Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor tyrosine-protein kinase erbB-3

Gene

ERBB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei742ATP1
Active sitei834Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi715 – 723ATP9
Nucleotide bindingi788 – 790ATP3
Nucleotide bindingi834 – 839ATP6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-1227986 Signaling by ERBB2
R-HSA-1236394 Signaling by ERBB4
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1306955 GRB7 events in ERBB2 signaling
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling
R-HSA-1963642 PI3K events in ERBB2 signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785631 ERBB2 Regulates Cell Motility
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847993 ERBB2 Activates PTK6 Signaling
R-HSA-8863795 Downregulation of ERBB2 signaling
SignaLinkiP21860
SIGNORiP21860

Protein family/group databases

MoonDBiP21860 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor tyrosine-protein kinase erbB-3 (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene-like protein c-ErbB-3
Tyrosine kinase-type cell surface receptor HER3
Gene namesi
Name:ERBB3
Synonyms:HER3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000065361.14
HGNCiHGNC:3431 ERBB3
MIMi190151 gene
neXtProtiNX_P21860

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 643ExtracellularSequence analysisAdd BLAST624
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 1342CytoplasmicSequence analysisAdd BLAST678

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Lethal congenital contracture syndrome 2 (LCCS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology.
See also OMIM:607598

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi742K → M: Strongly reduced autophosphorylation. 1 Publication1
Mutagenesisi868Y → E: Strongly reduced tyrosine phosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi2065
MalaCardsiERBB3
MIMi607598 phenotype
OpenTargetsiENSG00000065361
Orphaneti137776 Lethal congenital contracture syndrome type 2
PharmGKBiPA27846

Chemistry databases

ChEMBLiCHEMBL5838
GuidetoPHARMACOLOGYi1798

Polymorphism and mutation databases

BioMutaiERBB3
DMDMi119534

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001667220 – 1342Receptor tyrosine-protein kinase erbB-3Add BLAST1323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 561 Publication
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 1831 Publication
Disulfide bondi186 ↔ 1941 Publication
Disulfide bondi190 ↔ 2021 Publication
Disulfide bondi210 ↔ 2181 Publication
Disulfide bondi214 ↔ 2261 Publication
Disulfide bondi227 ↔ 2351 Publication
Disulfide bondi231 ↔ 2431 Publication
Disulfide bondi246 ↔ 2551 Publication
Glycosylationi250N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi259 ↔ 2861 Publication
Disulfide bondi290 ↔ 3011 Publication
Disulfide bondi305 ↔ 3201 Publication
Disulfide bondi323 ↔ 3271 Publication
Glycosylationi353N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi408N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi414N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi437N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi469N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi500 ↔ 5091 Publication
Disulfide bondi504 ↔ 5171 Publication
Disulfide bondi520 ↔ 5291 Publication
Glycosylationi522N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi533 ↔ 5491 Publication
Disulfide bondi552 ↔ 5651 Publication
Disulfide bondi556 ↔ 5731 Publication
Glycosylationi566N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi576 ↔ 5851 Publication
Disulfide bondi589 ↔ 610By similarity
Disulfide bondi613 ↔ 621By similarity
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi617 ↔ 629By similarity
Modified residuei686PhosphoserineCombined sources1
Modified residuei982PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP21860
MaxQBiP21860
PaxDbiP21860
PeptideAtlasiP21860
PRIDEiP21860
ProteomicsDBi53934
53935 [P21860-2]
53936 [P21860-3]
53937 [P21860-4]
53938 [P21860-5]

PTM databases

CarbonylDBiP21860
GlyConnecti1711
iPTMnetiP21860
PhosphoSitePlusiP21860

Expressioni

Tissue specificityi

Epithelial tissues and brain.

Developmental stagei

Overexpressed in a subset of human mammary tumors.

Gene expression databases

BgeeiENSG00000065361 Expressed in 217 organ(s), highest expression level in corpus callosum
CleanExiHS_ERBB3
ExpressionAtlasiP21860 baseline and differential
GenevisibleiP21860 HS

Organism-specific databases

HPAiCAB025331
HPA045396

Interactioni

Subunit structurei

Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 (PubMed:15358134). Interacts with GRB7 (PubMed:9516479). Interacts with MUC1 (PubMed:12939402). Interacts with MYOC (By similarity). Interacts with isoform 2 of PA2G4 (PubMed:11325528, PubMed:16832058). Found in a ternary complex with NRG1 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).By similarityCurated6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108377, 186 interactors
CORUMiP21860
DIPiDIP-36441N
ELMiP21860
IntActiP21860, 94 interactors
MINTiP21860
STRINGi9606.ENSP00000267101

Chemistry databases

BindingDBiP21860

Structurei

Secondary structure

11342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP21860
SMRiP21860
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21860

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini709 – 966Protein kinasePROSITE-ProRule annotationAdd BLAST258

Domaini

The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1025 Eukaryota
ENOG410XNSR LUCA
GeneTreeiENSGT00760000118799
HOGENOMiHOG000230982
HOVERGENiHBG000490
InParanoidiP21860
KOiK05084
OMAiCYHHSLN
OrthoDBiEOG091G00IX
PhylomeDBiP21860
TreeFamiTF106002

Family and domain databases

CDDicd00064 FU, 3 hits
Gene3Di3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR016245 Tyr_kinase_EGF/ERB/XmrK_rcpt
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF14843 GF_recep_IV, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 2 hits
PIRSFiPIRSF000619 TyrPK_EGF-R, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00261 FU, 5 hits
SUPFAMiSSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P21860-1) [UniParc]FASTAAdd to basket
Also known as: long form

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRANDALQVL GLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY
60 70 80 90 100
KLYERCEVVM GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP
110 120 130 140 150
NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRLTQLT EILSGGVYIE
160 170 180 190 200
KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG RSCPPCHEVC KGRCWGPGSE
210 220 230 240 250
DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD TDCFACRHFN
260 270 280 290 300
DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS
310 320 330 340 350
CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG
360 370 380 390 400
FVNCTKILGN LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ
410 420 430 440 450
SWPPHMHNFS VFSNLTTIGG RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS
460 470 480 490 500
AGRIYISANR QLCYHHSLNW TKVLRGPTEE RLDIKHNRPR RDCVAEGKVC
510 520 530 540 550
DPLCSSGGCW GPGPGQCLSC RNYSRGGVCV THCNFLNGEP REFAHEAECF
560 570 580 590 600
SCHPECQPME GTATCNGSGS DTCAQCAHFR DGPHCVSSCP HGVLGAKGPI
610 620 630 640 650
YKYPDVQNEC RPCHENCTQG CKGPELQDCL GQTLVLIGKT HLTMALTVIA
660 670 680 690 700
GLVVIFMMLG GTFLYWRGRR IQNKRAMRRY LERGESIEPL DPSEKANKVL
710 720 730 740 750
ARIFKETELR KLKVLGSGVF GTVHKGVWIP EGESIKIPVC IKVIEDKSGR
760 770 780 790 800
QSFQAVTDHM LAIGSLDHAH IVRLLGLCPG SSLQLVTQYL PLGSLLDHVR
810 820 830 840 850
QHRGALGPQL LLNWGVQIAK GMYYLEEHGM VHRNLAARNV LLKSPSQVQV
860 870 880 890 900
ADFGVADLLP PDDKQLLYSE AKTPIKWMAL ESIHFGKYTH QSDVWSYGVT
910 920 930 940 950
VWELMTFGAE PYAGLRLAEV PDLLEKGERL AQPQICTIDV YMVMVKCWMI
960 970 980 990 1000
DENIRPTFKE LANEFTRMAR DPPRYLVIKR ESGPGIAPGP EPHGLTNKKL
1010 1020 1030 1040 1050
EEVELEPELD LDLDLEAEED NLATTTLGSA LSLPVGTLNR PRGSQSLLSP
1060 1070 1080 1090 1100
SSGYMPMNQG NLGESCQESA VSGSSERCPR PVSLHPMPRG CLASESSEGH
1110 1120 1130 1140 1150
VTGSEAELQE KVSMCRSRSR SRSPRPRGDS AYHSQRHSLL TPVTPLSPPG
1160 1170 1180 1190 1200
LEEEDVNGYV MPDTHLKGTP SSREGTLSSV GLSSVLGTEE EDEDEEYEYM
1210 1220 1230 1240 1250
NRRRRHSPPH PPRPSSLEEL GYEYMDVGSD LSASLGSTQS CPLHPVPIMP
1260 1270 1280 1290 1300
TAGTTPDEDY EYMNRQRDGG GPGGDYAAMG ACPASEQGYE EMRAFQGPGH
1310 1320 1330 1340
QAPHVHYARL KTLRSLEATD SAFDNPDYWH SRLFPKANAQ RT
Length:1,342
Mass (Da):148,098
Last modified:May 1, 1991 - v1
Checksum:i7201E7F66CA374BD
GO
Isoform 2 (identifier: P21860-2) [UniParc]FASTAAdd to basket
Also known as: short form

The sequence of this isoform differs from the canonical sequence as follows:
     141-183: EILSGGVYIE...IVVKDNGRSC → GQFPMVPSGL...SKVPVTLAAV
     184-1342: Missing.

Show »
Length:183
Mass (Da):20,136
Checksum:iDA25DD25D34DE5E3
GO
Isoform 3 (identifier: P21860-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-331: C → F
     332-1342: Missing.

Show »
Length:331
Mass (Da):36,490
Checksum:i45B8EBEE683FE7E8
GO
Isoform 4 (identifier: P21860-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Show »
Length:1,283
Mass (Da):141,752
Checksum:iD40BB4459539D894
GO
Isoform 5 (identifier: P21860-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-643: Missing.

Show »
Length:699
Mass (Da):77,426
Checksum:iC7C94A8F051DCE15
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DGQ7B4DGQ7_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
921Annotation score:
F8VYK4F8VYK4_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
649Annotation score:
F8VW56F8VW56_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
583Annotation score:
F8VRL0F8VRL0_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
126Annotation score:
O75812O75812_HUMAN
ErbB-3 R31
ERBB3 c-erbB-3
81Annotation score:
B3KWG5B3KWG5_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
462Annotation score:
F8VX90F8VX90_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
115Annotation score:
F8VW48F8VW48_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
116Annotation score:
F8VRI5F8VRI5_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
43Annotation score:
A0A2R8Y6T4A0A2R8Y6T4_HUMAN
Receptor tyrosine-protein kinase er...
ERBB3
19Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti560E → G in AAA35979 (PubMed:2164210).Curated1
Sequence conflicti684G → S in BAF84370 (PubMed:14702039).Curated1
Sequence conflicti1064E → G in AAA35979 (PubMed:2164210).Curated1
Sequence conflicti1078C → S in BAG62544 (PubMed:14702039).Curated1
Sequence conflicti1163D → G in BAF84370 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04210120S → Y1 PublicationCorresponds to variant dbSNP:rs34379766Ensembl.1
Natural variantiVAR_04210230P → L1 PublicationCorresponds to variant dbSNP:rs56017157Ensembl.1
Natural variantiVAR_042103104V → M in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1057519893Ensembl.1
Natural variantiVAR_042104204T → I1 PublicationCorresponds to variant dbSNP:rs56107455Ensembl.1
Natural variantiVAR_049710385N → S. Corresponds to variant dbSNP:rs12320176Ensembl.1
Natural variantiVAR_042105683R → W1 PublicationCorresponds to variant dbSNP:rs56387488Ensembl.1
Natural variantiVAR_042106717S → L1 PublicationCorresponds to variant dbSNP:rs35961836Ensembl.1
Natural variantiVAR_042107744I → T1 PublicationCorresponds to variant dbSNP:rs55787439Ensembl.1
Natural variantiVAR_042108998K → R1 PublicationCorresponds to variant dbSNP:rs56259600Ensembl.1
Natural variantiVAR_0421091119S → C1 PublicationCorresponds to variant dbSNP:rs773123Ensembl.1
Natural variantiVAR_0421101127R → H1 PublicationCorresponds to variant dbSNP:rs2271188Ensembl.1
Natural variantiVAR_0421111177L → I1 PublicationCorresponds to variant dbSNP:rs55699040Ensembl.1
Natural variantiVAR_0421121254T → K1 PublicationCorresponds to variant dbSNP:rs55709407Ensembl.1
Natural variantiVAR_0497111271G → S. Corresponds to variant dbSNP:rs11171743Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0416611 – 643Missing in isoform 5. 1 PublicationAdd BLAST643
Alternative sequenceiVSP_0416621 – 59Missing in isoform 4. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_002893141 – 183EILSG…NGRSC → GQFPMVPSGLTPQPAQDWYL LDDDPRLLTLSASSKVPVTL AAV in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_002894184 – 1342Missing in isoform 2. 1 PublicationAdd BLAST1159
Alternative sequenceiVSP_041663331C → F in isoform 3. 2 Publications1
Alternative sequenceiVSP_041664332 – 1342Missing in isoform 3. 2 PublicationsAdd BLAST1011

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29366 mRNA Translation: AAA35790.1
M34309 mRNA Translation: AAA35979.1
S61953 mRNA Translation: AAB26935.1
BT007226 mRNA Translation: AAP35890.1
AK291681 mRNA Translation: BAF84370.1
AK295650 mRNA Translation: BAG58519.1
AK300909 mRNA Translation: BAG62544.1
AC034102 Genomic DNA No translation available.
BC002706 mRNA Translation: AAH02706.1
BC082992 mRNA Translation: AAH82992.1
CCDSiCCDS31833.1 [P21860-1]
CCDS44918.1 [P21860-2]
PIRiA36223
JH0803
RefSeqiNP_001005915.1, NM_001005915.1 [P21860-2]
NP_001973.2, NM_001982.3 [P21860-1]
UniGeneiHs.118681
Hs.622058

Genome annotation databases

EnsembliENST00000267101; ENSP00000267101; ENSG00000065361 [P21860-1]
ENST00000411731; ENSP00000415753; ENSG00000065361 [P21860-2]
ENST00000415288; ENSP00000408340; ENSG00000065361 [P21860-4]
ENST00000551242; ENSP00000447510; ENSG00000065361 [P21860-3]
GeneIDi2065
KEGGihsa:2065
UCSCiuc001sjg.4 human [P21860-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29366 mRNA Translation: AAA35790.1
M34309 mRNA Translation: AAA35979.1
S61953 mRNA Translation: AAB26935.1
BT007226 mRNA Translation: AAP35890.1
AK291681 mRNA Translation: BAF84370.1
AK295650 mRNA Translation: BAG58519.1
AK300909 mRNA Translation: BAG62544.1
AC034102 Genomic DNA No translation available.
BC002706 mRNA Translation: AAH02706.1
BC082992 mRNA Translation: AAH82992.1
CCDSiCCDS31833.1 [P21860-1]
CCDS44918.1 [P21860-2]
PIRiA36223
JH0803
RefSeqiNP_001005915.1, NM_001005915.1 [P21860-2]
NP_001973.2, NM_001982.3 [P21860-1]
UniGeneiHs.118681
Hs.622058

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M6BX-ray2.60A/B20-640[»]
2L9UNMR-A/B639-670[»]
3KEXX-ray2.80A/B698-1019[»]
3LMGX-ray2.80A/B684-1020[»]
3P11X-ray3.70A20-532[»]
4LEOX-ray2.64C20-631[»]
4OTWX-ray2.51A698-1020[»]
4P59X-ray3.40A20-640[»]
4RIWX-ray3.10A/C698-1020[»]
4RIXX-ray3.10A/C698-1020[»]
4RIYX-ray2.98A/C698-1020[»]
5CUSX-ray3.20A/B/C/D20-641[»]
5O4OX-ray3.40C1-643[»]
5O7PX-ray4.50C1-643[»]
ProteinModelPortaliP21860
SMRiP21860
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108377, 186 interactors
CORUMiP21860
DIPiDIP-36441N
ELMiP21860
IntActiP21860, 94 interactors
MINTiP21860
STRINGi9606.ENSP00000267101

Chemistry databases

BindingDBiP21860
ChEMBLiCHEMBL5838
GuidetoPHARMACOLOGYi1798

Protein family/group databases

MoonDBiP21860 Predicted

PTM databases

CarbonylDBiP21860
GlyConnecti1711
iPTMnetiP21860
PhosphoSitePlusiP21860

Polymorphism and mutation databases

BioMutaiERBB3
DMDMi119534

Proteomic databases

EPDiP21860
MaxQBiP21860
PaxDbiP21860
PeptideAtlasiP21860
PRIDEiP21860
ProteomicsDBi53934
53935 [P21860-2]
53936 [P21860-3]
53937 [P21860-4]
53938 [P21860-5]

Protocols and materials databases

DNASUi2065
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267101; ENSP00000267101; ENSG00000065361 [P21860-1]
ENST00000411731; ENSP00000415753; ENSG00000065361 [P21860-2]
ENST00000415288; ENSP00000408340; ENSG00000065361 [P21860-4]
ENST00000551242; ENSP00000447510; ENSG00000065361 [P21860-3]
GeneIDi2065
KEGGihsa:2065
UCSCiuc001sjg.4 human [P21860-1]

Organism-specific databases

CTDi2065
DisGeNETi2065
EuPathDBiHostDB:ENSG00000065361.14
GeneCardsiERBB3
HGNCiHGNC:3431 ERBB3
HPAiCAB025331
HPA045396
MalaCardsiERBB3
MIMi190151 gene
607598 phenotype
neXtProtiNX_P21860
OpenTargetsiENSG00000065361
Orphaneti137776 Lethal congenital contracture syndrome type 2
PharmGKBiPA27846
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1025 Eukaryota
ENOG410XNSR LUCA
GeneTreeiENSGT00760000118799
HOGENOMiHOG000230982
HOVERGENiHBG000490
InParanoidiP21860
KOiK05084
OMAiCYHHSLN
OrthoDBiEOG091G00IX
PhylomeDBiP21860
TreeFamiTF106002

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-1227986 Signaling by ERBB2
R-HSA-1236394 Signaling by ERBB4
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1306955 GRB7 events in ERBB2 signaling
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling
R-HSA-1963642 PI3K events in ERBB2 signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785631 ERBB2 Regulates Cell Motility
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847993 ERBB2 Activates PTK6 Signaling
R-HSA-8863795 Downregulation of ERBB2 signaling
SignaLinkiP21860
SIGNORiP21860

Miscellaneous databases

ChiTaRSiERBB3 human
EvolutionaryTraceiP21860
GeneWikiiERBB3
GenomeRNAii2065
PROiPR:P21860
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065361 Expressed in 217 organ(s), highest expression level in corpus callosum
CleanExiHS_ERBB3
ExpressionAtlasiP21860 baseline and differential
GenevisibleiP21860 HS

Family and domain databases

CDDicd00064 FU, 3 hits
Gene3Di3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR016245 Tyr_kinase_EGF/ERB/XmrK_rcpt
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF14843 GF_recep_IV, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 2 hits
PIRSFiPIRSF000619 TyrPK_EGF-R, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00261 FU, 5 hits
SUPFAMiSSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERBB3_HUMAN
AccessioniPrimary (citable) accession number: P21860
Secondary accession number(s): A8K6L6
, B4DIK7, B4DV32, E9PDT8, Q9BUD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 10, 2018
This is version 213 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again