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Entry version 202 (07 Oct 2020)
Sequence version 4 (23 Jan 2007)
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Protein

CD9 antigen

Gene

CD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:8478605, PubMed:14575715, PubMed:18541721). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (PubMed:18541721). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (PubMed:8478605, PubMed:7511626).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Fertilization

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P21926

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-114608, Platelet degranulation
R-HSA-1300645, Acrosome Reaction and Sperm:Oocyte Membrane Binding
R-HSA-5336415, Uptake and function of diphtheria toxin

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.40.1.9, the tetraspanin (tetraspanin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD9 antigen1 Publication
Alternative name(s):
5H9 antigen
Cell growth-inhibiting gene 2 protein1 Publication
Leukocyte antigen MIC3
Motility-related protein1 Publication
Short name:
MRP-11 Publication
Tetraspanin-29
Short name:
Tspan-29
p241 Publication
CD_antigen: CD91 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD91 PublicationImported
Synonyms:MIC3, TSPAN29
ORF Names:GIG21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000010278.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1709, CD9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
143030, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21926

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 12CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 55ExtracellularSequence analysisAdd BLAST22
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 87CytoplasmicSequence analysisAdd BLAST11
Transmembranei88 – 111HelicalSequence analysisAdd BLAST24
Topological domaini112 – 195ExtracellularSequence analysisAdd BLAST84
Transmembranei196 – 221HelicalSequence analysisAdd BLAST26
Topological domaini222 – 228CytoplasmicSequence analysis7

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi9C → A: Loss of palmitoylation; when associated with A-78; A-79; A-87; A-218 and A-219. 1 Publication1
Mutagenesisi78C → A: Loss of palmitoylation; when associated with A-9; A-79; A-87; A-218 and A-219. 1 Publication1
Mutagenesisi79C → A: Loss of palmitoylation; when associated with A-9; A-78; A-87; A-218 and A-219. 1 Publication1
Mutagenesisi87C → A: Loss of palmitoylation; when associated with A-9; A-78; A-79; A-218 and A-219. 1 Publication1
Mutagenesisi218C → A: Loss of palmitoylation; when associated with A-9; A-78; A-79; A-87 and A-219. 1 Publication1
Mutagenesisi219C → A: Loss of palmitoylation; when associated with A-9; A-78; A-79; A-87 and A-218. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
928

Open Targets

More...
OpenTargetsi
ENSG00000010278

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26247

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P21926, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB05398, C31G

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
231724

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192052 – 228CD9 antigenAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi9S-palmitoyl cysteine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi78S-palmitoyl cysteine1 Publication1
Lipidationi79S-palmitoyl cysteine1 Publication1
Lipidationi87S-palmitoyl cysteine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi152 ↔ 1811 Publication
Disulfide bondi153 ↔ 1671 Publication
Lipidationi218S-palmitoyl cysteine1 Publication1
Lipidationi219S-palmitoyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids (PubMed:11959120). Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion (PubMed:18508921).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P21926

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P21926

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P21926

MaxQB - The MaxQuant DataBase

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MaxQBi
P21926

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21926

PeptideAtlas

More...
PeptideAtlasi
P21926

PRoteomics IDEntifications database

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PRIDEi
P21926

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
53942

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P21926, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21926

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P21926

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P21926

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in platelets (at protein level) (PubMed:19640571). Expressed by a variety of hematopoietic and epithelial cells (PubMed:19640571).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000010278, Expressed in trigeminal ganglion and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P21926, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P21926, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000010278, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family (PubMed:14556650).

Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (PubMed:19640571, PubMed:27993971).

Interacts with integrin ITGA6:ITGB1; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). Part of integrin-tetraspanin complexes composed of CD81, beta-1 and beta-2 integrins in the membrane of monocyte/macrophages (PubMed:12796480).

Interacts with CD63; identified in a complex with CD63 and ITGB3 (PubMed:19640571). Associates with CR2/CD21 and with PTGFRN/CD9P1 (PubMed:11278880).

Part of a complex composed of CD9, CD81, PTGFRN and IGSF8 (By similarity).

Interacts directly with IGSF8 (PubMed:11504738).

Interacts with PDPN; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN (PubMed:18541721).

Interacts (on T cell side) with CD81 at immunological synapses between antigen-presenting cells and T cells (PubMed:23858057).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107366, 30 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P21926

Database of interacting proteins

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DIPi
DIP-1122N

Protein interaction database and analysis system

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IntActi
P21926, 90 interactors

Molecular INTeraction database

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MINTi
P21926

STRING: functional protein association networks

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STRINGi
9606.ENSP00000371958

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P21926, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P21926

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3882, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155083

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_055524_10_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P21926

KEGG Orthology (KO)

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KOi
K06460

Identification of Orthologs from Complete Genome Data

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OMAi
WLRFDTQ

Database of Orthologous Groups

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OrthoDBi
1205716at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P21926

TreeFam database of animal gene trees

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TreeFami
TF352895

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03152, CD9_LEL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1450.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR042055, CD9_LEL
IPR000301, Tetraspanin
IPR018499, Tetraspanin/Peripherin
IPR018503, Tetraspanin_CS
IPR008952, Tetraspanin_EC2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00335, Tetraspanin, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF002419, Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00259, TMFOUR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48652, SSF48652, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00421, TM4_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P21926-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVKGGTKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQETN
60 70 80 90 100
NNNSSFYTGV YILIGAGALM MLVGFLGCCG AVQESQCMLG LFFGFLLVIF
110 120 130 140 150
AIEIAAAIWG YSHKDEVIKE VQEFYKDTYN KLKTKDEPQR ETLKAIHYAL
160 170 180 190 200
NCCGLAGGVE QFISDICPKK DVLETFTVKS CPDAIKEVFD NKFHIIGAVG
210 220
IGIAVVMIFG MIFSMILCCA IRRNREMV
Length:228
Mass (Da):25,416
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF68333E0C20611D8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NNI4A6NNI4_HUMAN
Tetraspanin
CD9
159Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y478A0A2R8Y478_HUMAN
Tetraspanin
CD9
159Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G8JLH6G8JLH6_HUMAN
Tetraspanin
CD9
251Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU13A0A087WU13_HUMAN
Tetraspanin
CD9
182Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXT1F5GXT1_HUMAN
CD9 antigen
CD9
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti215M → T in AAH11988 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M38690 mRNA Translation: AAA80320.1
L34068 mRNA Translation: AAA59982.1
X60111 mRNA Translation: CAA42708.1
S60489 S60472 Genomic DNA Translation: AAC60586.1
L08118 Genomic DNA No translation available.
L08119 Genomic DNA Translation: AAA51954.1 Sequence problems.
L08120 Genomic DNA Translation: AAA51955.1 Sequence problems.
L08121 Genomic DNA Translation: AAA51956.1
L08122 Genomic DNA Translation: AAA51957.1
L08123 Genomic DNA Translation: AAA51958.1
L08124 Genomic DNA Translation: AAA51959.1
L08125 Genomic DNA No translation available.
AB079244 mRNA Translation: BAE71132.1
AY423720 mRNA Translation: AAS00483.1
AY422198 Genomic DNA Translation: AAQ87878.1
CH471116 Genomic DNA Translation: EAW88812.1
CH471116 Genomic DNA Translation: EAW88813.1
BC011988 mRNA Translation: AAH11988.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8540.1

Protein sequence database of the Protein Information Resource

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PIRi
A46123, A40402

NCBI Reference Sequences

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RefSeqi
NP_001317241.1, NM_001330312.1
NP_001760.1, NM_001769.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000009180; ENSP00000009180; ENSG00000010278
ENST00000382518; ENSP00000371958; ENSG00000010278
ENST00000538834; ENSP00000496639; ENSG00000010278

Database of genes from NCBI RefSeq genomes

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GeneIDi
928

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:928

UCSC genome browser

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UCSCi
uc001qnq.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38690 mRNA Translation: AAA80320.1
L34068 mRNA Translation: AAA59982.1
X60111 mRNA Translation: CAA42708.1
S60489 S60472 Genomic DNA Translation: AAC60586.1
L08118 Genomic DNA No translation available.
L08119 Genomic DNA Translation: AAA51954.1 Sequence problems.
L08120 Genomic DNA Translation: AAA51955.1 Sequence problems.
L08121 Genomic DNA Translation: AAA51956.1
L08122 Genomic DNA Translation: AAA51957.1
L08123 Genomic DNA Translation: AAA51958.1
L08124 Genomic DNA Translation: AAA51959.1
L08125 Genomic DNA No translation available.
AB079244 mRNA Translation: BAE71132.1
AY423720 mRNA Translation: AAS00483.1
AY422198 Genomic DNA Translation: AAQ87878.1
CH471116 Genomic DNA Translation: EAW88812.1
CH471116 Genomic DNA Translation: EAW88813.1
BC011988 mRNA Translation: AAH11988.1
CCDSiCCDS8540.1
PIRiA46123, A40402
RefSeqiNP_001317241.1, NM_001330312.1
NP_001760.1, NM_001769.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6K4JX-ray2.70A1-228[»]
SMRiP21926
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107366, 30 interactors
CORUMiP21926
DIPiDIP-1122N
IntActiP21926, 90 interactors
MINTiP21926
STRINGi9606.ENSP00000371958

Chemistry databases

DrugBankiDB05398, C31G

Protein family/group databases

TCDBi8.A.40.1.9, the tetraspanin (tetraspanin) family

PTM databases

GlyGeniP21926, 3 sites
iPTMnetiP21926
PhosphoSitePlusiP21926
SwissPalmiP21926

Polymorphism and mutation databases

BioMutaiCD9
DMDMi231724

Proteomic databases

EPDiP21926
jPOSTiP21926
MassIVEiP21926
MaxQBiP21926
PaxDbiP21926
PeptideAtlasiP21926
PRIDEiP21926
ProteomicsDBi53942

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3733, 1762 antibodies

The DNASU plasmid repository

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DNASUi
928

Genome annotation databases

EnsembliENST00000009180; ENSP00000009180; ENSG00000010278
ENST00000382518; ENSP00000371958; ENSG00000010278
ENST00000538834; ENSP00000496639; ENSG00000010278
GeneIDi928
KEGGihsa:928
UCSCiuc001qnq.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
928
DisGeNETi928
EuPathDBiHostDB:ENSG00000010278.11

GeneCards: human genes, protein and diseases

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GeneCardsi
CD9
HGNCiHGNC:1709, CD9
HPAiENSG00000010278, Low tissue specificity
MIMi143030, gene
neXtProtiNX_P21926
OpenTargetsiENSG00000010278
PharmGKBiPA26247

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3882, Eukaryota
GeneTreeiENSGT00940000155083
HOGENOMiCLU_055524_10_1_1
InParanoidiP21926
KOiK06460
OMAiWLRFDTQ
OrthoDBi1205716at2759
PhylomeDBiP21926
TreeFamiTF352895

Enzyme and pathway databases

PathwayCommonsiP21926
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-1300645, Acrosome Reaction and Sperm:Oocyte Membrane Binding
R-HSA-5336415, Uptake and function of diphtheria toxin

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
928, 28 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CD9, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
928
PharosiP21926, Tbio

Protein Ontology

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PROi
PR:P21926
RNActiP21926, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000010278, Expressed in trigeminal ganglion and 247 other tissues
ExpressionAtlasiP21926, baseline and differential
GenevisibleiP21926, HS

Family and domain databases

CDDicd03152, CD9_LEL, 1 hit
Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR042055, CD9_LEL
IPR000301, Tetraspanin
IPR018499, Tetraspanin/Peripherin
IPR018503, Tetraspanin_CS
IPR008952, Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335, Tetraspanin, 1 hit
PIRSFiPIRSF002419, Tetraspanin, 1 hit
PRINTSiPR00259, TMFOUR
SUPFAMiSSF48652, SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421, TM4_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21926
Secondary accession number(s): D3DUQ9, Q5J7W6, Q96ES4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: October 7, 2020
This is version 202 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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