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Protein

B-cell differentiation antigen CD72

Gene

CD72

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in B-cell proliferation and differentiation.

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-416700 Other semaphorin interactions
SIGNORiP21854

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell differentiation antigen CD72
Alternative name(s):
Lyb-2
CD_antigen: CD72
Gene namesi
Name:CD72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000137101.12
HGNCiHGNC:1696 CD72
MIMi107272 gene
neXtProtiNX_P21854

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 95CytoplasmicSequence analysisAdd BLAST95
Transmembranei96 – 116Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini117 – 359ExtracellularSequence analysisAdd BLAST243

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi971
OpenTargetsiENSG00000137101
PharmGKBiPA26235

Polymorphism and mutation databases

BioMutaiCD72
DMDMi116029

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465851 – 359B-cell differentiation antigen CD72Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Phosphotyrosine; by LYNBy similarity1
Modified residuei39Phosphotyrosine; by LYNBy similarity1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi233 ↔ 244PROSITE-ProRule annotation
Disulfide bondi261 ↔ 350PROSITE-ProRule annotation
Disulfide bondi325 ↔ 342PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP21854
PeptideAtlasiP21854
PRIDEiP21854
ProteomicsDBi53933

PTM databases

iPTMnetiP21854
PhosphoSitePlusiP21854
SwissPalmiP21854

Expressioni

Tissue specificityi

Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Gene expression databases

BgeeiENSG00000137101 Expressed in 131 organ(s), highest expression level in spleen
CleanExiHS_CD72
ExpressionAtlasiP21854 baseline and differential
GenevisibleiP21854 HS

Organism-specific databases

HPAiCAB002505
HPA044658

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107409, 10 interactors
IntActiP21854, 11 interactors
STRINGi9606.ENSP00000259633

Structurei

3D structure databases

ProteinModelPortaliP21854
SMRiP21854
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 352C-type lectinPROSITE-ProRule annotationAdd BLAST121

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00390000003668
HOGENOMiHOG000231523
HOVERGENiHBG002477
InParanoidiP21854
KOiK06504
OMAiERSCFYI
PhylomeDBiP21854
TreeFamiTF337121

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR039689 CD72-like
IPR016187 CTDL_fold
PANTHERiPTHR15028 PTHR15028, 1 hit
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P21854-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAITYADL RFVKAPLKKS ISSRLGQDPG ADDDGEITYE NVQVPAVLGV
60 70 80 90 100
PSSLASSVLG DKAAVKSEQP TASWRAVTSP AVGRILPCRT TCLRYLLLGL
110 120 130 140 150
LLTCLLLGVT AICLGVRYLQ VSQQLQQTNR VLEVTNSSLR QQLRLKITQL
160 170 180 190 200
GQSAEDLQGS RRELAQSQEA LQVEQRAHQA AEGQLQACQA DRQKTKETLQ
210 220 230 240 250
SEEQQRRALE QKLSNMENRL KPFFTCGSAD TCCPSGWIMH QKSCFYISLT
260 270 280 290 300
SKNWQESQKQ CETLSSKLAT FSEIYPQSHS YYFLNSLLPN GGSGNSYWTG
310 320 330 340 350
LSSNKDWKLT DDTQRTRTYA QSSKCNKVHK TWSWWTLESE SCRSSLPYIC

EMTAFRFPD
Length:359
Mass (Da):40,220
Last modified:May 1, 1991 - v1
Checksum:i87A52C028AC17E44
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0Y7A0A087X0Y7_HUMAN
B-cell differentiation antigen CD72
CD72
359Annotation score:
Q5T4Q8Q5T4Q8_HUMAN
B-cell differentiation antigen CD72
CD72
119Annotation score:
Q5T4Q7Q5T4Q7_HUMAN
B-cell differentiation antigen CD72
CD72
120Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033729234P → L. Corresponds to variant dbSNP:rs34791102Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54992 mRNA Translation: AAA36189.1
BC030227 mRNA Translation: AAH30227.1
CCDSiCCDS6581.1
PIRiA43532
RefSeqiNP_001773.1, NM_001782.2
UniGeneiHs.116481

Genome annotation databases

EnsembliENST00000259633; ENSP00000259633; ENSG00000137101
ENST00000396757; ENSP00000379980; ENSG00000137101
GeneIDi971
KEGGihsa:971

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54992 mRNA Translation: AAA36189.1
BC030227 mRNA Translation: AAH30227.1
CCDSiCCDS6581.1
PIRiA43532
RefSeqiNP_001773.1, NM_001782.2
UniGeneiHs.116481

3D structure databases

ProteinModelPortaliP21854
SMRiP21854
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107409, 10 interactors
IntActiP21854, 11 interactors
STRINGi9606.ENSP00000259633

PTM databases

iPTMnetiP21854
PhosphoSitePlusiP21854
SwissPalmiP21854

Polymorphism and mutation databases

BioMutaiCD72
DMDMi116029

Proteomic databases

PaxDbiP21854
PeptideAtlasiP21854
PRIDEiP21854
ProteomicsDBi53933

Protocols and materials databases

DNASUi971
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259633; ENSP00000259633; ENSG00000137101
ENST00000396757; ENSP00000379980; ENSG00000137101
GeneIDi971
KEGGihsa:971

Organism-specific databases

CTDi971
DisGeNETi971
EuPathDBiHostDB:ENSG00000137101.12
GeneCardsiCD72
HGNCiHGNC:1696 CD72
HPAiCAB002505
HPA044658
MIMi107272 gene
neXtProtiNX_P21854
OpenTargetsiENSG00000137101
PharmGKBiPA26235
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00390000003668
HOGENOMiHOG000231523
HOVERGENiHBG002477
InParanoidiP21854
KOiK06504
OMAiERSCFYI
PhylomeDBiP21854
TreeFamiTF337121

Enzyme and pathway databases

ReactomeiR-HSA-416700 Other semaphorin interactions
SIGNORiP21854

Miscellaneous databases

ChiTaRSiCD72 human
GenomeRNAii971
PROiPR:P21854
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137101 Expressed in 131 organ(s), highest expression level in spleen
CleanExiHS_CD72
ExpressionAtlasiP21854 baseline and differential
GenevisibleiP21854 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR039689 CD72-like
IPR016187 CTDL_fold
PANTHERiPTHR15028 PTHR15028, 1 hit
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD72_HUMAN
AccessioniPrimary (citable) accession number: P21854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 7, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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