanki
    DB07462, (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE
    DB02342, 2-Methoxyestradiol
    DB02105, 3,5-Dinitrocatechol
    DB08049, 7,8-dihydroxy-4-phenyl-2H-chromen-2-one
    DB00118, Ademetionine
    DB03336, BIA
    DB00286, Conjugated estrogens
    DB00255, Diethylstilbestrol
    DB00841, Dobutamine
    DB00988, Dopamine
    DB15488, Echinacoside
    DB00494, Entacapone
    DB00668, Epinephrine
    DB00783, Estradiol
    DB00977, Ethinylestradiol
    DB00968, Methyldopa
    DB01141, Micafungin
    DB03907, N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide
    DB04820, Nialamide
    DB06152, Nylidrin
    DB11632, Opicapone
    DB00252, Phenytoin
    DB01420, Testosterone propionate
    DB00323, Tolcapone

    DrugCentral

    More...
    DrugCentrali
    P21964

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2472

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    COMT

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    116907

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000209711 – 271Catechol O-methyltransferaseAdd BLAST271

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei267PhosphoserineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    The N-terminus is blocked.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...
    CPTACi
    CPTAC-482
    CPTAC-483

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P21964

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P21964

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P21964

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P21964

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P21964

    PeptideAtlas

    More...
    PeptideAtlasi
    P21964

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P21964

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    53945 [P21964-1]
    53946 [P21964-2]

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    P21964-1 [P21964-1]
    P21964-2 [P21964-2]

    2D gel databases

    REPRODUCTION-2DPAGE

    More...
    REPRODUCTION-2DPAGEi
    IPI00375513

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P21964

    MetOSite database of methionine sulfoxide sites

    More...
    MetOSitei
    P21964

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P21964

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P21964

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Brain, liver, placenta, lymphocytes and erythrocytes.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000093010, Expressed in liver and 245 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P21964, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P21964, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000093010, Tissue enhanced (liver)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    P21964
    With#Exp.IntAct
    AQP7 [Q6P5T0]3EBI-372265,EBI-10489564
    AVPR2 [P30518]3EBI-372265,EBI-11675746
    BEST2 [Q8NFU1]3EBI-372265,EBI-19947314
    CCL4L2 [Q8NHW4]3EBI-372265,EBI-10271156
    CNR2 [P34972]3EBI-372265,EBI-2835940
    CREB3L1 [Q96BA8]3EBI-372265,EBI-6942903
    EMD [P50402]3EBI-372265,EBI-489887
    FAM209A [Q5JX71]3EBI-372265,EBI-18304435
    FFAR3 [O14843]3EBI-372265,EBI-17762181
    GET1 [O00258]3EBI-372265,EBI-18908258
    GJB1 [P08034]3EBI-372265,EBI-17565645
    GJB3 [O75712]3EBI-372265,EBI-3908586
    GJB4 [Q9NTQ9]3EBI-372265,EBI-12831526
    GJB5 [O95377]3EBI-372265,EBI-3909454
    GPR152 [Q8TDT2]3EBI-372265,EBI-13345167
    GPR161 [Q8N6U8]3EBI-372265,EBI-6255622
    GPR42 [O15529]3EBI-372265,EBI-18076404
    HIBADH [P31937]3EBI-372265,EBI-11427100
    HSD3B7 [Q9H2F3]3EBI-372265,EBI-3918847
    KCNK5 [O95279]3EBI-372265,EBI-3934936
    MFSD14B [Q5SR56]3EBI-372265,EBI-373355
    MYADML2 [A6NDP7]3EBI-372265,EBI-17641390
    NIPAL4 [Q0D2K0]3EBI-372265,EBI-9550165
    OTOP3 [Q7RTS5]3EBI-372265,EBI-12853910
    PGAP2 - isoform 5 [Q9UHJ9-5]3EBI-372265,EBI-12092917
    PLPP6 [Q8IY26]3EBI-372265,EBI-11721828
    REEP4 [Q9H6H4]3EBI-372265,EBI-7545592
    RHBDD2 - isoform 3 [Q6NTF9-3]3EBI-372265,EBI-17589229
    RHBDL1 [O75783]3EBI-372265,EBI-12104986
    S1PR3 [Q99500]3EBI-372265,EBI-10634734
    SELENOK [Q9Y6D0]3EBI-372265,EBI-9679163
    SLC10A6 [Q3KNW5]3EBI-372265,EBI-18159983
    SLC16A7 [O60669]3EBI-372265,EBI-3921243
    SLC2A5 [P22732]3EBI-372265,EBI-2825135
    SLC35A4 [Q96G79]3EBI-372265,EBI-12363689
    SLC35F1 [Q5T1Q4]3EBI-372265,EBI-13365456
    SLC39A1 [Q9NY26]3EBI-372265,EBI-726491
    SLC39A2 [Q9NP94]3EBI-372265,EBI-12898013
    SLC48A1 [Q6P1K1]3EBI-372265,EBI-1222191
    SLC7A1 [P30825]3EBI-372265,EBI-4289564
    SLC7A8 [Q9UHI5]3EBI-372265,EBI-13292283
    SMIM1 [B2RUZ4]3EBI-372265,EBI-12188413
    THSD7A [Q9UPZ6]3EBI-372265,EBI-310962
    TLCD4 [Q96MV1]3EBI-372265,EBI-12947623
    TMEM100 [Q9NV29]3EBI-372265,EBI-8644968
    TMEM120B [A0PK00]3EBI-372265,EBI-10171534
    TMEM14B [Q9NUH8]3EBI-372265,EBI-8638294
    TMEM14C [Q9P0S9]3EBI-372265,EBI-2339195
    TMEM187 [Q14656]3EBI-372265,EBI-13046724
    TMEM205 [Q6UW68]3EBI-372265,EBI-6269551
    TMEM222 [Q9H0R3]3EBI-372265,EBI-347385
    TMEM50A [O95807]3EBI-372265,EBI-12903814
    TRHR [P34981]3EBI-372265,EBI-18055230
    TRIP13 [Q15645]3EBI-372265,EBI-358993
    VAMP3 [Q15836]3EBI-372265,EBI-722343
    VAMP5 [O95183]3EBI-372265,EBI-10191195
    Isoform Soluble [P21964-2]
    With#Exp.IntAct
    CDC27 [P30260]3EBI-10200977,EBI-994813
    KRT31 [Q15323]3EBI-10200977,EBI-948001
    KRT40 [Q6A162]3EBI-10200977,EBI-10171697
    KRTAP5-9 [P26371]3EBI-10200977,EBI-3958099
    TRIP13 [Q15645]3EBI-10200977,EBI-358993

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    107707, 126 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P21964, 93 interactors

    Molecular INTeraction database

    More...
    MINTi
    P21964

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000354511

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P21964

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P21964, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1271
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P21964

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P21964

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni167 – 170S-adenosyl-L-methionine binding4

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1663, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155317

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_050461_5_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P21964

    KEGG Orthology (KO)

    More...
    KOi
    K00545

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    CTHYSSY

    Database of Orthologous Groups

    More...
    OrthoDBi
    1274244at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P21964

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF329140

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR017128, Catechol_O-MeTrfase_euk
    IPR029063, SAM-dependent_MTases
    IPR002935, SAM_O-MeTrfase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01596, Methyltransf_3, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF037177, Catechol_O-mtfrase_euk, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53335, SSF53335, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51682, SAM_OMT_I, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform Membrane-bound (identifier: P21964-1) [UniParc]FASTAAdd to basket
    Also known as: MB-COMT

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL
    60 70 80 90 100
    MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV
    110 120 130 140 150
    DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ
    160 170 180 190 200
    RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD
    210 220 230 240 250
    TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY
    260 270
    REVVDGLEKA IYKGPGSEAG P
    Length:271
    Mass (Da):30,037
    Last modified:May 1, 1992 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2547A1C399AC758
    GO
    Isoform Soluble (identifier: P21964-2) [UniParc]FASTAAdd to basket
    Also known as: S-COMT

    The sequence of this isoform differs from the canonical sequence as follows:
         1-50: Missing.

    Show »
    Length:221
    Mass (Da):24,449
    Checksum:iF17399A01E493B63
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E7EMS6E7EMS6_HUMAN
    Catechol O-methyltransferase
    COMT
    223Annotation score:

    Annotation score:4 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7EUU8E7EUU8_HUMAN
    Catechol O-methyltransferase
    COMT
    235Annotation score:

    Annotation score:4 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7BZ45H7BZ45_HUMAN
    Catechol O-methyltransferase
    COMT
    152Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8WBW9F8WBW9_HUMAN
    Catechol O-methyltransferase
    COMT
    199Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH00419 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
    The sequence AAH05867 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
    The sequence ACI46037 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti245Q → N AA sequence (PubMed:1993083).Curated1

    <p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

    Two alleles, COMT*1 or COMT*H with Val-158 and COMT*2 or COMT*L with Met-158 are responsible for a three to four-fold difference in enzymatic activity.4 Publications
    Low enzyme activity alleles are associated with genetic susceptibility to alcoholism [MIMi:103780].1 Publication

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01392534C → S2 PublicationsCorresponds to variant dbSNP:rs6270Ensembl.1
    Natural variantiVAR_01392672A → S Correlated with reduced enzyme activity; associated with increased risk for schizophrenia. 3 PublicationsCorresponds to variant dbSNP:rs6267EnsemblClinVar.1
    Natural variantiVAR_020274102A → T. Corresponds to variant dbSNP:rs5031015EnsemblClinVar.1
    Natural variantiVAR_020275146A → V. Corresponds to variant dbSNP:rs4986871Ensembl.1
    Natural variantiVAR_005139158V → M in allele COMT*2; associated with low enzyme activity and thermolability; may increase the tendency to develop high blood pressure and abdominal obesity. 7 PublicationsCorresponds to variant dbSNP:rs4680EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0187781 – 50Missing in isoform Soluble. CuratedAdd BLAST50

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M65212 mRNA Translation: AAA68927.1
    M65213 mRNA Translation: AAA68928.1
    M58525 mRNA Translation: AAA68929.1
    Z26491 Genomic DNA Translation: CAA81263.1
    FJ224345 mRNA Translation: ACI46037.1 Different termination.
    AK290440 mRNA Translation: BAF83129.1
    CR456422 mRNA Translation: CAG30308.1
    CR456997 mRNA Translation: CAG33278.1
    AY341246 Genomic DNA Translation: AAP88929.1
    AC000080 Genomic DNA No translation available.
    AC000090 Genomic DNA No translation available.
    AC005663 Genomic DNA No translation available.
    CH471176 Genomic DNA Translation: EAX03010.1
    BC000419 mRNA Translation: AAH00419.2 Different termination.
    BC005867 mRNA Translation: AAH05867.1 Different termination.
    BC011935 mRNA Translation: AAH11935.1
    BC100018 mRNA Translation: AAI00019.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS13770.1 [P21964-1]
    CCDS46663.1 [P21964-2]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    I37256, A38459

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000745.1, NM_000754.3 [P21964-1]
    NP_001128633.1, NM_001135161.1 [P21964-1]
    NP_001128634.1, NM_001135162.1 [P21964-1]
    NP_009294.1, NM_007310.2 [P21964-2]
    XP_016884083.1, XM_017028594.1
    XP_016884084.1, XM_017028595.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000361682; ENSP00000354511; ENSG00000093010 [P21964-1]
    ENST00000403710; ENSP00000385917; ENSG00000093010 [P21964-1]
    ENST00000406520; ENSP00000385150; ENSG00000093010 [P21964-1]
    ENST00000407537; ENSP00000384654; ENSG00000093010 [P21964-1]
    ENST00000449653; ENSP00000416778; ENSG00000093010 [P21964-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1312

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:1312

    UCSC genome browser

    More...
    UCSCi
    uc002zqu.4, human [P21964-1]

    Keywords - Coding sequence diversityi

    Alternative initiation, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs
    Wikipedia

    Catechol-O-methyl transferase entry

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M65212 mRNA Translation: AAA68927.1
    M65213 mRNA Translation: AAA68928.1
    M58525 mRNA Translation: AAA68929.1
    Z26491 Genomic DNA Translation: CAA81263.1
    FJ224345 mRNA Translation: ACI46037.1 Different termination.
    AK290440 mRNA Translation: BAF83129.1
    CR456422 mRNA Translation: CAG30308.1
    CR456997 mRNA Translation: CAG33278.1
    AY341246 Genomic DNA Translation: AAP88929.1
    AC000080 Genomic DNA No translation available.
    AC000090 Genomic DNA No translation available.
    AC005663 Genomic DNA No translation available.
    CH471176 Genomic DNA Translation: EAX03010.1
    BC000419 mRNA Translation: AAH00419.2 Different termination.
    BC005867 mRNA Translation: AAH05867.1 Different termination.
    BC011935 mRNA Translation: AAH11935.1
    BC100018 mRNA Translation: AAI00019.1
    CCDSiCCDS13770.1 [P21964-1]
    CCDS46663.1 [P21964-2]
    PIRiI37256, A38459
    RefSeqiNP_000745.1, NM_000754.3 [P21964-1]
    NP_001128633.1, NM_001135161.1 [P21964-1]
    NP_001128634.1, NM_001135162.1 [P21964-1]
    NP_009294.1, NM_007310.2 [P21964-2]
    XP_016884083.1, XM_017028594.1
    XP_016884084.1, XM_017028595.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3A7EX-ray2.80A51-264[»]
    3BWMX-ray1.98A52-265[»]
    3BWYX-ray1.30A52-265[»]
    4PYIX-ray1.35A51-271[»]
    4PYJX-ray1.90A51-271[»]
    4PYKX-ray2.22A51-271[»]
    4XUCX-ray1.80A48-265[»]
    4XUDX-ray2.40A48-265[»]
    4XUEX-ray2.30A/B52-265[»]
    5LSAX-ray1.50A51-271[»]
    6I3CX-ray1.34A52-271[»]
    6I3DX-ray1.45A/B52-271[»]
    SMRiP21964
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi107707, 126 interactors
    IntActiP21964, 93 interactors
    MINTiP21964
    STRINGi9606.ENSP00000354511

    Chemistry databases

    BindingDBiP21964
    ChEMBLiCHEMBL2023
    DrugBankiDB07462, (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE
    DB02342, 2-Methoxyestradiol
    DB02105, 3,5-Dinitrocatechol
    DB08049, 7,8-dihydroxy-4-phenyl-2H-chromen-2-one
    DB00118, Ademetionine
    DB03336, BIA
    DB00286, Conjugated estrogens
    DB00255, Diethylstilbestrol
    DB00841, Dobutamine
    DB00988, Dopamine
    DB15488, Echinacoside
    DB00494, Entacapone
    DB00668, Epinephrine
    DB00783, Estradiol
    DB00977, Ethinylestradiol
    DB00968, Methyldopa
    DB01141, Micafungin
    DB03907, N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide
    DB04820, Nialamide
    DB06152, Nylidrin
    DB11632, Opicapone
    DB00252, Phenytoin
    DB01420, Testosterone propionate
    DB00323, Tolcapone
    DrugCentraliP21964
    GuidetoPHARMACOLOGYi2472
    SwissLipidsiSLP:000001714 [P21964-2]

    PTM databases

    iPTMnetiP21964
    MetOSiteiP21964
    PhosphoSitePlusiP21964
    SwissPalmiP21964

    Polymorphism and mutation databases

    BioMutaiCOMT
    DMDMi116907

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00375513

    Proteomic databases

    CPTACiCPTAC-482
    CPTAC-483
    EPDiP21964
    jPOSTiP21964
    MassIVEiP21964
    MaxQBiP21964
    PaxDbiP21964
    PeptideAtlasiP21964
    PRIDEiP21964
    ProteomicsDBi53945 [P21964-1]
    53946 [P21964-2]
    TopDownProteomicsiP21964-1 [P21964-1]
    P21964-2 [P21964-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    213, 621 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    1312

    Genome annotation databases

    EnsembliENST00000361682; ENSP00000354511; ENSG00000093010 [P21964-1]
    ENST00000403710; ENSP00000385917; ENSG00000093010 [P21964-1]
    ENST00000406520; ENSP00000385150; ENSG00000093010 [P21964-1]
    ENST00000407537; ENSP00000384654; ENSG00000093010 [P21964-1]
    ENST00000449653; ENSP00000416778; ENSG00000093010 [P21964-2]
    GeneIDi1312
    KEGGihsa:1312
    UCSCiuc002zqu.4, human [P21964-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    1312
    DisGeNETi1312
    EuPathDBiHostDB:ENSG00000093010.11

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    COMT
    HGNCiHGNC:2228, COMT
    HPAiENSG00000093010, Tissue enhanced (liver)
    MalaCardsiCOMT
    MIMi103780, phenotype
    116790, gene+phenotype
    181500, phenotype
    neXtProtiNX_P21964
    OpenTargetsiENSG00000093010
    Orphaneti567, 22q11.2 deletion syndrome
    240863, Cisplatin toxicity
    284121, Toxicity or absent response to clozapine
    PharmGKBiPA117

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1663, Eukaryota
    GeneTreeiENSGT00940000155317
    HOGENOMiCLU_050461_5_0_1
    InParanoidiP21964
    KOiK00545
    OMAiCTHYSSY
    OrthoDBi1274244at2759
    PhylomeDBiP21964
    TreeFamiTF329140

    Enzyme and pathway databases

    BioCyciMetaCyc:HS01791-MONOMER
    BRENDAi2.1.1.6, 2681
    PathwayCommonsiP21964
    ReactomeiR-HSA-156581, Methylation
    R-HSA-379397, Enzymatic degradation of dopamine by COMT
    R-HSA-379398, Enzymatic degradation of Dopamine by monoamine oxidase
    R-HSA-9679191, Potential therapeutics for SARS
    SIGNORiP21964

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    1312, 16 hits in 872 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    COMT, human
    EvolutionaryTraceiP21964

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Catechol-O-methyl_transferase

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    1312
    PharosiP21964, Tclin

    Protein Ontology

    More...
    PROi
    PR:P21964
    RNActiP21964, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000093010, Expressed in liver and 245 other tissues
    ExpressionAtlasiP21964, baseline and differential
    GenevisibleiP21964, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR017128, Catechol_O-MeTrfase_euk
    IPR029063, SAM-dependent_MTases
    IPR002935, SAM_O-MeTrfase
    PfamiView protein in Pfam
    PF01596, Methyltransf_3, 1 hit
    PIRSFiPIRSF037177, Catechol_O-mtfrase_euk, 1 hit
    SUPFAMiSSF53335, SSF53335, 1 hit
    PROSITEiView protein in PROSITE
    PS51682, SAM_OMT_I, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOMT_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21964
    Secondary accession number(s): A8MPV9
    , Q6IB07, Q6ICE6, Q9BWC7
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: May 1, 1992
    Last modified: October 7, 2020
    This is version 226 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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