UniProtKB - P21709 (EPHA1_HUMAN)
Ephrin type-A receptor 1
EPHA1
Functioni
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 656 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 749 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 630 – 638 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- transmembrane-ephrin receptor activity Source: UniProtKB
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- activation of GTPase activity Source: UniProtKB
- angiogenesis Source: UniProtKB-KW
- axon guidance Source: GO_Central
- cell surface receptor signaling pathway Source: UniProtKB
- ephrin receptor signaling pathway Source: Reactome
- multicellular organism development Source: GO_Central
- negative regulation of cell migration Source: UniProtKB
- negative regulation of protein kinase activity Source: UniProtKB
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of cell-matrix adhesion Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of kinase activity Source: GO_Central
- positive regulation of stress fiber assembly Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- regulation of GTPase activity Source: UniProtKB
- somatic stem cell population maintenance Source: Reactome
- substrate adhesion-dependent cell spreading Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Angiogenesis, Cell adhesion |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 2681 |
PathwayCommonsi | P21709 |
Reactomei | R-HSA-2682334, EPH-Ephrin signaling R-HSA-2892247, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-3928665, EPH-ephrin mediated repulsion of cells |
SignaLinki | P21709 |
SIGNORi | P21709 |
Names & Taxonomyi
Protein namesi | Recommended name: Ephrin type-A receptor 1 (EC:2.7.10.1)Short name: hEpha1 Alternative name(s): EPH tyrosine kinase EPH tyrosine kinase 1 Erythropoietin-producing hepatoma receptor Tyrosine-protein kinase receptor EPH |
Gene namesi | Name:EPHA1 Synonyms:EPH, EPHT, EPHT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000146904.8 |
HGNCi | HGNC:3385, EPHA1 |
MIMi | 179610, gene |
neXtProti | NX_P21709 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- neuron projection Source: GO_Central
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 547 | ExtracellularSequence analysisAdd BLAST | 522 | |
Transmembranei | 548 – 568 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 569 – 976 | CytoplasmicSequence analysisAdd BLAST | 408 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2041 |
OpenTargetsi | ENSG00000146904 |
PharmGKBi | PA27817 |
Miscellaneous databases
Pharosi | P21709, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5810 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P21709 |
GuidetoPHARMACOLOGYi | 1821 |
Polymorphism and mutation databases
BioMutai | EPHA1 |
DMDMi | 317373566 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000016798 | 26 – 976 | Ephrin type-A receptor 1Add BLAST | 951 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 414 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 599 | Phosphotyrosine; by autocatalysisSequence analysis | 1 | |
Modified residuei | 605 | Phosphotyrosine; by autocatalysisSequence analysis | 1 | |
Modified residuei | 781 | Phosphotyrosine; by autocatalysisSequence analysis | 1 | |
Modified residuei | 906 | PhosphoserineCombined sources | 1 | |
Modified residuei | 910 | PhosphoserineCombined sources | 1 | |
Modified residuei | 930 | Phosphotyrosine; by autocatalysisSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-2782 |
EPDi | P21709 |
jPOSTi | P21709 |
MassIVEi | P21709 |
MaxQBi | P21709 |
PaxDbi | P21709 |
PeptideAtlasi | P21709 |
PRIDEi | P21709 |
ProteomicsDBi | 53891 [P21709-1] |
PTM databases
GlyGeni | P21709, 1 site |
iPTMneti | P21709 |
PhosphoSitePlusi | P21709 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000146904, Expressed in lower esophagus mucosa and 142 other tissues |
Genevisiblei | P21709, HS |
Organism-specific databases
HPAi | ENSG00000146904, Tissue enhanced (parathyroid) |
Interactioni
Subunit structurei
Homodimer.
Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration.
Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1.
Interacts (kinase activity-dependent) with PTK2/FAK1.
2 PublicationsGO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108355, 97 interactors |
CORUMi | P21709 |
DIPi | DIP-34886N |
IntActi | P21709, 119 interactors |
MINTi | P21709 |
STRINGi | 9606.ENSP00000275815 |
Chemistry databases
BindingDBi | P21709 |
Miscellaneous databases
RNActi | P21709, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P21709 |
SMRi | P21709 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P21709 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 209 | Eph LBDPROSITE-ProRule annotationAdd BLAST | 183 | |
Domaini | 332 – 445 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 114 | |
Domaini | 447 – 538 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 624 – 884 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 261 | |
Domaini | 913 – 976 | SAMPROSITE-ProRule annotationAdd BLAST | 64 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 974 – 976 | PDZ-bindingSequence analysis | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 191 – 329 | Cys-richAdd BLAST | 139 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000160920 |
HOGENOMi | CLU_000288_141_0_1 |
InParanoidi | P21709 |
OMAi | YQRCPEA |
OrthoDBi | 933071at2759 |
PhylomeDBi | P21709 |
TreeFami | TF315363 |
Family and domain databases
CDDi | cd10479, EphR_LBD_A1, 1 hit cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR034251, EphA1_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM01411, Ephrin_rec_like, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERRWPLGLG LVLLLCAPLP PGARAKEVTL MDTSKAQGEL GWLLDPPKDG
60 70 80 90 100
WSEQQQILNG TPLYMYQDCP MQGRRDTDHW LRSNWIYRGE EASRVHVELQ
110 120 130 140 150
FTVRDCKSFP GGAGPLGCKE TFNLLYMESD QDVGIQLRRP LFQKVTTVAA
160 170 180 190 200
DQSFTIRDLV SGSVKLNVER CSLGRLTRRG LYLAFHNPGA CVALVSVRVF
210 220 230 240 250
YQRCPETLNG LAQFPDTLPG PAGLVEVAGT CLPHARASPR PSGAPRMHCS
260 270 280 290 300
PDGEWLVPVG RCHCEPGYEE GGSGEACVAC PSGSYRMDMD TPHCLTCPQQ
310 320 330 340 350
STAESEGATI CTCESGHYRA PGEGPQVACT GPPSAPRNLS FSASGTQLSL
360 370 380 390 400
RWEPPADTGG RQDVRYSVRC SQCQGTAQDG GPCQPCGVGV HFSPGARGLT
410 420 430 440 450
TPAVHVNGLE PYANYTFNVE AQNGVSGLGS SGHASTSVSI SMGHAESLSG
460 470 480 490 500
LSLRLVKKEP RQLELTWAGS RPRSPGANLT YELHVLNQDE ERYQMVLEPR
510 520 530 540 550
VLLTELQPDT TYIVRVRMLT PLGPGPFSPD HEFRTSPPVS RGLTGGEIVA
560 570 580 590 600
VIFGLLLGAA LLLGILVFRS RRAQRQRQQR QRDRATDVDR EDKLWLKPYV
610 620 630 640 650
DLQAYEDPAQ GALDFTRELD PAWLMVDTVI GEGEFGEVYR GTLRLPSQDC
660 670 680 690 700
KTVAIKTLKD TSPGGQWWNF LREATIMGQF SHPHILHLEG VVTKRKPIMI
710 720 730 740 750
ITEFMENGAL DAFLREREDQ LVPGQLVAML QGIASGMNYL SNHNYVHRDL
760 770 780 790 800
AARNILVNQN LCCKVSDFGL TRLLDDFDGT YETQGGKIPI RWTAPEAIAH
810 820 830 840 850
RIFTTASDVW SFGIVMWEVL SFGDKPYGEM SNQEVMKSIE DGYRLPPPVD
860 870 880 890 900
CPAPLYELMK NCWAYDRARR PHFQKLQAHL EQLLANPHSL RTIANFDPRM
910 920 930 940 950
TLRLPSLSGS DGIPYRTVSE WLESIRMKRY ILHFHSAGLD TMECVLELTA
960 970
EDLTQMGITL PGHQKRILCS IQGFKD
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 398 | G → A in AAD43440 (PubMed:10369740).Curated | 1 | |
Sequence conflicti | 398 | G → A in CAA81796 (Ref. 8) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028265 | 160 | V → A6 PublicationsCorresponds to variant dbSNP:rs4725617Ensembl. | 1 | |
Natural variantiVAR_042115 | 351 | R → C1 PublicationCorresponds to variant dbSNP:rs56006153Ensembl. | 1 | |
Natural variantiVAR_028266 | 492 | R → Q1 PublicationCorresponds to variant dbSNP:rs11768549Ensembl. | 1 | |
Natural variantiVAR_042116 | 575 | R → Q1 PublicationCorresponds to variant dbSNP:rs35719334Ensembl. | 1 | |
Natural variantiVAR_042117 | 585 | A → T1 PublicationCorresponds to variant dbSNP:rs34178823Ensembl. | 1 | |
Natural variantiVAR_042118 | 697 | P → L1 PublicationCorresponds to variant dbSNP:rs34372369Ensembl. | 1 | |
Natural variantiVAR_042119 | 703 | E → K in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042120 | 807 | S → R1 PublicationCorresponds to variant dbSNP:rs56244405Ensembl. | 1 | |
Natural variantiVAR_028267 | 900 | M → VCombined sources7 PublicationsCorresponds to variant dbSNP:rs6967117Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056010 | 446 – 490 | ESLSG…LNQDE → DPTLSLWTPRVTVRPVSETG EERTEATRADLGGVPAPKPW GEPDL in isoform 2. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_056011 | 446 – 474 | ESLSG…SRPRS → GERLRGAGTGTWWRQKGLRP QNKLMGRKP in isoform 3. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_056012 | 475 – 976 | Missing in isoform 3. 1 PublicationAdd BLAST | 502 | |
Alternative sequenceiVSP_056013 | 491 – 976 | Missing in isoform 2. 1 PublicationAdd BLAST | 486 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M18391 mRNA Translation: AAA36747.1 Frameshift. AF101171 , AF101165, AF101166, AF101167, AF101168, AF101169, AF101170 Genomic DNA Translation: AAD43440.1 EU826604 mRNA Translation: ACF47640.1 EU826605 mRNA Translation: ACF47641.1 AC092214 Genomic DNA Translation: AAS07458.1 CH236959 Genomic DNA Translation: EAL23789.1 CH471198 Genomic DNA Translation: EAW51846.1 CH471198 Genomic DNA Translation: EAW51847.1 BC130291 mRNA Translation: AAI30292.1 Z27409 mRNA Translation: CAA81796.1 |
CCDSi | CCDS5884.1 [P21709-1] |
PIRi | A34076 |
RefSeqi | NP_005223.4, NM_005232.4 [P21709-1] |
Genome annotation databases
Ensembli | ENST00000275815; ENSP00000275815; ENSG00000146904 [P21709-1] ENST00000645847; ENSP00000494931; ENSG00000284816 [P21709-1] |
GeneIDi | 2041 |
KEGGi | hsa:2041 |
UCSCi | uc003wcz.3, human [P21709-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M18391 mRNA Translation: AAA36747.1 Frameshift. AF101171 , AF101165, AF101166, AF101167, AF101168, AF101169, AF101170 Genomic DNA Translation: AAD43440.1 EU826604 mRNA Translation: ACF47640.1 EU826605 mRNA Translation: ACF47641.1 AC092214 Genomic DNA Translation: AAS07458.1 CH236959 Genomic DNA Translation: EAL23789.1 CH471198 Genomic DNA Translation: EAW51846.1 CH471198 Genomic DNA Translation: EAW51847.1 BC130291 mRNA Translation: AAI30292.1 Z27409 mRNA Translation: CAA81796.1 |
CCDSi | CCDS5884.1 [P21709-1] |
PIRi | A34076 |
RefSeqi | NP_005223.4, NM_005232.4 [P21709-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K1K | NMR | - | A/B | 536-573 | [»] | |
2K1L | NMR | - | A/B | 536-573 | [»] | |
3HIL | X-ray | 2.00 | A/B | 911-974 | [»] | |
3KKA | X-ray | 2.40 | A/B | 911-974 | [»] | |
BMRBi | P21709 | |||||
SMRi | P21709 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108355, 97 interactors |
CORUMi | P21709 |
DIPi | DIP-34886N |
IntActi | P21709, 119 interactors |
MINTi | P21709 |
STRINGi | 9606.ENSP00000275815 |
Chemistry databases
BindingDBi | P21709 |
ChEMBLi | CHEMBL5810 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P21709 |
GuidetoPHARMACOLOGYi | 1821 |
PTM databases
GlyGeni | P21709, 1 site |
iPTMneti | P21709 |
PhosphoSitePlusi | P21709 |
Polymorphism and mutation databases
BioMutai | EPHA1 |
DMDMi | 317373566 |
Proteomic databases
CPTACi | CPTAC-2782 |
EPDi | P21709 |
jPOSTi | P21709 |
MassIVEi | P21709 |
MaxQBi | P21709 |
PaxDbi | P21709 |
PeptideAtlasi | P21709 |
PRIDEi | P21709 |
ProteomicsDBi | 53891 [P21709-1] |
Protocols and materials databases
Antibodypediai | 32658, 571 antibodies |
DNASUi | 2041 |
Genome annotation databases
Ensembli | ENST00000275815; ENSP00000275815; ENSG00000146904 [P21709-1] ENST00000645847; ENSP00000494931; ENSG00000284816 [P21709-1] |
GeneIDi | 2041 |
KEGGi | hsa:2041 |
UCSCi | uc003wcz.3, human [P21709-1] |
Organism-specific databases
CTDi | 2041 |
DisGeNETi | 2041 |
EuPathDBi | HostDB:ENSG00000146904.8 |
GeneCardsi | EPHA1 |
HGNCi | HGNC:3385, EPHA1 |
HPAi | ENSG00000146904, Tissue enhanced (parathyroid) |
MIMi | 179610, gene |
neXtProti | NX_P21709 |
OpenTargetsi | ENSG00000146904 |
PharmGKBi | PA27817 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000160920 |
HOGENOMi | CLU_000288_141_0_1 |
InParanoidi | P21709 |
OMAi | YQRCPEA |
OrthoDBi | 933071at2759 |
PhylomeDBi | P21709 |
TreeFami | TF315363 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 2681 |
PathwayCommonsi | P21709 |
Reactomei | R-HSA-2682334, EPH-Ephrin signaling R-HSA-2892247, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-3928665, EPH-ephrin mediated repulsion of cells |
SignaLinki | P21709 |
SIGNORi | P21709 |
Miscellaneous databases
BioGRID-ORCSi | 2041, 4 hits in 875 CRISPR screens |
ChiTaRSi | EPHA1, human |
EvolutionaryTracei | P21709 |
GeneWikii | EPH_receptor_A1 |
GenomeRNAii | 2041 |
Pharosi | P21709, Tchem |
PROi | PR:P21709 |
RNActi | P21709, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000146904, Expressed in lower esophagus mucosa and 142 other tissues |
Genevisiblei | P21709, HS |
Family and domain databases
CDDi | cd10479, EphR_LBD_A1, 1 hit cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR034251, EphA1_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM01411, Ephrin_rec_like, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EPHA1_HUMAN | |
Accessioni | P21709Primary (citable) accession number: P21709 Secondary accession number(s): A1L3V3 Q15405 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 218 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index