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Protein

Cartilage matrix protein

Gene

MATN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • extracellular matrix structural constituent Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000178 ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cartilage matrix protein
Alternative name(s):
Matrilin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MATN1
Synonyms:CMP, CRTM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162510.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6907 MATN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
115437 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21941

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4146

Open Targets

More...
OpenTargetsi
ENSG00000162510

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30650

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MATN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
115556

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Add BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000749523 – 496Cartilage matrix proteinAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 221Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi227 ↔ 238By similarity
Disulfide bondi234 ↔ 247By similarity
Disulfide bondi249 ↔ 262By similarity
Disulfide bondi265 ↔ 452Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21941

PeptideAtlas

More...
PeptideAtlasi
P21941

PRoteomics IDEntifications database

More...
PRIDEi
P21941

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53943

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21941

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21941

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162510 Expressed in 84 organ(s), highest expression level in tibia

CleanEx database of gene expression profiles

More...
CleanExi
HS_MATN1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21941 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028580

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer. Interacts with COMP.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110316, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362870

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P21941

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21941

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 222VWFA 1PROSITE-ProRule annotationAdd BLAST200
Domaini223 – 263EGF-likeAdd BLAST41
Domaini264 – 453VWFA 2PROSITE-ProRule annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili467 – 495Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR75 Eukaryota
ENOG410XSCQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159638

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000263415

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056906

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21941

Identification of Orthologs from Complete Genome Data

More...
OMAi
NTWVFAA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G04O4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21941

TreeFam database of animal gene trees

More...
TreeFami
TF330078

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.30, 1 hit
3.40.50.410, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR030751 Matrilin-1
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR44857 PTHR44857, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 2 hits
SSF58002 SSF58002, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186 EGF_2, 1 hit
PS50234 VWFA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P21941-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVLSGTSLM LCSLLLLLQA LCSPGLAPQS RGHLCRTRPT DLVFVVDSSR
60 70 80 90 100
SVRPVEFEKV KVFLSQVIES LDVGPNATRV GMVNYASTVK QEFSLRAHVS
110 120 130 140 150
KAALLQAVRR IQPLSTGTMT GLAIQFAITK AFGDAEGGRS RSPDISKVVI
160 170 180 190 200
VVTDGRPQDS VQDVSARARA SGVELFAIGV GSVDKATLRQ IASEPQDEHV
210 220 230 240 250
DYVESYSVIE KLSRKFQEAF CVVSDLCATG DHDCEQVCIS SPGSYTCACH
260 270 280 290 300
EGFTLNSDGK TCNVCSGGGG SSATDLVFLI DGSKSVRPEN FELVKKFISQ
310 320 330 340 350
IVDTLDVSDK LAQVGLVQYS SSVRQEFPLG RFHTKKDIKA AVRNMSYMEK
360 370 380 390 400
GTMTGAALKY LIDNSFTVSS GARPGAQKVG IVFTDGRSQD YINDAAKKAK
410 420 430 440 450
DLGFKMFAVG VGNAVEDELR EIASEPVAEH YFYTADFKTI NQIGKKLQKK
460 470 480 490
ICVEEDPCAC ESLVKFQAKV EGLLQALTRK LEAVSKRLAI LENTVV
Length:496
Mass (Da):53,701
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D880A8114C7940F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti291F → L in AAA63904 (PubMed:2246248).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M55682
, M55675, M55676, M55677, M55679, M55680, M55681 Genomic DNA Translation: AAB38702.1
M55683 mRNA Translation: AAA63904.1
AK312949 mRNA Translation: BAG35790.1
AL137857 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS336.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A37979

NCBI Reference Sequences

More...
RefSeqi
NP_002370.1, NM_002379.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.150366

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373765; ENSP00000362870; ENSG00000162510

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4146

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4146

UCSC genome browser

More...
UCSCi
uc001brz.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55682
, M55675, M55676, M55677, M55679, M55680, M55681 Genomic DNA Translation: AAB38702.1
M55683 mRNA Translation: AAA63904.1
AK312949 mRNA Translation: BAG35790.1
AL137857 Genomic DNA No translation available.
CCDSiCCDS336.1
PIRiA37979
RefSeqiNP_002370.1, NM_002379.3
UniGeneiHs.150366

3D structure databases

ProteinModelPortaliP21941
SMRiP21941
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110316, 4 interactors
STRINGi9606.ENSP00000362870

PTM databases

iPTMnetiP21941
PhosphoSitePlusiP21941

Polymorphism and mutation databases

BioMutaiMATN1
DMDMi115556

Proteomic databases

PaxDbiP21941
PeptideAtlasiP21941
PRIDEiP21941
ProteomicsDBi53943

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4146
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373765; ENSP00000362870; ENSG00000162510
GeneIDi4146
KEGGihsa:4146
UCSCiuc001brz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4146
DisGeNETi4146
EuPathDBiHostDB:ENSG00000162510.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MATN1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0000347
HIX0028643
HIX0029177
HGNCiHGNC:6907 MATN1
HPAiHPA028580
MIMi115437 gene
neXtProtiNX_P21941
OpenTargetsiENSG00000162510
PharmGKBiPA30650

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IR75 Eukaryota
ENOG410XSCQ LUCA
GeneTreeiENSGT00940000159638
HOGENOMiHOG000263415
HOVERGENiHBG056906
InParanoidiP21941
OMAiNTWVFAA
OrthoDBiEOG091G04O4
PhylomeDBiP21941
TreeFamiTF330078

Enzyme and pathway databases

ReactomeiR-HSA-3000178 ECM proteoglycans

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MATN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4146

Protein Ontology

More...
PROi
PR:P21941

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162510 Expressed in 84 organ(s), highest expression level in tibia
CleanExiHS_MATN1
GenevisibleiP21941 HS

Family and domain databases

Gene3Di1.20.5.30, 1 hit
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR030751 Matrilin-1
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR44857 PTHR44857, 1 hit
PfamiView protein in Pfam
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF58002 SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50234 VWFA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMATN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21941
Secondary accession number(s): B2R7E3, Q5TBB9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: December 5, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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