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Entry version 167 (10 Feb 2021)
Sequence version 2 (05 Oct 2010)
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Protein

Malate synthase 2

Gene

DAL7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Allantoin metabolism-specific malate synthase involved in the recycling the glyoxylate generated during allantoin degradation by the ureidoglycollate (UG) hydrolase reaction.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei177Proton acceptorBy similarity1
Active sitei457Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • malate synthase activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processGlyoxylate bypass, Purine metabolism, Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:YIR031C-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Malate synthase 21 Publication (EC:2.3.3.9By similarity)
Alternative name(s):
Degradation of allantoin protein 71 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DAL71 Publication
Synonyms:MLS21 Publication
Ordered Locus Names:YIR031C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001470, DAL7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YIR031C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Diminishes the ureidoglycollate hydrolase activity by 3 to 4 fold.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001668651 – 554Malate synthase 2Add BLAST554

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P21826

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21826

PRoteomics IDEntifications database

More...
PRIDEi
P21826

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is insensitive to carbon catabolite repression, but highly sensitive to nitrogen catabolite repression (PubMed:8462696). Its expression is induced by allophanate or oxalurate (PubMed:3915539).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PEX9.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35022, 27 interactors

Database of interacting proteins

More...
DIPi
DIP-6744N

Protein interaction database and analysis system

More...
IntActi
P21826, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4932.YIR031C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P21826, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21826

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi552 – 554SKL peroxisome targeting motif1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the malate synthase family.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1261, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174673

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018928_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21826

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHKRGAP

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00727, malate_synt_A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011076, Malate_synth-like_sf
IPR006252, Malate_synthA
IPR001465, Malate_synthase
IPR019830, Malate_synthase_CS

The PANTHER Classification System

More...
PANTHERi
PTHR42902, PTHR42902, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01274, Malate_synthase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001363, Malate_synth, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51645, SSF51645, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01344, malate_syn_A, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00510, MALATE_SYNTHASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21826-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKISLDNTA LYADIDTTPQ FEPSKTTVAD ILTKDALEFI VLLHRTFNST
60 70 80 90 100
RKQLLANRSN LQSKLDSGEY RFDFLPETEQ IRNDPTWQGA IPAPGLINRS
110 120 130 140 150
SEITGPPLRN MLVNALNAEV TTYMTDFEDS SSPTWENMIY GQVNLYDAIR
160 170 180 190 200
NQIDFKTPRK EYRLKDDISR LPTLIVRPRG WHMVEKHLYI DDEPISASIF
210 220 230 240 250
DFGLYFYHNA KELVKIGKGP YFYLPKMEHH MEVKLWNDIF CVAQDFIGMP
260 270 280 290 300
RGTIRATVLI ETLPAAFQME EIIYQIREHS SGLNCGRWDY IFSTIKKLRN
310 320 330 340 350
LPEHVLPNRD LVTMTSPFMD AYVKRLINTC HRRGVHAMGG MAAQIPIKDD
360 370 380 390 400
PKANEAAMNK VRNDKIREMK NGHDGSWVAH PALAPICNEV FSNMGTANQI
410 420 430 440 450
YFVPDVHVTS SDLLNTKIQD AQVTTEGIRV NLDIGLQYME AWLRGSGCVP
460 470 480 490 500
INHLMEDAAT AEVSRCQLYQ WVKHGVVLSD TGDKVTPELT AKILNEETAK
510 520 530 540 550
LASASPLGEK NKFALAAKYF LPEVTGKIFS DFLTTLLYDE IIKPSAKPVD

LSKL
Length:554
Mass (Da):62,794
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i006BB05371CA96CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti115A → D in AAA50351 (PubMed:2552287).Curated1
Sequence conflicti115A → D no nucleotide entry (PubMed:8462696).Curated1
Sequence conflicti166D → G in AAA50351 (PubMed:2552287).Curated1
Sequence conflicti166D → G no nucleotide entry (PubMed:8462696).Curated1
Sequence conflicti302P → N in AAA50351 (PubMed:2552287).Curated1
Sequence conflicti302P → N no nucleotide entry (PubMed:8462696).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M28124 Genomic DNA Translation: AAA50351.1
Z38061 Genomic DNA Translation: CAA86191.1
BK006942 Genomic DNA Translation: DAA08578.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S48493

NCBI Reference Sequences

More...
RefSeqi
NP_012297.3, NM_001179553.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YIR031C_mRNA; YIR031C; YIR031C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854849

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YIR031C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28124 Genomic DNA Translation: AAA50351.1
Z38061 Genomic DNA Translation: CAA86191.1
BK006942 Genomic DNA Translation: DAA08578.1
PIRiS48493
RefSeqiNP_012297.3, NM_001179553.3

3D structure databases

SMRiP21826
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35022, 27 interactors
DIPiDIP-6744N
IntActiP21826, 1 interactor
STRINGi4932.YIR031C

Proteomic databases

MaxQBiP21826
PaxDbiP21826
PRIDEiP21826

Genome annotation databases

EnsemblFungiiYIR031C_mRNA; YIR031C; YIR031C
GeneIDi854849
KEGGisce:YIR031C

Organism-specific databases

SGDiS000001470, DAL7
VEuPathDBiFungiDB:YIR031C

Phylogenomic databases

eggNOGiKOG1261, Eukaryota
GeneTreeiENSGT00940000174673
HOGENOMiCLU_018928_3_0_1
InParanoidiP21826
OMAiCHKRGAP

Enzyme and pathway databases

BioCyciMetaCyc:YIR031C-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P21826
RNActiP21826, protein

Family and domain databases

CDDicd00727, malate_synt_A, 1 hit
InterProiView protein in InterPro
IPR011076, Malate_synth-like_sf
IPR006252, Malate_synthA
IPR001465, Malate_synthase
IPR019830, Malate_synthase_CS
PANTHERiPTHR42902, PTHR42902, 1 hit
PfamiView protein in Pfam
PF01274, Malate_synthase, 1 hit
PIRSFiPIRSF001363, Malate_synth, 1 hit
SUPFAMiSSF51645, SSF51645, 1 hit
TIGRFAMsiTIGR01344, malate_syn_A, 1 hit
PROSITEiView protein in PROSITE
PS00510, MALATE_SYNTHASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLS2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21826
Secondary accession number(s): D6VVW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: October 5, 2010
Last modified: February 10, 2021
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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