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Entry version 224 (13 Nov 2019)
Sequence version 1 (01 May 1991)
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Protein

Receptor tyrosine-protein kinase erbB-3

Gene

ERBB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei742ATP1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei834Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi715 – 723ATP9
Nucleotide bindingi788 – 790ATP3
Nucleotide bindingi834 – 839ATP6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1227986 Signaling by ERBB2 [P21860-1]
R-HSA-1236394 Signaling by ERBB4 [P21860-1]
R-HSA-1250196 SHC1 events in ERBB2 signaling [P21860-1]
R-HSA-1257604 PIP3 activates AKT signaling [P21860-1]
R-HSA-1306955 GRB7 events in ERBB2 signaling [P21860-1]
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling [P21860-1]
R-HSA-1963642 PI3K events in ERBB2 signaling [P21860-1]
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer [P21860-1]
R-HSA-5673001 RAF/MAP kinase cascade [P21860-1]
R-HSA-6785631 ERBB2 Regulates Cell Motility [P21860-1]
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [P21860-1]
R-HSA-8847993 ERBB2 Activates PTK6 Signaling [P21860-1]
R-HSA-8863795 Downregulation of ERBB2 signaling [P21860-1]

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P21860

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P21860

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P21860 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor tyrosine-protein kinase erbB-3 (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene-like protein c-ErbB-3
Tyrosine kinase-type cell surface receptor HER3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERBB3
Synonyms:HER3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3431 ERBB3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
190151 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21860

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 643ExtracellularSequence analysisAdd BLAST624
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 1342CytoplasmicSequence analysisAdd BLAST678

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lethal congenital contracture syndrome 2 (LCCS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology.
Related information in OMIM
Erythroleukemia, familial (FERLK)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood. Disease penetrance is incomplete.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0816411337A → T in FERLK; risk factor for erythroleukemia; results in increased ERBB-mediated signaling; results in a block of erythroid differentiation and increased cell proliferation. 1 PublicationCorresponds to variant dbSNP:rs755855285EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi742K → M: Strongly reduced autophosphorylation. 1 Publication1
Mutagenesisi868Y → E: Strongly reduced tyrosine phosphorylation. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2065

MalaCards human disease database

More...
MalaCardsi
ERBB3
MIMi133180 phenotype
607598 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000065361

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
137776 Lethal congenital contracture syndrome type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27846

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P21860

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5838

DrugCentral

More...
DrugCentrali
P21860

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1798

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ERBB3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
119534

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001667220 – 1342Receptor tyrosine-protein kinase erbB-3Add BLAST1323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 561 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 1831 Publication
Disulfide bondi186 ↔ 1941 Publication
Disulfide bondi190 ↔ 2021 Publication
Disulfide bondi210 ↔ 2181 Publication
Disulfide bondi214 ↔ 2261 Publication
Disulfide bondi227 ↔ 2351 Publication
Disulfide bondi231 ↔ 2431 Publication
Disulfide bondi246 ↔ 2551 Publication
Glycosylationi250N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi259 ↔ 2861 Publication
Disulfide bondi290 ↔ 3011 Publication
Disulfide bondi305 ↔ 3201 Publication
Disulfide bondi323 ↔ 3271 Publication
Glycosylationi353N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi408N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi414N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi437N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi469N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi500 ↔ 5091 Publication
Disulfide bondi504 ↔ 5171 Publication
Disulfide bondi520 ↔ 5291 Publication
Glycosylationi522N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi533 ↔ 5491 Publication
Disulfide bondi552 ↔ 5651 Publication
Disulfide bondi556 ↔ 5731 Publication
Glycosylationi566N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi576 ↔ 5851 Publication
Disulfide bondi589 ↔ 610By similarity
Disulfide bondi613 ↔ 621By similarity
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi617 ↔ 629By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei686PhosphoserineCombined sources1
Modified residuei982PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P21860

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P21860

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P21860

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21860

PeptideAtlas

More...
PeptideAtlasi
P21860

PRoteomics IDEntifications database

More...
PRIDEi
P21860

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53934 [P21860-1]
53935 [P21860-2]
53936 [P21860-3]
53937 [P21860-4]
53938 [P21860-5]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P21860

GlyConnect protein glycosylation platform

More...
GlyConnecti
1711

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21860

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21860

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Epithelial tissues and brain.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Overexpressed in a subset of human mammary tumors.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000065361 Expressed in 217 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P21860 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21860 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025331
HPA045396

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential).

Interacts with CSPG5 (PubMed:15358134).

Interacts with GRB7 (PubMed:9516479).

Interacts with MUC1 (PubMed:12939402).

Interacts with MYOC (By similarity).

Interacts with isoform 2 of PA2G4 (PubMed:11325528, PubMed:16832058).

Found in a ternary complex with NRG1 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).

By similarityCurated6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108377, 198 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P21860

Database of interacting proteins

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DIPi
DIP-36441N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P21860

Protein interaction database and analysis system

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IntActi
P21860, 130 interactors

Molecular INTeraction database

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MINTi
P21860

STRING: functional protein association networks

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STRINGi
9606.ENSP00000267101

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21860

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P21860

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P21860

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini709 – 966Protein kinasePROSITE-ProRule annotationAdd BLAST258

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1025 Eukaryota
ENOG410XNSR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230982

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21860

KEGG Orthology (KO)

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KOi
K05084

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDPNQCC

Database of Orthologous Groups

More...
OrthoDBi
81952at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21860

TreeFam database of animal gene trees

More...
TreeFami
TF106002

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00064 FU, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.20.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR016245 Tyr_kinase_EGF/ERB/XmrK_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00757 Furin-like, 1 hit
PF14843 GF_recep_IV, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000619 TyrPK_EGF-R, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00261 FU, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P21860-1) [UniParc]FASTAAdd to basket
Also known as: long form

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRANDALQVL GLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY
60 70 80 90 100
KLYERCEVVM GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP
110 120 130 140 150
NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRLTQLT EILSGGVYIE
160 170 180 190 200
KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG RSCPPCHEVC KGRCWGPGSE
210 220 230 240 250
DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD TDCFACRHFN
260 270 280 290 300
DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS
310 320 330 340 350
CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG
360 370 380 390 400
FVNCTKILGN LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ
410 420 430 440 450
SWPPHMHNFS VFSNLTTIGG RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS
460 470 480 490 500
AGRIYISANR QLCYHHSLNW TKVLRGPTEE RLDIKHNRPR RDCVAEGKVC
510 520 530 540 550
DPLCSSGGCW GPGPGQCLSC RNYSRGGVCV THCNFLNGEP REFAHEAECF
560 570 580 590 600
SCHPECQPME GTATCNGSGS DTCAQCAHFR DGPHCVSSCP HGVLGAKGPI
610 620 630 640 650
YKYPDVQNEC RPCHENCTQG CKGPELQDCL GQTLVLIGKT HLTMALTVIA
660 670 680 690 700
GLVVIFMMLG GTFLYWRGRR IQNKRAMRRY LERGESIEPL DPSEKANKVL
710 720 730 740 750
ARIFKETELR KLKVLGSGVF GTVHKGVWIP EGESIKIPVC IKVIEDKSGR
760 770 780 790 800
QSFQAVTDHM LAIGSLDHAH IVRLLGLCPG SSLQLVTQYL PLGSLLDHVR
810 820 830 840 850
QHRGALGPQL LLNWGVQIAK GMYYLEEHGM VHRNLAARNV LLKSPSQVQV
860 870 880 890 900
ADFGVADLLP PDDKQLLYSE AKTPIKWMAL ESIHFGKYTH QSDVWSYGVT
910 920 930 940 950
VWELMTFGAE PYAGLRLAEV PDLLEKGERL AQPQICTIDV YMVMVKCWMI
960 970 980 990 1000
DENIRPTFKE LANEFTRMAR DPPRYLVIKR ESGPGIAPGP EPHGLTNKKL
1010 1020 1030 1040 1050
EEVELEPELD LDLDLEAEED NLATTTLGSA LSLPVGTLNR PRGSQSLLSP
1060 1070 1080 1090 1100
SSGYMPMNQG NLGESCQESA VSGSSERCPR PVSLHPMPRG CLASESSEGH
1110 1120 1130 1140 1150
VTGSEAELQE KVSMCRSRSR SRSPRPRGDS AYHSQRHSLL TPVTPLSPPG
1160 1170 1180 1190 1200
LEEEDVNGYV MPDTHLKGTP SSREGTLSSV GLSSVLGTEE EDEDEEYEYM
1210 1220 1230 1240 1250
NRRRRHSPPH PPRPSSLEEL GYEYMDVGSD LSASLGSTQS CPLHPVPIMP
1260 1270 1280 1290 1300
TAGTTPDEDY EYMNRQRDGG GPGGDYAAMG ACPASEQGYE EMRAFQGPGH
1310 1320 1330 1340
QAPHVHYARL KTLRSLEATD SAFDNPDYWH SRLFPKANAQ RT
Length:1,342
Mass (Da):148,098
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7201E7F66CA374BD
GO
Isoform 2 (identifier: P21860-2) [UniParc]FASTAAdd to basket
Also known as: short form

The sequence of this isoform differs from the canonical sequence as follows:
     141-183: EILSGGVYIE...IVVKDNGRSC → GQFPMVPSGL...SKVPVTLAAV
     184-1342: Missing.

Show »
Length:183
Mass (Da):20,136
Checksum:iDA25DD25D34DE5E3
GO
Isoform 3 (identifier: P21860-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-331: C → F
     332-1342: Missing.

Show »
Length:331
Mass (Da):36,490
Checksum:i45B8EBEE683FE7E8
GO
Isoform 4 (identifier: P21860-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Show »
Length:1,283
Mass (Da):141,752
Checksum:iD40BB4459539D894
GO
Isoform 5 (identifier: P21860-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-643: Missing.

Show »
Length:699
Mass (Da):77,426
Checksum:iC7C94A8F051DCE15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DGQ7B4DGQ7_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
921Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYK4F8VYK4_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
649Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VW56F8VW56_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
583Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B3KWG5B3KWG5_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
462Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRI5F8VRI5_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRL0F8VRL0_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
O75812O75812_HUMAN
ErbB-3 R31
ERBB3 c-erbB-3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VW48F8VW48_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VX90F8VX90_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6T4A0A2R8Y6T4_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti560E → G in AAA35979 (PubMed:2164210).Curated1
Sequence conflicti684G → S in BAF84370 (PubMed:14702039).Curated1
Sequence conflicti1064E → G in AAA35979 (PubMed:2164210).Curated1
Sequence conflicti1078C → S in BAG62544 (PubMed:14702039).Curated1
Sequence conflicti1163D → G in BAF84370 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04210120S → Y1 PublicationCorresponds to variant dbSNP:rs34379766Ensembl.1
Natural variantiVAR_04210230P → L1 PublicationCorresponds to variant dbSNP:rs56017157Ensembl.1
Natural variantiVAR_042103104V → M in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1057519893EnsemblClinVar.1
Natural variantiVAR_042104204T → I1 PublicationCorresponds to variant dbSNP:rs56107455Ensembl.1
Natural variantiVAR_049710385N → S. Corresponds to variant dbSNP:rs12320176Ensembl.1
Natural variantiVAR_042105683R → W1 PublicationCorresponds to variant dbSNP:rs56387488Ensembl.1
Natural variantiVAR_042106717S → L1 PublicationCorresponds to variant dbSNP:rs35961836Ensembl.1
Natural variantiVAR_042107744I → T1 PublicationCorresponds to variant dbSNP:rs55787439Ensembl.1
Natural variantiVAR_042108998K → R1 PublicationCorresponds to variant dbSNP:rs56259600Ensembl.1
Natural variantiVAR_0421091119S → C1 PublicationCorresponds to variant dbSNP:rs773123Ensembl.1
Natural variantiVAR_0421101127R → H1 PublicationCorresponds to variant dbSNP:rs2271188Ensembl.1
Natural variantiVAR_0421111177L → I1 PublicationCorresponds to variant dbSNP:rs55699040Ensembl.1
Natural variantiVAR_0421121254T → K1 PublicationCorresponds to variant dbSNP:rs55709407Ensembl.1
Natural variantiVAR_0497111271G → S. Corresponds to variant dbSNP:rs11171743Ensembl.1
Natural variantiVAR_0816411337A → T in FERLK; risk factor for erythroleukemia; results in increased ERBB-mediated signaling; results in a block of erythroid differentiation and increased cell proliferation. 1 PublicationCorresponds to variant dbSNP:rs755855285EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0416611 – 643Missing in isoform 5. 1 PublicationAdd BLAST643
Alternative sequenceiVSP_0416621 – 59Missing in isoform 4. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_002893141 – 183EILSG…NGRSC → GQFPMVPSGLTPQPAQDWYL LDDDPRLLTLSASSKVPVTL AAV in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_002894184 – 1342Missing in isoform 2. 1 PublicationAdd BLAST1159
Alternative sequenceiVSP_041663331C → F in isoform 3. 2 Publications1
Alternative sequenceiVSP_041664332 – 1342Missing in isoform 3. 2 PublicationsAdd BLAST1011

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M29366 mRNA Translation: AAA35790.1
M34309 mRNA Translation: AAA35979.1
S61953 mRNA Translation: AAB26935.1
BT007226 mRNA Translation: AAP35890.1
AK291681 mRNA Translation: BAF84370.1
AK295650 mRNA Translation: BAG58519.1
AK300909 mRNA Translation: BAG62544.1
AC034102 Genomic DNA No translation available.
BC002706 mRNA Translation: AAH02706.1
BC082992 mRNA Translation: AAH82992.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31833.1 [P21860-1]
CCDS44918.1 [P21860-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A36223
JH0803

NCBI Reference Sequences

More...
RefSeqi
NP_001005915.1, NM_001005915.1 [P21860-2]
NP_001973.2, NM_001982.3 [P21860-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267101; ENSP00000267101; ENSG00000065361 [P21860-1]
ENST00000411731; ENSP00000415753; ENSG00000065361 [P21860-2]
ENST00000415288; ENSP00000408340; ENSG00000065361 [P21860-4]
ENST00000551242; ENSP00000447510; ENSG00000065361 [P21860-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2065

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2065

UCSC genome browser

More...
UCSCi
uc001sjg.4 human [P21860-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29366 mRNA Translation: AAA35790.1
M34309 mRNA Translation: AAA35979.1
S61953 mRNA Translation: AAB26935.1
BT007226 mRNA Translation: AAP35890.1
AK291681 mRNA Translation: BAF84370.1
AK295650 mRNA Translation: BAG58519.1
AK300909 mRNA Translation: BAG62544.1
AC034102 Genomic DNA No translation available.
BC002706 mRNA Translation: AAH02706.1
BC082992 mRNA Translation: AAH82992.1
CCDSiCCDS31833.1 [P21860-1]
CCDS44918.1 [P21860-2]
PIRiA36223
JH0803
RefSeqiNP_001005915.1, NM_001005915.1 [P21860-2]
NP_001973.2, NM_001982.3 [P21860-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M6BX-ray2.60A/B20-640[»]
2L9UNMR-A/B639-670[»]
3KEXX-ray2.80A/B698-1019[»]
3LMGX-ray2.80A/B684-1020[»]
3P11X-ray3.70A20-532[»]
4LEOX-ray2.64C20-631[»]
4P59X-ray3.40A20-640[»]
4RIWX-ray3.10A/C698-1020[»]
4RIXX-ray3.10A/C698-1020[»]
4RIYX-ray2.98A/C698-1020[»]
5CUSX-ray3.20A/B/C/D20-641[»]
5O4OX-ray3.40C1-643[»]
5O7PX-ray4.50C1-643[»]
6OP9X-ray2.50A674-1001[»]
SMRiP21860
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108377, 198 interactors
CORUMiP21860
DIPiDIP-36441N
ELMiP21860
IntActiP21860, 130 interactors
MINTiP21860
STRINGi9606.ENSP00000267101

Chemistry databases

BindingDBiP21860
ChEMBLiCHEMBL5838
DrugCentraliP21860
GuidetoPHARMACOLOGYi1798

Protein family/group databases

MoonDBiP21860 Predicted

PTM databases

CarbonylDBiP21860
GlyConnecti1711
iPTMnetiP21860
PhosphoSitePlusiP21860

Polymorphism and mutation databases

BioMutaiERBB3
DMDMi119534

Proteomic databases

jPOSTiP21860
MassIVEiP21860
MaxQBiP21860
PaxDbiP21860
PeptideAtlasiP21860
PRIDEiP21860
ProteomicsDBi53934 [P21860-1]
53935 [P21860-2]
53936 [P21860-3]
53937 [P21860-4]
53938 [P21860-5]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P21860

The DNASU plasmid repository

More...
DNASUi
2065

Genome annotation databases

EnsembliENST00000267101; ENSP00000267101; ENSG00000065361 [P21860-1]
ENST00000411731; ENSP00000415753; ENSG00000065361 [P21860-2]
ENST00000415288; ENSP00000408340; ENSG00000065361 [P21860-4]
ENST00000551242; ENSP00000447510; ENSG00000065361 [P21860-3]
GeneIDi2065
KEGGihsa:2065
UCSCiuc001sjg.4 human [P21860-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2065
DisGeNETi2065

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ERBB3
HGNCiHGNC:3431 ERBB3
HPAiCAB025331
HPA045396
MalaCardsiERBB3
MIMi133180 phenotype
190151 gene
607598 phenotype
neXtProtiNX_P21860
OpenTargetsiENSG00000065361
Orphaneti137776 Lethal congenital contracture syndrome type 2
PharmGKBiPA27846

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1025 Eukaryota
ENOG410XNSR LUCA
GeneTreeiENSGT00940000156107
HOGENOMiHOG000230982
InParanoidiP21860
KOiK05084
OMAiPDPNQCC
OrthoDBi81952at2759
PhylomeDBiP21860
TreeFamiTF106002

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-1227986 Signaling by ERBB2 [P21860-1]
R-HSA-1236394 Signaling by ERBB4 [P21860-1]
R-HSA-1250196 SHC1 events in ERBB2 signaling [P21860-1]
R-HSA-1257604 PIP3 activates AKT signaling [P21860-1]
R-HSA-1306955 GRB7 events in ERBB2 signaling [P21860-1]
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling [P21860-1]
R-HSA-1963642 PI3K events in ERBB2 signaling [P21860-1]
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer [P21860-1]
R-HSA-5673001 RAF/MAP kinase cascade [P21860-1]
R-HSA-6785631 ERBB2 Regulates Cell Motility [P21860-1]
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [P21860-1]
R-HSA-8847993 ERBB2 Activates PTK6 Signaling [P21860-1]
R-HSA-8863795 Downregulation of ERBB2 signaling [P21860-1]
SignaLinkiP21860
SIGNORiP21860

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ERBB3 human
EvolutionaryTraceiP21860

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ERBB3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2065
PharosiP21860

Protein Ontology

More...
PROi
PR:P21860

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000065361 Expressed in 217 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP21860 baseline and differential
GenevisibleiP21860 HS

Family and domain databases

CDDicd00064 FU, 3 hits
Gene3Di3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR016245 Tyr_kinase_EGF/ERB/XmrK_rcpt
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF14843 GF_recep_IV, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 2 hits
PIRSFiPIRSF000619 TyrPK_EGF-R, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00261 FU, 5 hits
SUPFAMiSSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERBB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21860
Secondary accession number(s): A8K6L6
, B4DIK7, B4DV32, E9PDT8, Q9BUD7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 13, 2019
This is version 224 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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