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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

SDHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhB), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdhA), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi98Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi101Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi113Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi186Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi189Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi192Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi196Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei201Ubiquinone; shared with DHSDBy similarity1
Metal bindingi243Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi249Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi253Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: GO_Central
  • respiratory electron transport chain Source: GO_Central
  • succinate metabolic process Source: Ensembl
  • tricarboxylic acid cycle Source: ProtInc

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
Ligand2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000117118-MONOMER
BRENDAi1.3.5.1 2681
ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-71403 Citric acid cycle (TCA cycle)
SIGNORiP21912
UniPathwayi
UPA00223;UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDHB
Synonyms:SDH, SDH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117118.9
HGNCiHGNC:10681 SDHB
MIMi185470 gene
neXtProtiNX_P21912

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Pheochromocytoma (PCC)7 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
See also OMIM:171300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03506329A → AQ in PCC. 1 Publication1
Natural variantiVAR_05437643A → P in PCC. 1 Publication1
Natural variantiVAR_03506446R → G in PCC. 3 PublicationsCorresponds to variant dbSNP:rs74315370EnsemblClinVar.1
Natural variantiVAR_05437853G → R in PCC. 1 Publication1
Natural variantiVAR_05437965L → H in PCC. 1 PublicationCorresponds to variant dbSNP:rs876659329EnsemblClinVar.1
Natural variantiVAR_05438065L → P in PCC. 1 Publication1
Natural variantiVAR_01851787L → S in PCC. 2 PublicationsCorresponds to variant dbSNP:rs727504457EnsemblClinVar.1
Natural variantiVAR_037620100S → F in PCC; absence of expression in tumor cells indicating complete loss of SDHB function. 1 PublicationCorresponds to variant dbSNP:rs121917755EnsemblClinVar.1
Natural variantiVAR_035065101C → Y in PCC. 2 PublicationsCorresponds to variant dbSNP:rs74315371EnsemblClinVar.1
Natural variantiVAR_054381127I → N in PCC. 1 Publication1
Natural variantiVAR_035066192C → R in PCC. 2 PublicationsCorresponds to variant dbSNP:rs786202732EnsemblClinVar.1
Natural variantiVAR_035067196C → Y in PCC. 2 PublicationsCorresponds to variant dbSNP:rs876658367EnsemblClinVar.1
Natural variantiVAR_054383230R → C in PCC. 1 PublicationCorresponds to variant dbSNP:rs138996609EnsemblClinVar.1
Paragangliomas 4 (PGL4)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.
See also OMIM:115310
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018518131P → R in PGL4. 1 Publication1
Natural variantiVAR_037621132H → P in PGL4. 1 PublicationCorresponds to variant dbSNP:rs74315372EnsemblClinVar.1
Natural variantiVAR_017868197P → R in PGL4. 2 PublicationsCorresponds to variant dbSNP:rs74315367EnsemblClinVar.1
Paraganglioma and gastric stromal sarcoma (PGGSS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionGastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance.
See also OMIM:606864

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6390
GeneReviewsiSDHB
MalaCardsiSDHB
MIMi115310 phenotype
171300 phenotype
606864 phenotype
OpenTargetsiENSG00000117118
Orphaneti97286 Carney-Stratakis syndrome
201 Cowden syndrome
44890 Gastrointestinal stromal tumor
29072 Hereditary pheochromocytoma-paraganglioma
3208 Isolated succinate-CoQ reductase deficiency
276624 Sporadic pheochromocytoma
PharmGKBiPA35606

Chemistry databases

DrugBankiDB00139 Succinic acid
DB08689 UBIQUINONE-1

Polymorphism and mutation databases

BioMutaiSDHB
DMDMi20455488

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionCombined sourcesAdd BLAST28
ChainiPRO_000001035529 – 280Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-acetyllysineBy similarity1
Modified residuei55N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP21912
MaxQBiP21912
PaxDbiP21912
PeptideAtlasiP21912
PRIDEiP21912
ProteomicsDBi53939

2D gel databases

UCD-2DPAGEiP21912

PTM databases

iPTMnetiP21912
PhosphoSitePlusiP21912
SwissPalmiP21912

Expressioni

Gene expression databases

BgeeiENSG00000117118 Expressed in 232 organ(s), highest expression level in muscle of leg
CleanExiHS_SDHB
ExpressionAtlasiP21912 baseline and differential
GenevisibleiP21912 HS

Organism-specific databases

HPAiCAB009822
CAB068233
CAB068234
CAB068235
HPA002868

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.

Binary interactionsi

Protein-protein interaction databases

BioGridi112291, 113 interactors
ComplexPortaliCPX-561 Mitochondrial respiratory chain complex II
DIPiDIP-39666N
IntActiP21912, 33 interactors
MINTiP21912
STRINGi9606.ENSP00000364649

Structurei

3D structure databases

ProteinModelPortaliP21912
SMRiP21912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 1332Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST94
Domaini176 – 2064Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3049 Eukaryota
COG0479 LUCA
GeneTreeiENSGT00390000013558
HOGENOMiHOG000160590
HOVERGENiHBG005483
InParanoidiP21912
KOiK00235
OMAiDGQYFGP
OrthoDBiEOG091G0EKC
PhylomeDBiP21912
TreeFamiTF300754

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P21912-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVVALSLR RRLPATTLGG ACLQASRGAQ TAAATAPRIK KFAIYRWDPD
60 70 80 90 100
KAGDKPHMQT YEVDLNKCGP MVLDALIKIK NEVDSTLTFR RSCREGICGS
110 120 130 140 150
CAMNINGGNT LACTRRIDTN LNKVSKIYPL PHMYVIKDLV PDLSNFYAQY
160 170 180 190 200
KSIEPYLKKK DESQEGKQQY LQSIEEREKL DGLYECILCA CCSTSCPSYW
210 220 230 240 250
WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL YRCHTIMNCT
260 270 280
RTCPKGLNPG KAIAEIKKMM ATYKEKKASV
Length:280
Mass (Da):31,630
Last modified:May 2, 2002 - v3
Checksum:iED12E7C3BA7B6D13
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWT1A0A087WWT1_HUMAN
Succinate dehydrogenase [ubiquinone...
SDHB
200Annotation score:
A0A087WXX8A0A087WXX8_HUMAN
Succinate dehydrogenase [ubiquinone...
SDHB
123Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19 – 21GGA → WRT in AAA35708 (PubMed:2302193).Curated3
Sequence conflicti19 – 21GGA → WRT in BAA01089 (PubMed:2302193).Curated3
Sequence conflicti62E → K in AAA81167 (PubMed:7622059).Curated1
Sequence conflicti62E → K in AAA35708 (PubMed:2302193).Curated1
Sequence conflicti62E → K in BAA01089 (PubMed:2302193).Curated1
Sequence conflicti67K → NR in AAA80581 (PubMed:7622059).Curated1
Sequence conflicti151K → R no nucleotide entry (PubMed:2494655).Curated1
Sequence conflicti172Q → E no nucleotide entry (PubMed:2494655).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0543743A → G Found in a patient with a Cowden-like phenotype; unknown pathological significance; associated with increased manganese superoxide dismutase expression and normal levels of reactive oxygen species; associated with a 1.2-fold increase in AKT expression and 1.3-fold change in MAPK expression. 1 PublicationCorresponds to variant dbSNP:rs11203289EnsemblClinVar.1
Natural variantiVAR_03506329A → AQ in PCC. 1 Publication1
Natural variantiVAR_05437540K → E1 Publication1
Natural variantiVAR_05437643A → P in PCC. 1 Publication1
Natural variantiVAR_03506446R → G in PCC. 3 PublicationsCorresponds to variant dbSNP:rs74315370EnsemblClinVar.1
Natural variantiVAR_05437746R → Q in PCC and PGL4. 3 PublicationsCorresponds to variant dbSNP:rs772551056EnsemblClinVar.1
Natural variantiVAR_05437853G → R in PCC. 1 Publication1
Natural variantiVAR_05437965L → H in PCC. 1 PublicationCorresponds to variant dbSNP:rs876659329EnsemblClinVar.1
Natural variantiVAR_05438065L → P in PCC. 1 Publication1
Natural variantiVAR_01851787L → S in PCC. 2 PublicationsCorresponds to variant dbSNP:rs727504457EnsemblClinVar.1
Natural variantiVAR_037620100S → F in PCC; absence of expression in tumor cells indicating complete loss of SDHB function. 1 PublicationCorresponds to variant dbSNP:rs121917755EnsemblClinVar.1
Natural variantiVAR_035065101C → Y in PCC. 2 PublicationsCorresponds to variant dbSNP:rs74315371EnsemblClinVar.1
Natural variantiVAR_054381127I → N in PCC. 1 Publication1
Natural variantiVAR_018518131P → R in PGL4. 1 Publication1
Natural variantiVAR_037621132H → P in PGL4. 1 PublicationCorresponds to variant dbSNP:rs74315372EnsemblClinVar.1
Natural variantiVAR_054382163S → P Found in a patient with a Cowden-like phenotype; unknown pathological significance; associated with increased manganese superoxide dismutase function and increased levels of reactive oxygen species; associated with a 2.7-fold change in AKT expression and a 1.7-fold increase in MAPK expression. 1 PublicationCorresponds to variant dbSNP:rs33927012EnsemblClinVar.1
Natural variantiVAR_035066192C → R in PCC. 2 PublicationsCorresponds to variant dbSNP:rs786202732EnsemblClinVar.1
Natural variantiVAR_035067196C → Y in PCC. 2 PublicationsCorresponds to variant dbSNP:rs876658367EnsemblClinVar.1
Natural variantiVAR_017868197P → R in PGL4. 2 PublicationsCorresponds to variant dbSNP:rs74315367EnsemblClinVar.1
Natural variantiVAR_054383230R → C in PCC. 1 PublicationCorresponds to variant dbSNP:rs138996609EnsemblClinVar.1
Natural variantiVAR_017869242R → H in PGL4 and PCC. 3 PublicationsCorresponds to variant dbSNP:rs74315368EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17248 mRNA Translation: AAA81167.1
U17886
, U17296, U17880, U17881, U17882, U17883, U17884, U17885 Genomic DNA Translation: AAA80581.1
AK312056 mRNA Translation: BAG34992.1
AL049569 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94828.1
BC007840 mRNA Translation: AAH07840.1
DQ403007 mRNA Translation: ABD77140.1
D10245 mRNA Translation: BAA01089.1
M32246 mRNA Translation: AAA35708.1
CCDSiCCDS176.1
PIRiI38895
RefSeqiNP_002991.2, NM_003000.2
UniGeneiHs.465924

Genome annotation databases

EnsembliENST00000375499; ENSP00000364649; ENSG00000117118
GeneIDi6390
KEGGihsa:6390
UCSCiuc001bae.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
TCA Cycle Gene Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17248 mRNA Translation: AAA81167.1
U17886
, U17296, U17880, U17881, U17882, U17883, U17884, U17885 Genomic DNA Translation: AAA80581.1
AK312056 mRNA Translation: BAG34992.1
AL049569 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94828.1
BC007840 mRNA Translation: AAH07840.1
DQ403007 mRNA Translation: ABD77140.1
D10245 mRNA Translation: BAA01089.1
M32246 mRNA Translation: AAA35708.1
CCDSiCCDS176.1
PIRiI38895
RefSeqiNP_002991.2, NM_003000.2
UniGeneiHs.465924

3D structure databases

ProteinModelPortaliP21912
SMRiP21912
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112291, 113 interactors
ComplexPortaliCPX-561 Mitochondrial respiratory chain complex II
DIPiDIP-39666N
IntActiP21912, 33 interactors
MINTiP21912
STRINGi9606.ENSP00000364649

Chemistry databases

DrugBankiDB00139 Succinic acid
DB08689 UBIQUINONE-1

PTM databases

iPTMnetiP21912
PhosphoSitePlusiP21912
SwissPalmiP21912

Polymorphism and mutation databases

BioMutaiSDHB
DMDMi20455488

2D gel databases

UCD-2DPAGEiP21912

Proteomic databases

EPDiP21912
MaxQBiP21912
PaxDbiP21912
PeptideAtlasiP21912
PRIDEiP21912
ProteomicsDBi53939

Protocols and materials databases

DNASUi6390
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375499; ENSP00000364649; ENSG00000117118
GeneIDi6390
KEGGihsa:6390
UCSCiuc001bae.5 human

Organism-specific databases

CTDi6390
DisGeNETi6390
EuPathDBiHostDB:ENSG00000117118.9
GeneCardsiSDHB
GeneReviewsiSDHB
HGNCiHGNC:10681 SDHB
HPAiCAB009822
CAB068233
CAB068234
CAB068235
HPA002868
MalaCardsiSDHB
MIMi115310 phenotype
171300 phenotype
185470 gene
606864 phenotype
neXtProtiNX_P21912
OpenTargetsiENSG00000117118
Orphaneti97286 Carney-Stratakis syndrome
201 Cowden syndrome
44890 Gastrointestinal stromal tumor
29072 Hereditary pheochromocytoma-paraganglioma
3208 Isolated succinate-CoQ reductase deficiency
276624 Sporadic pheochromocytoma
PharmGKBiPA35606
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3049 Eukaryota
COG0479 LUCA
GeneTreeiENSGT00390000013558
HOGENOMiHOG000160590
HOVERGENiHBG005483
InParanoidiP21912
KOiK00235
OMAiDGQYFGP
OrthoDBiEOG091G0EKC
PhylomeDBiP21912
TreeFamiTF300754

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01006

BioCyciMetaCyc:ENSG00000117118-MONOMER
BRENDAi1.3.5.1 2681
ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-71403 Citric acid cycle (TCA cycle)
SIGNORiP21912

Miscellaneous databases

ChiTaRSiSDHB human
GeneWikiiSDHB
GenomeRNAii6390
PROiPR:P21912
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117118 Expressed in 232 organ(s), highest expression level in muscle of leg
CleanExiHS_SDHB
ExpressionAtlasiP21912 baseline and differential
GenevisibleiP21912 HS

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDHB_HUMAN
AccessioniPrimary (citable) accession number: P21912
Secondary accession number(s): B2R545, Q0QEY7, Q9NQ12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 2, 2002
Last modified: November 7, 2018
This is version 213 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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