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Entry version 195 (13 Feb 2019)
Sequence version 1 (01 May 1991)
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Protein

D(1A) dopamine receptor

Gene

DRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dopamine binding Source: BHF-UCL
  • dopamine neurotransmitter receptor activity Source: MGI
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: BHF-UCL
  • G-protein alpha-subunit binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390651 Dopamine receptors
R-HSA-418555 G alpha (s) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DRD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184845.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3020 DRD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
126449 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21728

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 49Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini50 – 60CytoplasmicSequence analysisAdd BLAST11
Transmembranei61 – 87Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini88 – 96ExtracellularSequence analysis9
Transmembranei97 – 119Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 163Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini164 – 192ExtracellularSequence analysisAdd BLAST29
Transmembranei193 – 218Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini219 – 272CytoplasmicSequence analysisAdd BLAST54
Transmembranei273 – 299Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini300 – 312ExtracellularSequence analysisAdd BLAST13
Transmembranei313 – 337Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini338 – 446CytoplasmicSequence analysisAdd BLAST109

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1812

Open Targets

More...
OpenTargetsi
ENSG00000184845

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA147

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2056

Drug and drug target database

More...
DrugBanki
DB01614 Acepromazine
DB01063 Acetophenazine
DB00543 Amoxapine
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01038 Carphenazine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00363 Clozapine
DB00988 Dopamine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB00800 Fenoldopam
DB00875 Flupentixol
DB00623 Fluphenazine
DB00502 Haloperidol
DB04946 Iloperidone
DB00458 Imipramine
DB05816 intranasal apomorphine
DB01235 Levodopa
DB00589 Lisuride
DB00408 Loxapine
DB01403 Methotrimeprazine
DB00353 Methylergometrine
DB06148 Mianserin
DB00805 Minaprine
DB00370 Mirtazapine
DB00334 Olanzapine
DB01267 Paliperidone
DB01186 Pergolide
DB00850 Perphenazine
DB00397 Phenylpropanolamine
DB01621 Pipotiazine
DB00413 Pramipexole
DB00420 Promazine
DB01608 Propericiazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB05271 Rotigotine
DB00372 Thiethylperazine
DB01622 Thioproperazine
DB00679 Thioridazine
DB01623 Thiothixene
DB00508 Triflupromazine
DB00726 Trimipramine
DB00246 Ziprasidone
DB01624 Zuclopenthixol

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
214

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DRD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118228

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000693731 – 446D(1A) dopamine receptorAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi96 ↔ 186PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi347S-palmitoyl cysteine1 Publication1
Lipidationi351S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21728

PRoteomics IDEntifications database

More...
PRIDEi
P21728

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53892

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21728

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21728

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P21728

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in caudate, nucleus accumbens and in the olfactory tubercle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184845 Expressed in 76 organ(s), highest expression level in caudate nucleus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21728 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013393

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108146, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327652

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21728

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OZ5model-A1-446[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P21728

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21728

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155857

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239242

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106962

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21728

KEGG Orthology (KO)

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KOi
K04144

Identification of Orthologs from Complete Genome Data

More...
OMAi
SLNRMYA

Database of Orthologous Groups

More...
OrthoDBi
536204at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21728

TreeFam database of animal gene trees

More...
TreeFami
TF325181

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001413 Dopamine_D1_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...
PANTHERi
PTHR43893:SF10 PTHR43893:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00565 DOPAMINED1AR
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21728-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR
60 70 80 90 100
FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV
110 120 130 140 150
AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL
160 170 180 190 200
SVLISFIPVQ LSWHKAKPTS PSDGNATSLA ETIDNCDSSL SRTYAISSSV
210 220 230 240 250
ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN CQTTTGNGKP
260 270 280 290 300
VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS
310 320 330 340 350
GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL
360 370 380 390 400
CPATNNAIET VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED
410 420 430 440
LKKEEAAGIA RPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT
Length:446
Mass (Da):49,293
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64E062D765D0DBA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti438I → M in CAA41734 (PubMed:2168520).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01467037T → P. Corresponds to variant dbSNP:rs5327Ensembl.1
Natural variantiVAR_01467137T → R. Corresponds to variant dbSNP:rs5327Ensembl.1
Natural variantiVAR_01467250R → S. Corresponds to variant dbSNP:rs5330Ensembl.1
Natural variantiVAR_06457781K → R1 Publication1
Natural variantiVAR_014673199S → A. Corresponds to variant dbSNP:rs5331Ensembl.1
Natural variantiVAR_064578259S → Y1 PublicationCorresponds to variant dbSNP:rs74414188Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X55760 Genomic DNA Translation: CAA39286.1
X58987 mRNA Translation: CAA41734.1
X55758 Genomic DNA Translation: CAA39284.1
S58541 Genomic DNA Translation: AAB26273.1
AB065677 Genomic DNA Translation: BAC05902.1
AF498961 mRNA Translation: AAM18131.1
AK314031 mRNA Translation: BAG36741.1
CH471062 Genomic DNA Translation: EAW61377.1
BC074978 mRNA Translation: AAH74978.1
BC074979 mRNA Translation: AAH74979.1
BC096837 mRNA Translation: AAH96837.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4393.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S11377 DYHUD1

NCBI Reference Sequences

More...
RefSeqi
NP_000785.1, NM_000794.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2624

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393752; ENSP00000377353; ENSG00000184845

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1812

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1812

UCSC genome browser

More...
UCSCi
uc003mcz.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55760 Genomic DNA Translation: CAA39286.1
X58987 mRNA Translation: CAA41734.1
X55758 Genomic DNA Translation: CAA39284.1
S58541 Genomic DNA Translation: AAB26273.1
AB065677 Genomic DNA Translation: BAC05902.1
AF498961 mRNA Translation: AAM18131.1
AK314031 mRNA Translation: BAG36741.1
CH471062 Genomic DNA Translation: EAW61377.1
BC074978 mRNA Translation: AAH74978.1
BC074979 mRNA Translation: AAH74979.1
BC096837 mRNA Translation: AAH96837.1
CCDSiCCDS4393.1
PIRiS11377 DYHUD1
RefSeqiNP_000785.1, NM_000794.3
UniGeneiHs.2624

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OZ5model-A1-446[»]
ProteinModelPortaliP21728
SMRiP21728
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108146, 9 interactors
STRINGi9606.ENSP00000327652

Chemistry databases

BindingDBiP21728
ChEMBLiCHEMBL2056
DrugBankiDB01614 Acepromazine
DB01063 Acetophenazine
DB00543 Amoxapine
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01038 Carphenazine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00363 Clozapine
DB00988 Dopamine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB00800 Fenoldopam
DB00875 Flupentixol
DB00623 Fluphenazine
DB00502 Haloperidol
DB04946 Iloperidone
DB00458 Imipramine
DB05816 intranasal apomorphine
DB01235 Levodopa
DB00589 Lisuride
DB00408 Loxapine
DB01403 Methotrimeprazine
DB00353 Methylergometrine
DB06148 Mianserin
DB00805 Minaprine
DB00370 Mirtazapine
DB00334 Olanzapine
DB01267 Paliperidone
DB01186 Pergolide
DB00850 Perphenazine
DB00397 Phenylpropanolamine
DB01621 Pipotiazine
DB00413 Pramipexole
DB00420 Promazine
DB01608 Propericiazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB05271 Rotigotine
DB00372 Thiethylperazine
DB01622 Thioproperazine
DB00679 Thioridazine
DB01623 Thiothixene
DB00508 Triflupromazine
DB00726 Trimipramine
DB00246 Ziprasidone
DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYi214

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiP21728
PhosphoSitePlusiP21728
SwissPalmiP21728

Polymorphism and mutation databases

BioMutaiDRD1
DMDMi118228

Proteomic databases

PaxDbiP21728
PRIDEiP21728
ProteomicsDBi53892

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1812
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393752; ENSP00000377353; ENSG00000184845
GeneIDi1812
KEGGihsa:1812
UCSCiuc003mcz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1812
DisGeNETi1812
EuPathDBiHostDB:ENSG00000184845.3

GeneCards: human genes, protein and diseases

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GeneCardsi
DRD1
HGNCiHGNC:3020 DRD1
HPAiHPA013393
MIMi126449 gene
neXtProtiNX_P21728
OpenTargetsiENSG00000184845
PharmGKBiPA147

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000155857
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP21728
KOiK04144
OMAiSLNRMYA
OrthoDBi536204at2759
PhylomeDBiP21728
TreeFamiTF325181

Enzyme and pathway databases

ReactomeiR-HSA-390651 Dopamine receptors
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Dopamine_receptor_D1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1812

Protein Ontology

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PROi
PR:P21728

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000184845 Expressed in 76 organ(s), highest expression level in caudate nucleus
GenevisibleiP21728 HS

Family and domain databases

InterProiView protein in InterPro
IPR001413 Dopamine_D1_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR43893:SF10 PTHR43893:SF10, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00565 DOPAMINED1AR
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21728
Secondary accession number(s): B2RA44, Q4QRJ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: February 13, 2019
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
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