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Entry version 127 (12 Aug 2020)
Sequence version 2 (14 Dec 2011)
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Protein

Methyl-accepting chemotaxis serine transducer

Gene

tse

Organism
Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006) (Enterobacter aerogenes)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the attractant L-serine and related amino acids.
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer
Biological processChemotaxis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EAER1028307:G1GYC-3171-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methyl-accepting chemotaxis serine transducer
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tse
Ordered Locus Names:EAE_15535
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKlebsiella aerogenes (strain ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006) (Enterobacter aerogenes)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1028307 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008881 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 191PeriplasmicSequence analysisAdd BLAST161
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 556CytoplasmicSequence analysisAdd BLAST344

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001105431 – 556Methyl-accepting chemotaxis serine transducerAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei297Glutamate methyl ester (Gln)By similarity1
Modified residuei304Glutamate methyl ester (Glu)By similarity1
Modified residuei311Glutamate methyl ester (Gln)By similarity1
Modified residuei493Glutamate methyl ester (Glu)By similarity1
Modified residuei502Glutamate methyl ester (Glu)By similarity1

Keywords - PTMi

Methylation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1028307.EAE_15535

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21822

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini216 – 268HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini273 – 502Methyl-accepting transducerPROSITE-ProRule annotationAdd BLAST230

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni64 – 73The 3 Arg may form a positively charged pocket, which binds the alpha-carboxyl group of the attractant AABy similarity10

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0840, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000445_107_16_6

KEGG Orthology (KO)

More...
KOi
K05874

Identification of Orthologs from Complete Genome Data

More...
OMAi
QAIWVLI

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06225, HAMP, 1 hit
cd00181, Tar_Tsr_LBD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035440, 4HB_MCP_dom_sf
IPR004090, Chemotax_Me-accpt_rcpt
IPR004091, Chemotax_Me-accpt_rcpt_Me-site
IPR003660, HAMP_dom
IPR004089, MCPsignal_dom
IPR003122, Tar_rcpt_lig-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00672, HAMP, 1 hit
PF00015, MCPsignal, 1 hit
PF02203, TarH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00260, CHEMTRNSDUCR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00304, HAMP, 1 hit
SM00283, MA, 1 hit
SM00319, TarH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47170, SSF47170, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00538, CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111, CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885, HAMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21822-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNRIKVVTS LLLVLVLFGA LQLISGGLFF SSLKSDKENF TVLQTIRQQQ
60 70 80 90 100
LLLSESRVDL LQARNSLNRA GIRYMMDTNK IGSGATIDEL LAKAKEELAR
110 120 130 140 150
AERNYTAYEK IPQDPRQDPQ ATEKLKQQYG ILYGALSELI QLLGEGKINA
160 170 180 190 200
FFDQPTQKYQ DDFEQTYNAY LQQNGKLYQI AVDASNSSYS SAIWTLIVVI
210 220 230 240 250
IVVLAAIVGV WMGIHHILVR PLNRMIEHIK RIASGDLTQP IPVTSRNEIG
260 270 280 290 300
VLAASLKHMQ NELIETVSGV RQGADAIYSG ASEIAAGNND LSSRTEQQAA
310 320 330 340 350
SLEETAASME QLTATVKQNA ENARQASQLA LSASETAQKG GKVVANVVET
360 370 380 390 400
MHDIASSSQK IADITGVIDG IAFQTNILAL NAAVEAARAG EQGRGFAVVA
410 420 430 440 450
GEVRNLAQRS AQAAKEIKAL IEDSVNRVDM GSVLVESAGD TMGDIVNAVT
460 470 480 490 500
RVTDIMGEIA SASDEQSRGI DQVGQAVAEM DRVTQQNASL VEESASAAAA
510 520 530 540 550
LEEQASLLTQ SVAVFRLKSE GQEEYKAPVS NKTAPAAIAT HKKTSASDYQ

DNWETF
Length:556
Mass (Da):60,038
Last modified:December 14, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2DE0FCA1865C9A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35S → G in AAA24797 (PubMed:2496104).Curated1
Sequence conflicti94A → AE in AAA24797 (PubMed:2496104).Curated1
Sequence conflicti97E → K in AAA24797 (PubMed:2496104).Curated1
Sequence conflicti145 – 146EG → GGC in AAA24797 (PubMed:2496104).Curated2
Sequence conflicti276 – 279AIYS → RSID in AAA24797 (PubMed:2496104).Curated4
Sequence conflicti284I → S in AAA24797 (PubMed:2496104).Curated1
Sequence conflicti301S → A in AAA24797 (PubMed:2496104).Curated1
Sequence conflicti370G → V in AAA24797 (PubMed:2496104).Curated1
Sequence conflicti395G → A in AAA24797 (PubMed:2496104).Curated1
Sequence conflicti478A → R in AAA24797 (PubMed:2496104).Curated1
Sequence conflicti500Missing in AAA24797 (PubMed:2496104).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M26411 Genomic DNA Translation: AAA24797.1
CP002824 Genomic DNA Translation: AEG98018.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C32302

NCBI Reference Sequences

More...
RefSeqi
WP_015367342.1, NC_015663.1
YP_004593297.1, NC_015663.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AEG98018; AEG98018; EAE_15535

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51771982

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
eae:EAE_15535

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1028307.3.peg.3107

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26411 Genomic DNA Translation: AAA24797.1
CP002824 Genomic DNA Translation: AEG98018.1
PIRiC32302
RefSeqiWP_015367342.1, NC_015663.1
YP_004593297.1, NC_015663.1

3D structure databases

SMRiP21822
ModBaseiSearch...

Protein-protein interaction databases

STRINGi1028307.EAE_15535

Genome annotation databases

EnsemblBacteriaiAEG98018; AEG98018; EAE_15535
GeneIDi51771982
KEGGieae:EAE_15535
PATRICifig|1028307.3.peg.3107

Phylogenomic databases

eggNOGiCOG0840, Bacteria
HOGENOMiCLU_000445_107_16_6
KOiK05874
OMAiQAIWVLI

Enzyme and pathway databases

BioCyciEAER1028307:G1GYC-3171-MONOMER

Family and domain databases

CDDicd06225, HAMP, 1 hit
cd00181, Tar_Tsr_LBD, 1 hit
InterProiView protein in InterPro
IPR035440, 4HB_MCP_dom_sf
IPR004090, Chemotax_Me-accpt_rcpt
IPR004091, Chemotax_Me-accpt_rcpt_Me-site
IPR003660, HAMP_dom
IPR004089, MCPsignal_dom
IPR003122, Tar_rcpt_lig-bd
PfamiView protein in Pfam
PF00672, HAMP, 1 hit
PF00015, MCPsignal, 1 hit
PF02203, TarH, 1 hit
PRINTSiPR00260, CHEMTRNSDUCR
SMARTiView protein in SMART
SM00304, HAMP, 1 hit
SM00283, MA, 1 hit
SM00319, TarH, 1 hit
SUPFAMiSSF47170, SSF47170, 1 hit
PROSITEiView protein in PROSITE
PS00538, CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111, CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885, HAMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCPS_KLEAK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21822
Secondary accession number(s): G0DZQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: December 14, 2011
Last modified: August 12, 2020
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
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