UniProtKB - P21744 (IBP4_RAT)
Protein
Insulin-like growth factor-binding protein 4
Gene
Igfbp4
Organism
Rattus norvegicus (Rat)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular functioni
- insulin-like growth factor binding Source: RGD
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
GO - Biological processi
- inflammatory response Source: RGD
- intracellular signal transduction Source: RGD
- positive regulation of insulin-like growth factor receptor signaling pathway Source: RGD
- positive regulation of MAPK cascade Source: RGD
- regulation of cell growth Source: RGD
- regulation of glucose metabolic process Source: RGD
- regulation of growth Source: RGD
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
- type B pancreatic cell proliferation Source: RGD
Keywordsi
Molecular function | Growth factor binding |
Enzyme and pathway databases
Reactomei | R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-RNO-8957275, Post-translational protein phosphorylation |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 4Short name: IBP-4 Short name: IGF-binding protein 4 Short name: IGFBP-4 |
Gene namesi | Name:Igfbp4 Synonyms:Igfbp-4 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2875, Igfbp4 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000014384 | 22 – 254 | Insulin-like growth factor-binding protein 4Add BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 53 | PROSITE-ProRule annotation | ||
Disulfide bondi | 30 ↔ 55 | PROSITE-ProRule annotation | ||
Disulfide bondi | 38 ↔ 59 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 44 ↔ 56 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 67 ↔ 80 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 74 ↔ 100 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 131 ↔ 138 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 170 ↔ 200 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 211 ↔ 222 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 224 ↔ 245 | PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 251 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P21744 |
PRIDEi | P21744 |
PTM databases
GlyGeni | P21744, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000010635, Expressed in liver and 21 other tissues |
Genevisiblei | P21744, RN |
Interactioni
Subunit structurei
Binds IGF2 more than IGF1.
GO - Molecular functioni
- insulin-like growth factor binding Source: RGD
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 262076, 2 interactors |
STRINGi | 10116.ENSRNOP00000014153 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 103 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 167 – 245 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 79 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
GeneTreei | ENSGT00940000159647 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P21744 |
OMAi | GLCMELA |
OrthoDBi | 979270at2759 |
PhylomeDBi | P21744 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P21744-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE
60 70 80 90 100
PGCGCCATCA LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC
110 120 130 140 150
TELSEIEAIQ ESLQTSDKDE SEHPNNSFNP CSAHDHRCLQ KHMAKVRDRS
160 170 180 190 200
KMKVVGTPRE EPRPVPQGSC QSELHRALER LAASQSRTHE DLFIIPIPNC
210 220 230 240 250
DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK GELDCHQLAD
SLQE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08276 Genomic DNA No translation available. AY686592 mRNA Translation: AAT96376.1 BC098750 mRNA Translation: AAH98750.1 |
PIRi | JC1464 |
RefSeqi | NP_001004274.1, NM_001004274.2 |
Genome annotation databases
Ensembli | ENSRNOT00000014153; ENSRNOP00000014153; ENSRNOG00000010635 |
GeneIDi | 360622 |
KEGGi | rno:360622 |
UCSCi | RGD:2875, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08276 Genomic DNA No translation available. AY686592 mRNA Translation: AAT96376.1 BC098750 mRNA Translation: AAH98750.1 |
PIRi | JC1464 |
RefSeqi | NP_001004274.1, NM_001004274.2 |
3D structure databases
SMRi | P21744 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 262076, 2 interactors |
STRINGi | 10116.ENSRNOP00000014153 |
Protein family/group databases
MEROPSi | I31.952 |
PTM databases
GlyGeni | P21744, 1 site |
Proteomic databases
PaxDbi | P21744 |
PRIDEi | P21744 |
Genome annotation databases
Ensembli | ENSRNOT00000014153; ENSRNOP00000014153; ENSRNOG00000010635 |
GeneIDi | 360622 |
KEGGi | rno:360622 |
UCSCi | RGD:2875, rat |
Organism-specific databases
CTDi | 3487 |
RGDi | 2875, Igfbp4 |
Phylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
GeneTreei | ENSGT00940000159647 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P21744 |
OMAi | GLCMELA |
OrthoDBi | 979270at2759 |
PhylomeDBi | P21744 |
TreeFami | TF331211 |
Enzyme and pathway databases
Reactomei | R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-RNO-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
PROi | PR:P21744 |
Gene expression databases
Bgeei | ENSRNOG00000010635, Expressed in liver and 21 other tissues |
Genevisiblei | P21744, RN |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP4_RAT | |
Accessioni | P21744Primary (citable) accession number: P21744 Secondary accession number(s): Q68J74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |