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Protein

Fibroin light chain

Gene

FIBL

Organism
Bombyx mori (Silk moth)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

It is likely that the major role of L-chain is to prevent the retention of H-chain in ER by forming the disulfide linkage.

Keywordsi

Molecular functionSilk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroin light chain
Short name:
Fib-L
Alternative name(s):
L-fibroin
Cleaved into the following chain:
Gene namesi
Name:FIBL
OrganismiBombyx mori (Silk moth)
Taxonomic identifieri7091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
Proteomesi
  • UP000005204 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000002125617 – 262Fibroin light chainAdd BLAST246
ChainiPRO_000038955919 – 262Fibroin light chain, short formAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19N-acetylserine; in short form1 Publication1
Disulfide bondi101 ↔ 160Sequence analysis
Disulfide bondi190Interchain (with C-5244 in heavy chain)

Post-translational modificationi

The interchain disulfide bridge is essential for the intracellular transport and secretion of fibroin.
Partially N-terminally processed to yield a short form which lacks the first two residues of the long form.

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PRIDEiP21828

PTM databases

iPTMnetiP21828

Expressioni

Tissue specificityi

Produced exclusively in the posterior (PSG) section of silk glands, which are essentially modified salivary glands.

Interactioni

Subunit structurei

Silk fibroin elementary unit consists in a disulfide-linked heavy and light chain and a p25 glycoprotein in molar ratios of 6:6:1. This results in a complex of approximately 2.3 MDa.1 Publication

Protein-protein interaction databases

STRINGi7091.BGIBMGA009393-TA

Structurei

3D structure databases

ProteinModelPortaliP21828
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KH5Y Eukaryota
ENOG4110RKT LUCA
InParanoidiP21828
OMAiNEEYCAA

Family and domain databases

InterProiView protein in InterPro
IPR008660 L-fibroin
PfamiView protein in Pfam
PF05849 L-fibroin, 1 hit
PIRSFiPIRSF005765 L-fibroin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21828-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPIFLVLLV ATSAYAAPSV TINQYSDNEI PRDIDDGKAS SVISRAWDYV
60 70 80 90 100
DDTDKSIAIL NVQEILKDMA SQGDYASQAS AVAQTAGIIA HLSAGIPGDA
110 120 130 140 150
CAAANVINSY TDGVRSGNFA GFRQSLGPFF GHVGQNLNLI NQLVINPGQL
160 170 180 190 200
RYSVGPALGC AGGGRIYDFE AAWDAILASS DSSFLNEEYC IVKRLYNSRN
210 220 230 240 250
SQSNNIAAYI TAHLLPPVAQ VFHQSAGSIT DLLRGVGNGN DATGLVANAQ
260
RYIAQAASQV HV
Length:262
Mass (Da):27,669
Last modified:May 1, 1991 - v1
Checksum:i66C68F8BE453B349
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46A → R in AAA27840 (PubMed:1347033).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17291 mRNA Translation: CAA35180.1
CK545649 mRNA No translation available.
CK545775 mRNA No translation available.
M76430 Genomic DNA Translation: AAA27840.1
PIRiA33470
RefSeqiNP_001037488.1, NM_001044023.1
UniGeneiBmo.3038
Bmo.6952

Genome annotation databases

EnsemblMetazoaiBGIBMGA009393-RA; BGIBMGA009393-TA; BGIBMGA009393
GeneIDi693047
KEGGibmor:693047

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17291 mRNA Translation: CAA35180.1
CK545649 mRNA No translation available.
CK545775 mRNA No translation available.
M76430 Genomic DNA Translation: AAA27840.1
PIRiA33470
RefSeqiNP_001037488.1, NM_001044023.1
UniGeneiBmo.3038
Bmo.6952

3D structure databases

ProteinModelPortaliP21828
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7091.BGIBMGA009393-TA

PTM databases

iPTMnetiP21828

Proteomic databases

PRIDEiP21828

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiBGIBMGA009393-RA; BGIBMGA009393-TA; BGIBMGA009393
GeneIDi693047
KEGGibmor:693047

Organism-specific databases

CTDi693047

Phylogenomic databases

eggNOGiENOG410KH5Y Eukaryota
ENOG4110RKT LUCA
InParanoidiP21828
OMAiNEEYCAA

Family and domain databases

InterProiView protein in InterPro
IPR008660 L-fibroin
PfamiView protein in Pfam
PF05849 L-fibroin, 1 hit
PIRSFiPIRSF005765 L-fibroin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFIBL_BOMMO
AccessioniPrimary (citable) accession number: P21828
Secondary accession number(s): Q17224
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 25, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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