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UniProtKB - P21881 (ODPA_BACSU)
Protein
Pyruvate dehydrogenase E1 component subunit alpha
Gene
pdhA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
The B.subtilis PDH complex possesses also branched-chain 2-oxoacid dehydrogenase (BCDH) activity.
Catalytic activityi
- [dihydrolipoyllysine-residue acetyltransferase]-(R)-N6-lipoyl-L-lysine + H+ + pyruvate = [dihydrolipoyllysine-residue acetyltransferase]-(R)-N6-(S8-acetyldihydrolipoyl)-L-lysine + CO2EC:1.2.4.1
Cofactori
GO - Molecular functioni
- pyruvate dehydrogenase (acetyl-transferring) activity Source: GO_Central
GO - Biological processi
- acetyl-CoA biosynthetic process from pyruvate Source: GO_Central
- glycolytic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Glycolysis |
Ligand | Pyruvate, Thiamine pyrophosphate |
Enzyme and pathway databases
BioCyci | BSUB:BSU14580-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)Alternative name(s): S complex, 42 kDa subunit Vegetative protein 220 Short name: VEG220 |
Gene namesi | Name:pdhA Synonyms:aceA Ordered Locus Names:BSU14580 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000162199 | 2 – 371 | Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST | 370 |
Proteomic databases
jPOSTi | P21881 |
PaxDbi | P21881 |
PRIDEi | P21881 |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta chain.
Protein-protein interaction databases
IntActi | P21881, 1 interactor |
MINTi | P21881 |
STRINGi | 224308.BSU14580 |
Family & Domainsi
Phylogenomic databases
eggNOGi | COG1071, Bacteria |
InParanoidi | P21881 |
OMAi | GMFRGVN |
PhylomeDBi | P21881 |
Family and domain databases
InterProi | View protein in InterPro IPR001017, DH_E1 IPR017596, PdhA/BkdA IPR029061, THDP-binding |
PANTHERi | PTHR11516:SF41, PTHR11516:SF41, 1 hit |
Pfami | View protein in Pfam PF00676, E1_dh, 1 hit |
SUPFAMi | SSF52518, SSF52518, 1 hit |
TIGRFAMsi | TIGR03181, PDH_E1_alph_x, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P21881-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAKTKKAIV DSKKQFDAIK KQFETFQILN EKGEVVNEAA MPDLTDDQLK
60 70 80 90 100
ELMRRMVFTR VLDQRSISLN RQGRLGFYAP TAGQEASQIA THFALEKEDF
110 120 130 140 150
VLPGYRDVPQ LIWHGLPLYQ AFLFSRGHFR GNQMPDDVNA LSPQIIIGAQ
160 170 180 190 200
YIQTAGVALG LKKRGKKAVA ITYTGDGGAS QGDFYEGINF AGAYKAPAIF
210 220 230 240 250
VVQNNRYAIS TPVEKQSAAE TIAQKAVAAG IVGVQVDGMD PLAVYAATAE
260 270 280 290 300
ARERAINGEG PTLIETLTFR YGPHTMAGDD PTKYRTKEIE NEWEQKDPLV
310 320 330 340 350
RFRAFLENKG LWSEEEEAKV IEDAKEEIKQ AIKKADAEPK QKVTDLMKIM
360 370
YEKMPHNLEE QFEIYTQKES K
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 179 | A → R in AAA62681 (PubMed:1697575).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57435 Genomic DNA Translation: AAA62681.1 AF012285 Genomic DNA Translation: AAC24932.1 AL009126 Genomic DNA Translation: CAB13331.1 |
PIRi | B36718, DEBSPA |
RefSeqi | NP_389341.1, NC_000964.3 WP_003222294.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB13331; CAB13331; BSU_14580 |
GeneIDi | 64303347 936005 |
KEGGi | bsu:BSU14580 |
PATRICi | fig|224308.179.peg.1590 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57435 Genomic DNA Translation: AAA62681.1 AF012285 Genomic DNA Translation: AAC24932.1 AL009126 Genomic DNA Translation: CAB13331.1 |
PIRi | B36718, DEBSPA |
RefSeqi | NP_389341.1, NC_000964.3 WP_003222294.1, NZ_JNCM01000035.1 |
3D structure databases
SMRi | P21881 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P21881, 1 interactor |
MINTi | P21881 |
STRINGi | 224308.BSU14580 |
Proteomic databases
jPOSTi | P21881 |
PaxDbi | P21881 |
PRIDEi | P21881 |
Genome annotation databases
EnsemblBacteriai | CAB13331; CAB13331; BSU_14580 |
GeneIDi | 64303347 936005 |
KEGGi | bsu:BSU14580 |
PATRICi | fig|224308.179.peg.1590 |
Phylogenomic databases
eggNOGi | COG1071, Bacteria |
InParanoidi | P21881 |
OMAi | GMFRGVN |
PhylomeDBi | P21881 |
Enzyme and pathway databases
BioCyci | BSUB:BSU14580-MONOMER |
Miscellaneous databases
PROi | PR:P21881 |
Family and domain databases
InterProi | View protein in InterPro IPR001017, DH_E1 IPR017596, PdhA/BkdA IPR029061, THDP-binding |
PANTHERi | PTHR11516:SF41, PTHR11516:SF41, 1 hit |
Pfami | View protein in Pfam PF00676, E1_dh, 1 hit |
SUPFAMi | SSF52518, SSF52518, 1 hit |
TIGRFAMsi | TIGR03181, PDH_E1_alph_x, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ODPA_BACSU | |
Accessioni | P21881Primary (citable) accession number: P21881 Secondary accession number(s): Q59227 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |