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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

sdh2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdh2), Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdh1)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi98Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi103Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi106Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi118Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi188Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi191Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi194Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi198Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei203Ubiquinone; shared with DHSDBy similarity1
Metal bindingi245Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi251Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi255Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
Ligand2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-71403 Citric acid cycle (TCA cycle)
UniPathwayi
UPA00223;UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:sdh2
ORF Names:SPAC140.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC140.01
PomBaseiSPAC140.01 sdh2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionSequence analysisAdd BLAST24
ChainiPRO_000001035025 – 275Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialAdd BLAST251

Proteomic databases

MaxQBiP21911
PaxDbiP21911
PRIDEiP21911

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

BioGridi279288, 2 interactors
ComplexPortaliCPX-566 Mitochondrial respiratory chain complex II
STRINGi4896.SPAC140.01.1

Structurei

3D structure databases

SMRiP21911
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 1372Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST81
Domaini178 – 2084Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000160590
InParanoidiP21911
KOiK00235
OMAiDGQYFGP
OrthoDBiEOG092C401C

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21911-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSRRIQVLS PFLKHFVNRN ARMMATEANI SATSANPQSQ GENLKTFEIY
60 70 80 90 100
RWNPEKPEVK PKLQKYTVDL TKCGPMVLDA LIKIKNEQDP TLTFRRSCRE
110 120 130 140 150
GICGSCAMNI NGSNTLACIC NIKKDNKPTK IYPLPHCFIV KDLVPDLTYF
160 170 180 190 200
YKQYKSIEPW LQNDNIPKDK EFYQSRADRA KLDGLYECIL CACCSTSCPS
210 220 230 240 250
YWWNSEEYLG PAVLMQAYRW IIDSRDQATA KRLDVMQNSM SVYRCHTIMN
260 270
CARTCPKGLN PGLAIAKVKA LMATA
Length:275
Mass (Da):31,426
Last modified:June 13, 2012 - v3
Checksum:iF44661005266A678
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB86412.2
PIRiD32394
T37633
RefSeqiNP_593530.2, NM_001018964.2

Genome annotation databases

EnsemblFungiiSPAC140.01.1; SPAC140.01.1:pep; SPAC140.01
GeneIDi2542842
KEGGispo:SPAC140.01

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB86412.2
PIRiD32394
T37633
RefSeqiNP_593530.2, NM_001018964.2

3D structure databases

SMRiP21911
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279288, 2 interactors
ComplexPortaliCPX-566 Mitochondrial respiratory chain complex II
STRINGi4896.SPAC140.01.1

Proteomic databases

MaxQBiP21911
PaxDbiP21911
PRIDEiP21911

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC140.01.1; SPAC140.01.1:pep; SPAC140.01
GeneIDi2542842
KEGGispo:SPAC140.01

Organism-specific databases

EuPathDBiFungiDB:SPAC140.01
PomBaseiSPAC140.01 sdh2

Phylogenomic databases

HOGENOMiHOG000160590
InParanoidiP21911
KOiK00235
OMAiDGQYFGP
OrthoDBiEOG092C401C

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01006

ReactomeiR-SPO-71403 Citric acid cycle (TCA cycle)

Miscellaneous databases

PROiPR:P21911

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDHB_SCHPO
AccessioniPrimary (citable) accession number: P21911
Secondary accession number(s): P21915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: June 13, 2012
Last modified: June 20, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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