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Protein

Peripherin

Gene

Prph

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Class-III neuronal intermediate filament protein.

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • structural molecule activity Source: InterPro

GO - Biological processi

  • intermediate filament cytoskeleton organization Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Peripherin
Gene namesi
Name:Prph
Synonyms:Prph1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3414 Prph

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637811 – 468PeripherinAdd BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Nitrated tyrosine1 Publication1
Modified residuei28PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei376Nitrated tyrosine1 Publication1
Modified residuei468Phosphotyrosine1 Publication1

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

PaxDbiP21807
PeptideAtlasiP21807
PRIDEiP21807

PTM databases

iPTMnetiP21807
PhosphoSitePlusiP21807

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DstQ91ZU63EBI-446227,EBI-446159From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP21807, 3 interactors
MINTiP21807
STRINGi10116.ENSRNOP00000021010

Structurei

3D structure databases

ProteinModelPortaliP21807
SMRiP21807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 404IF rodPROSITE-ProRule annotationAdd BLAST311

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 96HeadAdd BLAST96
Regioni97 – 129Coil 1AAdd BLAST33
Regioni130 – 140Linker 1Add BLAST11
Regioni141 – 236Coil 1BAdd BLAST96
Regioni237 – 259Linker 2Add BLAST23
Regioni260 – 402Coil 2Add BLAST143
Regioni403 – 468TailAdd BLAST66

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE39 Eukaryota
ENOG410YCMG LUCA
HOGENOMiHOG000230977
HOVERGENiHBG013015
InParanoidiP21807
PhylomeDBiP21807

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR006821 Intermed_filament_DNA-bd
IPR002957 Keratin_I
IPR027700 PRPH/Plasticin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF29 PTHR23239:SF29, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF04732 Filament_head, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P21807-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHHSSGLRS SISSTSYRRT FGPPPSLSPG AFSYSSSSRF SSSRLLGSGS
60 70 80 90 100
PSSSARLGSF RAPRAGALRL PSERLDFSMA EALNQEFLAT RSNEKQELQE
110 120 130 140 150
LNDRFANFIE KVRFLEQQNA ALRGELSQAR GQEPARADQL CQQELRELRR
160 170 180 190 200
ELELLGRERD RVQVERDGLA EDLGALKQRL EEETRKREDA EHNLVLFRKD
210 220 230 240 250
VDDATLSRLE LERKIESLMD EIEFLKKLHE EELRDLQVSV ESQQVQQVEV
260 270 280 290 300
EATVKPELTA ALRDIRAQYE NIAAKNLQEA EEWYKSKYAD LSDAANRNHE
310 320 330 340 350
ALRQAKQEMN ESRRQIQSLT CEVDGLRGTN EALLRQLREL EEQFALEAGG
360 370 380 390 400
YQAGAARLEE ELRQLKEEMA RHLREYQELL NVKMALDIEI ATYRKLLEGE
410 420 430 440 450
ESRISVPVHS FASLSLKTTV PEVEPPQDSH SRKMVLIRTI ETRDGEKVVT
460
ESQKEQHSEL DKSSIHSY
Length:468
Mass (Da):53,550
Last modified:May 1, 1991 - v1
Checksum:iE42543338EBA5C05
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M7P4F1M7P4_RAT
Peripherin
Prph
473Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158 – 160ERD → SAY (PubMed:3339087).Curated3
Sequence conflicti291L → K (PubMed:3339087).Curated1
Sequence conflicti436L → K (PubMed:3339087).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26232 Genomic DNA Translation: AAA41829.1
AF031878 mRNA Translation: AAB87067.1
PIRiJN0016
UniGeneiRn.11086

Genome annotation databases

UCSCiRGD:3414 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26232 Genomic DNA Translation: AAA41829.1
AF031878 mRNA Translation: AAB87067.1
PIRiJN0016
UniGeneiRn.11086

3D structure databases

ProteinModelPortaliP21807
SMRiP21807
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21807, 3 interactors
MINTiP21807
STRINGi10116.ENSRNOP00000021010

PTM databases

iPTMnetiP21807
PhosphoSitePlusiP21807

Proteomic databases

PaxDbiP21807
PeptideAtlasiP21807
PRIDEiP21807

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3414 rat

Organism-specific databases

RGDi3414 Prph

Phylogenomic databases

eggNOGiENOG410IE39 Eukaryota
ENOG410YCMG LUCA
HOGENOMiHOG000230977
HOVERGENiHBG013015
InParanoidiP21807
PhylomeDBiP21807

Miscellaneous databases

PROiPR:P21807

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR006821 Intermed_filament_DNA-bd
IPR002957 Keratin_I
IPR027700 PRPH/Plasticin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF29 PTHR23239:SF29, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF04732 Filament_head, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPERI_RAT
AccessioniPrimary (citable) accession number: P21807
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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