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Protein

D(1A) dopamine receptor

Gene

DRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • dopamine binding Source: BHF-UCL
  • dopamine neurotransmitter receptor activity Source: MGI
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390651 Dopamine receptors
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:DRD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000184845.3
HGNCiHGNC:3020 DRD1
MIMi126449 gene
neXtProtiNX_P21728

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 49Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini50 – 60CytoplasmicSequence analysisAdd BLAST11
Transmembranei61 – 87Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini88 – 96ExtracellularSequence analysis9
Transmembranei97 – 119Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 163Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini164 – 192ExtracellularSequence analysisAdd BLAST29
Transmembranei193 – 218Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini219 – 272CytoplasmicSequence analysisAdd BLAST54
Transmembranei273 – 299Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini300 – 312ExtracellularSequence analysisAdd BLAST13
Transmembranei313 – 337Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini338 – 446CytoplasmicSequence analysisAdd BLAST109

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1812
OpenTargetsiENSG00000184845
PharmGKBiPA147

Chemistry databases

ChEMBLiCHEMBL2056
DrugBankiDB01614 Acepromazine
DB01063 Acetophenazine
DB00543 Amoxapine
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01038 Carphenazine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00363 Clozapine
DB00988 Dopamine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB00800 Fenoldopam
DB00875 Flupentixol
DB00623 Fluphenazine
DB00502 Haloperidol
DB04946 Iloperidone
DB00458 Imipramine
DB05816 intranasal apomorphine
DB01235 Levodopa
DB00589 Lisuride
DB00408 Loxapine
DB01403 Methotrimeprazine
DB00353 Methylergometrine
DB06148 Mianserin
DB00805 Minaprine
DB00370 Mirtazapine
DB00334 Olanzapine
DB01267 Paliperidone
DB01186 Pergolide
DB00850 Perphenazine
DB00397 Phenylpropanolamine
DB01621 Pipotiazine
DB00413 Pramipexole
DB00420 Promazine
DB01608 Propericiazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB05271 Rotigotine
DB00372 Thiethylperazine
DB01622 Thioproperazine
DB00679 Thioridazine
DB01623 Thiothixene
DB00508 Triflupromazine
DB00726 Trimipramine
DB00246 Ziprasidone
DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYi214

Polymorphism and mutation databases

BioMutaiDRD1
DMDMi118228

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693731 – 446D(1A) dopamine receptorAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 186PROSITE-ProRule annotation
Lipidationi347S-palmitoyl cysteine1 Publication1
Lipidationi351S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21728
PRIDEiP21728
ProteomicsDBi53892

PTM databases

iPTMnetiP21728
PhosphoSitePlusiP21728
SwissPalmiP21728

Expressioni

Tissue specificityi

Detected in caudate, nucleus accumbens and in the olfactory tubercle.1 Publication

Gene expression databases

BgeeiENSG00000184845 Expressed in 76 organ(s), highest expression level in caudate nucleus
CleanExiHS_DRD1
GenevisibleiP21728 HS

Organism-specific databases

HPAiHPA013393

Interactioni

Subunit structurei

Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.By similarity

Protein-protein interaction databases

BioGridi108146, 9 interactors
STRINGi9606.ENSP00000327652

Chemistry databases

BindingDBiP21728

Structurei

3D structure databases

ProteinModelPortaliP21728
SMRiP21728
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP21728
KOiK04144
OMAiSLNRMYA
OrthoDBiEOG091G06VI
PhylomeDBiP21728
TreeFamiTF325181

Family and domain databases

InterProiView protein in InterPro
IPR001413 Dopamine_D1_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR43893:SF10 PTHR43893:SF10, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00565 DOPAMINED1AR
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P21728-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR
60 70 80 90 100
FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV
110 120 130 140 150
AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL
160 170 180 190 200
SVLISFIPVQ LSWHKAKPTS PSDGNATSLA ETIDNCDSSL SRTYAISSSV
210 220 230 240 250
ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN CQTTTGNGKP
260 270 280 290 300
VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS
310 320 330 340 350
GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL
360 370 380 390 400
CPATNNAIET VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED
410 420 430 440
LKKEEAAGIA RPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT
Length:446
Mass (Da):49,293
Last modified:May 1, 1991 - v1
Checksum:i64E062D765D0DBA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti438I → M in CAA41734 (PubMed:2168520).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01467037T → P. Corresponds to variant dbSNP:rs5327Ensembl.1
Natural variantiVAR_01467137T → R. Corresponds to variant dbSNP:rs5327Ensembl.1
Natural variantiVAR_01467250R → S. Corresponds to variant dbSNP:rs5330Ensembl.1
Natural variantiVAR_06457781K → R1 Publication1
Natural variantiVAR_014673199S → A. Corresponds to variant dbSNP:rs5331Ensembl.1
Natural variantiVAR_064578259S → Y1 PublicationCorresponds to variant dbSNP:rs74414188Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55760 Genomic DNA Translation: CAA39286.1
X58987 mRNA Translation: CAA41734.1
X55758 Genomic DNA Translation: CAA39284.1
S58541 Genomic DNA Translation: AAB26273.1
AB065677 Genomic DNA Translation: BAC05902.1
AF498961 mRNA Translation: AAM18131.1
AK314031 mRNA Translation: BAG36741.1
CH471062 Genomic DNA Translation: EAW61377.1
BC074978 mRNA Translation: AAH74978.1
BC074979 mRNA Translation: AAH74979.1
BC096837 mRNA Translation: AAH96837.1
CCDSiCCDS4393.1
PIRiS11377 DYHUD1
RefSeqiNP_000785.1, NM_000794.3
UniGeneiHs.2624

Genome annotation databases

EnsembliENST00000393752; ENSP00000377353; ENSG00000184845
GeneIDi1812
KEGGihsa:1812
UCSCiuc003mcz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55760 Genomic DNA Translation: CAA39286.1
X58987 mRNA Translation: CAA41734.1
X55758 Genomic DNA Translation: CAA39284.1
S58541 Genomic DNA Translation: AAB26273.1
AB065677 Genomic DNA Translation: BAC05902.1
AF498961 mRNA Translation: AAM18131.1
AK314031 mRNA Translation: BAG36741.1
CH471062 Genomic DNA Translation: EAW61377.1
BC074978 mRNA Translation: AAH74978.1
BC074979 mRNA Translation: AAH74979.1
BC096837 mRNA Translation: AAH96837.1
CCDSiCCDS4393.1
PIRiS11377 DYHUD1
RefSeqiNP_000785.1, NM_000794.3
UniGeneiHs.2624

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OZ5model-A1-446[»]
ProteinModelPortaliP21728
SMRiP21728
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108146, 9 interactors
STRINGi9606.ENSP00000327652

Chemistry databases

BindingDBiP21728
ChEMBLiCHEMBL2056
DrugBankiDB01614 Acepromazine
DB01063 Acetophenazine
DB00543 Amoxapine
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01038 Carphenazine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00363 Clozapine
DB00988 Dopamine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB00800 Fenoldopam
DB00875 Flupentixol
DB00623 Fluphenazine
DB00502 Haloperidol
DB04946 Iloperidone
DB00458 Imipramine
DB05816 intranasal apomorphine
DB01235 Levodopa
DB00589 Lisuride
DB00408 Loxapine
DB01403 Methotrimeprazine
DB00353 Methylergometrine
DB06148 Mianserin
DB00805 Minaprine
DB00370 Mirtazapine
DB00334 Olanzapine
DB01267 Paliperidone
DB01186 Pergolide
DB00850 Perphenazine
DB00397 Phenylpropanolamine
DB01621 Pipotiazine
DB00413 Pramipexole
DB00420 Promazine
DB01608 Propericiazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB05271 Rotigotine
DB00372 Thiethylperazine
DB01622 Thioproperazine
DB00679 Thioridazine
DB01623 Thiothixene
DB00508 Triflupromazine
DB00726 Trimipramine
DB00246 Ziprasidone
DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYi214

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP21728
PhosphoSitePlusiP21728
SwissPalmiP21728

Polymorphism and mutation databases

BioMutaiDRD1
DMDMi118228

Proteomic databases

PaxDbiP21728
PRIDEiP21728
ProteomicsDBi53892

Protocols and materials databases

DNASUi1812
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393752; ENSP00000377353; ENSG00000184845
GeneIDi1812
KEGGihsa:1812
UCSCiuc003mcz.4 human

Organism-specific databases

CTDi1812
DisGeNETi1812
EuPathDBiHostDB:ENSG00000184845.3
GeneCardsiDRD1
HGNCiHGNC:3020 DRD1
HPAiHPA013393
MIMi126449 gene
neXtProtiNX_P21728
OpenTargetsiENSG00000184845
PharmGKBiPA147
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP21728
KOiK04144
OMAiSLNRMYA
OrthoDBiEOG091G06VI
PhylomeDBiP21728
TreeFamiTF325181

Enzyme and pathway databases

ReactomeiR-HSA-390651 Dopamine receptors
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiiDopamine_receptor_D1
GenomeRNAii1812
PROiPR:P21728
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184845 Expressed in 76 organ(s), highest expression level in caudate nucleus
CleanExiHS_DRD1
GenevisibleiP21728 HS

Family and domain databases

InterProiView protein in InterPro
IPR001413 Dopamine_D1_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR43893:SF10 PTHR43893:SF10, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00565 DOPAMINED1AR
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRD1_HUMAN
AccessioniPrimary (citable) accession number: P21728
Secondary accession number(s): B2RA44, Q4QRJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 10, 2018
This is version 191 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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