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UniProtKB - P21873 (ODPA_GEOSE)
Protein
Pyruvate dehydrogenase E1 component subunit alpha
Gene
pdhA
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Functioni
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Catalytic activityi
- (R)-N6-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H+ + pyruvate = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2EC:1.2.4.1
Cofactori
GO - Molecular functioni
- pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
GO - Biological processi
- glycolytic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Glycolysis |
Ligand | Pyruvate, Thiamine pyrophosphate |
Enzyme and pathway databases
SABIO-RKi | P21873 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pdhA |
Organismi | Geobacillus stearothermophilus (Bacillus stearothermophilus) |
Taxonomic identifieri | 1422 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Geobacillus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000162198 | 2 – 369 | Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST | 368 |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta chain.
Binary interactionsi
P21873
With | #Exp. | IntAct |
---|---|---|
pdhB [P21874] | 3 | EBI-1040686,EBI-1040700 |
Protein-protein interaction databases
DIPi | DIP-29596N |
IntActi | P21873, 2 interactors |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P21873 |
SMRi | P21873 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P21873 |
Family & Domainsi
Family and domain databases
InterProi | View protein in InterPro IPR001017, DH_E1 IPR017596, PdhA/BkdA IPR029061, THDP-binding |
PANTHERi | PTHR11516:SF41, PTHR11516:SF41, 1 hit |
Pfami | View protein in Pfam PF00676, E1_dh, 1 hit |
SUPFAMi | SSF52518, SSF52518, 1 hit |
TIGRFAMsi | TIGR03181, PDH_E1_alph_x, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P21873-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVKTFQFPF AEQLEKVAEQ FPTFQILNEE GEVVNEEAMP ELSDEQLKEL
60 70 80 90 100
MRRMVYTRIL DQRSISLNRQ GRLGFYAPTA GQEASQIASH FALEKEDFIL
110 120 130 140 150
PGYRDVPQII WHGLPLYQAF LFSRGHFHGN QIPEGVNVLP PQIIIGAQYI
160 170 180 190 200
QAAGVALGLK MRGKKAVAIT YTGDGGTSQG DFYEGINFAG AFKAPAIFVV
210 220 230 240 250
QNNRFAISTP VEKQTVAKTL AQKAVAAGIP GIQVDGMDPL AVYAAVKAAR
260 270 280 290 300
ERAINGEGPT LIETLCFRYG PHTMSGDDPT RYRSKELENE WAKKDPLVRF
310 320 330 340 350
RKFLEAKGLW SEEEENNVIE QAKEEIKEAI KKADETPKQK VTDLISIMFE
360
ELPFNLKEQY EIYKEKESK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53560 Genomic DNA Translation: CAA37628.1 |
PIRi | S10798, DEBSPF |
RefSeqi | WP_033016215.1, NZ_RCTK01000001.1 |
Genome annotation databases
GeneIDi | 58572153 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53560 Genomic DNA Translation: CAA37628.1 |
PIRi | S10798, DEBSPF |
RefSeqi | WP_033016215.1, NZ_RCTK01000001.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1W85 | X-ray | 2.00 | A/C/E/G | 2-369 | [»] | |
1W88 | X-ray | 2.30 | A/C/E/G | 2-369 | [»] | |
3DUF | X-ray | 2.50 | A/C/E/G | 1-369 | [»] | |
3DV0 | X-ray | 2.50 | A/C/E/G | 1-369 | [»] | |
3DVA | X-ray | 2.35 | A/C/E/G | 1-369 | [»] | |
AlphaFoldDBi | P21873 | |||||
SMRi | P21873 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-29596N |
IntActi | P21873, 2 interactors |
Genome annotation databases
GeneIDi | 58572153 |
Enzyme and pathway databases
SABIO-RKi | P21873 |
Miscellaneous databases
EvolutionaryTracei | P21873 |
Family and domain databases
InterProi | View protein in InterPro IPR001017, DH_E1 IPR017596, PdhA/BkdA IPR029061, THDP-binding |
PANTHERi | PTHR11516:SF41, PTHR11516:SF41, 1 hit |
Pfami | View protein in Pfam PF00676, E1_dh, 1 hit |
SUPFAMi | SSF52518, SSF52518, 1 hit |
TIGRFAMsi | TIGR03181, PDH_E1_alph_x, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ODPA_GEOSE | |
Accessioni | P21873Primary (citable) accession number: P21873 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 110 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references