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Entry version 202 (13 Feb 2019)
Sequence version 2 (01 Mar 1992)
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Protein

D(1B) dopamine receptor

Gene

DRD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dopamine binding Source: UniProtKB
  • dopamine neurotransmitter receptor activity Source: UniProtKB
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: GO_Central
  • G-protein alpha-subunit binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390651 Dopamine receptors
R-HSA-418555 G alpha (s) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
D1beta dopamine receptor
Dopamine D5 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DRD5
Synonyms:DRD1B, DRD1L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169676.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3026 DRD5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
126453 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21918

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 66Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini67 – 77CytoplasmicSequence analysisAdd BLAST11
Transmembranei78 – 104Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini105 – 114ExtracellularSequence analysis10
Transmembranei115 – 136Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini137 – 158CytoplasmicSequence analysisAdd BLAST22
Transmembranei159 – 180Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini181 – 223ExtracellularSequence analysisAdd BLAST43
Transmembranei224 – 246Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini247 – 296CytoplasmicSequence analysisAdd BLAST50
Transmembranei297 – 320Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini321 – 340ExtracellularSequence analysisAdd BLAST20
Transmembranei341 – 360Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini361 – 477CytoplasmicSequence analysisAdd BLAST117

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Benign essential blepharospasm (BEB)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
See also OMIM:606798

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7N → Q: Impairs subcellular location. 1 Publication1

Keywords - Diseasei

Dystonia

Organism-specific databases

DisGeNET

More...
DisGeNETi
1816

MalaCards human disease database

More...
MalaCardsi
DRD5
MIMi606798 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000169676

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA148

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1850

Drug and drug target database

More...
DrugBanki
DB00714 Apomorphine
DB01238 Aripiprazole
DB01200 Bromocriptine
DB00248 Cabergoline
DB01038 Carphenazine
DB00477 Chlorpromazine
DB00568 Cinnarizine
DB00988 Dopamine
DB00696 Ergotamine
DB00800 Fenoldopam
DB00458 Imipramine
DB01235 Levodopa
DB00589 Lisuride
DB00408 Loxapine
DB01403 Methotrimeprazine
DB06148 Mianserin
DB00370 Mirtazapine
DB00334 Olanzapine
DB01186 Pergolide
DB00413 Pramipexole
DB01224 Quetiapine
DB00268 Ropinirole
DB05271 Rotigotine
DB00726 Trimipramine
DB00246 Ziprasidone
DB01624 Zuclopenthixol

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
218

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DRD5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118214

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000694051 – 477D(1B) dopamine receptorAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi7N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi113 ↔ 217PROSITE-ProRule annotation
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi375S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P21918

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21918

PeptideAtlas

More...
PeptideAtlasi
P21918

PRoteomics IDEntifications database

More...
PRIDEi
P21918

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53941

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21918

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Neuron-specific, localized primarily within limbic regions of the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169676 Expressed in 53 organ(s), highest expression level in anterior cingulate cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21918 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048930

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108150, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P21918, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000306129

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21918

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P21918

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157037

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239242

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106962

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21918

KEGG Orthology (KO)

More...
KOi
K05840

Identification of Orthologs from Complete Genome Data

More...
OMAi
SVWELDC

Database of Orthologous Groups

More...
OrthoDBi
646662at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21918

TreeFam database of animal gene trees

More...
TreeFami
TF325181

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000497 Dopamine_D5_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...
PANTHERi
PTHR43893:SF8 PTHR43893:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00566 DOPAMINED1BR
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21918-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL
60 70 80 90 100
IIWTLLGNVL VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV
110 120 130 140 150
AEVAGYWPFG AFCDVWVAFD IMCSTASILN LCVISVDRYW AISRPFRYKR
160 170 180 190 200
KMTQRMALVM VGLAWTLSIL ISFIPVQLNW HRDQAASWGG LDLPNNLANW
210 220 230 240 250
TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI MIVTYTRIYR
260 270 280 290 300
IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV
310 320 330 340 350
IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA
360 370 380 390 400
NSSLNPVIYA FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI
410 420 430 440 450
VFHKEIAAAY IHMMPNAVTP GNREVDNDEE EGPFDRMFQI YQTSPDGDPV
460 470
AESVWELDCE GEISLDKITP FTPNGFH
Length:477
Mass (Da):52,951
Last modified:March 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBACCB85E5A72F9CA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02921062C → S. Corresponds to variant dbSNP:rs2227840Ensembl.1
Natural variantiVAR_01183788L → R1 PublicationCorresponds to variant dbSNP:rs6282Ensembl.1
Natural variantiVAR_029211110G → E. Corresponds to variant dbSNP:rs2227849Ensembl.1
Natural variantiVAR_029212207F → V. Corresponds to variant dbSNP:rs2227845Ensembl.1
Natural variantiVAR_029213233S → N. Corresponds to variant dbSNP:rs2227843Ensembl.1
Natural variantiVAR_024254238V → I. Corresponds to variant dbSNP:rs2227852Ensembl.1
Natural variantiVAR_003458269A → V1 PublicationCorresponds to variant dbSNP:rs538877978Ensembl.1
Natural variantiVAR_029215286A → V. Corresponds to variant dbSNP:rs2227850Ensembl.1
Natural variantiVAR_061217297T → P. Corresponds to variant dbSNP:rs2227851Ensembl.1
Natural variantiVAR_003459330P → Q1 PublicationCorresponds to variant dbSNP:rs1800762Ensembl.1
Natural variantiVAR_003460351N → D1 Publication1
Natural variantiVAR_003461453S → C1 PublicationCorresponds to variant dbSNP:rs776114395Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X58454 Genomic DNA Translation: CAA41360.1
M67439 Genomic DNA Translation: AAA52329.1
AY136750 mRNA Translation: AAN01276.1
AK313897 mRNA Translation: BAG36620.1
CH471069 Genomic DNA Translation: EAW92679.1
BC009748 mRNA Translation: AAH09748.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3405.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S15080 DYHUD5

NCBI Reference Sequences

More...
RefSeqi
NP_000789.1, NM_000798.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.380681

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304374; ENSP00000306129; ENSG00000169676

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1816

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1816

UCSC genome browser

More...
UCSCi
uc003gmb.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58454 Genomic DNA Translation: CAA41360.1
M67439 Genomic DNA Translation: AAA52329.1
AY136750 mRNA Translation: AAN01276.1
AK313897 mRNA Translation: BAG36620.1
CH471069 Genomic DNA Translation: EAW92679.1
BC009748 mRNA Translation: AAH09748.1
CCDSiCCDS3405.1
PIRiS15080 DYHUD5
RefSeqiNP_000789.1, NM_000798.4
UniGeneiHs.380681

3D structure databases

ProteinModelPortaliP21918
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108150, 3 interactors
IntActiP21918, 1 interactor
STRINGi9606.ENSP00000306129

Chemistry databases

BindingDBiP21918
ChEMBLiCHEMBL1850
DrugBankiDB00714 Apomorphine
DB01238 Aripiprazole
DB01200 Bromocriptine
DB00248 Cabergoline
DB01038 Carphenazine
DB00477 Chlorpromazine
DB00568 Cinnarizine
DB00988 Dopamine
DB00696 Ergotamine
DB00800 Fenoldopam
DB00458 Imipramine
DB01235 Levodopa
DB00589 Lisuride
DB00408 Loxapine
DB01403 Methotrimeprazine
DB06148 Mianserin
DB00370 Mirtazapine
DB00334 Olanzapine
DB01186 Pergolide
DB00413 Pramipexole
DB01224 Quetiapine
DB00268 Ropinirole
DB05271 Rotigotine
DB00726 Trimipramine
DB00246 Ziprasidone
DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYi218

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP21918

Polymorphism and mutation databases

BioMutaiDRD5
DMDMi118214

Proteomic databases

jPOSTiP21918
PaxDbiP21918
PeptideAtlasiP21918
PRIDEiP21918
ProteomicsDBi53941

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1816
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304374; ENSP00000306129; ENSG00000169676
GeneIDi1816
KEGGihsa:1816
UCSCiuc003gmb.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1816
DisGeNETi1816
EuPathDBiHostDB:ENSG00000169676.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DRD5

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0029583
HGNCiHGNC:3026 DRD5
HPAiHPA048930
MalaCardsiDRD5
MIMi126453 gene
606798 phenotype
neXtProtiNX_P21918
OpenTargetsiENSG00000169676
PharmGKBiPA148

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000157037
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP21918
KOiK05840
OMAiSVWELDC
OrthoDBi646662at2759
PhylomeDBiP21918
TreeFamiTF325181

Enzyme and pathway databases

ReactomeiR-HSA-390651 Dopamine receptors
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Dopamine_receptor_D5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1816

Protein Ontology

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PROi
PR:P21918

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000169676 Expressed in 53 organ(s), highest expression level in anterior cingulate cortex
GenevisibleiP21918 HS

Family and domain databases

InterProiView protein in InterPro
IPR000497 Dopamine_D5_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR43893:SF8 PTHR43893:SF8, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00566 DOPAMINED1BR
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRD5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21918
Secondary accession number(s): B2R9S3, Q8NEQ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: March 1, 1992
Last modified: February 13, 2019
This is version 202 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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