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UniProtKB - P21918 (DRD5_HUMAN)
Protein
D(1B) dopamine receptor
Gene
DRD5
Organism
Homo sapiens (Human)
Status
Functioni
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
1 PublicationGO - Molecular functioni
- dopamine binding Source: UniProtKB
- dopamine neurotransmitter receptor activity Source: UniProtKB
- dopamine neurotransmitter receptor activity, coupled via Gs Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- activation of adenylate cyclase activity Source: BHF-UCL
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adenylate cyclase-activating dopamine receptor signaling pathway Source: UniProtKB
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- associative learning Source: Ensembl
- cellular calcium ion homeostasis Source: BHF-UCL
- cellular response to catecholamine stimulus Source: BHF-UCL
- chemical synaptic transmission Source: UniProtKB
- dopamine receptor signaling pathway Source: GO_Central
- long-term synaptic depression Source: Ensembl
- negative regulation of blood pressure Source: Ensembl
- negative regulation of NAD(P)H oxidase activity Source: UniProtKB
- norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
- phospholipase C-activating dopamine receptor signaling pathway Source: BHF-UCL
- positive regulation of adenylate cyclase activity Source: UniProtKB
- reactive oxygen species metabolic process Source: UniProtKB
- regulation of female receptivity Source: Ensembl
- regulation of systemic arterial blood pressure by vasopressin Source: Ensembl
- response to amphetamine Source: Ensembl
- response to cocaine Source: Ensembl
- sensitization Source: Ensembl
- synaptic transmission, dopaminergic Source: UniProtKB
- transmission of nerve impulse Source: Ensembl
- wound healing Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P21918 |
Reactomei | R-HSA-390651, Dopamine receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P21918 |
SIGNORi | P21918 |
Names & Taxonomyi
Protein namesi | Recommended name: D(1B) dopamine receptorAlternative name(s): D(5) dopamine receptor D1beta dopamine receptor Dopamine D5 receptor |
Gene namesi | Name:DRD5 Synonyms:DRD1B, DRD1L2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3026, DRD5 |
MIMi | 126453, gene |
neXtProti | NX_P21918 |
VEuPathDBi | HostDB:ENSG00000169676 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- brush border membrane Source: Ensembl
- ciliary membrane Source: SYSCILIA_CCNET
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cilium Source: MGI
- non-motile cilium Source: SYSCILIA_CCNET
- synapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | ExtracellularSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 66 | Helical; Name=1Sequence analysisAdd BLAST | 27 | |
Topological domaini | 67 – 77 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 78 – 104 | Helical; Name=2Sequence analysisAdd BLAST | 27 | |
Topological domaini | 105 – 114 | ExtracellularSequence analysis | 10 | |
Transmembranei | 115 – 136 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 137 – 158 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 159 – 180 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 181 – 223 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 224 – 246 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 247 – 296 | CytoplasmicSequence analysisAdd BLAST | 50 | |
Transmembranei | 297 – 320 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 321 – 340 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 341 – 360 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 361 – 477 | CytoplasmicSequence analysisAdd BLAST | 117 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Benign essential blepharospasm (BEB)1 Publication
Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Disease descriptionA primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 7 | N → Q: Impairs subcellular location. 1 Publication | 1 |
Keywords - Diseasei
DystoniaOrganism-specific databases
DisGeNETi | 1816 |
MalaCardsi | DRD5 |
MIMi | 606798, phenotype |
OpenTargetsi | ENSG00000169676 |
PharmGKBi | PA148 |
Miscellaneous databases
Pharosi | P21918, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1850 |
DrugBanki | DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB01200, Bromocriptine DB00248, Cabergoline DB01038, Carphenazine DB00477, Chlorpromazine DB00568, Cinnarizine DB11274, Dihydro-alpha-ergocryptine DB13345, Dihydroergocristine DB00988, Dopamine DB11275, Epicriptine DB01049, Ergoloid mesylate DB00696, Ergotamine DB00800, Fenoldopam DB00458, Imipramine DB00555, Lamotrigine DB01235, Levodopa DB00589, Lisuride DB00408, Loxapine DB01403, Methotrimeprazine DB06148, Mianserin DB08804, Nandrolone decanoate DB00334, Olanzapine DB00715, Paroxetine DB01186, Pergolide DB11584, Pipradrol DB01224, Quetiapine DB09097, Quinagolide DB05271, Rotigotine DB00726, Trimipramine DB00246, Ziprasidone DB09225, Zotepine DB01624, Zuclopenthixol |
DrugCentrali | P21918 |
GuidetoPHARMACOLOGYi | 218 |
Genetic variation databases
BioMutai | DRD5 |
DMDMi | 118214 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069405 | 1 – 477 | D(1B) dopamine receptorAdd BLAST | 477 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 113 ↔ 217 | PROSITE-ProRule annotation | ||
Glycosylationi | 222 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 375 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
jPOSTi | P21918 |
MassIVEi | P21918 |
PaxDbi | P21918 |
PeptideAtlasi | P21918 |
PRIDEi | P21918 |
PTM databases
GlyGeni | P21918, 2 sites |
iPTMneti | P21918 |
PhosphoSitePlusi | P21918 |
Expressioni
Tissue specificityi
Neuron-specific, localized primarily within limbic regions of the brain.1 Publication
Gene expression databases
Bgeei | ENSG00000169676, Expressed in prefrontal cortex and 62 other tissues |
Genevisiblei | P21918, HS |
Organism-specific databases
HPAi | ENSG00000169676, Tissue enhanced (brain, stomach) |
Interactioni
Binary interactionsi
P21918
With | #Exp. | IntAct |
---|---|---|
NOTCH2NLC [P0DPK4] | 3 | EBI-12139313,EBI-22310682 |
Protein-protein interaction databases
BioGRIDi | 108150, 7 interactors |
IntActi | P21918, 1 interactor |
STRINGi | 9606.ENSP00000306129 |
Chemistry databases
BindingDBi | P21918 |
Miscellaneous databases
RNActi | P21918, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000157037 |
HOGENOMi | CLU_009579_11_0_1 |
InParanoidi | P21918 |
OMAi | NNLANWT |
OrthoDBi | 1045889at2759 |
PhylomeDBi | P21918 |
TreeFami | TF325181 |
Family and domain databases
InterProi | View protein in InterPro IPR000497, Dopamine_D5_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00566, DOPAMINED1BR PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P21918-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL
60 70 80 90 100
IIWTLLGNVL VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV
110 120 130 140 150
AEVAGYWPFG AFCDVWVAFD IMCSTASILN LCVISVDRYW AISRPFRYKR
160 170 180 190 200
KMTQRMALVM VGLAWTLSIL ISFIPVQLNW HRDQAASWGG LDLPNNLANW
210 220 230 240 250
TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI MIVTYTRIYR
260 270 280 290 300
IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV
310 320 330 340 350
IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA
360 370 380 390 400
NSSLNPVIYA FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI
410 420 430 440 450
VFHKEIAAAY IHMMPNAVTP GNREVDNDEE EGPFDRMFQI YQTSPDGDPV
460 470
AESVWELDCE GEISLDKITP FTPNGFH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029210 | 62 | C → S. Corresponds to variant dbSNP:rs2227840Ensembl. | 1 | |
Natural variantiVAR_011837 | 88 | L → R1 PublicationCorresponds to variant dbSNP:rs6282Ensembl. | 1 | |
Natural variantiVAR_029211 | 110 | G → E. Corresponds to variant dbSNP:rs2227849Ensembl. | 1 | |
Natural variantiVAR_029212 | 207 | F → V. Corresponds to variant dbSNP:rs2227845Ensembl. | 1 | |
Natural variantiVAR_029213 | 233 | S → N. Corresponds to variant dbSNP:rs2227843Ensembl. | 1 | |
Natural variantiVAR_024254 | 238 | V → I. Corresponds to variant dbSNP:rs2227852Ensembl. | 1 | |
Natural variantiVAR_003458 | 269 | A → V1 PublicationCorresponds to variant dbSNP:rs538877978Ensembl. | 1 | |
Natural variantiVAR_029215 | 286 | A → V. Corresponds to variant dbSNP:rs2227850Ensembl. | 1 | |
Natural variantiVAR_061217 | 297 | T → P. Corresponds to variant dbSNP:rs2227851Ensembl. | 1 | |
Natural variantiVAR_003459 | 330 | P → Q1 PublicationCorresponds to variant dbSNP:rs1800762Ensembl. | 1 | |
Natural variantiVAR_003460 | 351 | N → D1 PublicationCorresponds to variant dbSNP:rs1577263526Ensembl. | 1 | |
Natural variantiVAR_003461 | 453 | S → C1 PublicationCorresponds to variant dbSNP:rs776114395Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58454 Genomic DNA Translation: CAA41360.1 M67439 Genomic DNA Translation: AAA52329.1 AY136750 mRNA Translation: AAN01276.1 AK313897 mRNA Translation: BAG36620.1 CH471069 Genomic DNA Translation: EAW92679.1 BC009748 mRNA Translation: AAH09748.1 |
CCDSi | CCDS3405.1 |
PIRi | S15080, DYHUD5 |
RefSeqi | NP_000789.1, NM_000798.4 |
Genome annotation databases
Ensembli | ENST00000304374.4; ENSP00000306129.2; ENSG00000169676.6 |
GeneIDi | 1816 |
KEGGi | hsa:1816 |
MANE-Selecti | ENST00000304374.4; ENSP00000306129.2; NM_000798.5; NP_000789.1 |
UCSCi | uc003gmb.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58454 Genomic DNA Translation: CAA41360.1 M67439 Genomic DNA Translation: AAA52329.1 AY136750 mRNA Translation: AAN01276.1 AK313897 mRNA Translation: BAG36620.1 CH471069 Genomic DNA Translation: EAW92679.1 BC009748 mRNA Translation: AAH09748.1 |
CCDSi | CCDS3405.1 |
PIRi | S15080, DYHUD5 |
RefSeqi | NP_000789.1, NM_000798.4 |
3D structure databases
AlphaFoldDBi | P21918 |
SMRi | P21918 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108150, 7 interactors |
IntActi | P21918, 1 interactor |
STRINGi | 9606.ENSP00000306129 |
Chemistry databases
BindingDBi | P21918 |
ChEMBLi | CHEMBL1850 |
DrugBanki | DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB01200, Bromocriptine DB00248, Cabergoline DB01038, Carphenazine DB00477, Chlorpromazine DB00568, Cinnarizine DB11274, Dihydro-alpha-ergocryptine DB13345, Dihydroergocristine DB00988, Dopamine DB11275, Epicriptine DB01049, Ergoloid mesylate DB00696, Ergotamine DB00800, Fenoldopam DB00458, Imipramine DB00555, Lamotrigine DB01235, Levodopa DB00589, Lisuride DB00408, Loxapine DB01403, Methotrimeprazine DB06148, Mianserin DB08804, Nandrolone decanoate DB00334, Olanzapine DB00715, Paroxetine DB01186, Pergolide DB11584, Pipradrol DB01224, Quetiapine DB09097, Quinagolide DB05271, Rotigotine DB00726, Trimipramine DB00246, Ziprasidone DB09225, Zotepine DB01624, Zuclopenthixol |
DrugCentrali | P21918 |
GuidetoPHARMACOLOGYi | 218 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P21918, 2 sites |
iPTMneti | P21918 |
PhosphoSitePlusi | P21918 |
Genetic variation databases
BioMutai | DRD5 |
DMDMi | 118214 |
Proteomic databases
jPOSTi | P21918 |
MassIVEi | P21918 |
PaxDbi | P21918 |
PeptideAtlasi | P21918 |
PRIDEi | P21918 |
Protocols and materials databases
Antibodypediai | 9652, 423 antibodies from 39 providers |
DNASUi | 1816 |
Genome annotation databases
Ensembli | ENST00000304374.4; ENSP00000306129.2; ENSG00000169676.6 |
GeneIDi | 1816 |
KEGGi | hsa:1816 |
MANE-Selecti | ENST00000304374.4; ENSP00000306129.2; NM_000798.5; NP_000789.1 |
UCSCi | uc003gmb.5, human |
Organism-specific databases
CTDi | 1816 |
DisGeNETi | 1816 |
GeneCardsi | DRD5 |
HGNCi | HGNC:3026, DRD5 |
HPAi | ENSG00000169676, Tissue enhanced (brain, stomach) |
MalaCardsi | DRD5 |
MIMi | 126453, gene 606798, phenotype |
neXtProti | NX_P21918 |
OpenTargetsi | ENSG00000169676 |
PharmGKBi | PA148 |
VEuPathDBi | HostDB:ENSG00000169676 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000157037 |
HOGENOMi | CLU_009579_11_0_1 |
InParanoidi | P21918 |
OMAi | NNLANWT |
OrthoDBi | 1045889at2759 |
PhylomeDBi | P21918 |
TreeFami | TF325181 |
Enzyme and pathway databases
PathwayCommonsi | P21918 |
Reactomei | R-HSA-390651, Dopamine receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P21918 |
SIGNORi | P21918 |
Miscellaneous databases
BioGRID-ORCSi | 1816, 163 hits in 1066 CRISPR screens |
GeneWikii | Dopamine_receptor_D5 |
GenomeRNAii | 1816 |
Pharosi | P21918, Tchem |
PROi | PR:P21918 |
RNActi | P21918, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169676, Expressed in prefrontal cortex and 62 other tissues |
Genevisiblei | P21918, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000497, Dopamine_D5_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00566, DOPAMINED1BR PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DRD5_HUMAN | |
Accessioni | P21918Primary (citable) accession number: P21918 Secondary accession number(s): B2R9S3, Q8NEQ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | March 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 220 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families