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UniProtKB - P21836 (ACES_MOUSE)

Entry version 187 (07 Apr 2021)
Sequence version 1 (01 May 1991)
Previous versions | rss
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Protein

Acetylcholinesterase

Gene

Ache

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

Miscellaneous

Synapses usually contain asymmetric molecules of cholinesterase, with a collagen-like part disulfide-bonded to the catalytic part. A different, globular type of cholinesterase occurs on the outer surfaces of cell membranes, including those of erythrocytes.
This is the catalytic subunit of an asymmetric or soluble form of ACHE.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei234Acyl-ester intermediate1
Active sitei365Charge relay system1
Active sitei478Charge relay system1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Serine esterase
Biological processNeurotransmitter degradation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.1.7, 3474

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P21836

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		mouse-ACHE, AChE

MEROPS protease database

More...MEROPSi		S09.979

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acetylcholinesterase (EC:3.1.1.7)
Short name:
AChE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ache
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:87876, Ache

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3198

DrugCentral

More...DrugCentrali		P21836

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Add BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000858832 – 614AcetylcholinesteraseAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi100 ↔ 127
Disulfide bondi288 ↔ 303
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagine1
Disulfide bondi440 ↔ 560
Glycosylationi495N-linked (GlcNAc...) asparagine1
Disulfide bondi611InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P21836

PRoteomics IDEntifications database

More...PRIDEi		P21836

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		285642 [P21836-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2100, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P21836, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P21836

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P21836

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P21836

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominates in most expressing tissues except erythrocytes where a glycophospholipid-attached form of ACHE predominates.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000023328, Expressed in hypothalamus and 111 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P21836, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers (By similarity).

Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers.

By similarity2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		197921, 3 interactors

Protein interaction database and analysis system

More...IntActi		P21836, 2 interactors

Molecular INTeraction database

More...MINTi		P21836

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000024099

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P21836

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P21836, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1614
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P21836

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P21836

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4389, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157637

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P21836

Identification of Orthologs from Complete Genome Data

More...OMAi		PWCPLHT

Database of Orthologous Groups

More...OrthoDBi		754103at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P21836

TreeFam database of animal gene trees

More...TreeFami		TF315470

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR014788, AChE_tetra
IPR002018, CarbesteraseB
IPR019826, Carboxylesterase_B_AS
IPR019819, Carboxylesterase_B_CS
IPR000997, Cholinesterase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08674, AChE_tetra, 1 hit
PF00135, COesterase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00878, CHOLNESTRASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00122, CARBOXYLESTERASE_B_1, 1 hit
PS00941, CARBOXYLESTERASE_B_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform T (identifier: P21836-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPPWYPLHT PSLAFPLLFL LLSLLGGGAR AEGREDPQLL VRVRGGQLRG 
        60         70         80         90        100
IRLKAPGGPV SAFLGIPFAE PPVGSRRFMP PEPKRPWSGV LDATTFQNVC 
       110        120        130        140        150
YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPA SPTPVLIWIY 
       160        170        180        190        200
GGGFYSGAAS LDVYDGRFLA QVEGAVLVSM NYRVGTFGFL ALPGSREAPG 
       210        220        230        240        250
NVGLLDQRLA LQWVQENIAA FGGDPMSVTL FGESAGAASV GMHILSLPSR 
       260        270        280        290        300
SLFHRAVLQS GTPNGPWATV SAGEARRRAT LLARLVGCPP GGAGGNDTEL 
       310        320        330        340        350
IACLRTRPAQ DLVDHEWHVL PQESIFRFSF VPVVDGDFLS DTPEALINTG 
       360        370        380        390        400
DFQDLQVLVG VVKDEGSYFL VYGVPGFSKD NESLISRAQF LAGVRIGVPQ 
       410        420        430        440        450
ASDLAAEAVV LHYTDWLHPE DPTHLRDAMS AVVGDHNVVC PVAQLAGRLA 
       460        470        480        490        500
AQGARVYAYI FEHRASTLTW PLWMGVPHGY EIEFIFGLPL DPSLNYTTEE 
       510        520        530        540        550
RIFAQRLMKY WTNFARTGDP NDPRDSKSPQ WPPYTTAAQQ YVSLNLKPLE 
       560        570        580        590        600
VRRGLRAQTC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN 
       610 
QFDHYSKQER CSDL
Length:614
Mass (Da):68,169
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66E2512463C21172
GO
Isoform H (identifier: P21836-2)
Sequence is not available
Length:–
Mass (Da):–

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDM6A0A0G2JDM6_MOUSE
Carboxylic ester hydrolase
Ache
526Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z064D3Z064_MOUSE
Acetylcholinesterase
Ache
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X56518 mRNA Translation: CAA39867.1
AF312033 Genomic DNA Translation: AAK28816.1
BC046327 mRNA Translation: AAH46327.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS19763.1 [P21836-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JH0314

NCBI Reference Sequences

More...RefSeqi		NP_001276939.1, NM_001290010.1 [P21836-1]
NP_033729.1, NM_009599.4 [P21836-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000024099; ENSMUSP00000024099; ENSMUSG00000023328 [P21836-1]
ENSMUST00000085934; ENSMUSP00000083097; ENSMUSG00000023328 [P21836-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11423

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:11423

UCSC genome browser

More...UCSCi		uc009abt.1, mouse [P21836-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56518 mRNA Translation: CAA39867.1
AF312033 Genomic DNA Translation: AAK28816.1
BC046327 mRNA Translation: AAH46327.1
CCDSiCCDS19763.1 [P21836-1]
PIRiJH0314
RefSeqiNP_001276939.1, NM_001290010.1 [P21836-1]
NP_033729.1, NM_009599.4 [P21836-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C2BX-ray4.50A35-574[»]
1C2OX-ray4.20A/B/C/D36-574[»]
1J06X-ray2.35A/B32-574[»]
1J07X-ray2.35A/B32-574[»]
1KU6X-ray2.50A32-580[»]
1MAAX-ray2.90A/B/C/D32-578[»]
1MAHX-ray3.20A32-574[»]
1N5MX-ray2.20A/B32-572[»]
1N5RX-ray2.25A/B32-574[»]
1Q83X-ray2.65A/B1-580[»]
1Q84X-ray2.45A/B1-580[»]
2C0PX-ray2.50A/B32-574[»]
2C0QX-ray2.50A/B32-574[»]
2GYUX-ray2.20A/B32-574[»]
2GYVX-ray2.50A/B32-574[»]
2GYWX-ray2.40A/B32-574[»]
2H9YX-ray2.40A/B32-574[»]
2HA0X-ray2.20A/B32-574[»]
2HA2X-ray2.05A/B32-574[»]
2HA3X-ray2.25A/B32-574[»]
2HA4X-ray2.56A/B32-574[»]
2HA5X-ray2.15A/B32-574[»]
2HA6X-ray2.25A/B32-574[»]
2HA7X-ray2.66A/B32-574[»]
2JEYX-ray2.70A/B32-574[»]
2JEZX-ray2.60A/B32-574[»]
2JF0X-ray2.50A/B32-574[»]
2JGEX-ray2.60A/B32-574[»]
2JGFX-ray2.50A/B32-574[»]
2JGIX-ray2.90A/B32-574[»]
2JGJX-ray2.50A/B32-574[»]
2JGKX-ray2.90A/B32-574[»]
2JGLX-ray2.60A/B32-574[»]
2JGMX-ray2.90A/B32-574[»]
2WHPX-ray2.20A/B32-573[»]
2WHQX-ray2.15A/B32-574[»]
2WHRX-ray2.54A/B32-574[»]
2WLSX-ray2.60A/B32-574[»]
2WU3X-ray2.70A/B32-574[»]
2WU4X-ray2.40A/B32-574[»]
2XUDX-ray2.65A/B32-574[»]
2XUFX-ray2.55A/B32-575[»]
2XUGX-ray2.60A/B32-575[»]
2XUHX-ray2.65A/B32-574[»]
2XUIX-ray2.60A/B32-574[»]
2XUJX-ray2.65A/B32-574[»]
2XUKX-ray2.75A/B32-574[»]
2XUOX-ray2.80A/B32-574[»]
2XUPX-ray2.70A/B32-574[»]
2XUQX-ray2.70A/B32-574[»]
2Y2UX-ray2.60A/B32-574[»]
2Y2VX-ray2.45A/B32-574[»]
3DL4X-ray2.50A/B32-574[»]
3DL7X-ray2.50A/B32-574[»]
3ZLTX-ray2.60A/B32-574[»]
3ZLUX-ray2.60A/B32-574[»]
3ZLVX-ray2.50A/B32-574[»]
4A16X-ray2.65A/B/C/D35-574[»]
4A23X-ray2.40A/B32-574[»]
4ARAX-ray2.50A/B32-574[»]
4ARBX-ray2.25A/B32-574[»]
4B7ZX-ray2.30A/B32-574[»]
4B80X-ray2.50A/B32-574[»]
4B81X-ray2.80A/B32-574[»]
4B82X-ray2.10A/B32-574[»]
4B83X-ray2.40A/B32-574[»]
4B84X-ray2.60A/B32-574[»]
4B85X-ray2.10A/B32-574[»]
4BC0X-ray3.35A/B/C/D32-574[»]
4BC1X-ray2.95A/B/C/D32-574[»]
4BTLX-ray2.50A/B32-574[»]
5DTIX-ray2.00A/B32-573[»]
5DTJX-ray2.71A/B32-573[»]
5EHNX-ray2.60A/B32-574[»]
5EHQX-ray2.50A/B32-574[»]
5EHZX-ray2.50A/B32-574[»]
5EIAX-ray2.70A/B32-574[»]
5EIEX-ray2.10A/B32-574[»]
5EIHX-ray2.70A/B32-574[»]
5FKJX-ray3.13A/B/C/D32-574[»]
5FPPX-ray2.40A/B32-574[»]
5FUMX-ray2.50A/B32-574[»]
5HCUX-ray2.42A/B32-571[»]
5OV9X-ray2.40A/B32-574[»]
6FSDX-ray2.70A/B32-574[»]
6FSEX-ray2.70A/B32-574[»]
6TD2X-ray2.80A/B32-574[»]
SMRiP21836
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi197921, 3 interactors
IntActiP21836, 2 interactors
MINTiP21836
STRINGi10090.ENSMUSP00000024099

Chemistry databases

BindingDBiP21836
ChEMBLiCHEMBL3198
DrugCentraliP21836

Protein family/group databases

ESTHERimouse-ACHE, AChE
MEROPSiS09.979

PTM databases

GlyConnecti2100, 2 N-Linked glycans (1 site)
GlyGeniP21836, 3 sites
iPTMnetiP21836
PhosphoSitePlusiP21836
SwissPalmiP21836

Proteomic databases

PaxDbiP21836
PRIDEiP21836
ProteomicsDBi285642 [P21836-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16701, 764 antibodies

Genome annotation databases

EnsembliENSMUST00000024099; ENSMUSP00000024099; ENSMUSG00000023328 [P21836-1]
ENSMUST00000085934; ENSMUSP00000083097; ENSMUSG00000023328 [P21836-1]
GeneIDi11423
KEGGimmu:11423
UCSCiuc009abt.1, mouse [P21836-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		43
MGIiMGI:87876, Ache

Phylogenomic databases

eggNOGiKOG4389, Eukaryota
GeneTreeiENSGT00940000157637
InParanoidiP21836
OMAiPWCPLHT
OrthoDBi754103at2759
PhylomeDBiP21836
TreeFamiTF315470

Enzyme and pathway databases

BRENDAi3.1.1.7, 3474
SABIO-RKiP21836

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11423, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ache, mouse
EvolutionaryTraceiP21836

Protein Ontology

More...PROi		PR:P21836
RNActiP21836, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000023328, Expressed in hypothalamus and 111 other tissues
GenevisibleiP21836, MM

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR014788, AChE_tetra
IPR002018, CarbesteraseB
IPR019826, Carboxylesterase_B_AS
IPR019819, Carboxylesterase_B_CS
IPR000997, Cholinesterase
PfamiView protein in Pfam
PF08674, AChE_tetra, 1 hit
PF00135, COesterase, 1 hit
PRINTSiPR00878, CHOLNESTRASE
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122, CARBOXYLESTERASE_B_1, 1 hit
PS00941, CARBOXYLESTERASE_B_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACES_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21836
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 7, 2021
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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