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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
The B.subtilis PDH complex possesses also branched-chain 2-oxoacid dehydrogenase (BCDH) activity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBSUB:BSU14580-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Alternative name(s):
S complex, 42 kDa subunit
Vegetative protein 220
Short name:
VEG220
Gene namesi
Name:pdhA
Synonyms:aceA
Ordered Locus Names:BSU14580
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001621992 – 371Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST370

Proteomic databases

PaxDbiP21881
PRIDEiP21881

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

IntActiP21881, 1 interactor
MINTiP21881
STRINGi224308.Bsubs1_010100008086

Structurei

3D structure databases

ProteinModelPortaliP21881
SMRiP21881
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071 LUCA
HOGENOMiHOG000281335
InParanoidiP21881
KOiK00161
OMAiNTMDKIL
PhylomeDBiP21881

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017596 PdhA/BkdA
IPR029061 THDP-binding
PANTHERiPTHR11516:SF41 PTHR11516:SF41, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03181 PDH_E1_alph_x, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKTKKAIV DSKKQFDAIK KQFETFQILN EKGEVVNEAA MPDLTDDQLK
60 70 80 90 100
ELMRRMVFTR VLDQRSISLN RQGRLGFYAP TAGQEASQIA THFALEKEDF
110 120 130 140 150
VLPGYRDVPQ LIWHGLPLYQ AFLFSRGHFR GNQMPDDVNA LSPQIIIGAQ
160 170 180 190 200
YIQTAGVALG LKKRGKKAVA ITYTGDGGAS QGDFYEGINF AGAYKAPAIF
210 220 230 240 250
VVQNNRYAIS TPVEKQSAAE TIAQKAVAAG IVGVQVDGMD PLAVYAATAE
260 270 280 290 300
ARERAINGEG PTLIETLTFR YGPHTMAGDD PTKYRTKEIE NEWEQKDPLV
310 320 330 340 350
RFRAFLENKG LWSEEEEAKV IEDAKEEIKQ AIKKADAEPK QKVTDLMKIM
360 370
YEKMPHNLEE QFEIYTQKES K
Length:371
Mass (Da):41,548
Last modified:January 23, 2007 - v3
Checksum:i984AE665278C1462
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179A → R in AAA62681 (PubMed:1697575).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57435 Genomic DNA Translation: AAA62681.1
AF012285 Genomic DNA Translation: AAC24932.1
AL009126 Genomic DNA Translation: CAB13331.1
PIRiB36718 DEBSPA
RefSeqiNP_389341.1, NC_000964.3
WP_003222294.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13331; CAB13331; BSU14580
GeneIDi936005
KEGGibsu:BSU14580
PATRICifig|224308.179.peg.1590

Similar proteinsi

Entry informationi

Entry nameiODPA_BACSU
AccessioniPrimary (citable) accession number: P21881
Secondary accession number(s): Q59227
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

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