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Entry version 185 (13 Feb 2019)
Sequence version 2 (02 Nov 2010)
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Protein

C5a anaphylatoxin chemotactic receptor 1

Gene

C5AR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • complement component C5a binding Source: Ensembl
  • complement component C5a receptor activity Source: UniProtKB
  • G protein-coupled receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
R-HSA-977606 Regulation of Complement cascade

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P21730

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P21730

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 1
Alternative name(s):
C5a anaphylatoxin chemotactic receptor
Short name:
C5a-R
Short name:
C5aR
CD_antigen: CD88
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C5AR1
Synonyms:C5AR, C5R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197405.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1338 C5AR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
113995 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21730

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 37Extracellular1 PublicationAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 64Helical; Name=11 PublicationAdd BLAST27
Topological domaini65 – 69Cytoplasmic1 Publication5
Transmembranei70 – 93Helical; Name=21 PublicationAdd BLAST24
Topological domaini94 – 110Extracellular1 PublicationAdd BLAST17
Transmembranei111 – 132Helical; Name=31 PublicationAdd BLAST22
Topological domaini133 – 153Cytoplasmic1 PublicationAdd BLAST21
Transmembranei154 – 174Helical; Name=41 PublicationAdd BLAST21
Topological domaini175 – 200Extracellular1 PublicationAdd BLAST26
Transmembranei201 – 226Helical; Name=51 PublicationAdd BLAST26
Topological domaini227 – 242Cytoplasmic1 PublicationAdd BLAST16
Transmembranei243 – 265Helical; Name=61 PublicationAdd BLAST23
Topological domaini266 – 282Extracellular1 PublicationAdd BLAST17
Transmembranei283 – 303Helical; Name=71 PublicationAdd BLAST21
Topological domaini304 – 350Cytoplasmic1 PublicationAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2 – 30Missing : Strongly impairs C5a binding (45,000-fold). 1 PublicationAdd BLAST29
Mutagenesisi2 – 22Missing : Impairs C5a binding. Strongly impairs C5a binding; when associated with A-27. 1 PublicationAdd BLAST21
Mutagenesisi10D → A: Strongly impairs C5a binding; when associated with A-15; A-16; A-18 and A-21 (PubMed:8182049). Moderately impairs CHIPS binding (PubMed:15542591). Strongly impairs CHIPS binding; when associated with A-15 (PubMed:15542591). Strongly impairs CHIPS binding; when associated with A-18 (PubMed:15542591). 2 Publications1
Mutagenesisi11Y → F: Weakly impairs CHIPS binding. Loss of CHIPS binding; when associated with F-14. 1 Publication1
Mutagenesisi12G → A: Moderately impairs CHIPS binding. 1 Publication1
Mutagenesisi14Y → F: Weakly impairs CHIPS binding (PubMed:15542591). Strongly impairs CHIPS binding (PubMed:21706042). Loss of CHIPS binding; when associated with F-11 (PubMed:21706042). 2 Publications1
Mutagenesisi15D → A: Strongly impairs C5a binding; when associated with A-10; A-16; A-18 and A-21 (PubMed:8182049). Moderately impairs CHIPS binding (PubMed:15542591). Strongly impairs CHIPS binding; when associated with A-10 (PubMed:15542591). Strongly impairs CHIPS binding; when associated with A-18 (PubMed:15542591). 2 Publications1
Mutagenesisi16D → A: Strongly impairs C5a binding; when associated with A-10; A-15; A-18 and A-21. 1 Publication1
Mutagenesisi18D → A: Strongly impairs C5a binding; when associated with A-10; A-15; A-16 and A-21 (PubMed:8182049). Impairs CHIPS binding (PubMed:15542591). Strongly impairs CHIPS binding; when associated with A-10 (PubMed:15542591). Strongly impairs CHIPS binding; when associated with A-15 (PubMed:15542591). 2 Publications1
Mutagenesisi21D → A: Strongly impairs C5a binding; when associated with A-10; A-15; A-16 and A-18. 1 Publication1
Mutagenesisi27D → A: Strongly impairs C5a binding; when associated with 2-D--L-22 Del. 1 Publication1
Mutagenesisi144C → S: Fails to homodimerize. 1 Publication1
Mutagenesisi157C → S: No effect on homodimer formation. 1 Publication1
Mutagenesisi199E → Q: Impairs C5a binding (10-fold reduction) and C5a-induced 5-HT secretion. 1 Publication1
Mutagenesisi221C → S: No effect on homodimer formation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
728

Open Targets

More...
OpenTargetsi
ENSG00000197405

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25920

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2373

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
32

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C5AR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033355

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000692091 – 350C5a anaphylatoxin chemotactic receptor 1Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11Sulfotyrosine1 Publication1
Modified residuei14Sulfotyrosine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi109 ↔ 188PROSITE-ProRule annotationCombined sources1 Publication
Modified residuei314Phosphoserine1 Publication1
Modified residuei317Phosphoserine2 Publications1
Modified residuei327Phosphoserine2 Publications1
Modified residuei332Phosphoserine2 Publications1
Modified residuei334Phosphoserine2 Publications1
Modified residuei338Phosphoserine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042).1 Publication1 Publication
Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand. The key residues involved in this process are Ser-334 and Ser-338.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P21730

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21730

PeptideAtlas

More...
PeptideAtlasi
P21730

PRoteomics IDEntifications database

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PRIDEi
P21730

ProteomicsDB human proteome resource

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ProteomicsDBi
53893

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21730

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21730

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197405 Expressed in 166 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P21730 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21730 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002720
HPA014520

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. May also form higher-order oligomers (PubMed:12835319). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR (PubMed:12464600). Interacts (via N-terminal domain) with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response (PubMed:15153520, PubMed:15542591, PubMed:21706042).1 Publication5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107189, 5 interactors

Protein interaction database and analysis system

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IntActi
P21730, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347197

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21730

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5O9HX-ray2.70A/B31-333[»]
6C1QX-ray2.90B30-331[»]
6C1RX-ray2.20B30-331[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P21730

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21730

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni10 – 18Required for CHIPS binding1 Publication9
Regioni21 – 30Involved in C5a binding1 Publication10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IF0K Eukaryota
ENOG410Y9HH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153397

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234122

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107547

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P21730

KEGG Orthology (KO)

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KOi
K04010

Identification of Orthologs from Complete Genome Data

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OMAi
NPIWCQN

Database of Orthologous Groups

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OrthoDBi
156081at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P21730

TreeFam database of animal gene trees

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TreeFami
TF330976

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001274 Anaphtx_C5AR1/C5AR2
IPR002234 Anphylx_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

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PANTHERi
PTHR24225 PTHR24225, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01104 ANPHYLATOXNR
PR00426 C5ANPHYLTXNR
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P21730-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSFNYTTPD YGHYDDKDTL DLNTPVDKTS NTLRVPDILA LVIFAVVFLV
60 70 80 90 100
GVLGNALVVW VTAFEAKRTI NAIWFLNLAV ADFLSCLALP ILFTSIVQHH
110 120 130 140 150
HWPFGGAACS ILPSLILLNM YASILLLATI SADRFLLVFK PIWCQNFRGA
160 170 180 190 200
GLAWIACAVA WGLALLLTIP SFLYRVVREE YFPPKVLCGV DYSHDKRRER
210 220 230 240 250
AVAIVRLVLG FLWPLLTLTI CYTFILLRTW SRRATRSTKT LKVVVAVVAS
260 270 280 290 300
FFIFWLPYQV TGIMMSFLEP SSPTFLLLKK LDSLCVSFAY INCCINPIIY
310 320 330 340 350
VVAGQGFQGR LRKSLPSLLR NVLTEESVVR ESKSFTRSTV DTMAQKTQAV
Length:350
Mass (Da):39,336
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9334BB39A2C96D3D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZK7M0QZK7_HUMAN
C5a anaphylatoxin chemotactic recep...
C5AR1
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0493772D → N6 PublicationsCorresponds to variant dbSNP:rs4467185Ensembl.1
Natural variantiVAR_049378279K → N5 PublicationsCorresponds to variant dbSNP:rs11880097Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M62505 mRNA Translation: AAA62831.1
X57250 mRNA Translation: CAA40530.1
X58674 Genomic DNA Translation: CAB37830.1
AY221091 Genomic DNA Translation: AAO65969.1
BT007358 mRNA Translation: AAP36022.1
AC099491 Genomic DNA No translation available.
BC008982 mRNA Translation: AAH08982.1
S56556, S56557 Genomic DNA Translation: AAD14919.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33063.1

Protein sequence database of the Protein Information Resource

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PIRi
A37963

NCBI Reference Sequences

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RefSeqi
NP_001727.1, NM_001736.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.2161

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355085; ENSP00000347197; ENSG00000197405

Database of genes from NCBI RefSeq genomes

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GeneIDi
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KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:728

UCSC genome browser

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UCSCi
uc002pgj.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62505 mRNA Translation: AAA62831.1
X57250 mRNA Translation: CAA40530.1
X58674 Genomic DNA Translation: CAB37830.1
AY221091 Genomic DNA Translation: AAO65969.1
BT007358 mRNA Translation: AAP36022.1
AC099491 Genomic DNA No translation available.
BC008982 mRNA Translation: AAH08982.1
S56556, S56557 Genomic DNA Translation: AAD14919.1
CCDSiCCDS33063.1
PIRiA37963
RefSeqiNP_001727.1, NM_001736.3
UniGeneiHs.2161

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5O9HX-ray2.70A/B31-333[»]
6C1QX-ray2.90B30-331[»]
6C1RX-ray2.20B30-331[»]
ProteinModelPortaliP21730
SMRiP21730
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107189, 5 interactors
IntActiP21730, 1 interactor
STRINGi9606.ENSP00000347197

Chemistry databases

BindingDBiP21730
ChEMBLiCHEMBL2373
GuidetoPHARMACOLOGYi32

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiP21730
PhosphoSitePlusiP21730

Polymorphism and mutation databases

BioMutaiC5AR1
DMDMi311033355

Proteomic databases

jPOSTiP21730
PaxDbiP21730
PeptideAtlasiP21730
PRIDEiP21730
ProteomicsDBi53893

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
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Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355085; ENSP00000347197; ENSG00000197405
GeneIDi728
KEGGihsa:728
UCSCiuc002pgj.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
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DisGeNETi728
EuPathDBiHostDB:ENSG00000197405.7

GeneCards: human genes, protein and diseases

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GeneCardsi
C5AR1
HGNCiHGNC:1338 C5AR1
HPAiCAB002720
HPA014520
MIMi113995 gene
neXtProtiNX_P21730
OpenTargetsiENSG00000197405
PharmGKBiPA25920

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IF0K Eukaryota
ENOG410Y9HH LUCA
GeneTreeiENSGT00940000153397
HOGENOMiHOG000234122
HOVERGENiHBG107547
InParanoidiP21730
KOiK04010
OMAiNPIWCQN
OrthoDBi156081at2759
PhylomeDBiP21730
TreeFamiTF330976

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
R-HSA-977606 Regulation of Complement cascade
SignaLinkiP21730
SIGNORiP21730

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
C5AR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C5a_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
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Protein Ontology

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PROi
PR:P21730

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000197405 Expressed in 166 organ(s), highest expression level in blood
ExpressionAtlasiP21730 baseline and differential
GenevisibleiP21730 HS

Family and domain databases

InterProiView protein in InterPro
IPR001274 Anaphtx_C5AR1/C5AR2
IPR002234 Anphylx_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01104 ANPHYLATOXNR
PR00426 C5ANPHYLTXNR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC5AR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21730
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 2, 2010
Last modified: February 13, 2019
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  8. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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