Igfbp4

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functionⁱ

insulin-like growth factor binding
Source: RGD
Traceable author statementⁱ
- 11145587
- 7679899
insulin-like growth factor I binding Source: GO_Central
insulin-like growth factor II binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

inflammatory response
Source: RGD
Inferred from expression patternⁱ
- 11145587
intracellular signal transduction
Source: RGD
Traceable author statementⁱ
- 12193414
positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
positive regulation of MAPK cascade Source: Ensembl
regulation of cell growth Source: Ensembl
regulation of glucose metabolic process Source: Ensembl
regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
type B pancreatic cell proliferation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Enzyme and pathway databases

Reactomeⁱ	R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-RNO-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 4 Short name: IBP-4 Short name: IGF-binding protein 4 Short name: IGFBP-4
Gene namesⁱ	Name:Igfbp4 Synonyms:Igfbp-4
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	2875 Igfbp4

RGDⁱ

2875 Igfbp4

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	1 PublicationAdd BLAST		21
ChainⁱPRO_0000014384	22 – 254	Insulin-like growth factor-binding protein 4Add BLAST		233

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	27 ↔ 53	PROSITE-ProRule annotation
Disulfide bondⁱ	30 ↔ 55	PROSITE-ProRule annotation
Disulfide bondⁱ	38 ↔ 59	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	44 ↔ 56	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	67 ↔ 80	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	74 ↔ 100	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	125	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	131 ↔ 138	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	170 ↔ 200	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	211 ↔ 222	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	224 ↔ 245	PROSITE-ProRule annotation1 Publication
Modified residueⁱ	251	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P21744
PRIDEⁱ	P21744

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000010635 Expressed in 10 organ(s), highest expression level in liver
Genevisibleⁱ	P21744 RN

Interactionⁱ

Subunit structureⁱ

Binds IGF2 more than IGF1.

GO - Molecular functionⁱ

insulin-like growth factor binding
Source: RGD
Traceable author statementⁱ
- 11145587
- 7679899
insulin-like growth factor I binding Source: GO_Central
insulin-like growth factor II binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	262076, 2 interactors
STRINGⁱ	10116.ENSRNOP00000014153

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P21744
SMRⁱ	P21744
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	23 – 103	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		81
Domainⁱ	167 – 245	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		79

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IKZ1 Eukaryota ENOG4111HXV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P21744
OMAⁱ	KGMPCGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EIN
PhylomeDBⁱ	P21744
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022327 IGFBP-4 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF7 PTHR11551:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01980 IGFBPFAMILY4
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P21744-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE 
        60         70         80         90        100
PGCGCCATCA LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC 
       110        120        130        140        150
TELSEIEAIQ ESLQTSDKDE SEHPNNSFNP CSAHDHRCLQ KHMAKVRDRS 
       160        170        180        190        200
KMKVVGTPRE EPRPVPQGSC QSELHRALER LAASQSRTHE DLFIIPIPNC 
       210        220        230        240        250
DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK GELDCHQLAD 

SLQE

Length:254

Mass (Da):27,745

Last modified:August 1, 1991 - v2

Checksum:ⁱ97D37AC98BD0E787

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L08276 Genomic DNA No translation available. AY686592 mRNA Translation: AAT96376.1 BC098750 mRNA Translation: AAH98750.1
PIRⁱ	JC1464
NCBI Reference Sequences More...RefSeqⁱ	NP_001004274.1, NM_001004274.2
UniGeneⁱ	Rn.160666

Genome annotation databases

Ensemblⁱ	ENSRNOT00000014153; ENSRNOP00000014153; ENSRNOG00000010635
GeneIDⁱ	360622
KEGGⁱ	rno:360622
UCSC genome browser More...UCSCⁱ	RGD:2875 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P21744	Insulin-like growth factor-binding protein 4	)	HUMAN		258	UniRef90_P22692
Insulin-like growth factor-binding protein 4		PIG		259
Insulin-like growth factor-binding protein 4		BOVIN		258
Insulin-like growth factor-binding protein 4		MOUSE		254
Insulin-like growth factor-binding protein 4		MACMU		258
+105

Protein	Similar proteins		Species	Score	Length	Source
P21744	Insulin-like growth factor-binding protein 4	)	HUMAN		258	UniRef50_P22692
Insulin-like growth factor-binding protein 4		PIG		259
Insulin-like growth factor-binding protein 4		BOVIN		258
Insulin-like growth factor-binding protein 4		MOUSE		254
Insulin-like growth factor-binding protein 4		MACMU		258
+106

Entry informationⁱ

Entry nameⁱ	IBP4_RAT
Accessionⁱ	P21744Primary (citable) accession number: P21744 Secondary accession number(s): Q68J74
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
	Last sequence update:	August 1, 1991
	Last modified:	September 12, 2018
	This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P21744 (IBP4_RAT)

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Insulin-like growth factor-binding protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ