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Entry version 118 (08 May 2019)
Sequence version 2 (15 Feb 2005)
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Protein

Glucose facilitated diffusion protein

Gene

glf

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Allows uptake of glucose by the cell; allows growth on glucose minimal medium by E.coli cells impaired in glucose transport (PubMed:8144485). Also transports fructose, but has a strong preference for glucose (PubMed:7768841).2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.1 mM for glucose uptake in E.coli at 10 degrees Celsius1 Publication
  2. KM=39 mM for fructose uptake in E.coli at 15 degrees Celsius1 Publication
  1. Vmax=42 nmol/min/mg enzyme for glucose uptake in E.coli at 10 degrees Celsius1 Publication
  2. Vmax=93 nmol/min/mg enzyme for fructose uptake in E.coli at 15 degrees Celsius1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ZMOB264203:G1FZK-315-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.1.4 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucose facilitated diffusion protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:glf1 Publication
Ordered Locus Names:ZMO0366
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri264203 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001173 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini35 – 59PeriplasmicSequence analysisAdd BLAST25
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 85CytoplasmicSequence analysis5
Transmembranei86 – 106Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 112PeriplasmicSequence analysis6
Transmembranei113 – 133Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini134 – 158CytoplasmicSequence analysisAdd BLAST25
Transmembranei159 – 179Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini180 – 187PeriplasmicSequence analysis8
Transmembranei188 – 208Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini209 – 257CytoplasmicSequence analysisAdd BLAST49
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini279 – 303PeriplasmicSequence analysisAdd BLAST25
Transmembranei304 – 324Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini325 – 335CytoplasmicSequence analysisAdd BLAST11
Transmembranei336 – 356Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini357 – 366PeriplasmicSequence analysis10
Transmembranei367 – 387Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini388 – 396CytoplasmicSequence analysis9
Transmembranei397 – 417Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini418 – 429PeriplasmicSequence analysisAdd BLAST12
Transmembranei430 – 450Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini451 – 473CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000503021 – 473Glucose facilitated diffusion proteinAdd BLAST473

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
264203.ZMO0366

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000202868

KEGG Orthology (KO)

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KOi
K13854

Identification of Orthologs from Complete Genome Data

More...
OMAi
TSSMNWG

Database of Orthologous Groups

More...
OrthoDBi
955823at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083 Sugar_tr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00171 SUGRTRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00879 SP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21906-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSESSQGLV TRLALIAAIG GLLFGYDSAV IAAIGTPVDI HFIAPRHLSA
60 70 80 90 100
TAAASLSGMV VVAVLVGCVT GSLLSGWIGI RFGRRGGLLM SSICFVAAGF
110 120 130 140 150
GAALTEKLFG TGGSALQIFC FFRFLAGLGI GVVSTLTPTY IAEIAPPDKR
160 170 180 190 200
GQMVSGQQMA IVTGALTGYI FTWLLAHFGS IDWVNASGWC WSPASEGLIG
210 220 230 240 250
IAFLLLLLTA PDTPHWLVMK GRHSEASKIL ARLEPQADPN LTIQKIKAGF
260 270 280 290 300
DKAMDKSSAG LFAFGITVVF AGVSVAAFQQ LVGINAVLYY APQMFQNLGF
310 320 330 340 350
GADTALLQTI SIGVVNFIFT MIASRVVDRF GRKPLLIWGA LGMAAMMAVL
360 370 380 390 400
GCCFWFKVGG VLPLASVLLY IAVFGMSWGP VCWVVLSEMF PSSIKGAAMP
410 420 430 440 450
IAVTGQWLAN ILVNFLFKVA DGSPALNQTF NHGFSYLVFA ALSILGGLIV
460 470
ARFVPETKGR SLDEIEEMWR SQK
Length:473
Mass (Da):50,115
Last modified:February 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3886E6A18ACD6926
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti145A → R in AAA27691 (PubMed:2254282).Curated1
Sequence conflicti145A → R in AAG29864 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60615 Genomic DNA Translation: AAA27691.1
AF313764 Genomic DNA Translation: AAG29864.1
AE008692 Genomic DNA Translation: AAV88990.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A37855

NCBI Reference Sequences

More...
RefSeqi
WP_011240287.1, NZ_CP035711.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAV88990; AAV88990; ZMO0366

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33073252

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
zmo:ZMO0366

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60615 Genomic DNA Translation: AAA27691.1
AF313764 Genomic DNA Translation: AAG29864.1
AE008692 Genomic DNA Translation: AAV88990.1
PIRiA37855
RefSeqiWP_011240287.1, NZ_CP035711.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi264203.ZMO0366

Protein family/group databases

TCDBi2.A.1.1.4 the major facilitator superfamily (mfs)

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV88990; AAV88990; ZMO0366
GeneIDi33073252
KEGGizmo:ZMO0366

Phylogenomic databases

HOGENOMiHOG000202868
KOiK13854
OMAiTSSMNWG
OrthoDBi955823at2

Enzyme and pathway databases

BioCyciZMOB264203:G1FZK-315-MONOMER

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLF_ZYMMO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21906
Secondary accession number(s): Q5NQL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 15, 2005
Last modified: May 8, 2019
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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