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Entry version 184 (17 Jun 2020)
Sequence version 1 (01 May 1991)
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Protein

Midkine

Gene

MDK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity).By similarity11 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei103Required for high affinity binding to PTRZ1 by interacting with the chondroitin sulfate chains of PTRZ1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P21741

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P21741

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Midkine1 Publication
Short name:
MK1 Publication
Alternative name(s):
Amphiregulin-associated protein1 Publication
Short name:
ARAP1 Publication
Midgestation and kidney protein
Neurite outgrowth-promoting factor 2
Neurite outgrowth-promoting protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MDKImported
Synonyms:MK1, NEGF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110492.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6972 MDK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
162096 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21741

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4192

Open Targets

More...
OpenTargetsi
ENSG00000110492

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30717

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P21741 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1949490

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MDK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
127116

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 203 PublicationsAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002466221 – 143MidkineAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 61
Disulfide bondi45 ↔ 70
Disulfide bondi52 ↔ 74
Disulfide bondi84 ↔ 116
Disulfide bondi94 ↔ 126

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P21741

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P21741

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P21741

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P21741

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21741

PeptideAtlas

More...
PeptideAtlasi
P21741

PRoteomics IDEntifications database

More...
PRIDEi
P21741

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53896 [P21741-1]
61338

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21741

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21741

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By heparin and retinoic acid.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110492 Expressed in adenohypophysis and 90 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P21741 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21741 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000110492 Tissue enhanced (ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with ALK (PubMed:12122009).

Interacts with LRP1; promotes neuronal survival (PubMed:10772929).

Interacts with LRP2 (PubMed:10772929).

Interacts with NCAM1 (PubMed:10772929).

Interacts (via C-terminal) with PTPRZ1 (via chondroitin sulfate chains); this interaction is inhibited by PTN; this interaction promotes neuronal migration (PubMed:10212223).

Interacts with NCL; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization (PubMed:12147681).

Interacts with LRP6 and LRP8: this interaction is calcium dependent (PubMed:12573468).

Interacts with ITGA4 (PubMed:15466886).

Interacts with ITGA6 (PubMed:15466886).

Interacts with ITGB1 (PubMed:15466886).

Interacts with ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886).

Interacts with ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886).

Interacts with NOTCH2; this interaction mediates a nuclear accumulation of NOTCH2 and therefore activation of NOTCH2 signaling leading to interaction between HES1 and STAT3 (PubMed:18469519).

Interacts with GPC2 (via heparan sulfate chain); this interaction is inhibited by heparin followed by chondroitin sulfate E; this interaction induces GPC2 clustering through heparan sulfate chain; this interaction induces neuronal cell adhesion and neurite outgrowth (PubMed:12084985).

Interacts with SDC3; this interaction induces SDC3 clustering; this interaction induces neuronal cell adhesion and neurite outgrowth (PubMed:12084985).

Interacts with SDC1 (By similarity).

Interacts with CSPG5; this interaction promotes elongation of oligodendroglial precursor-like cells (By similarity).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110357, 48 interactors

Database of interacting proteins

More...
DIPi
DIP-5789N

Protein interaction database and analysis system

More...
IntActi
P21741, 45 interactors

Molecular INTeraction database

More...
MINTi
P21741

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000385451

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21741

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P21741 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1143
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P21741

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P21741

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pleiotrophin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0E8 Eukaryota
ENOG4111ZWP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007640

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_136864_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21741

KEGG Orthology (KO)

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KOi
K06828

Database of Orthologous Groups

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OrthoDBi
1489280at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21741

TreeFam database of animal gene trees

More...
TreeFami
TF332376

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.60.10, 1 hit
2.30.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000762 Midkine_heparin-bd_GF
IPR020090 PTN/MK_C_dom
IPR038130 PTN/MK_C_dom_sf
IPR020091 PTN/MK_diS_sf
IPR020089 PTN/MK_N_dom
IPR037122 PTN/MK_N_dom_sf
IPR020092 PTN_MK_heparin-bd_GF_CS

The PANTHER Classification System

More...
PANTHERi
PTHR13850 PTHR13850, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01091 PTN_MK_C, 1 hit
PF05196 PTN_MK_N, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00269 PTNMIDKINE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00193 PTN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57288 SSF57288, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00619 PTN_MK_1, 1 hit
PS00620 PTN_MK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P21741-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK
60 70 80 90 100
DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT
110 120 130 140
KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD
Length:143
Mass (Da):15,585
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i414A627FF39953C3
GO
Isoform 2 (identifier: P21741-2) [UniParc]FASTAAdd to basket
Also known as: tMKA

The sequence of this isoform differs from the canonical sequence as follows:
     26-81: Missing.

Note: Found in cancer tissues with expression in the tumor bodies and surrounding normal cells.Curated
Show »
Length:87
Mass (Da):9,512
Checksum:i555280233CBB0AC6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXB6A0A087WXB6_HUMAN
Midkine
MDK
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLM6E9PLM6_HUMAN
Midkine
MDK
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPJ5E9PPJ5_HUMAN
Midkine
MDK
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHA4C9JHA4_HUMAN
Midkine
MDK
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00635321 – 22Missing in 35% of the chains. 2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04745226 – 81Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M69148 mRNA Translation: AAA58478.1
X55110 mRNA Translation: CAA38908.1
D10604 Genomic DNA Translation: BAA01457.1
M94250 Genomic DNA Translation: AAA59850.1
DQ323888 mRNA Translation: ABC55425.1
AC116021 Genomic DNA No translation available.
BC011704 mRNA Translation: AAH11704.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS59226.1 [P21741-2]
CCDS7919.1 [P21741-1]

Protein sequence database of the Protein Information Resource

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PIRi
JH0385

NCBI Reference Sequences

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RefSeqi
NP_001012333.1, NM_001012333.2 [P21741-1]
NP_001012334.1, NM_001012334.2 [P21741-1]
NP_001257479.1, NM_001270550.1 [P21741-1]
NP_001257480.1, NM_001270551.1 [P21741-1]
NP_001257481.1, NM_001270552.1 [P21741-2]
NP_002382.1, NM_002391.4 [P21741-1]
XP_011518418.1, XM_011520116.2 [P21741-1]
XP_016873253.1, XM_017017764.1 [P21741-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000359803; ENSP00000352852; ENSG00000110492 [P21741-1]
ENST00000395565; ENSP00000378932; ENSG00000110492 [P21741-1]
ENST00000395566; ENSP00000378933; ENSG00000110492 [P21741-1]
ENST00000395569; ENSP00000378936; ENSG00000110492 [P21741-2]
ENST00000405308; ENSP00000385451; ENSG00000110492 [P21741-1]
ENST00000407067; ENSP00000384034; ENSG00000110492 [P21741-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4192

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4192

UCSC genome browser

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UCSCi
uc001nco.5 human [P21741-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69148 mRNA Translation: AAA58478.1
X55110 mRNA Translation: CAA38908.1
D10604 Genomic DNA Translation: BAA01457.1
M94250 Genomic DNA Translation: AAA59850.1
DQ323888 mRNA Translation: ABC55425.1
AC116021 Genomic DNA No translation available.
BC011704 mRNA Translation: AAH11704.1
CCDSiCCDS59226.1 [P21741-2]
CCDS7919.1 [P21741-1]
PIRiJH0385
RefSeqiNP_001012333.1, NM_001012333.2 [P21741-1]
NP_001012334.1, NM_001012334.2 [P21741-1]
NP_001257479.1, NM_001270550.1 [P21741-1]
NP_001257480.1, NM_001270551.1 [P21741-1]
NP_001257481.1, NM_001270552.1 [P21741-2]
NP_002382.1, NM_002391.4 [P21741-1]
XP_011518418.1, XM_011520116.2 [P21741-1]
XP_016873253.1, XM_017017764.1 [P21741-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MKCNMR-A84-126[»]
1MKNNMR-A23-81[»]
SMRiP21741
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110357, 48 interactors
DIPiDIP-5789N
IntActiP21741, 45 interactors
MINTiP21741
STRINGi9606.ENSP00000385451

Chemistry databases

BindingDBiP21741
ChEMBLiCHEMBL1949490

PTM databases

iPTMnetiP21741
PhosphoSitePlusiP21741

Polymorphism and mutation databases

BioMutaiMDK
DMDMi127116

Proteomic databases

EPDiP21741
jPOSTiP21741
MassIVEiP21741
MaxQBiP21741
PaxDbiP21741
PeptideAtlasiP21741
PRIDEiP21741
ProteomicsDBi53896 [P21741-1]
61338

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P21741 1 sequenced antibody

Antibodypedia a portal for validated antibodies

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Antibodypediai
4105 551 antibodies

The DNASU plasmid repository

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DNASUi
4192

Genome annotation databases

EnsembliENST00000359803; ENSP00000352852; ENSG00000110492 [P21741-1]
ENST00000395565; ENSP00000378932; ENSG00000110492 [P21741-1]
ENST00000395566; ENSP00000378933; ENSG00000110492 [P21741-1]
ENST00000395569; ENSP00000378936; ENSG00000110492 [P21741-2]
ENST00000405308; ENSP00000385451; ENSG00000110492 [P21741-1]
ENST00000407067; ENSP00000384034; ENSG00000110492 [P21741-1]
GeneIDi4192
KEGGihsa:4192
UCSCiuc001nco.5 human [P21741-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4192
DisGeNETi4192
EuPathDBiHostDB:ENSG00000110492.15

GeneCards: human genes, protein and diseases

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GeneCardsi
MDK
HGNCiHGNC:6972 MDK
HPAiENSG00000110492 Tissue enhanced (ovary)
MIMi162096 gene
neXtProtiNX_P21741
OpenTargetsiENSG00000110492
PharmGKBiPA30717

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0E8 Eukaryota
ENOG4111ZWP LUCA
GeneTreeiENSGT00390000007640
HOGENOMiCLU_136864_0_0_1
InParanoidiP21741
KOiK06828
OrthoDBi1489280at2759
PhylomeDBiP21741
TreeFamiTF332376

Enzyme and pathway databases

ReactomeiR-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
SignaLinkiP21741
SIGNORiP21741

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
4192 6 hits in 793 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MDK human
EvolutionaryTraceiP21741

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Midkine

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4192
PharosiP21741 Tchem

Protein Ontology

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PROi
PR:P21741
RNActiP21741 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110492 Expressed in adenohypophysis and 90 other tissues
ExpressionAtlasiP21741 baseline and differential
GenevisibleiP21741 HS

Family and domain databases

Gene3Di2.20.60.10, 1 hit
2.30.90.10, 1 hit
InterProiView protein in InterPro
IPR000762 Midkine_heparin-bd_GF
IPR020090 PTN/MK_C_dom
IPR038130 PTN/MK_C_dom_sf
IPR020091 PTN/MK_diS_sf
IPR020089 PTN/MK_N_dom
IPR037122 PTN/MK_N_dom_sf
IPR020092 PTN_MK_heparin-bd_GF_CS
PANTHERiPTHR13850 PTHR13850, 1 hit
PfamiView protein in Pfam
PF01091 PTN_MK_C, 1 hit
PF05196 PTN_MK_N, 1 hit
PRINTSiPR00269 PTNMIDKINE
SMARTiView protein in SMART
SM00193 PTN, 1 hit
SUPFAMiSSF57288 SSF57288, 2 hits
PROSITEiView protein in PROSITE
PS00619 PTN_MK_1, 1 hit
PS00620 PTN_MK_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21741
Secondary accession number(s): Q2LEK4, Q9UCC7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 17, 2020
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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