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Protein

Insulin-like growth factor-binding protein 1

Gene

Igfbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI31.951

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 1
Short name:
IBP-1
Short name:
IGF-binding protein 1
Short name:
IGFBP-1
Gene namesi
Name:Igfbp1
Synonyms:Igfbp-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2872 Igfbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001436826 – 272Insulin-like growth factor-binding protein 1Add BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi73 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 106PROSITE-ProRule annotation
Modified residuei139PhosphoserineBy similarity1
Modified residuei157PhosphoserineBy similarity1
Modified residuei169PhosphoserineBy similarity1
Modified residuei170PhosphothreonineBy similarity1
Modified residuei171PhosphotyrosineBy similarity1
Disulfide bondi189 ↔ 219PROSITE-ProRule annotation
Disulfide bondi230 ↔ 241PROSITE-ProRule annotation
Disulfide bondi243 ↔ 264PROSITE-ProRule annotation
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP21743
PRIDEiP21743

Expressioni

Gene expression databases

BgeeiENSRNOG00000058780 Expressed in 4 organ(s), highest expression level in liver
GenevisibleiP21743 RN

Interactioni

Subunit structurei

Binds equally well IGF1 and IGF2.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011338

Structurei

3D structure databases

ProteinModelPortaliP21743
SMRiP21743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 109IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST82
Domaini186 – 264Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi259 – 261Cell attachment site3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IITJ Eukaryota
ENOG4111H9A LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP21743
OMAiGLCWCVY
OrthoDBiEOG091G0EIN
PhylomeDBiP21743
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR022322 IGFBP1
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01977 IGFBPFAMILY1
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21743-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEFLTVVSW PFLILLSFQV RVVAGAPQPW HCAPCTAERL ELCPPVPASC
60 70 80 90 100
PEISRPAGCG CCPTCALPLG AACGVATARC AQGLSCRALP GEPRPLHALT
110 120 130 140 150
RGQGACVLEP AAPATSSLSG SQHEEAKAAV ASEDELAESP EMTEEQLLDS
160 170 180 190 200
FHLMAPSRED QPILWNAIST YSSMRAREIT DLKKWKEPCQ RELYKVLERL
210 220 230 240 250
AAAQQKAGDE IYKFYLPNCN KNGFYHSKQC ETSLDGEAGL CWCVYPWSGK
260 270
KIPGSLETRG DPNCHQYFNV QN
Length:272
Mass (Da):29,684
Last modified:June 1, 1994 - v2
Checksum:i12B9F3A42200753D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79R → A (PubMed:1691820).Curated1
Sequence conflicti79R → A (PubMed:7514892).Curated1
Sequence conflicti111 – 112AA → PP (PubMed:1691820).Curated2
Sequence conflicti201A → R in AAA41382 (PubMed:1283442).Curated1
Sequence conflicti265H → N (PubMed:1691820).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58634 mRNA Translation: AAA41380.1
M89791 mRNA Translation: AAA41382.1
L22979 Genomic DNA Translation: AAA82581.1
BC078889 mRNA Translation: AAH78889.1
PIRiA36082
RefSeqiNP_037276.1, NM_013144.1
UniGeneiRn.34026

Genome annotation databases

EnsembliENSRNOT00000077177; ENSRNOP00000069247; ENSRNOG00000058780
GeneIDi25685
KEGGirno:25685
UCSCiRGD:2872 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58634 mRNA Translation: AAA41380.1
M89791 mRNA Translation: AAA41382.1
L22979 Genomic DNA Translation: AAA82581.1
BC078889 mRNA Translation: AAH78889.1
PIRiA36082
RefSeqiNP_037276.1, NM_013144.1
UniGeneiRn.34026

3D structure databases

ProteinModelPortaliP21743
SMRiP21743
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011338

Protein family/group databases

MEROPSiI31.951

Proteomic databases

PaxDbiP21743
PRIDEiP21743

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077177; ENSRNOP00000069247; ENSRNOG00000058780
GeneIDi25685
KEGGirno:25685
UCSCiRGD:2872 rat

Organism-specific databases

CTDi3484
RGDi2872 Igfbp1

Phylogenomic databases

eggNOGiENOG410IITJ Eukaryota
ENOG4111H9A LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP21743
OMAiGLCWCVY
OrthoDBiEOG091G0EIN
PhylomeDBiP21743
TreeFamiTF331211

Enzyme and pathway databases

ReactomeiR-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Miscellaneous databases

PROiPR:P21743

Gene expression databases

BgeeiENSRNOG00000058780 Expressed in 4 organ(s), highest expression level in liver
GenevisibleiP21743 RN

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR022322 IGFBP1
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01977 IGFBPFAMILY1
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP1_RAT
AccessioniPrimary (citable) accession number: P21743
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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