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Entry version 146 (17 Jun 2020)
Sequence version 2 (01 Nov 1997)
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Protein

Single-stranded-DNA-specific exonuclease RecJ

Gene

recJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10830-MONOMER
ECOL316407:JW2860-MONOMER
MetaCyc:EG10830-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Single-stranded-DNA-specific exonuclease RecJ (EC:3.1.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:recJ
Ordered Locus Names:b2892, JW2860
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000972281 – 577Single-stranded-DNA-specific exonuclease RecJAdd BLAST577

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P21893

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21893

PRoteomics IDEntifications database

More...
PRIDEi
P21893

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4262338, 178 interactors
851690, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-10654N

Protein interaction database and analysis system

More...
IntActi
P21893, 26 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2892

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21893

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RecJ family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C2R Bacteria
COG0608 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009736_5_1_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21893

KEGG Orthology (KO)

More...
KOi
K07462

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21893

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001667 DDH_dom
IPR038763 DHH_sf
IPR003156 DHHA1_dom
IPR004610 RecJ
IPR041122 RecJ_OB

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01368 DHH, 1 hit
PF02272 DHHA1, 1 hit
PF17768 RecJ_OB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF64182 SSF64182, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00644 recJ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21893-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQQIQLRRR EVDETADLPA ELPPLLRRLY ASRGVRSAQE LERSVKGMLP
60 70 80 90 100
WQQLSGVEKA VEILYNAFRE GTRIIVVGDF DADGATSTAL SVLAMRSLGC
110 120 130 140 150
SNIDYLVPNR FEDGYGLSPE VVDQAHARGA QLIVTVDNGI SSHAGVEHAR
160 170 180 190 200
SLGIPVIVTD HHLPGDTLPA AEAIINPNLR DCNFPSKSLA GVGVAFYLML
210 220 230 240 250
ALRTFLRDQG WFDERNIAIP NLAELLDLVA LGTVADVVPL DANNRILTWQ
260 270 280 290 300
GMSRIRAGKC RPGIKALLEV ANRDAQKLAA SDLGFALGPR LNAAGRLDDM
310 320 330 340 350
SVGVALLLCD NIGEARVLAN ELDALNQTRK EIEQGMQIEA LTLCEKLERS
360 370 380 390 400
RDTLPGGLAM YHPEWHQGVV GILASRIKER FHRPVIAFAP AGDGTLKGSG
410 420 430 440 450
RSIQGLHMRD ALERLDTLYP GMMLKFGGHA MAAGLSLEED KFKLFQQRFG
460 470 480 490 500
ELVTEWLDPS LLQGEVVSDG PLSPAEMTME VAQLLRDAGP WGQMFPEPLF
510 520 530 540 550
DGHFRLLQQR LVGERHLKVM VEPVGGGPLL DGIAFNVDTA LWPDNGVREV
560 570
QLAYKLDINE FRGNRSLQII IDNIWPI
Length:577
Mass (Da):63,389
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF7724B36D7701DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6Q → H in AAA62789 (PubMed:1987126).Curated1
Sequence conflicti20A → AA in AAA62789 (PubMed:1987126).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M54884 Genomic DNA Translation: AAA62789.1
U28375 Genomic DNA Translation: AAA83073.1
U00096 Genomic DNA Translation: AAC75930.1
AP009048 Genomic DNA Translation: BAE76957.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D65073

NCBI Reference Sequences

More...
RefSeqi
NP_417368.1, NC_000913.3
WP_000813200.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75930; AAC75930; b2892
BAE76957; BAE76957; BAE76957

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947367

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2860
eco:b2892

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3841

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54884 Genomic DNA Translation: AAA62789.1
U28375 Genomic DNA Translation: AAA83073.1
U00096 Genomic DNA Translation: AAC75930.1
AP009048 Genomic DNA Translation: BAE76957.1
PIRiD65073
RefSeqiNP_417368.1, NC_000913.3
WP_000813200.1, NZ_LN832404.1

3D structure databases

SMRiP21893
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4262338, 178 interactors
851690, 2 interactors
DIPiDIP-10654N
IntActiP21893, 26 interactors
STRINGi511145.b2892

Proteomic databases

jPOSTiP21893
PaxDbiP21893
PRIDEiP21893

Genome annotation databases

EnsemblBacteriaiAAC75930; AAC75930; b2892
BAE76957; BAE76957; BAE76957
GeneIDi947367
KEGGiecj:JW2860
eco:b2892
PATRICifig|1411691.4.peg.3841

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0823

Phylogenomic databases

eggNOGiENOG4105C2R Bacteria
COG0608 LUCA
HOGENOMiCLU_009736_5_1_6
InParanoidiP21893
KOiK07462
PhylomeDBiP21893

Enzyme and pathway databases

BioCyciEcoCyc:EG10830-MONOMER
ECOL316407:JW2860-MONOMER
MetaCyc:EG10830-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P21893

Family and domain databases

InterProiView protein in InterPro
IPR001667 DDH_dom
IPR038763 DHH_sf
IPR003156 DHHA1_dom
IPR004610 RecJ
IPR041122 RecJ_OB
PfamiView protein in Pfam
PF01368 DHH, 1 hit
PF02272 DHHA1, 1 hit
PF17768 RecJ_OB, 1 hit
SUPFAMiSSF64182 SSF64182, 1 hit
TIGRFAMsiTIGR00644 recJ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRECJ_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21893
Secondary accession number(s): Q2M9U9, Q46823
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: June 17, 2020
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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