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Entry version 214 (08 May 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Voltage-dependent anion-selective channel protein 1

Gene

VDAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).6 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by nitric oxide.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei73Critical for channel structural stability and gating1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi242 – 244NAD1 Publication3
Nucleotide bindingi260 – 264NAD1 Publication5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionPorin
Biological processApoptosis, Host-virus interaction, Ion transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-5689880 Ub-specific processing proteases
R-HSA-70268 Pyruvate metabolism
R-HSA-8949215 Mitochondrial calcium ion transport

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P21796

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 1
Short name:
VDAC-1
Short name:
hVDAC1
Alternative name(s):
Outer mitochondrial membrane protein porin 1
Plasmalemmal porin
Porin 31HL
Porin 31HM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VDAC1
Synonyms:VDAC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12669 VDAC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604492 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21796

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 35Beta stranded2 Publications10
Transmembranei39 – 47Beta stranded2 Publications9
Transmembranei54 – 64Beta stranded2 PublicationsAdd BLAST11
Transmembranei69 – 76Beta stranded2 Publications8
Transmembranei80 – 89Beta stranded2 Publications10
Transmembranei95 – 104Beta stranded2 Publications10
Transmembranei111 – 120Beta stranded2 Publications10
Transmembranei123 – 130Beta stranded2 Publications8
Transmembranei137 – 145Beta stranded2 Publications9
Transmembranei150 – 158Beta stranded2 Publications9
Transmembranei163 – 175Beta stranded2 PublicationsAdd BLAST13
Transmembranei178 – 185Beta stranded2 Publications8
Transmembranei189 – 198Beta stranded2 Publications10
Transmembranei202 – 211Beta stranded2 Publications10
Transmembranei218 – 227Beta stranded2 Publications10
Transmembranei231 – 238Beta stranded2 Publications8
Transmembranei242 – 251Beta stranded2 Publications10
Transmembranei254 – 263Beta stranded2 Publications10
Transmembranei273 – 282Beta stranded2 Publications10

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi193S → A: Conformation remains open and constitutively allows cytochrome c efflux. 1 Publication1
Mutagenesisi193S → E: Conformation remains closed and prevents cytochrome c leakage. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7416
MIMi604492 gene+phenotype

Open Targets

More...
OpenTargetsi
ENSG00000213585

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37292

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01375 Aluminium monostearate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VDAC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
130683

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources4 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000504992 – 283Voltage-dependent anion-selective channel protein 1Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei13PhosphoserineBy similarity1
Modified residuei19PhosphothreonineBy similarity1
Modified residuei20N6-acetyllysine; alternateCombined sources1
Modified residuei20N6-succinyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei67PhosphotyrosineBy similarity1
Modified residuei107PhosphothreonineCombined sources1
Modified residuei109N6-acetyllysine; alternateBy similarity1
Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki161Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei193Phosphoserine; by NEK11 Publication1
Modified residuei240PhosphoserineCombined sources1
Modified residuei252N6-acetyllysineBy similarity1
Modified residuei266N6-acetyllysine; alternateCombined sources1
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. Phosphorylation by the AKT-GSK3B axis stabilizes the protein probably by preventing ubiquitin-mediated proteasomal degradation.1 Publication
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P21796

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P21796

MaxQB - The MaxQuant DataBase

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MaxQBi
P21796

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P21796

PeptideAtlas

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PeptideAtlasi
P21796

PRoteomics IDEntifications database

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PRIDEi
P21796

ProteomicsDB human proteome resource

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ProteomicsDBi
53904

Consortium for Top Down Proteomics

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TopDownProteomicsi
P21796

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P21796

USC-OGP 2-DE database

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OGPi
P21796

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00216308
P21796

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P21796

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P21796

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P21796

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21796

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P21796

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Heart, liver and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213585 Expressed in 226 organ(s), highest expression level in biceps brachii

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P21796 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P21796 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005885
CAB072343
HPA030780

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hexokinases including HK1 (PubMed:8420959, PubMed:22304920). The HK1-VDAC1 complex interacts with ATF2 (PubMed:22304920). Interacts with BCL2L1 (PubMed:18755977, PubMed:25296756). Interacts with BAK1 (PubMed:25296756). Interacts with RTL10/BOP (via BH3 domain) (PubMed:23055042). Interacts with amyloid-beta and APP; induces VDAC1 dephosphorylation (PubMed:25168729). Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF (PubMed:26387735). Interacts with SPG7, NIPSNAP2 and SLC25A30 (PubMed:26387735).7 Publications
(Microbial infection) Interacts with influenza A virus PB1-F2 protein.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113259, 294 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P21796

Database of interacting proteins

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DIPi
DIP-32862N

Protein interaction database and analysis system

More...
IntActi
P21796, 214 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000265333

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1283
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JK4X-ray4.10A2-283[»]
2K4TNMR-A1-283[»]
5JDPNMR-A2-283[»]
5XDNX-ray3.15A/B1-283[»]
5XDOX-ray3.10A/B1-283[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P21796

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P21796

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3126 Eukaryota
ENOG410ZBK1 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000188277

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P21796

KEGG Orthology (KO)

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KOi
K05862

Identification of Orthologs from Complete Genome Data

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OMAi
KYKWAEH

Database of Orthologous Groups

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OrthoDBi
938262at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P21796

TreeFam database of animal gene trees

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TreeFami
TF315091

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023614 Porin_dom_sf
IPR001925 Porin_Euk
IPR027246 Porin_Euk/Tom40
IPR030270 VDAC1

The PANTHER Classification System

More...
PANTHERi
PTHR11743 PTHR11743, 1 hit
PTHR11743:SF13 PTHR11743:SF13, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01459 Porin_3, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00185 EUKARYTPORIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00558 EUKARYOTIC_PORIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P21796-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE
60 70 80 90 100
TTKVTGSLET KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD
110 120 130 140 150
SSFSPNTGKK NAKIKTGYKR EHINLGCDMD FDIAGPSIRG ALVLGYEGWL
160 170 180 190 200
AGYQMNFETA KSRVTQSNFA VGYKTDEFQL HTNVNDGTEF GGSIYQKVNK
210 220 230 240 250
KLETAVNLAW TAGNSNTRFG IAAKYQIDPD ACFSAKVNNS SLIGLGYTQT
260 270 280
LKPGIKLTLS ALLDGKNVNA GGHKLGLGLE FQA
Length:283
Mass (Da):30,773
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89BA3378B04020D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JI87C9JI87_HUMAN
Voltage-dependent anion-selective c...
VDAC1
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti225Y → L in CAB58127 (PubMed:10772903).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L06132 mRNA Translation: AAA61272.1
AJ250032
, AJ250033, AJ250034, AJ250035, AJ250036, AJ250037, AJ250038, AJ250039 Genomic DNA Translation: CAB58127.1
AF151097
, AF151093, AF151094, AF151095, AF151096 Genomic DNA Translation: AAD54939.1
AC005200 Genomic DNA Translation: AAC24723.1
AK122953 mRNA Translation: BAG53816.1
AC008608 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62281.1
CH471062 Genomic DNA Translation: EAW62282.1
CH471062 Genomic DNA Translation: EAW62283.1
CH471062 Genomic DNA Translation: EAW62285.1
CH471062 Genomic DNA Translation: EAW62286.1
BC008482 mRNA Translation: AAH08482.1
BC071168 mRNA Translation: AAH71168.1
BC090042 mRNA Translation: AAH90042.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4168.1

Protein sequence database of the Protein Information Resource

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PIRi
A44422 MMHUP3

NCBI Reference Sequences

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RefSeqi
NP_003365.1, NM_003374.2
XP_005272132.1, XM_005272075.3
XP_016865310.1, XM_017009821.1
XP_016865311.1, XM_017009822.1
XP_016865312.1, XM_017009823.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265333; ENSP00000265333; ENSG00000213585
ENST00000395044; ENSP00000378484; ENSG00000213585
ENST00000395047; ENSP00000378487; ENSG00000213585

Database of genes from NCBI RefSeq genomes

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GeneIDi
7416

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7416

UCSC genome browser

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UCSCi
uc003kyp.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06132 mRNA Translation: AAA61272.1
AJ250032
, AJ250033, AJ250034, AJ250035, AJ250036, AJ250037, AJ250038, AJ250039 Genomic DNA Translation: CAB58127.1
AF151097
, AF151093, AF151094, AF151095, AF151096 Genomic DNA Translation: AAD54939.1
AC005200 Genomic DNA Translation: AAC24723.1
AK122953 mRNA Translation: BAG53816.1
AC008608 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62281.1
CH471062 Genomic DNA Translation: EAW62282.1
CH471062 Genomic DNA Translation: EAW62283.1
CH471062 Genomic DNA Translation: EAW62285.1
CH471062 Genomic DNA Translation: EAW62286.1
BC008482 mRNA Translation: AAH08482.1
BC071168 mRNA Translation: AAH71168.1
BC090042 mRNA Translation: AAH90042.1
CCDSiCCDS4168.1
PIRiA44422 MMHUP3
RefSeqiNP_003365.1, NM_003374.2
XP_005272132.1, XM_005272075.3
XP_016865310.1, XM_017009821.1
XP_016865311.1, XM_017009822.1
XP_016865312.1, XM_017009823.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JK4X-ray4.10A2-283[»]
2K4TNMR-A1-283[»]
5JDPNMR-A2-283[»]
5XDNX-ray3.15A/B1-283[»]
5XDOX-ray3.10A/B1-283[»]
SMRiP21796
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113259, 294 interactors
CORUMiP21796
DIPiDIP-32862N
IntActiP21796, 214 interactors
STRINGi9606.ENSP00000265333

Chemistry databases

DrugBankiDB01375 Aluminium monostearate

PTM databases

CarbonylDBiP21796
iPTMnetiP21796
PhosphoSitePlusiP21796
SwissPalmiP21796

Polymorphism and mutation databases

BioMutaiVDAC1
DMDMi130683

2D gel databases

DOSAC-COBS-2DPAGEiP21796
OGPiP21796
REPRODUCTION-2DPAGEiIPI00216308
P21796
UCD-2DPAGEiP21796

Proteomic databases

EPDiP21796
jPOSTiP21796
MaxQBiP21796
PaxDbiP21796
PeptideAtlasiP21796
PRIDEiP21796
ProteomicsDBi53904
TopDownProteomicsiP21796

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7416
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265333; ENSP00000265333; ENSG00000213585
ENST00000395044; ENSP00000378484; ENSG00000213585
ENST00000395047; ENSP00000378487; ENSG00000213585
GeneIDi7416
KEGGihsa:7416
UCSCiuc003kyp.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7416
DisGeNETi7416

GeneCards: human genes, protein and diseases

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GeneCardsi
VDAC1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0056260
HGNCiHGNC:12669 VDAC1
HPAiCAB005885
CAB072343
HPA030780
MIMi604492 gene+phenotype
neXtProtiNX_P21796
OpenTargetsiENSG00000213585
PharmGKBiPA37292

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3126 Eukaryota
ENOG410ZBK1 LUCA
GeneTreeiENSGT00950000182869
HOGENOMiHOG000188277
InParanoidiP21796
KOiK05862
OMAiKYKWAEH
OrthoDBi938262at2759
PhylomeDBiP21796
TreeFamiTF315091

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-5689880 Ub-specific processing proteases
R-HSA-70268 Pyruvate metabolism
R-HSA-8949215 Mitochondrial calcium ion transport
SIGNORiP21796

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VDAC1 human
EvolutionaryTraceiP21796

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
VDAC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7416

Protein Ontology

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PROi
PR:P21796

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000213585 Expressed in 226 organ(s), highest expression level in biceps brachii
ExpressionAtlasiP21796 baseline and differential
GenevisibleiP21796 HS

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001925 Porin_Euk
IPR027246 Porin_Euk/Tom40
IPR030270 VDAC1
PANTHERiPTHR11743 PTHR11743, 1 hit
PTHR11743:SF13 PTHR11743:SF13, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
PRINTSiPR00185 EUKARYTPORIN
PROSITEiView protein in PROSITE
PS00558 EUKARYOTIC_PORIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVDAC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21796
Secondary accession number(s): B3KVK4
, D3DQ93, Q5FVE7, Q9UIQ5, Q9UPL0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: May 8, 2019
This is version 214 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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