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UniProtKB - P21918 (DRD5_HUMAN)

Entry version 216 (07 Apr 2021)
Sequence version 2 (01 Mar 1992)
Previous versions | rss
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Protein

D(1B) dopamine receptor

Gene

DRD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P21918

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390651, Dopamine receptors
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

SIGNOR Signaling Network Open Resource

More...SIGNORi		P21918

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
D1beta dopamine receptor
Dopamine D5 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DRD5
Synonyms:DRD1B, DRD1L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3026, DRD5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		126453, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P21918

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000169676.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 66Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini67 – 77CytoplasmicSequence analysisAdd BLAST11
Transmembranei78 – 104Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini105 – 114ExtracellularSequence analysis10
Transmembranei115 – 136Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini137 – 158CytoplasmicSequence analysisAdd BLAST22
Transmembranei159 – 180Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini181 – 223ExtracellularSequence analysisAdd BLAST43
Transmembranei224 – 246Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini247 – 296CytoplasmicSequence analysisAdd BLAST50
Transmembranei297 – 320Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini321 – 340ExtracellularSequence analysisAdd BLAST20
Transmembranei341 – 360Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini361 – 477CytoplasmicSequence analysisAdd BLAST117

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Benign essential blepharospasm (BEB)1 Publication
Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Disease descriptionA primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7N → Q: Impairs subcellular location. 1 Publication1

Keywords - Diseasei

Dystonia

Organism-specific databases

DisGeNET

More...DisGeNETi		1816

MalaCards human disease database

More...MalaCardsi		DRD5
MIMi606798, phenotype

Open Targets

More...OpenTargetsi		ENSG00000169676

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA148

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P21918, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1850

Drug and drug target database

More...DrugBanki		DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB01200, Bromocriptine
DB00248, Cabergoline
DB01038, Carphenazine
DB00477, Chlorpromazine
DB00568, Cinnarizine
DB11274, Dihydro-alpha-ergocryptine
DB13345, Dihydroergocristine
DB00988, Dopamine
DB11275, Epicriptine
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB00800, Fenoldopam
DB00458, Imipramine
DB00555, Lamotrigine
DB01235, Levodopa
DB00589, Lisuride
DB00408, Loxapine
DB01403, Methotrimeprazine
DB06148, Mianserin
DB00334, Olanzapine
DB00715, Paroxetine
DB01186, Pergolide
DB11584, Pipradrol
DB01224, Quetiapine
DB09097, Quinagolide
DB05271, Rotigotine
DB00726, Trimipramine
DB00246, Ziprasidone
DB09225, Zotepine
DB01624, Zuclopenthixol

DrugCentral

More...DrugCentrali		P21918

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		218

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DRD5

Domain mapping of disease mutations (DMDM)

More...DMDMi		118214

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000694051 – 477D(1B) dopamine receptorAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi7N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi113 ↔ 217PROSITE-ProRule annotation
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi375S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P21918

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P21918

PeptideAtlas

More...PeptideAtlasi		P21918

PRoteomics IDEntifications database

More...PRIDEi		P21918

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53941

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P21918, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P21918

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Neuron-specific, localized primarily within limbic regions of the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169676, Expressed in prefrontal cortex and 62 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P21918, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169676, Group enriched (brain, lymphoid tissue, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108150, 5 interactors

Protein interaction database and analysis system

More...IntActi		P21918, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306129

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P21918

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P21918, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157037

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P21918

Identification of Orthologs from Complete Genome Data

More...OMAi		FCSGHPE

Database of Orthologous Groups

More...OrthoDBi		1045889at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P21918

TreeFam database of animal gene trees

More...TreeFami		TF325181

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000497, Dopamine_D5_rcpt
IPR000929, Dopamine_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00566, DOPAMINED1BR
PR00242, DOPAMINER
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21918-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL 
        60         70         80         90        100
IIWTLLGNVL VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV 
       110        120        130        140        150
AEVAGYWPFG AFCDVWVAFD IMCSTASILN LCVISVDRYW AISRPFRYKR 
       160        170        180        190        200
KMTQRMALVM VGLAWTLSIL ISFIPVQLNW HRDQAASWGG LDLPNNLANW 
       210        220        230        240        250
TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI MIVTYTRIYR 
       260        270        280        290        300
IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV 
       310        320        330        340        350
IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA 
       360        370        380        390        400
NSSLNPVIYA FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI 
       410        420        430        440        450
VFHKEIAAAY IHMMPNAVTP GNREVDNDEE EGPFDRMFQI YQTSPDGDPV 
       460        470 
AESVWELDCE GEISLDKITP FTPNGFH
Length:477
Mass (Da):52,951
Last modified:March 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBACCB85E5A72F9CA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02921062C → S. Corresponds to variant dbSNP:rs2227840Ensembl.1
Natural variantiVAR_01183788L → R1 PublicationCorresponds to variant dbSNP:rs6282Ensembl.1
Natural variantiVAR_029211110G → E. Corresponds to variant dbSNP:rs2227849Ensembl.1
Natural variantiVAR_029212207F → V. Corresponds to variant dbSNP:rs2227845Ensembl.1
Natural variantiVAR_029213233S → N. Corresponds to variant dbSNP:rs2227843Ensembl.1
Natural variantiVAR_024254238V → I. Corresponds to variant dbSNP:rs2227852Ensembl.1
Natural variantiVAR_003458269A → V1 PublicationCorresponds to variant dbSNP:rs538877978Ensembl.1
Natural variantiVAR_029215286A → V. Corresponds to variant dbSNP:rs2227850Ensembl.1
Natural variantiVAR_061217297T → P. Corresponds to variant dbSNP:rs2227851Ensembl.1
Natural variantiVAR_003459330P → Q1 PublicationCorresponds to variant dbSNP:rs1800762Ensembl.1
Natural variantiVAR_003460351N → D1 Publication1
Natural variantiVAR_003461453S → C1 PublicationCorresponds to variant dbSNP:rs776114395Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X58454 Genomic DNA Translation: CAA41360.1
M67439 Genomic DNA Translation: AAA52329.1
AY136750 mRNA Translation: AAN01276.1
AK313897 mRNA Translation: BAG36620.1
CH471069 Genomic DNA Translation: EAW92679.1
BC009748 mRNA Translation: AAH09748.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3405.1

Protein sequence database of the Protein Information Resource

More...PIRi		S15080, DYHUD5

NCBI Reference Sequences

More...RefSeqi		NP_000789.1, NM_000798.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000304374; ENSP00000306129; ENSG00000169676

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1816

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1816

UCSC genome browser

More...UCSCi		uc003gmb.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58454 Genomic DNA Translation: CAA41360.1
M67439 Genomic DNA Translation: AAA52329.1
AY136750 mRNA Translation: AAN01276.1
AK313897 mRNA Translation: BAG36620.1
CH471069 Genomic DNA Translation: EAW92679.1
BC009748 mRNA Translation: AAH09748.1
CCDSiCCDS3405.1
PIRiS15080, DYHUD5
RefSeqiNP_000789.1, NM_000798.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi108150, 5 interactors
IntActiP21918, 1 interactor
STRINGi9606.ENSP00000306129

Chemistry databases

BindingDBiP21918
ChEMBLiCHEMBL1850
DrugBankiDB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB01200, Bromocriptine
DB00248, Cabergoline
DB01038, Carphenazine
DB00477, Chlorpromazine
DB00568, Cinnarizine
DB11274, Dihydro-alpha-ergocryptine
DB13345, Dihydroergocristine
DB00988, Dopamine
DB11275, Epicriptine
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB00800, Fenoldopam
DB00458, Imipramine
DB00555, Lamotrigine
DB01235, Levodopa
DB00589, Lisuride
DB00408, Loxapine
DB01403, Methotrimeprazine
DB06148, Mianserin
DB00334, Olanzapine
DB00715, Paroxetine
DB01186, Pergolide
DB11584, Pipradrol
DB01224, Quetiapine
DB09097, Quinagolide
DB05271, Rotigotine
DB00726, Trimipramine
DB00246, Ziprasidone
DB09225, Zotepine
DB01624, Zuclopenthixol
DrugCentraliP21918
GuidetoPHARMACOLOGYi218

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP21918, 2 sites
iPTMnetiP21918

Genetic variation databases

BioMutaiDRD5
DMDMi118214

Proteomic databases

jPOSTiP21918
PaxDbiP21918
PeptideAtlasiP21918
PRIDEiP21918
ProteomicsDBi53941

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9652, 414 antibodies

The DNASU plasmid repository

More...DNASUi		1816

Genome annotation databases

EnsembliENST00000304374; ENSP00000306129; ENSG00000169676
GeneIDi1816
KEGGihsa:1816
UCSCiuc003gmb.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1816
DisGeNETi1816

GeneCards: human genes, protein and diseases

More...GeneCardsi		DRD5
HGNCiHGNC:3026, DRD5
HPAiENSG00000169676, Group enriched (brain, lymphoid tissue, stomach)
MalaCardsiDRD5
MIMi126453, gene
606798, phenotype
neXtProtiNX_P21918
OpenTargetsiENSG00000169676
PharmGKBiPA148
VEuPathDBiHostDB:ENSG00000169676.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00940000157037
HOGENOMiCLU_009579_11_0_1
InParanoidiP21918
OMAiFCSGHPE
OrthoDBi1045889at2759
PhylomeDBiP21918
TreeFamiTF325181

Enzyme and pathway databases

PathwayCommonsiP21918
ReactomeiR-HSA-390651, Dopamine receptors
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
SIGNORiP21918

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1816, 155 hits in 977 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Dopamine_receptor_D5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1816
PharosiP21918, Tchem

Protein Ontology

More...PROi		PR:P21918
RNActiP21918, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169676, Expressed in prefrontal cortex and 62 other tissues
GenevisibleiP21918, HS

Family and domain databases

InterProiView protein in InterPro
IPR000497, Dopamine_D5_rcpt
IPR000929, Dopamine_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00566, DOPAMINED1BR
PR00242, DOPAMINER
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRD5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21918
Secondary accession number(s): B2R9S3, Q8NEQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: March 1, 1992
Last modified: April 7, 2021
This is version 216 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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